Motohiro Sekiya

Author PubWeight™ 27.72‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nat Med 2007 3.54
2 The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages. Circ Res 2010 1.92
3 Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice. Diabetes 2004 1.68
4 Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling. Mol Endocrinol 2003 1.49
5 Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma. Eur J Cancer 2005 1.42
6 p53 Activation in adipocytes of obese mice. J Biol Chem 2003 1.28
7 Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages. J Biol Chem 2008 1.27
8 Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab 2013 1.19
9 p53 involvement in the pathogenesis of fatty liver disease. J Biol Chem 2004 1.18
10 Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis. Diabetes 2006 1.17
11 FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products. J Biol Chem 2002 1.17
12 Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide. J Biol Chem 2004 1.15
13 Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene. J Biol Chem 2003 1.06
14 Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit. J Biol Chem 2010 1.03
15 High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding. J Biol Chem 2005 0.97
16 Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence. J Lipid Res 2009 0.89
17 Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 2011 0.89
18 Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase. J Biol Chem 2002 0.89
19 Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death. Arterioscler Thromb Vasc Biol 2012 0.87
20 In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression. Biochem Biophys Res Commun 2007 0.85
21 Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver. J Lipid Res 2006 0.83
22 Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 2011 0.81
23 Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement. Biochem Biophys Res Commun 2010 0.75
24 Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene. J Atheroscler Thromb 2013 0.75