Published in J Infect Dis on May 11, 2006
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin Immunopathol (2007) 2.42
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Neutrophil recruitment to the lungs during bacterial pneumonia. Infect Immun (2008) 1.87
Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila. PLoS Pathog (2008) 1.70
Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila. PLoS Pathog (2009) 1.66
Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection. J Immunol (2009) 1.48
Retracted Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells. BMC Microbiol (2010) 1.46
Caspase-11 activation in response to bacterial secretion systems that access the host cytosol. PLoS Pathog (2013) 1.38
Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila. PLoS Pathog (2009) 1.37
TLR-dependent control of Francisella tularensis infection and host inflammatory responses. PLoS One (2009) 1.33
Activation of Toll-like receptors by Burkholderia pseudomallei. BMC Immunol (2008) 1.33
MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei. PLoS One (2008) 1.33
Mechanisms of neutrophil accumulation in the lungs against bacteria. Am J Respir Cell Mol Biol (2009) 1.28
Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans. Eur J Immunol (2012) 1.24
Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa. Infect Immun (2007) 1.20
Interferons direct an effective innate response to Legionella pneumophila infection. J Biol Chem (2009) 1.19
Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila. Infect Immun (2010) 1.13
The gene history of zebrafish tlr4a and tlr4b is predictive of their divergent functions. J Immunol (2009) 1.12
NOD1 and NOD2 regulation of pulmonary innate immunity to Legionella pneumophila. Eur J Immunol (2010) 1.09
IL-1α signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo. J Immunol (2013) 1.08
In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice. PLoS Pathog (2012) 1.04
Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila. Cell Microbiol (2008) 1.02
Activation of host mitogen-activated protein kinases by secreted Legionella pneumophila effectors that inhibit host protein translation. Infect Immun (2012) 1.01
Role of Toll-like receptor 9 in Legionella pneumophila-induced interleukin-12 p40 production in bone marrow-derived dendritic cells and macrophages from permissive and nonpermissive mice. Infect Immun (2006) 1.00
Inhalation of Francisella novicida Delta mglA causes replicative infection that elicits innate and adaptive responses but is not protective against invasive pneumonic tularemia. Microbes Infect (2008) 0.95
Innate immunity to legionella pneumophila. Front Microbiol (2011) 0.94
Review: Toll-like receptors and NOD-like receptors in pulmonary antibacterial immunity. Innate Immun (2010) 0.92
Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages. J Biol Chem (2013) 0.91
Legionella pneumophila type II secretion dampens the cytokine response of infected macrophages and epithelia. Infect Immun (2011) 0.91
In vivo function of airway epithelial TLR2 in host defense against bacterial infection. Am J Physiol Lung Cell Mol Physiol (2011) 0.90
Chemoproteomics reveals Toll-like receptor fatty acylation. BMC Biol (2014) 0.86
The Legionella pneumophila EnhC protein interferes with immunostimulatory muramyl peptide production to evade innate immunity. Cell Host Microbe (2012) 0.83
Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophages. Exp Mol Med (2009) 0.83
A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis. Cell Host Microbe (2014) 0.83
A TLR6 polymorphism is associated with increased risk of Legionnaires' disease. Genes Immun (2013) 0.81
Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis. PLoS Pathog (2014) 0.79
Nucleotide-binding oligomerization domain containing-like receptor family, caspase recruitment domain (CARD) containing 4 (NLRC4) regulates intrapulmonary replication of aerosolized Legionella pneumophila. BMC Infect Dis (2013) 0.77
Divergent functions of Toll-like receptors during bacterial lung infections. Am J Respir Crit Care Med (2014) 0.77
Subversion of Cell-Autonomous Immunity and Cell Migration by Legionella pneumophila Effectors. Front Immunol (2015) 0.76
Multiple roles of Myd88 in the immune response to the plague F1-V vaccine and in protection against an aerosol challenge of Yersinia pestis CO92 in mice. J Immunol Res (2014) 0.75
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol (2006) 9.64
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature (2004) 9.40
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature (2006) 6.28
Systems biology of vaccination for seasonal influenza in humans. Nat Immunol (2011) 6.09
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol (2010) 6.05
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc Natl Acad Sci U S A (2010) 5.59
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Nat Immunol (2003) 5.18
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol (2004) 4.91
Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science (2003) 4.80
The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci U S A (2005) 4.42
Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med (2008) 4.16
Caspase-11 protects against bacteria that escape the vacuole. Science (2013) 4.01
Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals. Nat Immunol (2009) 3.60
Caspase-1-induced pyroptotic cell death. Immunol Rev (2011) 3.47
Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci U S A (2005) 3.35
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med (2003) 3.30
Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions. PLoS Pathog (2010) 3.15
Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics. PLoS Comput Biol (2008) 3.02
Pseudomonas aeruginosa activates caspase 1 through Ipaf. Proc Natl Acad Sci U S A (2008) 2.99
Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. J Immunol (2008) 2.87
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol (2003) 2.73
Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. Nat Immunol (2012) 2.72
