Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trials.

PubWeight™: 1.63‹?› | Rank: Top 4%

🔗 View Article (PMID 16699448)

Published in Transplantation on May 15, 2006

Authors

Angela C Webster1, Vincent W S Lee, Jeremy R Chapman, Jonathan C Craig

Author Affiliations

1: Cochrane Renal Group, Children's Hospital at Westmead, Westmead, and School of Public Health, University of Sydney, Sydney, Australia. angela.webster@gmail.com

Associated clinical trials:

Conversion to Everolimus From Calcineurin Inhibitor With Mycophenolic Acid: Impact on Long Term Renal Function in Liver Transplantation. | NCT01936519

Articles citing this

PEComas: the past, the present and the future. Virchows Arch (2007) 3.93

Antiviral drug resistance of human cytomegalovirus. Clin Microbiol Rev (2010) 2.70

Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasms. Hum Pathol (2007) 1.99

Norovirus gastroenteritis in immunocompromised patients. N Engl J Med (2012) 1.93

Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids. J Nutr (2011) 1.60

Clinical outcomes in kidney transplant recipients receiving long-term therapy with inhibitors of the mammalian target of rapamycin. Am J Transplant (2011) 1.56

Effect of sirolimus on malignancy and survival after kidney transplantation: systematic review and meta-analysis of individual patient data. BMJ (2014) 1.50

Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer. Curr Mol Med (2010) 1.17

mTOR signaling contributes to chondrocyte differentiation. Dev Dyn (2008) 1.12

Combination of temsirolimus (CCI-779) with chemoradiation in newly diagnosed glioblastoma multiforme (GBM) (NCCTG trial N027D) is associated with increased infectious risks. Clin Cancer Res (2010) 1.08

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Exp Gerontol (2012) 1.07

Meta-analysis of calcineurin-inhibitor-sparing regimens in kidney transplantation. J Am Soc Nephrol (2011) 1.04

Inhibitors of mTOR and risks of allograft failure and mortality in kidney transplantation. Am J Transplant (2012) 0.93

Porcine cytomegalovirus infection is associated with early rejection of kidney grafts in a pig to baboon xenotransplantation model. Transplantation (2014) 0.92

Skin cancer in solid organ transplant recipients: are mTOR inhibitors a game changer? Transplant Res (2015) 0.91

Mammalian target of rapamycin regulates IL-10 and resistance to Pseudomonas aeruginosa corneal infection. J Immunol (2013) 0.90

Rapamycin inhibits transforming growth factor β1-induced fibrogenesis in primary human lung fibroblasts. Yonsei Med J (2013) 0.86

Budget impact analysis of conversion from cyclosporine to sirolimus as immunosuppressive medication in renal transplantation therapy. Clinicoecon Outcomes Res (2013) 0.83

Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle. Metabolism (2012) 0.83

A patient presenting with a perivascular epithelioid cell tumor in the broad ligament: a case report. J Med Case Rep (2011) 0.82

Norovirus gastroenteritis in immunocompromised patients. N Engl J Med (2013) 0.82

Inhibitory effects of rapamycin on the different stages of hepatic fibrosis. World J Gastroenterol (2014) 0.81

Adenosine triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit allograft rejection. Am J Transplant (2014) 0.81

Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase. Lab Invest (2015) 0.81

Post-transplantation malignancies: here today, gone tomorrow? Nat Rev Clin Oncol (2015) 0.81

Antineoplastic effects of mammalian target of rapamycine inhibitors. World J Transplant (2012) 0.80

IL-10 function, regulation, and in bacterial keratitis. J Ocul Pharmacol Ther (2014) 0.79

Safety of immunosuppressive drugs used as maintenance therapy in kidney transplantation: a systematic review and meta-analysis. Pharmaceuticals (Basel) (2013) 0.79

Lymphatic disorders after renal transplantation: new insights for an old complication. Clin Kidney J (2015) 0.79

