Published in Lancet on July 20, 1991
Folic Acid Dosage and Malformations Reduction | NCT01244347
Effect of Folic Acid Supplementation in Pregnant Women Having Thalassaemia Trait | NCT04310059
Statistics notes. Treatment allocation in controlled trials: why randomise? BMJ (1999) 5.86
Risk factor thresholds: their existence under scrutiny. BMJ (2002) 5.55
Total folate and folic acid intake from foods and dietary supplements in the United States: 2003-2006. Am J Clin Nutr (2009) 4.57
Monitoring clinical trials--interim data should be publicly available. BMJ (2001) 4.20
Six paths for the future of social epidemiology. Am J Epidemiol (2013) 4.12
Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA (2013) 4.08
Long term trends in prevalence of neural tube defects in Europe: population based study. BMJ (2015) 3.75
Critical windows for nutritional interventions against stunting. Am J Clin Nutr (2013) 3.52
Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology (2011) 3.15
Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? Hum Genet (2007) 3.13
Mendelian randomisation and causal inference in observational epidemiology. PLoS Med (2008) 3.12
Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr (2006) 2.83
Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions. BMC Pregnancy Childbirth (2010) 2.63
Incidence of open neural tube defects in Nova Scotia after folic acid fortification. CMAJ (2002) 2.58
Taking folate in pregnancy and risk of maternal breast cancer. BMJ (2004) 2.46
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development (2007) 2.45
Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals. Lancet (2013) 2.37
Effects and safety of periconceptional folate supplementation for preventing birth defects. Cochrane Database Syst Rev (2010) 2.31
Neural tube defects and folate: case far from closed. Nat Rev Neurosci (2006) 2.30
Genetics of human neural tube defects. Hum Mol Genet (2009) 2.28
Folic acid supplements in pregnancy and severe language delay in children. JAMA (2011) 2.18
Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr (2012) 2.14
Folic acid to reduce neonatal mortality from neural tube disorders. Int J Epidemiol (2010) 2.12
Genetics and development of neural tube defects. J Pathol (2010) 2.10
Folic acid supplements in pregnancy and early childhood respiratory health. Arch Dis Child (2008) 2.06
Epidemiologic and genetic aspects of spina bifida and other neural tube defects. Dev Disabil Res Rev (2010) 1.96
Birth outcomes and maternal residential proximity to natural gas development in rural Colorado. Environ Health Perspect (2014) 1.96
Is folic acid the ultimate functional food component for disease prevention? BMJ (2004) 1.95
Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects. Am J Obstet Gynecol (2011) 1.89
The continuing challenge of understanding, preventing, and treating neural tube defects. Science (2013) 1.86
Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model. BMJ (2014) 1.84
Colloquium paper: human skin pigmentation as an adaptation to UV radiation. Proc Natl Acad Sci U S A (2010) 1.83
118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects. BMC Med Genet (2009) 1.74
Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr (2006) 1.71
Neural tube defects and maternal folate intake among pregnancies conceived after folic acid fortification in the United States. Am J Epidemiol (2008) 1.69
Neural tube defects. Annu Rev Neurosci (2014) 1.69
Neural tube defects: recent advances, unsolved questions, and controversies. Lancet Neurol (2013) 1.68
Neural tube defects and periconceptional folic acid in England and Wales: retrospective study. BMJ (1999) 1.66
Importance of methyl donors during reproduction. Am J Clin Nutr (2008) 1.62
Commentary: Advent of sibling designs. Int J Epidemiol (2011) 1.60
Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy. Epigenetics (2011) 1.60
U.S. women of childbearing age who are at possible increased risk of a neural tube defect-affected pregnancy due to suboptimal red blood cell folate concentrations, National Health and Nutrition Examination Survey 2007 to 2012. Birth Defects Res A Clin Mol Teratol (2015) 1.53
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. Am J Clin Nutr (2011) 1.53
Epidemiology of neural tube defects. Saudi Med J (2014) 1.53
Public health 101 for informaticians. J Am Med Inform Assoc (2001) 1.51
Retracted Folic acid supplementation, dietary folate intake during pregnancy and risk for spontaneous preterm delivery: a prospective observational cohort study. BMC Pregnancy Childbirth (2013) 1.50
Folic acid food fortification-its history, effect, concerns, and future directions. Nutrients (2011) 1.46
Maternal folate levels in pregnancy and asthma in children at age 3 years. J Allergy Clin Immunol (2010) 1.44
Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification. Pediatrics (2009) 1.44
Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study. PLoS Med (2009) 1.43
