Published in Bioorg Med Chem Lett on June 05, 2006
Secondary structure, a missing component of sequence-based minimotif definitions. PLoS One (2012) 0.77
Ligand binding efficiency: trends, physical basis, and implications. J Med Chem (2008) 1.59
Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation. Drug Alcohol Depend (2012) 1.37
Ligand efficiency and fragment-based drug discovery. Drug Discov Today (2008) 1.13
Collagen-related peptides: self-assembly of short, single strands into a functional biomaterial of micrometer scale. J Am Chem Soc (2007) 1.09
The role of molecular size in ligand efficiency. Bioorg Med Chem Lett (2007) 1.08
Extracellular mediators in atherosclerosis and thrombosis: lessons from thrombin receptor knockout mice. Arterioscler Thromb Vasc Biol (2003) 1.05
Riluzole prodrugs for melanoma and ALS: design, synthesis, and in vitro metabolic profiling. Bioorg Med Chem (2012) 1.02
Stereochemistry of mephedrone neuropharmacology: enantiomer-specific behavioural and neurochemical effects in rats. Br J Pharmacol (2014) 0.99
2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead. J Med Chem (2007) 0.97
Potential anxiolytic agents. Part 4: novel orally-active N(5)-substituted pyrido[1,2-a]benzimidazoles with high GABA-A receptor affinity. Bioorg Med Chem Lett (2002) 0.95
Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Res (2013) 0.91
Mephedrone interactions with cocaine: prior exposure to the 'bath salt' constituent enhances cocaine-induced locomotor activation in rats. Behav Pharmacol (2013) 0.90
Emerging beta-amyloid therapies for the treatment of Alzheimer's disease. Curr Pharm Des (2003) 0.89
Development of a novel nonradiometric assay for nucleic acid binding to TDP-43 suitable for high-throughput screening using AlphaScreen technology. J Biomol Screen (2010) 0.87
2,3-Diaryl-5-anilino[1,2,4]thiadiazoles as melanocortin MC4 receptor agonists and their effects on feeding behavior in rats. Bioorg Med Chem (2003) 0.85
Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection. J Med Chem (2012) 0.85
Structure-function analysis of urotensin II and its use in the construction of a ligand-receptor working model. Angew Chem Int Ed Engl (2002) 0.85
Current nervous system related drug targets for the treatment of amyotrophic lateral sclerosis. Curr Pharm Des (2010) 0.84
Detection of a novel reactive metabolite of diclofenac: evidence for CYP2C9-mediated bioactivation via arene oxides. Drug Metab Dispos (2005) 0.84
Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines. Biochim Biophys Acta (2013) 0.84
Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: extending towards the β-exosite. Bioorg Med Chem Lett (2012) 0.83
Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function. Biochimie (2012) 0.82
Pseudomonas aeruginosa porphobilinogen synthase assembly state regulators: hit discovery and initial SAR studies. ARKIVOC (2010) 0.82
Design, synthesis, and conformational analysis of eight-membered cyclic peptidomimetics prepared using ring closing metathesis. Bioorg Med Chem (2004) 0.81
Hit triage using efficiency indices after screening of compound libraries in drug discovery. Curr Top Med Chem (2009) 0.81
Efficient conversion of substituted aryl thioureas to 2-aminobenzothiazoles using benzyltrimethylammonium tribromide. J Org Chem (2003) 0.81
Effects of atypical anxiolytic N-phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats. Alcohol Clin Exp Res (2007) 0.81
Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ. Bioorg Med Chem (2012) 0.81
Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain. J Med Chem (2014) 0.80
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. J Med Chem (2009) 0.80
A two-state homology model of the hERG K+ channel: application to ligand binding. Bioorg Med Chem Lett (2005) 0.80
Synthesis and SAR of pyridazinone-substituted phenylalanine amide alpha4 integrin antagonists. Bioorg Med Chem Lett (2008) 0.80
Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists. J Med Chem (2006) 0.79
Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives. Bioorg Med Chem Lett (2008) 0.78
Chemically-blocked antibody microarray for multiplexed high-throughput profiling of specific protein glycosylation in complex samples. J Vis Exp (2012) 0.78
Electron density guided fragment-based lead discovery of ketohexokinase inhibitors. J Med Chem (2010) 0.78