Moving Past Anti-VEGF: Novel Therapies for Treating Diabetic Retinopathy. Int J Mol Sci (2016) 0.76

Icotinib combined with rapamycin in a renal transplant recipient with epidermal growth factor receptor-mutated non-small cell lung cancer: A case report. Oncol Lett (2013) 0.75

A prospective, multinational pharmacoepidemiological study of clinical conversion to sirolimus immunosuppression after renal transplantation. J Transplant (2012) 0.75

Anemia control in kidney transplant recipients using once-monthly continuous erythropoietin receptor activator: a prospective, observational study. J Transplant (2014) 0.75

Efficacy and Safety of Everolimus for Maintenance Immunosuppression of Kidney Transplantation: A Meta-Analysis of Randomized Controlled Trials. PLoS One (2017) 0.75

Everolimus in the management of metastatic neuroendocrine tumours. Therap Adv Gastroenterol (2016) 0.75

Transplantation: Are calcineurin inhibitors safer than mTOR inhibitors? Nat Rev Nephrol (2012) 0.75

Efficacy and safety of early tacrolimus conversion to sirolimus after kidney transplantation: Long-term results of a prospective randomized study. Indian J Nephrol (2017) 0.75

mTOR inhibitor versus mycophenolic acid as the primary immunosuppression regime combined with calcineurin inhibitor for kidney transplant recipients: a meta-analysis. BMC Nephrol (2015) 0.75

Sirolimus effects on cancer incidence after kidney transplantation: a meta-analysis. Cancer Med (2015) 0.75

Enhanced genetic modification of adult growth factor mobilized peripheral blood hematopoietic stem and progenitor cells with rapamycin. Stem Cells Transl Med (2014) 0.75

Cost utility analysis of immunosuppressive regimens in adult renal transplant recipients in England and Wales. Patient Prefer Adherence (2014) 0.75

The role of genetics in drug dosing. Pediatr Nephrol (2012) 0.75

Clinical Utility of Epstein-Barr Virus Viral Load Monitoring and Risk Factors for Posttransplant Lymphoproliferative Disorders After Kidney Transplantation: A Single-Center, 10-Year Observational Cohort Study. Transplant Direct (2017) 0.75

Articles by these authors

A randomized, controlled trial of early versus late initiation of dialysis. N Engl J Med (2010) 10.33

The natural history of chronic allograft nephropathy. N Engl J Med (2003) 8.70

Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev (2012) 6.38

Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. Lancet Infect Dis (2007) 5.84

Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis. JAMA (2011) 5.54

Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med (2009) 4.90

Cancer incidence before and after kidney transplantation. JAMA (2006) 4.77

Meta-analysis: vitamin D compounds in chronic kidney disease. Ann Intern Med (2007) 4.23

Long-term survival of children with end-stage renal disease. N Engl J Med (2004) 4.10

Clinical trials in children. Lancet (2004) 3.97

Effects of antiplatelet therapy on mortality and cardiovascular and bleeding outcomes in persons with chronic kidney disease: a systematic review and meta-analysis. Ann Intern Med (2012) 3.78

Benefits and harms of statin therapy for persons with chronic kidney disease: a systematic review and meta-analysis. Ann Intern Med (2012) 3.62

Acute rejection, T-cell-depleting antibodies, and cancer after transplantation. Transplantation (2014) 3.40

Effects of statins in patients with chronic kidney disease: meta-analysis and meta-regression of randomised controlled trials. BMJ (2008) 3.35

The number, quality, and coverage of randomized controlled trials in nephrology. J Am Soc Nephrol (2004) 3.30

Diagnostic accuracy of urine dipsticks for detection of albuminuria in the general community. Am J Kidney Dis (2011) 3.29

Strategies for increasing recruitment to randomised controlled trials: systematic review. PLoS Med (2010) 3.18

How can we achieve global equity in provision of renal replacement therapy? Bull World Health Organ (2008) 3.00