Laboratory testing for and diagnosis of nutritional deficiencies in pregnancy before and after bariatric surgery. J Womens Health (Larchmt) (2013) 1.42
Inositol for the prevention of neural tube defects: a pilot randomised controlled trial. Br J Nutr (2016) 1.41
International retrospective cohort study of neural tube defects in relation to folic acid recommendations: are the recommendations working? BMJ (2005) 1.39
Preventing neural tube defects in Europe: population based study. BMJ (2005) 1.38
Periconceptional intake of vitamins and fetal death: a cohort study on multivitamins and folate. Int J Epidemiol (2014) 1.38
Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. J Inherit Metab Dis (2010) 1.37
Understanding nutritional epidemiology and its role in policy. Adv Nutr (2015) 1.37
Novel mutations in VANGL1 in neural tube defects. Hum Mutat (2009) 1.37
Effects of cultivation conditions on folate production by lactic acid bacteria. Appl Environ Microbiol (2003) 1.37
Maternal lifestyle and environmental risk factors for autism spectrum disorders. Int J Epidemiol (2014) 1.36
The changing incidence of myelomeningocele and its impact on pediatric neurosurgery: a review from the Children's Memorial Hospital. Childs Nerv Syst (2009) 1.36
Prenatal nutritional deficiency and risk of adult schizophrenia. Schizophr Bull (2008) 1.34
Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry (2013) 1.34
Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ Health Perspect (2006) 1.33
Folic acid and orofacial clefts: a review of the evidence. Oral Dis (2010) 1.33
Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function. Hum Mol Genet (2008) 1.33
Reducing stillbirths: behavioural and nutritional interventions before and during pregnancy. BMC Pregnancy Childbirth (2009) 1.32
Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull (2008) 1.32
Dietary supplements contribute substantially to the total nutrient intake in pregnant Norwegian women. Ann Nutr Metab (2008) 1.30
Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST). BMC Public Health (2011) 1.29
Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. Birth Defects Res A Clin Mol Teratol (2009) 1.29
Total folate and folic acid intakes from foods and dietary supplements of US children aged 1-13 y. Am J Clin Nutr (2010) 1.27
Perinatal choline influences brain structure and function. Nutr Rev (2006) 1.26
Targeted disruption of the methionine synthase gene in mice. Mol Cell Biol (2001) 1.26
Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects. Proc Nutr Soc (2011) 1.25
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab (2007) 1.24
The treatment of hyperhomocysteinemia. Annu Rev Med (2009) 1.23
Contribution of VANGL2 mutations to isolated neural tube defects. Clin Genet (2010) 1.23
Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6. Proc Natl Acad Sci U S A (2005) 1.23
Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proc Natl Acad Sci U S A (2005) 1.22
Maternal occupational exposure during pregnancy and the risk of spina bifida. Occup Environ Med (1996) 1.22
Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation. Final report. Arch Gynecol Obstet (1994) 1.22
Delaying folic acid fortification of flour. BMJ (2002) 1.19
Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study. BMJ Open (2015) 1.18
Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression. J Cell Physiol (2012) 1.17
Population-level changes in folate intake by age, gender, and race/ethnicity after folic acid fortification. Am J Public Health (2006) 1.17
Folic acid to prevent neural tube defects. Lancet (1991) 1.17
Folic acid in early pregnancy: a public health success story. FASEB J (2010) 1.16
Prevention of neural tube defects: a cross-sectional study of the uptake of folic acid supplementation in nearly half a million women. PLoS One (2014) 1.16
A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency. Hum Mutat (2009) 1.15
A comprehensive evaluation of food fortification with folic acid for the primary prevention of neural tube defects. BMC Pregnancy Childbirth (2004) 1.15
Enhancement of folates in plants through metabolic engineering. Proc Natl Acad Sci U S A (2004) 1.15
Health care provider knowledge and practices regarding folic acid, United States, 2002-2003. Matern Child Health J (2006) 1.15
Gene-environment interactions, folate metabolism and the embryonic nervous system. Wiley Interdiscip Rev Syst Biol Med (2010) 1.14
Mechanistic insights into folate supplementation from Crooked tail and other NTD-prone mutant mice. Birth Defects Res A Clin Mol Teratol (2009) 1.14
The maternal-age-associated risk of congenital heart disease is modifiable. Nature (2015) 1.14
Reevaluating the benefits of folic acid fortification in the United States: economic analysis, regulation, and public health. Am J Public Health (2005) 1.13
Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida. Am J Obstet Gynecol (2009) 1.12
FZD6 is a novel gene for human neural tube defects. Hum Mutat (2011) 1.10