A common human TLR1 polymorphism regulates the innate immune response to lipopeptides. Eur J Immunol (2007) 2.71
The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A (2006) 2.63
Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion. Cell Host Microbe (2010) 2.49
TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med (2006) 2.44
Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity (2009) 2.44
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin Immunopathol (2007) 2.42
Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection. J Infect Dis (2007) 2.33
TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol (2008) 2.23
Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infect Immun (2006) 2.18
Management of the critically ill patient with severe acute pancreatitis. Crit Care Med (2004) 2.16
Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL. Immunity (2008) 2.13
Flagellin induces antibody responses through a TLR5- and inflammasome-independent pathway. J Immunol (2014) 2.11
Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. J Immunol (2003) 2.02
Systems biology of innate immunity. Immunol Rev (2009) 1.87
Type IV pili-mediated secretion modulates Francisella virulence. Mol Microbiol (2006) 1.83
A 2020 vision for vaccines against HIV, tuberculosis and malaria. Nature (2011) 1.80
Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. J Immunol (2010) 1.77
Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation. Cell (2013) 1.69
Transcription factor expression in lipopolysaccharide-activated peripheral-blood-derived mononuclear cells. Proc Natl Acad Sci U S A (2007) 1.63
Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog. J Immunol (2002) 1.60
Leishmania promotes its own virulence by inducing expression of the host immune inhibitory ligand CD200. Cell Host Microbe (2011) 1.59
A Francisella mutant in lipid A carbohydrate modification elicits protective immunity. PLoS Pathog (2008) 1.58
Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages. J Immunol (2003) 1.57
Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection. J Immunol (2007) 1.57
Development of a guideline for the management of ventilator-associated pneumonia based on local microbiologic findings and impact of the guideline on antimicrobial use practices. Infect Control Hosp Epidemiol (2008) 1.56
Burkholderia thailandensis as a model system for the study of the virulence-associated type III secretion system of Burkholderia pseudomallei. Infect Immun (2008) 1.52
A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin. J Exp Med (2007) 1.51
Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. PLoS One (2009) 1.49
Merck Ad5/HIV induces broad innate immune activation that predicts CD8⁺ T-cell responses but is attenuated by preexisting Ad5 immunity. Proc Natl Acad Sci U S A (2012) 1.46
A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses. Nature (2012) 1.44
Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia. J Immunol (2007) 1.43
Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles. PLoS Pathog (2008) 1.41
Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A (2010) 1.41
Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection. AIDS (2007) 1.39
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. Proc Natl Acad Sci U S A (2005) 1.39
Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy. J Infect Dis (2008) 1.34
An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia. Am J Respir Cell Mol Biol (2005) 1.34
Activation of Toll-like receptors by Burkholderia pseudomallei. BMC Immunol (2008) 1.33
Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production. J Immunol (2007) 1.29
Mutational analysis of Burkholderia thailandensis quorum sensing and self-aggregation. J Bacteriol (2009) 1.28
Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila. J Immunol (2007) 1.28
Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes. J Immunol (2002) 1.28
The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection. J Virol (2011) 1.27
A systems approach to dissecting immunity and inflammation. Semin Immunol (2004) 1.26
Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia. J Immunol (2009) 1.25
ATF3, an adaptive-response gene, enhances TGF{beta} signaling and cancer-initiating cell features in breast cancer cells. J Cell Sci (2010) 1.23
Local role for tumor necrosis factor alpha in the pulmonary inflammatory response to Mycobacterium tuberculosis infection. Infect Immun (2002) 1.22
Genome-wide histone acetylation data improve prediction of mammalian transcription factor binding sites. Bioinformatics (2010) 1.22
A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. Proc Natl Acad Sci U S A (2005) 1.21
CD4+ T cells and toll-like receptors recognize Salmonella antigens expressed in bacterial surface organelles. Infect Immun (2005) 1.20
Inhalation of Burkholderia thailandensis results in lethal necrotizing pneumonia in mice: a surrogate model for pneumonic melioidosis. Trans R Soc Trop Med Hyg (2008) 1.20
Animal models of human pneumonia. Am J Physiol Lung Cell Mol Physiol (2007) 1.20
Bright field microscopy as an alternative to whole cell fluorescence in automated analysis of macrophage images. PLoS One (2009) 1.19
Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation. J Exp Med (2008) 1.18
ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation. J Exp Med (2012) 1.15
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses. Proc Natl Acad Sci U S A (2011) 1.13
ATF3 regulates MCMV infection in mice by modulating IFN-gamma expression in natural killer cells. Proc Natl Acad Sci U S A (2008) 1.13
A microfluidic device for multiplexed protein detection in nano-liter volumes. Anal Biochem (2008) 1.12
The Innate Immune Database (IIDB). BMC Immunol (2008) 1.11
Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease. J Immunol (2008) 1.11
Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens. Infect Immun (2003) 1.11
Combination of peritubular c4d and transplant glomerulopathy predicts late renal allograft failure. J Am Soc Nephrol (2009) 1.11