Thrombospondin-1 expression in urothelial carcinoma: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components.

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Published in BMC Cancer on May 29, 2006

Authors

E Ioachim1, M C Michael, M Salmas, K Damala, E Tsanou, M M Michael, V Malamou-Mitsi, N E Stavropoulos

Author Affiliations

1: Department of Pathology, University Hospital of Ioannina, Ioannina, Greece. vmalamou@cc.uoi.gr

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Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science (1994) 5.54

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Tenascin interferes with fibronectin action. Cell (1988) 2.60

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Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. J Cell Biol (1990) 2.00

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Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines. Int J Cancer (1994) 1.57

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Thrombospondin-induced tumor cell migration: haptotaxis and chemotaxis are mediated by different molecular domains. J Cell Biol (1987) 1.56

Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity. Oncogene (1997) 1.47

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Thrombospondin promotes cell-substratum adhesion. Science (1987) 1.44

Modulation of keratinocyte motility. Correlation with production of extracellular matrix molecules in response to growth promoting and antiproliferative factors. Am J Pathol (1988) 1.29

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Molecular mediators of angiogenesis in bladder cancer. Cancer Res (1998) 1.20

Colocalization of thrombospondin and syndecan during murine development. Dev Dyn (1992) 1.17

Tumor stroma as a regulator of neoplastic behavior. Agonistic and antagonistic elements embedded in the same connective tissue. Lab Invest (1995) 1.16

Chemotaxis of aortic endothelial cells in response to fibronectin. Cancer Res (1982) 1.14

Fibronectin promotes the elongation of microvessels during angiogenesis in vitro. J Cell Physiol (1993) 1.13

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