Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
|
J Med Chem
|
2007
|
2.09
|
2
|
Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins.
|
J Med Chem
|
2008
|
1.85
|
3
|
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
|
J Med Chem
|
2015
|
1.22
|
4
|
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.
|
J Med Chem
|
2007
|
1.06
|
5
|
The 2beta2-2beta3 loop of anthrax protective antigen contains a dominant neutralizing epitope.
|
Biochem Biophys Res Commun
|
2006
|
1.02
|
6
|
Implication of the Akt2/survivin pathway as a critical target in paclitaxel treatment in human ovarian cancer cells.
|
Cancer Lett
|
2008
|
0.98
|
7
|
Does topical application of adrenaline on nasal mucosa induce significant haemodynamic changes under general anaesthesia?
|
Eur J Anaesthesiol
|
2009
|
0.91
|
8
|
Heat shock proteins and p53 play a critical role in K+ channel-mediated tumor cell proliferation and apoptosis.
|
Apoptosis
|
2007
|
0.90
|
9
|
Effect of tumor suppressor gene PTEN on the resistance to cisplatin in human ovarian cancer cell lines and related mechanisms.
|
Cancer Lett
|
2008
|
0.89
|
10
|
Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).
|
J Med Chem
|
2006
|
0.89
|
11
|
N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
|
Bioorg Med Chem Lett
|
2010
|
0.86
|
12
|
Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins.
|
Virol J
|
2012
|
0.83
|
13
|
Chimeric hepatitis B virus core particles carrying an epitope of anthrax protective antigen induce protective immunity against Bacillus anthracis.
|
Vaccine
|
2008
|
0.82
|
14
|
Single nucleotide polymorphisms in thymic stromal lymphopoietin gene are not associated with allergic rhinitis susceptibility in Chinese subjects.
|
BMC Med Genet
|
2012
|
0.82
|
15
|
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
|
Bioorg Med Chem Lett
|
2006
|
0.82
|
16
|
Reversal of the malignant phenotype of ovarian cancer A2780 cells through transfection with wild-type PTEN gene.
|
Cancer Lett
|
2008
|
0.82
|
17
|
Regulation of circadian gene expression in the kidney by light and food cues in rats.
|
Am J Physiol Regul Integr Comp Physiol
|
2010
|
0.82
|
18
|
Fibronectin-mediated activation of Akt2 protects human ovarian and breast cancer cells from docetaxel-induced apoptosis via inhibition of the p38 pathway.
|
Apoptosis
|
2008
|
0.81
|
19
|
Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities.
|
Fitoterapia
|
2010
|
0.81
|
20
|
Olfactory bulb axonal outgrowth is inhibited by draxin.
|
Biochem Biophys Res Commun
|
2010
|
0.80
|
21
|
Intramuscular delivery of adenovirus serotype 5 vector expressing humanized protective antigen induces rapid protection against anthrax that may bypass intranasally originated preexisting adenovirus immunity.
|
Clin Vaccine Immunol
|
2013
|
0.80
|
22
|
Fusion protein of Delta 27LFn and EFn has the potential as a novel anthrax toxin inhibitor.
|
FEBS Lett
|
2009
|
0.79
|
23
|
Phase-dependent above-barrier ionization of excited-state electrons.
|
Opt Express
|
2012
|
0.78
|
24
|
Molecular photoelectron holography with circularly polarized laser pulses.
|
Opt Express
|
2014
|
0.78
|
25
|
Quantum path interferences of electron trajectories in two-center molecules.
|
Opt Express
|
2010
|
0.78
|
26
|
Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase.
|
Bioorg Med Chem Lett
|
2006
|
0.77
|
27
|
Inhibition of Akt signaling by SN-38 induces apoptosis in cervical cancer.
|
Cancer Lett
|
2008
|
0.77
|
28
|
Enterovirus 71 inhibits cellular type I interferon signaling by downregulating JAK1 protein expression.
|
Viral Immunol
|
2014
|
0.77
|
29
|
Study on the pharmacokinetics drug-drug interaction potential of Glycyrrhiza uralensis, a traditional Chinese medicine, with lidocaine in rats.
|
Phytother Res
|
2009
|
0.77
|
30
|
Antiviral potential of exogenous human omega interferon to inhibit pandemic 2009 A (H1N1) influenza virus.
|
Viral Immunol
|
2011
|
0.77
|
31
|
The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation.
|
Dev Biol
|
2012
|
0.77
|
32
|
Clinicopathological Significance of VEGF-C, VEGFR-3 and Cyclooxygenase-2 in Early-Stage Cervical Cancer.
|
Int J Biomed Sci
|
2008
|
0.77
|
33
|
Creation of a six-fingered artificial transcription factor that represses the hepatitis B virus HBx gene integrated into a human hepatocellular carcinoma cell line.
|
J Biomol Screen
|
2012
|
0.77
|
34
|
Generation of an extreme ultraviolet supercontinuum in a two-color laser field.
|
Phys Rev Lett
|
2007
|
0.77
|
35
|
Effects of ephedrine on human nasal ciliary beat frequency.
|
ORL J Otorhinolaryngol Relat Spec
|
2008
|
0.76
|
36
|
Effect of oxymetazoline on healthy human nasal ciliary beat frequency measured with high-speed digital microscopy and mucociliary transport time.
|
Ann Otol Rhinol Laryngol
|
2008
|
0.76
|
37
|
Akhirin regulates the proliferation and differentiation of neural stem cells in intact and injured mouse spinal cord.
|
Dev Neurobiol
|
2014
|
0.76
|
38
|
Correction to Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity.
|
J Med Chem
|
2015
|
0.76
|
39
|
Fatty acid synthase inhibitors from Geum japonicum Thunb. var. chinense.
|
Chem Biodivers
|
2009
|
0.75
|
40
|
A conformational change of C fragment of tetanus neurotoxin reduces its ganglioside-binding activity but does not destroy its immunogenicity.
|
Clin Vaccine Immunol
|
2011
|
0.75
|
41
|
Direction-tunable enhanced emission from a subwavelength metallic double-nanoslit structure.
|
Opt Express
|
2017
|
0.75
|
42
|
[Preparation and biological activity analysis of chimeric antibody against capsular F1 antigen of Yersinia pestis].
|
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
|
2013
|
0.75
|
43
|
Near dipole-dipole effects on the propagation of few-cycle pulse in a dense two-level medium.
|
Opt Express
|
2005
|
0.75
|
44
|
Two new resveratrol tetramers isolated from Cayratia japonica (Thunb.) Gagn. with strong inhibitory activity on fatty acid synthase and antioxidant activity.
|
Chem Biodivers
|
2010
|
0.75
|
45
|
Carrier-envelope phase dependence of few-cycle ultrashort laser pulse propagation in a polar molecule medium.
|
Phys Rev Lett
|
2007
|
0.75
|
46
|
Dependence of dynamic Lorentz frequency shift on carrier-envelope phase and including local field effects.
|
Opt Express
|
2009
|
0.75
|
47
|
Carrier-envelope phase control of carrier-wave Rabi flopping in asymmetric semiparabolic quantum well.
|
Opt Express
|
2008
|
0.75
|
48
|
Preparation of CHO cell-derived rhIFN-ω-Fc with improved pharmacokinetics.
|
Antiviral Res
|
2011
|
0.75
|
49
|
Theoretical investigation of single attosecond pulse generation in an orthogonally polarized two-color laser field.
|
Opt Express
|
2008
|
0.75
|