Meta-analysis: erythropoiesis-stimulating agents in patients with chronic kidney disease. Ann Intern Med (2010) 2.97

KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary. Kidney Int (2009) 2.72

Cost-effectiveness of initiating dialysis early: a randomized controlled trial. Am J Kidney Dis (2011) 2.62

Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation. Transplantation (2013) 2.55

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis. Cochrane Database Syst Rev (2014) 2.35

Screening and follow-up of living kidney donors: a systematic review of clinical practice guidelines. Transplantation (2011) 2.34

Parents' attitudes to children's participation in randomized controlled trials. J Pediatr (2003) 2.26

Haemoglobin targets: we were wrong, time to move on. Lancet (2007) 2.26

Role of blood pressure targets and specific antihypertensive agents used to prevent diabetic nephropathy and delay its progression. J Am Soc Nephrol (2006) 2.24

Associations between hemodialysis access type and clinical outcomes: a systematic review. J Am Soc Nephrol (2013) 2.22

HMG CoA reductase inhibitors (statins) for dialysis patients. Cochrane Database Syst Rev (2013) 2.21

Fluid and nutrient intake and risk of chronic kidney disease. Nephrology (Carlton) (2011) 2.18

Antibiotics for acute pyelonephritis in children. Cochrane Database Syst Rev (2014) 2.17

Accuracy of the "traffic light" clinical decision rule for serious bacterial infections in young children with fever: a retrospective cohort study. BMJ (2013) 2.14

Measuring the quality of public open space using Google Earth. Am J Prev Med (2011) 2.11

Antiviral medications to prevent cytomegalovirus disease and early death in recipients of solid-organ transplants: a systematic review of randomised controlled trials. Lancet (2005) 2.09

Enteral vs intravenous rehydration therapy for children with gastroenteritis: a meta-analysis of randomized controlled trials. Arch Pediatr Adolesc Med (2004) 2.03

Pediatricians' attitudes toward randomized controlled trials involving children. J Pediatr (2002) 2.01

Value of routine monitoring of bone mineral density after starting bisphosphonate treatment: secondary analysis of trial data. BMJ (2009) 2.00

Biological variation of high sensitivity cardiac troponin-T in stable dialysis patients: implications for clinical practice. Clin Chem Lab Med (2015) 1.98

Is low birth weight an antecedent of CKD in later life? A systematic review of observational studies. Am J Kidney Dis (2009) 1.94

Effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists on mortality and renal outcomes in diabetic nephropathy: systematic review. BMJ (2004) 1.92

Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data. BMJ (2005) 1.90

Vitamin D compounds for people with chronic kidney disease not requiring dialysis. Cochrane Database Syst Rev (2009) 1.88

The role of surveillance chest X-rays in the follow-up of high-risk melanoma patients. Ann Surg Oncol (2008) 1.87

Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology. Transplantation (2004) 1.82

Prevalence and correlates of self-reported sexual dysfunction in CKD: a meta-analysis of observational studies. Am J Kidney Dis (2010) 1.81

Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstet Gynecol (2002) 1.79

Chronic allograft nephropathy: current concepts and future directions. Transplantation (2006) 1.79

The motivations and experiences of living kidney donors: a thematic synthesis. Am J Kidney Dis (2012) 1.78

Comparative accuracy of renal duplex sonographic parameters in the diagnosis of renal artery stenosis: paired and unpaired analysis. AJR Am J Roentgenol (2007) 1.77

The impact of neutral-pH peritoneal dialysates with reduced glucose degradation products on clinical outcomes in peritoneal dialysis patients. Kidney Int (2013) 1.75

Support interventions for caregivers of people with chronic kidney disease: a systematic review. Nephrol Dial Transplant (2008) 1.74

Evidence-based management of steroid-sensitive nephrotic syndrome. Pediatr Nephrol (2005) 1.72

Long-term antibiotics for preventing recurrent urinary tract infection in children. Cochrane Database Syst Rev (2011) 1.69

