PubRank

Robert B Moreland

Author PubWeight™ 34.68‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels. Pain 2005 1.46
2 Molecular determinants of species-specific activation or blockade of TRPA1 channels. J Neurosci 2008 1.42
3 Transient receptor potential A1 mediates an osmotically activated ion channel. Eur J Neurosci 2008 1.23
4 TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells. J Neurochem 2006 1.05
5 Role of central and peripheral mGluR5 receptors in post-operative pain in rats. Pain 2005 0.96
6 Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A 2004 0.96
7 Reconstitution of human corpus cavernosum smooth muscle in vitro and in vivo. Tissue Eng 2002 0.95
8 Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes. Biochem Pharmacol 2007 0.93
9 Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597). Mol Pharmacol 2007 0.93
10 Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. J Med Chem 2004 0.92
11 A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats. Pharmacol Biochem Behav 2005 0.92
12 Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. J Med Chem 2005 0.91
13 Reperfusion of ischemic corporal tissue: physiologic and biochemical changes in an animal model of ischemic priapism. Urology 2003 0.90
14 Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test. Neuropsychopharmacology 2005 0.89
15 Central mechanisms regulating penile erection in conscious rats: the dopaminergic systems related to the proerectile effect of apomorphine. J Pharmacol Exp Ther 2003 0.88
16 Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. J Med Chem 2006 0.88
17 YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats. Eur J Pharmacol 2003 0.87
18 Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system. Eur J Pharmacol 2006 0.86
19 A-350619: a novel activator of soluble guanylyl cyclase. Life Sci 2003 0.85
20 Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists. Bioorg Med Chem Lett 2006 0.85
21 Effects of selective dopamine receptor subtype agonists on cardiac contractility and regional haemodynamics in rats. Clin Exp Pharmacol Physiol 2004 0.84
22 Quantification of TRPV1 protein levels in rat tissues to understand its physiological roles. J Mol Neurosci 2012 0.83
23 Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. J Med Chem 2004 0.82
24 Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonists. J Biomol Screen 2006 0.82
25 Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol Biochem Behav 2005 0.81
26 A cell-based microarrayed compound screening format for identifying agonists of G-protein-coupled receptors. Anal Biochem 2003 0.81
27 Discovery of TRPV1 antagonist ABT-116. Bioorg Med Chem Lett 2010 0.81
28 Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats. Eur J Pharmacol 2007 0.81
29 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. J Med Chem 2006 0.81
30 Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists. Bioorg Med Chem 2004 0.80
31 Application of large-scale transiently transfected cells to functional assays of ion channels: different targets and assay formats. Assay Drug Dev Technol 2007 0.80
32 Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation. Neuropharmacology 2005 0.79
33 Expression and purification of human TRPV1 in baculovirus-infected insect cells for structural studies. Protein Expr Purif 2008 0.78
34 Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists. Bioorg Med Chem Lett 2007 0.77
35 Acrylamide analog as a novel nitric oxide-independent soluble guanylyl cyclase activator. J Pharmacol Sci 2006 0.77
36 Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists. Bioorg Med Chem 2005 0.77
37 Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia. Eur J Pharmacol 2008 0.77
38 [3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor. J Pharmacol Exp Ther 2007 0.76
39 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Neuropharmacology 2005 0.75
40 Central oxytocinergic and dopaminergic mechanisms regulating penile erection in conscious rats. Pharmacol Biochem Behav 2005 0.75
41 Development of ELISA to measure TRPV1 protein in rat tissues. J Neurosci Methods 2011 0.75
42 Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand. Bioorg Med Chem Lett 2004 0.75