Published in Annu Rev Biochem on January 01, 2006
A microhomology-mediated break-induced replication model for the origin of human copy number variation. PLoS Genet (2009) 6.39
Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nat Genet (2007) 4.59
Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet (2010) 4.26
DNA end resection: many nucleases make light work. DNA Repair (Amst) (2009) 3.28
Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J (2009) 2.68
Break-induced replication is highly inaccurate. PLoS Biol (2011) 2.45
Double-strand breaks associated with repetitive DNA can reshape the genome. Proc Natl Acad Sci U S A (2008) 2.28
Mating-type genes and MAT switching in Saccharomyces cerevisiae. Genetics (2012) 1.96
Inverted genomic segments and complex triplication rearrangements are mediated by inverted repeats in the human genome. Nat Genet (2011) 1.93
Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science (2013) 1.90
Nonrecurrent MECP2 duplications mediated by genomic architecture-driven DNA breaks and break-induced replication repair. Genome Res (2008) 1.81
The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination. Mol Cell Biol (2007) 1.77
A recombination execution checkpoint regulates the choice of homologous recombination pathway during DNA double-strand break repair. Genes Dev (2009) 1.77
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev (2010) 1.71
Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata. Proc Natl Acad Sci U S A (2009) 1.69
Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase. Genes Dev (2007) 1.67
Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol (2009) 1.66
Sources of DNA double-strand breaks and models of recombinational DNA repair. Cold Spring Harb Perspect Biol (2014) 1.65
Molecular mechanisms underlying the control of antigenic variation in African trypanosomes. Curr Opin Microbiol (2010) 1.64
Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics. Leukemia (2009) 1.63
Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination. Genes Dev (2009) 1.59
Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end. Genetics (2012) 1.56
Replicative mechanisms for CNV formation are error prone. Nat Genet (2013) 1.54
Defective break-induced replication leads to half-crossovers in Saccharomyces cerevisiae. Genetics (2008) 1.52
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev (2009) 1.51
Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement. Mol Cell (2007) 1.49
Aberrant double-strand break repair resulting in half crossovers in mutants defective for Rad51 or the DNA polymerase delta complex. Mol Cell Biol (2009) 1.47
DNA breaks are masked by multiple Rap1 binding in yeast: implications for telomere capping and telomerase regulation. Genes Dev (2007) 1.45
GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution. Genes Dev (2010) 1.44
The budding yeast nucleus. Cold Spring Harb Perspect Biol (2010) 1.43
Inhibition of telomere recombination by inactivation of KEOPS subunit Cgi121 promotes cell longevity. PLoS Genet (2015) 1.41
Break-induced replication: functions and molecular mechanism. Curr Opin Genet Dev (2013) 1.39
Trypanosoma brucei homologous recombination is dependent on substrate length and homology, though displays a differential dependence on mismatch repair as substrate length decreases. Nucleic Acids Res (2007) 1.29
The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants. Mol Cell Biol (2009) 1.26
Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends. PLoS Genet (2010) 1.25
A role for monoubiquitinated FANCD2 at telomeres in ALT cells. Nucleic Acids Res (2009) 1.24
Short telomeres initiate telomere recombination in primary and tumor cells. PLoS Genet (2009) 1.21
Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain. Mol Cell Biol (2007) 1.20
Replication and recombination factors contributing to recombination-dependent bypass of DNA lesions by template switch. PLoS Genet (2010) 1.19
XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids. Mol Cell Biol (2009) 1.19
Break-induced DNA replication. Cold Spring Harb Perspect Biol (2013) 1.17
Plasticity of telomere maintenance mechanisms in yeast. Trends Biochem Sci (2009) 1.14
RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology. Genome Res (2011) 1.14
Mammalian 5' C-rich telomeric overhangs are a mark of recombination-dependent telomere maintenance. Mol Cell (2011) 1.12
Taming the tiger by the tail: modulation of DNA damage responses by telomeres. EMBO J (2009) 1.12
Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement. Clin Cancer Res (2012) 1.11
