| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.
|
Mol Cancer Ther
|
2005
|
2.15
|
|
2
|
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.
|
J Med Chem
|
2007
|
1.06
|
|
3
|
Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors.
|
Bioorg Med Chem
|
2006
|
0.99
|
|
4
|
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
|
Bioorg Med Chem Lett
|
2006
|
0.82
|
|
5
|
Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation.
|
Bioorg Med Chem Lett
|
2006
|
0.79
|
|
6
|
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
|
Bioorg Med Chem Lett
|
2004
|
0.78
|
|
7
|
Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase.
|
Bioorg Med Chem Lett
|
2006
|
0.77
|
|
8
|
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.
|
Bioorg Med Chem Lett
|
2005
|
0.77
|
|
9
|
Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists.
|
Bioorg Med Chem Lett
|
2011
|
0.75
|
|
10
|
Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
|
Bioorg Med Chem Lett
|
2003
|
0.75
|
|
11
|
Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.
|
Bioorg Med Chem Lett
|
2004
|
0.75
|
|
12
|
[The study of risk factors of nasal septal perforation in rats].
|
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
|
2012
|
0.75
|