Published in J Cancer Res Clin Oncol on June 23, 2006
Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion. World J Gastroenterol (2007) 1.25
Activation of MAP kinase signaling through ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC). Neoplasia (2008) 1.17
Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells. J Cancer Res Clin Oncol (2006) 0.98
Expression of CDX2 and hepatocyte antigen in benign and malignant lesions of gallbladder and its correlation with histopathologic type and clinical outcome. Pathol Oncol Res (2011) 0.92
Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations. J Exp Clin Cancer Res (2009) 0.90
Prognostic significance of Cdx2 immunohistochemical expression in gastric cancer: a meta-analysis of published literatures. J Exp Clin Cancer Res (2012) 0.81
Combination of celecoxib and PD184161 exerts synergistic inhibitory effects on gallbladder cancer cell proliferation. Oncol Lett (2017) 0.75
DUSP1 inhibits cell proliferation, metastasis and invasion and angiogenesis in gallbladder cancer. Oncotarget (2017) 0.75
Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer (2004) 6.07
Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Gut (2003) 3.91
Cdx1 and cdx2 expression during intestinal development. Gastroenterology (2000) 3.03
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia (2003) 2.89
A review and update on cholangiocarcinoma. Oncology (2004) 2.49
Control of gut differentiation and intestinal-type gastric carcinogenesis. Nat Rev Cancer (2003) 2.40
Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. Biochem Pharmacol (2004) 2.07
ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours. Br J Cancer (2004) 1.88
Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc Natl Acad Sci U S A (1998) 1.63
Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa. J Gastroenterol (2003) 1.59
ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. Hepatology (2002) 1.54
Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Biochem Biophys Res Commun (2003) 1.45
Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett (2002) 1.45
Expression and prognostic significance of kit, protein kinase B, and mitogen-activated protein kinase in patients with small cell lung cancer. Clin Cancer Res (2003) 1.38
Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand. Mol Carcinog (1993) 1.20
Expression of Cdx2 and the phenotype of advanced gastric cancers: relationship with prognosis. J Cancer Res Clin Oncol (2003) 1.20
An intraductal papillary component is associated with prolonged survival after hepatic resection for intrahepatic cholangiocarcinoma. Br J Surg (2004) 1.15
Anatomic and molecular pathology of intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg (2003) 1.13
Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis. Lab Invest (2004) 1.09
Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater. J Clin Oncol (2005) 1.02
Homeobox genes and gut development. Bioessays (2000) 1.01
IHPBA concordant classification of primary liver cancer: working group report. J Hepatobiliary Pancreat Surg (2003) 0.98
Comparative clinicopathological study of resected intrahepatic cholangiocarcinoma in northeast Thailand and Japan. J Hepatobiliary Pancreat Surg (2000) 0.92
EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade. Lab Invest (2005) 0.89
Expression of homeodomain protein CDX2 in gallbladder carcinomas. J Cancer Res Clin Oncol (2005) 0.86
Analyses of the APC and TGF-beta type II receptor genes, and microsatellite instability in mucosal colorectal carcinomas. Jpn J Cancer Res (1997) 0.81
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet (2004) 7.78
Liver fluke induces cholangiocarcinoma. PLoS Med (2007) 3.89
Exome sequencing of liver fluke-associated cholangiocarcinoma. Nat Genet (2012) 3.63
Cholangiocarcinoma: lessons from Thailand. Curr Opin Gastroenterol (2008) 2.44
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol (2003) 2.42
Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma. Clin Cancer Res (2003) 2.28
Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers. Nat Genet (2013) 2.15
Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma. Int J Oncol (2004) 1.79
GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer. Clin Cancer Res (2009) 1.78
Identification of serum microRNAs as novel non-invasive biomarkers for early detection of gastric cancer. PLoS One (2012) 1.66
DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients. Int J Cancer (2009) 1.56
ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. Hepatology (2002) 1.54
Hypermethylation of the GATA genes in lung cancer. Clin Cancer Res (2004) 1.45
Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Biochem Biophys Res Commun (2003) 1.45
Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett (2002) 1.45
Comparison of gene expression profiles between Opisthorchis viverrini and non-Opisthorchis viverrini associated human intrahepatic cholangiocarcinoma. Hepatology (2006) 1.40
BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells. Biochem Biophys Res Commun (2004) 1.39
Tumor-specific immunological recognition of frameshift-mutated peptides in colon cancer with microsatellite instability. Cancer Res (2003) 1.38
Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem Biophys Res Commun (2006) 1.38
MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. PLoS One (2011) 1.38
miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer. Int J Cancer (2010) 1.37
The fission yeast pfh1(+) gene encodes an essential 5' to 3' DNA helicase required for the completion of S-phase. Nucleic Acids Res (2002) 1.25
Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. Proc Natl Acad Sci U S A (2013) 1.24
Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. Carcinogenesis (2010) 1.23
Multiple-to-multiple relationships between microRNAs and target genes in gastric cancer. PLoS One (2013) 1.22
MiR-9 downregulates CDX2 expression in gastric cancer cells. Int J Cancer (2011) 1.21
Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer. Cancer Res (2004) 1.20