Extensive DNA end processing by exo1 and sgs1 inhibits break-induced replication. PLoS Genet (2010) 1.07
Mutants defective in Rad1-Rad10-Slx4 exhibit a unique pattern of viability during mating-type switching in Saccharomyces cerevisiae. Genetics (2008) 1.06
Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms. Proc Natl Acad Sci U S A (2012) 1.06
Recovery of arrested replication forks by homologous recombination is error-prone. PLoS Genet (2012) 1.05
Long telomeres are preferentially extended during recombination-mediated telomere maintenance. Nat Struct Mol Biol (2011) 1.05
Diverse mutational mechanisms cause pathogenic subtelomeric rearrangements. Hum Mol Genet (2011) 1.05
Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns. EMBO Rep (2010) 1.04
Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence. Nucleic Acids Res (2012) 1.03
Evidence that a RecQ helicase slows senescence by resolving recombining telomeres. PLoS Biol (2007) 1.02
Chromosomal translocations caused by either pol32-dependent or pol32-independent triparental break-induced replication. Mol Cell Biol (2009) 1.02
Telomerase core components protect Candida telomeres from aberrant overhang accumulation. Proc Natl Acad Sci U S A (2007) 1.01
RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks. Mol Cell Biol (2011) 0.99
Repair of DNA interstrand cross-links during S phase of the mammalian cell cycle. Environ Mol Mutagen (2010) 0.99
HAATI survivors replace canonical telomeres with blocks of generic heterochromatin. Nature (2010) 0.98
Interchromosomal crossover in human cells is associated with long gene conversion tracts. Mol Cell Biol (2007) 0.98
Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications. DNA Repair (Amst) (2008) 0.96
BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids. Nat Commun (2013) 0.96
Complex genomic rearrangements at the PLP1 locus include triplication and quadruplication. PLoS Genet (2015) 0.93
Telomerase- and Rad52-independent immortalization of budding yeast by an inherited-long-telomere pathway of telomeric repeat amplification. Mol Cell Biol (2008) 0.93
Template switching during break-induced replication is promoted by the Mph1 helicase in Saccharomyces cerevisiae. Genetics (2014) 0.93
Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52. Genetics (2009) 0.93
Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases. PLoS Genet (2012) 0.93
Molecular mechanisms of activity and derepression of alternative lengthening of telomeres. Nat Struct Mol Biol (2015) 0.92
Noncanonical views of homology-directed DNA repair. Genes Dev (2016) 0.92
Telomerase-null survivor screening identifies novel telomere recombination regulators. PLoS Genet (2013) 0.92
Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination. PLoS Genet (2013) 0.91
Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication. Nucleic Acids Res (2007) 0.91
Deficient SUMO attachment to Flp recombinase leads to homologous recombination-dependent hyperamplification of the yeast 2 microm circle plasmid. Mol Biol Cell (2008) 0.91
The Mph1 helicase can promote telomere uncapping and premature senescence in budding yeast. PLoS One (2012) 0.91
Mutant telomeric repeats in yeast can disrupt the negative regulation of recombination-mediated telomere maintenance and create an alternative lengthening of telomeres-like phenotype. Mol Cell Biol (2008) 0.90
Telomerase is essential to alleviate pif1-induced replication stress at telomeres. Genetics (2009) 0.90
The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres. Cell Cycle (2014) 0.89
Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. Nucleic Acids Res (2013) 0.89
Functional interactions of meiotic recombination factors Rdh54 and Dmc1. DNA Repair (Amst) (2008) 0.88
Large inverted repeats in the vicinity of a single double-strand break strongly affect repair in yeast diploids lacking Rad51. Mutat Res (2008) 0.88
Whole genome mapping and re-organization of the nuclear and mitochondrial genomes of Babesia microti isolates. PLoS One (2013) 0.88
Leaping forks at inverted repeats. Genes Dev (2010) 0.88
The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres. Nucleic Acids Res (2012) 0.87
Break-induced replication and genome stability. Biomolecules (2012) 0.87
Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania. Nucleic Acids Res (2011) 0.86
Multiple cellular mechanisms prevent chromosomal rearrangements involving repetitive DNA. Crit Rev Biochem Mol Biol (2012) 0.86
DNA repair pathways in trypanosomatids: from DNA repair to drug resistance. Microbiol Mol Biol Rev (2014) 0.86
Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition. Mol Cell Biol (2007) 0.85
Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast. G3 (Bethesda) (2011) 0.85
A mutant allele of the transcription factor IIH helicase gene, RAD3, promotes loss of heterozygosity in response to a DNA replication defect in Saccharomyces cerevisiae. Genetics (2007) 0.84
A common copy-number breakpoint of ERBB2 amplification in breast cancer colocalizes with a complex block of segmental duplications. Breast Cancer Res (2012) 0.84
Localization of telomeres and telomere-associated proteins in telomerase-negative Saccharomyces cerevisiae. Chromosome Res (2007) 0.84
DNA repair pathway selection caused by defects in TEL1, SAE2, and de novo telomere addition generates specific chromosomal rearrangement signatures. PLoS Genet (2014) 0.84
Enlightenment of yeast mitochondrial homoplasmy: diversified roles of gene conversion. Genes (Basel) (2011) 0.84
Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication. EMBO Rep (2016) 0.84
RecO-mediated DNA homology search and annealing is facilitated by SsbA. Nucleic Acids Res (2010) 0.83
Telomeres do the (un)twist: helicase actions at chromosome termini. Biochim Biophys Acta (2009) 0.82
Chk2 and p53 are haploinsufficient with dependent and independent functions to eliminate cells after telomere loss. PLoS Genet (2011) 0.81
Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination. Nucleic Acids Res (2009) 0.81
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature (2004) 6.94
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell (2003) 5.45
DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol Cell (2004) 4.54
Surviving the breakup: the DNA damage checkpoint. Annu Rev Genet (2006) 4.42
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr Biol (2004) 4.35
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Cell (2004) 4.20
Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase. Mol Cell (2002) 3.76
In vivo roles of Rad52, Rad54, and Rad55 proteins in Rad51-mediated recombination. Mol Cell (2003) 3.76
Break-induced replication and telomerase-independent telomere maintenance require Pol32. Nature (2007) 3.37
Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol Cell Biol (2003) 3.32
Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes Dev (2005) 2.91
Histone chaperones: an escort network regulating histone traffic. Nat Struct Mol Biol (2007) 2.84
Increased mutagenesis and unique mutation signature associated with mitotic gene conversion. Science (2010) 2.72
Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals. J Cell Biol (2007) 2.55
Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination. Genes Dev (2009) 2.43
Anaphase onset before complete DNA replication with intact checkpoint responses. Science (2007) 2.37
Characterization of RAD51-independent break-induced replication that acts preferentially with short homologous sequences. Mol Cell Biol (2002) 2.35
Fast live simultaneous multiwavelength four-dimensional optical microscopy. Proc Natl Acad Sci U S A (2010) 2.17
DNA breaks promote genomic instability by impeding proper chromosome segregation. Curr Biol (2004) 2.14
Role of Saccharomyces single-stranded DNA-binding protein RPA in the strand invasion step of double-strand break repair. PLoS Biol (2004) 2.06
RAD51-dependent break-induced replication differs in kinetics and checkpoint responses from RAD51-mediated gene conversion. Mol Cell Biol (2005) 1.94
Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J (2008) 1.90
Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science (2013) 1.90
Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres. EMBO J (2008) 1.89
PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol Cell (2003) 1.88
Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1. Proc Natl Acad Sci U S A (2004) 1.87
Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae. Mol Cell Biol (2004) 1.87
Real-time analysis of double-strand DNA break repair by homologous recombination. Proc Natl Acad Sci U S A (2011) 1.80
Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell (2009) 1.78
A recombination execution checkpoint regulates the choice of homologous recombination pathway during DNA double-strand break repair. Genes Dev (2009) 1.77
In vivo assembly and disassembly of Rad51 and Rad52 complexes during double-strand break repair. EMBO J (2004) 1.77
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev (2010) 1.71
Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol (2006) 1.71
