Chemokines and cancer.

PubWeight™: 2.75‹?› | Rank: Top 1%

🔗 View Article (PMID 16671092)

Published in Int J Cancer on November 01, 2006

Authors

Albert Zlotnik1

Author Affiliations

1: Department of Discovery Biology, Neurocrine Biosciences, San Diego, CA, USA. azlotnik@neurocrine.com

Articles citing this

(truncated to the top 100)

Role of chemokines in tumor growth. Cancer Lett (2007) 3.36

Breast cancer: origins and evolution. J Clin Invest (2007) 3.31

Regulation of CXCR4 signaling. Biochim Biophys Acta (2006) 3.16

Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12. Sci Signal (2008) 2.33

Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiology. Prog Neurobiol (2007) 2.18

Why cancer and inflammation? Yale J Biol Med (2006) 2.13

Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model. J Clin Invest (2010) 1.96

CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration. J Biol Chem (2011) 1.78

Cancer-associated fibroblasts and their putative role in potentiating the initiation and development of epithelial ovarian cancer. Neoplasia (2011) 1.56

Chemokines: novel targets for breast cancer metastasis. Cancer Metastasis Rev (2007) 1.49

Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis. J Exp Clin Cancer Res (2010) 1.44

Slit-2 induces a tumor-suppressive effect by regulating beta-catenin in breast cancer cells. J Biol Chem (2008) 1.38

AMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome. J Cell Mol Med (2011) 1.14

CXCR4 inhibition with AMD3100 sensitizes prostate cancer to docetaxel chemotherapy. Neoplasia (2012) 1.12

Low-dose paclitaxel prior to intratumoral dendritic cell vaccine modulates intratumoral cytokine network and lung cancer growth. Clin Cancer Res (2007) 1.12

Chemokine receptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications. Ann Oncol (2009) 1.12

Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J Transl Med (2012) 1.09

Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4. Mol Cancer (2011) 1.08

Engineering lymph node homing of ex vivo-expanded human natural killer cells via trogocytosis of the chemokine receptor CCR7. Blood (2012) 1.07

Roles of inflammatory cytokines in the progression of gastric cancer: friends or foes? Gastric Cancer (2010) 1.06

Down-regulation of CXCL12 mRNA expression by promoter hypermethylation and its association with metastatic progression in human breast carcinomas. J Cancer Res Clin Oncol (2008) 1.05

CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation. Cell Prolif (2011) 1.03

Role of eotaxin-1 signaling in ovarian cancer. Clin Cancer Res (2009) 1.01

Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma. AIDS Res Treat (2010) 1.01

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity. Oncotarget (2014) 1.00

CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis. PLoS One (2010) 1.00

CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. PLoS One (2014) 0.99

A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis. Mol Cancer (2010) 0.97

The CXCR4/CXCL12 axis in endometrial cancer. Clin Exp Metastasis (2009) 0.97

The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility. Clin Exp Immunol (2007) 0.97

Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer. J Exp Clin Cancer Res (2008) 0.97

CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment. Front Cell Neurosci (2014) 0.96

Staphylococcal superantigen-like 10 inhibits CXCL12-induced human tumor cell migration. Neoplasia (2009) 0.94

Novel anti-metastatic action of cidofovir mediated by inhibition of E6/E7, CXCR4 and Rho/ROCK signaling in HPV tumor cells. PLoS One (2009) 0.94

Dynamic regulation of ROCK in tumor cells controls CXCR4-driven adhesion events. J Cell Sci (2010) 0.93

Site-specific metastasis formation: chemokines as regulators of tumor cell adhesion, motility and invasion. Cell Adh Migr (2009) 0.92

Perineural growth in head and neck squamous cell carcinoma: a review. Oral Oncol (2014) 0.92

Molecular characterization of the tumor-suppressive function of nischarin in breast cancer. J Natl Cancer Inst (2011) 0.92

Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck (SCCHN) cell lines. Radiat Environ Biophys (2010) 0.92

PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells. Mol Cancer (2010) 0.91

Overexpression of HIF-2α, TWIST, and CXCR4 is associated with lymph node metastasis in papillary thyroid carcinoma. Clin Dev Immunol (2013) 0.91

Chemokine receptor CXCR4 as a therapeutic target for neuroectodermal tumors. Semin Cancer Biol (2008) 0.90

Cysteinyl leukotrienes and their receptors: bridging inflammation and colorectal cancer. World J Gastroenterol (2014) 0.90

Molecular signatures of metastasis in head and neck cancer. Head Neck (2008) 0.89

Chemokines and chemokine receptors: update on utility and challenges for the clinician. Surgery (2014) 0.89

Inhibition of tumor growth and histopathological changes following treatment with a chemokine receptor CXCR4 antagonist in a prostate cancer xenograft model. Oncol Lett (2013) 0.89

CXCR4/CXCL12 expression profile is associated with tumor microenvironment and clinical outcome of liver metastases of colorectal cancer. Clin Exp Metastasis (2011) 0.88

Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium. Oncogene (2012) 0.87

Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma. J Immunother (2015) 0.87

Dietary fiber is associated with circulating concentrations of C-reactive protein in breast cancer survivors: the HEAL study. Breast Cancer Res Treat (2011) 0.87

PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA. J Cell Sci (2013) 0.86

Chemokine receptor CXCR4 is a novel marker for the progression of cutaneous malignant melanomas. Acta Histochem Cytochem (2012) 0.86

Benzenesulfonamides: a unique class of chemokine receptor type 4 inhibitors. ChemMedChem (2013) 0.85

Downregulation of the CXCR4 receptor inhibits cervical carcinoma metastatic behavior in vitro and in vivo. Int J Oncol (2014) 0.85

Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. Mol Cancer (2013) 0.85

CXCR4 in Cancer and Its Regulation by PPARgamma. PPAR Res (2008) 0.85

Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma. Mamm Genome (2007) 0.84

An essential role of the cytoplasmic tail of CXCR4 in G-protein signaling and organogenesis. PLoS One (2010) 0.84

Platelet-activating factor enhances tumour metastasis via the reactive oxygen species-dependent protein kinase casein kinase 2-mediated nuclear factor-κB activation. Immunology (2014) 0.84

CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis. Oncotarget (2015) 0.84

Microbial-based therapy of cancer: current progress and future prospects. Bioeng Bugs (2009) 0.83

Diagnostic significance of serum eotaxin-1 level in gastric cancer patients. Dis Markers (2013) 0.83

Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling. Cancer Res (2015) 0.82

Prognostic molecular biomarkers for cutaneous malignant melanoma. J Surg Oncol (2011) 0.82

The Activity of CCL18 is Principally Mediated through Interaction with Glycosaminoglycans. Front Immunol (2013) 0.82

Epigenetic silencing of CXCR4 promotes loss of cell adhesion in cervical cancer. Biomed Res Int (2014) 0.81

Modulation of Chemokine Responses: Synergy and Cooperativity. Front Immunol (2016) 0.81

Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists. PLoS One (2013) 0.81

Targeting the CCL2-CCR2 signaling axis in cancer metastasis. Oncotarget (2016) 0.81

Inhibition of formyl peptide receptor in high-grade astrocytoma by CHemotaxis Inhibitory Protein of S. aureus. Br J Cancer (2013) 0.80

Immunohistochemical analysis of CXCR4 expression in fibrohistiocytic tumors. Acta Histochem Cytochem (2010) 0.79

CC chemokine receptor 5: the interface of host immunity and cancer. Dis Markers (2014) 0.79

Expression of chemokine receptor CCR7 is a negative prognostic factor for patients with gastric cancer: a meta-analysis. Gastric Cancer (2016) 0.79

Protective effect of eotaxin-2 inhibition in adjuvant-induced arthritis. Clin Exp Immunol (2010) 0.79

The role of chemokines in migration of metastatic-like lymphangioleiomyomatosis cells. Crit Rev Immunol (2010) 0.79

Inhibition of chemokine receptor expression on uveal melanomas by CXCR4 siRNA and its effect on uveal melanoma liver metastases. Invest Ophthalmol Vis Sci (2009) 0.79

Local and transient gene expression primes the liver to resist cancer metastasis. Sci Transl Med (2016) 0.79

Effect of genetic variants in two chemokine decoy receptor genes, DARC and CCBP2, on metastatic potential of breast cancer. PLoS One (2013) 0.78

CXC and CC chemokines as angiogenic modulators in nonhaematological tumors. Biomed Res Int (2014) 0.78

CCL2/CCR2 axis is associated with postoperative survival and recurrence of patients with non-metastatic clear-cell renal cell carcinoma. Oncotarget (2016) 0.78

Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity. Environ Health Perspect (2016) 0.78

Crosstalk between CCL7 and CCR3 promotes metastasis of colon cancer cells via ERK-JNK signaling pathways. Oncotarget (2016) 0.78

Epigenetic regulation of CXCR4 expression by the ocular microenvironment. Invest Ophthalmol Vis Sci (2013) 0.78

Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer. Endocrinol Metab (Seoul) (2016) 0.78

Expression of the chemokine CCL28 in pleomorphic adenoma and adenolymphoma of the human salivary glands. Exp Ther Med (2012) 0.77

Atypical chemokine receptor D6 inhibits human non-small cell lung cancer growth by sequestration of chemokines. Oncol Lett (2013) 0.77

Transcriptional regulation of chemokine expression in ovarian cancer. Biomolecules (2015) 0.77

Brain metastases from colorectal cancer: risk factors, incidence, and the possible role of chemokines. Clin Colorectal Cancer (2009) 0.77

Photo-activation of the hydrophobic probe iodonaphthylazide in cells alters membrane protein function leading to cell death. BMC Cell Biol (2009) 0.77

The expression of Duffy antigen receptor for chemokines by epithelial ovarian cancer decreases growth potential. Oncol Lett (2017) 0.76

The Role of Vascular Endothelial Growth Factor Receptor-1 Signaling in the Recovery from Ischemia. PLoS One (2015) 0.76

CXC chemokine receptor 4 expression, CXC chemokine receptor 4 activation, and wild-type nucleophosmin are independently associated with unfavorable prognosis in patients with acute myeloid leukemia. Clin Lymphoma Myeloma Leuk (2013) 0.76

Teleost Chemokines and Their Receptors. Biology (Basel) (2015) 0.76

Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues. Oncol Lett (2016) 0.76

Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System. Int J Endocrinol (2014) 0.75

The Effects of Tamoxifen in Combination with Tranilast on CXCL12-CXCR4 Axis and Invasion in Breast Cancer Cell Lines. Iran J Pharm Res (2014) 0.75

CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses. Sci Rep (2017) 0.75

Biological and Structural Characterization of Rotamers of C-C Chemokine Receptor Type 5 (CCR5) Inhibitor GSK214096. ACS Med Chem Lett (2014) 0.75

The SDF-1α3'A genetic variation is correlated with susceptibility of asthma in Iranian patients. Biomed Res Int (2013) 0.75

Increases in serum TARC/CCL17 levels are associated with progression-free survival in advanced melanoma patients in response to dendritic cell-based immunotherapy. J Clin Immunol (2009) 0.75