Assessing activity onset time and efficacy for clinically effective antidepressant and antimanic drugs in animal models based on dominant-submissive relationships. Neurosci Biobehav Rev (2007) 0.78
Discovery of piperidine carboxamide TRPV1 antagonists. Bioorg Med Chem Lett (2008) 0.78
Small molecule anticonvulsant agents with potent in vitro neuroprotection. J Mol Neurosci (2012) 0.77
Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor. Bioorg Med Chem Lett (2005) 0.77
Selection of a 2-azabicyclo[2.2.2]octane-based alpha4beta1 integrin antagonist as an inhaled anti-asthmatic agent. Bioorg Med Chem (2006) 0.77
Aza-bicyclic amino acid carboxamides as alpha4beta1/alpha4beta7 integrin receptor antagonists. Bioorg Med Chem (2005) 0.77
3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor. Bioorg Med Chem Lett (2006) 0.77
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112). J Med Chem (2013) 0.76
Linear interaction energy models for beta-secretase (BACE) inhibitors: Role of van der Waals, electrostatic, and continuum-solvation terms. J Mol Graph Model (2005) 0.76
Synthesis of (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: an inhibitor of beta-amyloid(1-42) aggregation. Bioorg Med Chem (2002) 0.76
A high-throughput monoamine oxidase inhibition assay using liquid chromatography with tandem mass spectrometry. Rapid Commun Mass Spectrom (2004) 0.76
5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic. J Pharmacol Exp Ther (2002) 0.76
Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins. Bioorg Med Chem Lett (2004) 0.75
Small-molecule anticonvulsant agents with potent in vitro neuroprotection and favorable drug-like properties. J Mol Neurosci (2013) 0.75
Facile Synthesis of Mutagen X (MX): 3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one. Tetrahedron Lett (2012) 0.75
Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads. Bioorg Med Chem Lett (2010) 0.75
The synthesis and evaluation of 10- and 12-membered ring benzofused enediyne amino acids. Bioorg Med Chem (2005) 0.75
Suzuki-Miyaura approach to JNJ-26076713, an orally active tetrahydroquinoline-containing alphaVbeta3/alphaVbeta5 integrin antagonist. enantioselective synthesis and stereochemical studies. J Org Chem (2008) 0.75
In vitro metabolism of the new anxiolytic agent, RWJ-52763 in human hepatic S9 fraction-API-MS/MS identification of metabolites. J Pharm Biomed Anal (2003) 0.75
Filling the pipeline for neglected diseases: creation of a medicinal chemistry-centric international drug discovery institute [iDDi]. Drug Discov Today (2008) 0.75
A Web-based chemoinformatics system for drug discovery. Methods Mol Biol (2004) 0.75
Noncovalent self-assembly of bicyclo[4.2.2]diketopiperazines: influence of saturation in the bridging carbacyclic ring. Org Lett (2004) 0.75
Diarylacetylene piperidinyl amides as novel anxiolytics. Bioorg Med Chem Lett (2006) 0.75
Distribution and metabolism of the antipsychotic agent mazapertine succinate in rats. J Pharm Biomed Anal (2005) 0.75
Editorial. Curr Top Med Chem (2009) 0.75
Metabolic fate of the antipsychotic agent, mazapertine, in man--API-MS and MS/MS identification of urinary metabolites. Eur J Drug Metab Pharmacokinet (2007) 0.75
8-(Heteroaryl)phenalkyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-ones as opioid receptor modulators. Med Chem (2005) 0.75
Aza-bicyclic amino acid sulfonamides as alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists. Bioorg Med Chem Lett (2004) 0.75
New approaches to target gram-negative bacteria. Curr Top Med Chem (2010) 0.75
Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial kappa-opioid agonist effect. Bioorg Med Chem Lett (2004) 0.75
In-vitro metabolism of the new anxiolytic agent, RWJ-50172, in rat hepatic S9 fraction and microbial transformation in fungi, Cunninghamella sp. J Pharm Pharmacol (2003) 0.75
Preface. Curr Top Med Chem (2012) 0.75
1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability. Bioorg Med Chem Lett (2004) 0.75
Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism. Eur J Drug Metab Pharmacokinet (2007) 0.75
Many, diverse topics have been covered in recent years in CTMC. Preface. Curr Top Med Chem (2015) 0.75
Chiral liquid chromatography separation and chiroptical properties of the enantiomers of dimethyl alpha-hydroxyfarnesylphosphonate, a precursor of a farnesyl protein transferase inhibitor. J Chromatogr A (2002) 0.75