DNA methylation in peripheral blood: a potential biomarker for cancer molecular epidemiology. J Epidemiol (2012) 1.19
Roles of liver fluke infection as risk factor for cholangiocarcinoma. J Hepatobiliary Pancreat Sci (2014) 1.18
Hypermethylation of the GATA gene family in esophageal cancer. Int J Cancer (2006) 1.12
Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis. Cancer Lett (2005) 1.10
Periostin activates integrin α5β1 through a PI3K/AKT‑dependent pathway in invasion of cholangiocarcinoma. Int J Oncol (2012) 1.09
Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer. Gut (2011) 1.08
Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins. Biochem J (2005) 1.07
Hath1 up-regulates gastric mucin gene expression in gastric cells. Biochem Biophys Res Commun (2006) 1.05
Requirement of the MAP kinase signaling pathways for mouse preimplantation development. Development (2005) 1.04
Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression. J Cancer Res Clin Oncol (2006) 1.03
Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury. Int J Parasitol (2009) 1.03
CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Oncogene (2003) 1.03
Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis. Int J Cancer (2010) 1.02
Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. Proc Natl Acad Sci U S A (2002) 1.01
Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer. Gastroenterology (2008) 1.01
Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients. Carcinogenesis (2004) 1.00
Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages. Cancer Res (2013) 0.99
Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies. Oncogene (2005) 0.99
Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells. J Cancer Res Clin Oncol (2006) 0.98
Retracted Proteomics-based identification of α-enolase as a potential prognostic marker in cholangiocarcinoma. Clin Biochem (2012) 0.97
The human DNA methyltransferases DNMT3A and DNMT3B have two types of promoters with different CpG contents. Biochim Biophys Acta (2002) 0.96
Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas. World J Gastroenterol (2010) 0.95
The role of CT scan in preoperative staging of colorectal carcinoma. J Med Assoc Thai (2005) 0.93
Inflammation-related DNA damage and expression of CD133 and Oct3/4 in cholangiocarcinoma patients with poor prognosis. Free Radic Biol Med (2013) 0.93
Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion. World J Gastroenterol (2005) 0.93
Human G(salpha) mutant causes pseudohypoparathyroidism type Ia/neonatal diarrhea, a potential cell-specific role of the palmitoylation cycle. Proc Natl Acad Sci U S A (2007) 0.93
IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells. Int J Cancer (2008) 0.93
Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model. Int J Cancer (2010) 0.92
Anti-inflammatory, antioxidant and hepatoprotective effects of Thunbergia laurifolia Linn. on experimental opisthorchiasis. Parasitol Res (2012) 0.92
Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma. Cancer Biomark (2012) 0.92
Annexin A1: A new immunohistological marker of cholangiocarcinoma. World J Gastroenterol (2013) 0.91
A novel serum carbohydrate marker on mucin 5AC: values for diagnostic and prognostic indicators for cholangiocarcinoma. Cancer (2011) 0.91
Microsatellite alterations in liver fluke related cholangiocarcinoma are associated with poor prognosis. Cancer Lett (2002) 0.90
CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation. Cancer Sci (2011) 0.90
Comparative studies on animal models for Opisthorchis viverrini infection: host interaction through susceptibility and pathology. Parasitol Res (2011) 0.90
Transcription factor GATA-5 selectively up-regulates mucin gene expression. J Cancer Res Clin Oncol (2004) 0.89
CA-S27: a novel Lewis a associated carbohydrate epitope is diagnostic and prognostic for cholangiocarcinoma. Cancer Sci (2013) 0.88
Promoter hypermethylation is a major event of hMLH1 gene inactivation in liver fluke related cholangiocarcinoma. Cancer Lett (2005) 0.88
Amplification of chromosome 21q22.3 harboring trefoil factor family genes in liver fluke related cholangiocarcinoma is associated with poor prognosis. World J Gastroenterol (2006) 0.88
Prognostic value of serum MUC5AC mucin in patients with cholangiocarcinoma. Cancer (2003) 0.88
Gastrointestinal stromal tumor: computed tomographic features. J Med Assoc Thai (2009) 0.87
Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. PLoS Negl Trop Dis (2013) 0.86
Prognostic significance of peroxiredoxin 1 and ezrin-radixin-moesin-binding phosphoprotein 50 in cholangiocarcinoma. Hum Pathol (2012) 0.86
The carcinogenic liver fluke Opisthorchis viverrini is a reservoir for species of Helicobacter. Asian Pac J Cancer Prev (2015) 0.86
Inflammation-induced protein carbonylation contributes to poor prognosis for cholangiocarcinoma. Free Radic Biol Med (2012) 0.86
Expression of homeodomain protein CDX2 in gallbladder carcinomas. J Cancer Res Clin Oncol (2005) 0.86
Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk. Int J Cancer (2012) 0.85
Up-regulation of annexin A2 in cholangiocarcinoma caused by Opisthorchis viverrini and its implication as a prognostic marker. Int J Parasitol (2010) 0.85
Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis. Cancer Sci (2011) 0.84
Gene expression profiling of intrahepatic cholangiocarcinoma. Asian Pac J Cancer Prev (2013) 0.83
Identification of biliary bile acids in patients with benign biliary diseases, hepatocellular carcinoma and cholangiocarcinoma. Asian Pac J Cancer Prev (2012) 0.83
A novel EID-1 family member, EID-2, associates with histone deacetylases and inhibits muscle differentiation. J Biol Chem (2003) 0.82
Effects of thymidine phosphorylase on tumor aggressiveness and 5-fluorouracil sensitivity in cholangiocarcinoma. World J Gastroenterol (2010) 0.82
Histological confirmation of periductal fibrosis from ultrasound diagnosis in cholangiocarcinoma patients. J Hepatobiliary Pancreat Sci (2014) 0.82