Published in Chem Res Toxicol on May 01, 2006
Mammary gland development as a sensitive end point after acute prenatal exposure to an atrazine metabolite mixture in female Long-Evans rats. Environ Health Perspect (2006) 0.98
Effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male Long-Evans rats. Reprod Toxicol (2010) 0.83
Disposition of the herbicide 2-chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine (Atrazine) and its major metabolites in mice: a liquid chromatography/mass spectrometry analysis of urine, plasma, and tissue levels. Drug Metab Dispos (2008) 0.82
The atrazine metabolite diaminochlorotriazine suppresses LH release from murine LβT2 cells by suppressing GnRH-induced intracellular calcium transients. Toxicol Res (Camb) (2013) 0.76
Toxicity testing in the 21st century: implications for human health risk assessment. Risk Anal (2008) 5.57
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Inhaled carbon nanotubes reach the subpleural tissue in mice. Nat Nanotechnol (2009) 2.78
Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes (2007) 2.59
Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment. Toxicol Sci (2011) 2.03
A comprehensive statistical analysis of predicting in vivo hazard using high-throughput in vitro screening. Toxicol Sci (2012) 1.81
ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol (2009) 1.63
Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress. Environ Health Perspect (2010) 1.47
Organotypic liver culture models: meeting current challenges in toxicity testing. Crit Rev Toxicol (2012) 1.46
Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene. Crit Rev Toxicol (2004) 1.45
Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise. Toxicol Sci (2003) 1.44
Application of biologically based computer modeling to simple or complex mixtures. Environ Health Perspect (2002) 1.42
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. Toxicol Sci (2010) 1.30
A systems biology perspective on Nrf2-mediated antioxidant response. Toxicol Appl Pharmacol (2009) 1.25
A deterministic map of Waddington's epigenetic landscape for cell fate specification. BMC Syst Biol (2011) 1.21
Activator-dependent p300 acetylation of chromatin in vitro: enhancement of transcription by disruption of repressive nucleosome-nucleosome interactions. J Biol Chem (2010) 1.19
Ultrasensitive response motifs: basic amplifiers in molecular signalling networks. Open Biol (2013) 1.16
Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages. Toxicol Appl Pharmacol (2009) 1.15
Is the relationship between prenatal exposure to PCB-153 and decreased birth weight attributable to pharmacokinetics? Environ Health Perspect (2013) 1.14
Single cell analysis of switch-like induction of CYP1A1 in liver cell lines. Toxicol Sci (2004) 1.13
The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative. Arch Toxicol (2007) 1.11
Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome. Diabetes (2012) 1.10
Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework. Toxicol Sci (2013) 1.10
New directions in toxicity testing. Annu Rev Public Health (2011) 1.09
Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways. PLoS One (2011) 1.09
Induction of CYP1A1 in primary rat hepatocytes by 3,3',4,4',5-pentachlorobiphenyl: evidence for a switch circuit element. Toxicol Sci (2004) 1.08
Dose-dependent transitions in mechanisms of toxicity: case studies. Toxicol Appl Pharmacol (2004) 1.08
Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes. Environ Health Perspect (2010) 1.07
The identification and location of succinyl residues and the characterization of the interior arabinan region allow for a model of the complete primary structure of Mycobacterium tuberculosis mycolyl arabinogalactan. J Biol Chem (2008) 1.07
Dose response relationship in anti-stress gene regulatory networks. PLoS Comput Biol (2006) 1.07
Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation. Toxicol Sci (2007) 1.07
Quantitative interpretation of human biomonitoring data. Toxicol Appl Pharmacol (2008) 1.07
Linear low-dose extrapolation for noncancer heath effects is the exception, not the rule. Crit Rev Toxicol (2011) 1.07
Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. Free Radic Biol Med (2011) 1.07
t4 workshop report: Pathways of Toxicity. ALTEX (2013) 1.06
Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays. Toxicol Sci (2013) 1.03
Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment. Toxicol Sci (2010) 1.03
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury. Hepatology (2010) 1.03
Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response. Biochem Biophys Res Commun (2011) 1.02
In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI. J Pharmacokinet Pharmacodyn (2012) 1.02
Descriptive proteomic analysis shows protein variability between closely related clinical isolates of Mycobacterium tuberculosis. Proteomics (2010) 1.02
Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid. Toxicol Appl Pharmacol (2007) 1.02
Rice bran fermented with saccharomyces boulardii generates novel metabolite profiles with bioactivity. J Agric Food Chem (2011) 1.02
Development of PBPK models for PFOA and PFOS for human pregnancy and lactation life stages. J Toxicol Environ Health A (2013) 1.00
A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure. Toxicol Sci (2007) 1.00
Analysis of manganese tracer kinetics and target tissue dosimetry in monkeys and humans with multi-route physiologically based pharmacokinetic models. Toxicol Sci (2010) 0.99
Non-monotonic dose-response relationship in steroid hormone receptor-mediated gene expression. J Mol Endocrinol (2007) 0.99
In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane. Environ Health Perspect (2002) 0.98