Migrating bubble during break-induced replication drives conservative DNA synthesis. Nature (2013) 1.66
Gene conversion and crossing over along the 405-kb left arm of Saccharomyces cerevisiae chromosome VII. Genetics (2004) 1.65
Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast. Mol Cell Biol (2007) 1.61
Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance. DNA Repair (Amst) (2002) 1.57
Mating type-dependent constraints on the mobility of the left arm of yeast chromosome III. J Cell Biol (2004) 1.41
Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses. Cell (2007) 1.41
Repair of DNA double strand breaks: in vivo biochemistry. Methods Enzymol (2006) 1.36
Conservative inheritance of newly synthesized DNA in double-strand break-induced gene conversion. Mol Cell Biol (2006) 1.32
Mutations arising during repair of chromosome breaks. Annu Rev Genet (2012) 1.31
Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends. PLoS Genet (2010) 1.25
Chromatin assembly factors Asf1 and CAF-1 have overlapping roles in deactivating the DNA damage checkpoint when DNA repair is complete. Proc Natl Acad Sci U S A (2009) 1.25
Yeast Rad52 and Rad51 recombination proteins define a second pathway of DNA damage assessment in response to a single double-strand break. Mol Cell Biol (2003) 1.24
The Saccharomyces cerevisiae chromatin remodeler Fun30 regulates DNA end resection and checkpoint deactivation. Mol Cell Biol (2012) 1.22
Mad2 prolongs DNA damage checkpoint arrest caused by a double-strand break via a centromere-dependent mechanism. Curr Biol (2010) 1.20
Functional interactions between Sae2 and the Mre11 complex. Genetics (2008) 1.20
Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair. PLoS Genet (2010) 1.19
Break-induced DNA replication. Cold Spring Harb Perspect Biol (2013) 1.17
Saccharomyces forkhead protein Fkh1 regulates donor preference during mating-type switching through the recombination enhancer. Genes Dev (2002) 1.16
Microhomology-dependent end joining and repair of transposon-induced DNA hairpins by host factors in Saccharomyces cerevisiae. Mol Cell Biol (2004) 1.16
V(D)J recombination and RAG-mediated transposition in yeast. Mol Cell (2003) 1.06
Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1-Rad10-dependent cleavage of non-homologous DNA tails. DNA Repair (Amst) (2010) 1.03
The yeast DNA damage checkpoint proteins control a cytoplasmic response to DNA damage. Proc Natl Acad Sci U S A (2007) 1.02
Mechanisms of Rad52-independent spontaneous and UV-induced mitotic recombination in Saccharomyces cerevisiae. Genetics (2008) 1.00
Different mating-type-regulated genes affect the DNA repair defects of Saccharomyces RAD51, RAD52 and RAD55 mutants. Genetics (2006) 0.98
Chromatin modifications and chromatin remodeling during DNA repair in budding yeast. Curr Opin Genet Dev (2013) 0.95
DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase. Proc Natl Acad Sci U S A (2012) 0.94
Cell cycle-dependent regulation of Saccharomyces cerevisiae donor preference during mating-type switching by SBF (Swi4/Swi6) and Fkh1. Mol Cell Biol (2006) 0.92
Regulation of budding yeast mating-type switching donor preference by the FHA domain of Fkh1. PLoS Genet (2012) 0.92
Protein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination. Mol Cell Biol (2010) 0.89
Saccharomyces cerevisiae donor preference during mating-type switching is dependent on chromosome architecture and organization. Genetics (2006) 0.89
Inactivation of Ku-mediated end joining suppresses mec1Delta lethality by depleting the ribonucleotide reductase inhibitor Sml1 through a pathway controlled by Tel1 kinase and the Mre11 complex. Mol Cell Biol (2005) 0.89
Dynamics of homology searching during gene conversion in Saccharomyces cerevisiae revealed by donor competition. Genetics (2011) 0.87
The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast. J Biol Chem (2005) 0.86
SMC proteins, new players in the maintenance of genomic stability. Cell Cycle (2007) 0.84
Monitoring DNA recombination initiated by HO endonuclease. Methods Mol Biol (2012) 0.82
Mating-type Gene Switching in Saccharomyces cerevisiae. Microbiol Spectr (2015) 0.81
DNA damage signaling triggers the cytoplasm-to-vacuole pathway of autophagy to regulate cell cycle progression. Autophagy (2013) 0.77
Retrospective. Fred Sherman (1932-2013). Science (2013) 0.76
QnAs with James E. Haber. Proc Natl Acad Sci U S A (2011) 0.75
Repair of site-specific DNA cleavage: old-school lessons for Cas9-mediated gene editing. ACS Chem Biol (2017) 0.75
The 2005 Genetics Society of America Medal. Steven J. Elledge. Genetics (2005) 0.75