Copper induces conformational changes in the N-terminal part of cell-surface PrPC.

PubWeight™: 0.80‹?›

🔗 View Article (PMID 16791441)

Published in Arch Virol on June 22, 2006

Authors

E Leclerc1, H Serban, S B Prusiner, D R Burton, R A Williamson

Author Affiliations

1: Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Articles by these authors

Novel proteinaceous infectious particles cause scrapie. Science (1982) 24.09

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature (1992) 9.01

Eight prion strains have PrP(Sc) molecules with different conformations. Nat Med (1998) 9.01

Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro. J Virol (2001) 8.64

Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41. J Virol (2001) 8.25

Scrapie prions aggregate to form amyloid-like birefringent rods. Cell (1983) 7.92

Identification of a protein that purifies with the scrapie prion. Science (1982) 7.00

A protease-resistant protein is a structural component of the scrapie prion. Cell (1983) 6.72

Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity. Science (1996) 6.71

Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG. J Virol (1995) 6.33

Purification and structural studies of a major scrapie prion protein. Cell (1984) 5.98

Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1. J Virol (1994) 5.76

Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science (1989) 5.73

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science (2001) 5.39

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein. Cell (1995) 5.16

Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell (1987) 5.12

Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. Lab Invest (1987) 4.98

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell (1986) 4.82

Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. Cell (1989) 4.73

Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome. Nature (1989) 4.69

Separation and properties of cellular and scrapie prion proteins. Proc Natl Acad Sci U S A (1986) 4.38

Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120. J Virol (1995) 4.33

Spontaneous neurodegeneration in transgenic mice with mutant prion protein. Science (1990) 4.19

Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible. Proc Natl Acad Sci U S A (1997) 4.10

Further purification and characterization of scrapie prions. Biochemistry (1982) 4.01

Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation. Proc Natl Acad Sci U S A (1997) 3.78

A transmembrane form of the prion protein in neurodegenerative disease. Science (1998) 3.76

Linkage of prion protein and scrapie incubation time genes. Cell (1986) 3.69

Measurement of the scrapie agent using an incubation time interval assay. Ann Neurol (1982) 3.68

Regional mapping of prion proteins in brain. Proc Natl Acad Sci U S A (1992) 3.68

Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J Cell Biol (1995) 3.66

Passive immunization with a human monoclonal antibody protects hu-PBL-SCID mice against challenge by primary isolates of HIV-1. Nat Med (1997) 3.63

The neutralizing antibody response to HIV-1: viral evasion and escape from humoral immunity. AIDS (1999) 3.57

Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. Biochemistry (1993) 3.54

Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells. J Cell Biol (1990) 3.46

Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res (1998) 3.44

Ebola virus can be effectively neutralized by antibody produced in natural human infection. J Virol (1999) 3.44

Structural clues to prion replication. Science (1994) 3.43

Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans. Proc Natl Acad Sci U S A (1999) 3.43

Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform. Proc Natl Acad Sci U S A (1997) 3.42

Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease. Nat Immunol (2001) 3.39

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. Proc Natl Acad Sci U S A (2001) 3.39

Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins. J Virol (1988) 3.37

The mammalian sodium channel BNC1 is required for normal touch sensation. Nature (2000) 3.30

The antiviral activity of antibodies in vitro and in vivo. Adv Immunol (2001) 3.29

Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity. J Virol (1998) 3.23

Distinct prion proteins in short and long scrapie incubation period mice. Cell (1987) 3.21

Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science (1998) 3.18

Immunoglobulin G: functional sites. Mol Immunol (1985) 3.12

Antibodies to a scrapie prion protein. Nature (1984) 3.09

Identification of prion amyloid filaments in scrapie-infected brain. Cell (1985) 3.04

A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform. J Mol Biol (1997) 2.95

Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes. Cell (1993) 2.93

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J Mol Biol (1999) 2.92

Rapid detection of Creutzfeldt-Jakob disease and scrapie prion proteins. Neurology (1990) 2.90

Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters. Genes Dev (1992) 2.87

Transmissible and genetic prion diseases share a common pathway of neurodegeneration. Nature (1999) 2.83

Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains. Proc Natl Acad Sci U S A (1996) 2.79

Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature (2001) 2.78

gp120: Biologic aspects of structural features. Annu Rev Immunol (2001) 2.70

Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein. Proc Natl Acad Sci U S A (1994) 2.70

Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins. Cell (1994) 2.68

Evidence for synthesis of scrapie prion proteins in the endocytic pathway. J Biol Chem (1992) 2.67

Chimeric prion protein expression in cultured cells and transgenic mice. Protein Sci (1992) 2.67

Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo. Immunity (1999) 2.67

Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid. Proc Natl Acad Sci U S A (1992) 2.64

Mapping the prion protein using recombinant antibodies. J Virol (1998) 2.64

Purified prion proteins and scrapie infectivity copartition into liposomes. Proc Natl Acad Sci U S A (1987) 2.61

Strain-specified relative conformational stability of the scrapie prion protein. Protein Sci (2001) 2.60

Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning. Proc Natl Acad Sci U S A (1991) 2.60

Scrapie prion proteins are synthesized in neurons. Am J Pathol (1986) 2.54

Pathologic conformations of prion proteins. Annu Rev Biochem (1998) 2.50

Copper binding to the prion protein: structural implications of four identical cooperative binding sites. Proc Natl Acad Sci U S A (1999) 2.44

HIV-1 antibody--debris or virion? Nat Med (1997) 2.44

Molecular cloning of a human prion protein cDNA. DNA (1986) 2.43

Prion protein gene variation among primates. J Mol Biol (1995) 2.43

Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies. J Virol (2001) 2.42

Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries. J Mol Biol (1993) 2.42

Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells. J Cell Biol (1990) 2.42

Scrapie PrP 27-30 is a sialoglycoprotein. J Virol (1985) 2.40

Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice. Genes Dev (1996) 2.39

Cultured cell sublines highly susceptible to prion infection. J Virol (2000) 2.38

Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice. Proc Natl Acad Sci U S A (1994) 2.38

Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein. Proc Natl Acad Sci U S A (1994) 2.37

Purification and properties of the cellular and scrapie hamster prion proteins. Eur J Biochem (1988) 2.35

Prion protein selectively binds copper(II) ions. Biochemistry (1998) 2.32

A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis. J Virol (1997) 2.32

Inhibition of virus attachment to CD4+ target cells is a major mechanism of T cell line-adapted HIV-1 neutralization. J Exp Med (1997) 2.31

Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble CD4 and monoclonal antibodies. J Virol (1998) 2.28

Changes in the localization of brain prion proteins during scrapie infection. Neurology (1987) 2.27