Risk factors for nocturnal enuresis in school-age children. J Urol (2009) 1.68

Biocompatible dialysis fluids for peritoneal dialysis. Cochrane Database Syst Rev (2014) 1.63

Interleukin 2 receptor antagonists for renal transplant recipients: a meta-analysis of randomized trials. Transplantation (2004) 1.58

Interventions for primary vesicoureteric reflux. Cochrane Database Syst Rev (2011) 1.58

Association of CKD and cancer risk in older people. J Am Soc Nephrol (2009) 1.57

Erythropoiesis-stimulating agents for anaemia in adults with chronic kidney disease: a network meta-analysis. Cochrane Database Syst Rev (2014) 1.55

4. Bedwetting and toileting problems in children. Med J Aust (2005) 1.54

Experiences and perspectives of adults living with systemic lupus erythematosus: thematic synthesis of qualitative studies. Arthritis Care Res (Hoboken) (2013) 1.53

Time on dialysis and cancer risk after kidney transplantation. Transplantation (2013) 1.53

Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies. Kidney Int (2013) 1.52

HMG CoA reductase inhibitors (statins) for kidney transplant recipients. Cochrane Database Syst Rev (2014) 1.52

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis. Cochrane Database Syst Rev (2009) 1.52

Cardiac testing for coronary artery disease in potential kidney transplant recipients. Cochrane Database Syst Rev (2011) 1.52

Clinical practice guidelines on wait-listing for kidney transplantation: consistent and equitable? Transplantation (2012) 1.50

The cost-effectiveness of increasing kidney transplantation and home-based dialysis. Nephrology (Carlton) (2009) 1.48

Health benefits and costs of screening for colorectal cancer in people on dialysis or who have received a kidney transplant. Nephrol Dial Transplant (2012) 1.48

The pattern of excess cancer in dialysis and transplantation. Nephrol Dial Transplant (2009) 1.48

Factors influencing quality of life in children with urinary incontinence. J Urol (2011) 1.47

Interventions for bone disease in children with chronic kidney disease. Cochrane Database Syst Rev (2010) 1.47

Interventions for haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura. Cochrane Database Syst Rev (2009) 1.46

Long-term cancer risk of immunosuppressive regimens after kidney transplantation. J Am Soc Nephrol (2010) 1.45

IL-10/TGF-beta-modified macrophages induce regulatory T cells and protect against adriamycin nephrosis. J Am Soc Nephrol (2010) 1.44

The risk of cancer in recipients of living-donor, standard and expanded criteria deceased donor kidney transplants: a registry analysis. Transplantation (2014) 1.44

Prognostic value of cardiac tests in potential kidney transplant recipients: a systematic review. Transplantation (2015) 1.43

Comparative survival and economic benefits of deceased donor kidney transplantation and dialysis in people with varying ages and co-morbidities. PLoS One (2012) 1.42

Children are not just small adults: the urgent need for high-quality trial evidence in children. PLoS Med (2008) 1.41

The relative benefits and costs of solid phase bead technology to detect preformed donor specific antihuman leukocyte antigen antibodies in determining suitability for kidney transplantation. Transplantation (2015) 1.40

The Initiating Dialysis Early and Late (IDEAL) study: study rationale and design. Perit Dial Int (2004) 1.40

Questioning the myth: benefits of renin-angiotensin system blockade in kidney transplant recipients. Transplantation (2014) 1.39

Parenteral versus oral iron therapy for adults and children with chronic kidney disease. Cochrane Database Syst Rev (2012) 1.39

Cost-effectiveness of breast cancer screening in women on dialysis. Am J Kidney Dis (2008) 1.39

Sevelamer: a promising but unproven drug. Nephrol Dial Transplant (2007) 1.39

Catheter-related interventions to prevent peritonitis in peritoneal dialysis: a systematic review of randomized, controlled trials. J Am Soc Nephrol (2004) 1.37