An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury. J Pharmacol Exp Ther (2012) 0.98
Temporal concordance between apical and transcriptional points of departure for chemical risk assessment. Toxicol Sci (2013) 0.98
Application of pharmacokinetic data to the risk assessment of inhaled manganese. Neurotoxicology (2006) 0.98
Response of the mitochondrial proteome of rat renal proximal convoluted tubules to chronic metabolic acidosis. Am J Physiol Renal Physiol (2012) 0.98
A mechanistic redefinition of adverse effects - a key step in the toxicity testing paradigm shift. ALTEX (2010) 0.96
The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene. Regul Toxicol Pharmacol (2006) 0.96
Dose-dependent transitions in mechanisms of toxicity. Toxicol Appl Pharmacol (2004) 0.95
Time dependencies in perfluorooctylacids disposition in rat and monkeys: a kinetic analysis. Toxicol Lett (2007) 0.95
Progestin receptor expression in the developing rat brain depends upon activation of estrogen receptor alpha and not estrogen receptor beta. Brain Res (2006) 0.94
Pharmacokinetic modeling of disposition and time-course studies with [14C]atrazine. J Toxicol Environ Health A (2003) 0.94
Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results. Crit Rev Toxicol (2012) 0.93
Evidence that atrazine and diaminochlorotriazine inhibit the estrogen/progesterone induced surge of luteinizing hormone in female Sprague-Dawley rats without changing estrogen receptor action. Toxicol Sci (2004) 0.93
Physiologically based pharmacokinetic modeling of fetal and neonatal manganese exposure in humans: describing manganese homeostasis during development. Toxicol Sci (2011) 0.92
Linker histone H1.0 interacts with an extensive network of proteins found in the nucleolus. Nucleic Acids Res (2013) 0.92
Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: a five chemical case study. Mutat Res (2012) 0.92
Detection and localization of an estrogen receptor beta splice variant protein (ERbeta2) in the adult female rat forebrain and midbrain regions. J Comp Neurol (2007) 0.92
Assessing the relevance of in vitro measures of phthalate inhibition of steroidogenesis for in vivo response. Toxicol In Vitro (2009) 0.91
Regional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153. Toxicol Pathol (2004) 0.90
Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes. Environ Health Perspect (2012) 0.90
Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study. Environ Toxicol Chem (2011) 0.89
A framework for the next generation of risk science. Environ Health Perspect (2014) 0.89
Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK). Environ Health Perspect (2015) 0.88
Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses. Toxicol Appl Pharmacol (2009) 0.88
A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci (2010) 0.88
Association of serum concentration of organochlorine pesticides with dietary intake and other lifestyle factors among urban Chinese women. Environ Int (2006) 0.88
Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid challenge by transcription profiling. Am J Physiol Lung Cell Mol Physiol (2007) 0.87
Pharmacokinetic modeling of manganese in the rat IV: Assessing factors that contribute to brain accumulation during inhalation exposure. J Toxicol Environ Health A (2008) 0.87
Closed-chamber inhalation pharmacokinetic studies with hexamethyldisiloxane in the rat. Inhal Toxicol (2003) 0.86
Computational systems biology and dose-response modeling in relation to new directions in toxicity testing. J Toxicol Environ Health B Crit Rev (2010) 0.86
Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylene) under resting and working conditions using PBPK modeling. J Occup Environ Hyg (2005) 0.86
Accelerating the development of 21st-century toxicology: outcome of a Human Toxicology Project Consortium workshop. Toxicol Sci (2011) 0.86
A genome-wide assessment of variability in human serum metabolism. Hum Mutat (2013) 0.86
Use of short-term transcriptional profiles to assess the long-term cancer-related safety of environmental and industrial chemicals. Toxicol Sci (2009) 0.86
Binary gene induction and protein expression in individual cells. Theor Biol Med Model (2006) 0.86
Hormesis and adaptive cellular control systems. Dose Response (2008) 0.86
Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane. Toxicol Sci (2002) 0.86
Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress response. Environ Health Perspect (2012) 0.86
Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure. Toxicol Sci (2010) 0.86
Characterization of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach. Inhal Toxicol (2003) 0.85
Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage. Toxicol Appl Pharmacol (2012) 0.85
A dermatotoxicokinetic model of human exposures to jet fuel. Toxicol Sci (2006) 0.85
Evaluating placental transfer and tissue concentrations of manganese in the pregnant rat and fetuses after inhalation exposures with a PBPK model. Toxicol Sci (2009) 0.85
Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans. Toxicol Sci (2006) 0.85
A physiologically based pharmacokinetic model for lactational transfer of PCB 153 with or without PCB 126 in mice. Arch Toxicol (2006) 0.85
PBPK modeling of complex hydrocarbon mixtures: gasoline. Environ Toxicol Pharmacol (2004) 0.84
Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model. Reprod Toxicol (2011) 0.84
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches. Front Physiol (2012) 0.84
Recombinant factor C (rFC) assay and gas chromatography/mass spectrometry (GC/MS) analysis of endotoxin variability in four agricultural dusts. Ann Occup Hyg (2009) 0.84
Evaluating transport of manganese from olfactory mucosa to striatum by pharmacokinetic modeling. Toxicol Sci (2007) 0.84