Regulon and promoter analysis of the E. coli heat-shock factor, sigma32, reveals a multifaceted cellular response to heat stress.

PubWeight™: 2.50‹?› | Rank: Top 2%

🔗 View Article (PMC 1522074)

Published in Genes Dev on July 01, 2006

Authors

Gen Nonaka1, Matthew Blankschien, Christophe Herman, Carol A Gross, Virgil A Rhodius

Author Affiliations

1: Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California 94143, USA.

Articles citing this

EcoCyc: a comprehensive view of Escherichia coli biology. Nucleic Acids Res (2008) 7.05

Hfq modulates the sigmaE-mediated envelope stress response and the sigma32-mediated cytoplasmic stress response in Escherichia coli. J Bacteriol (2006) 1.86

Proteotoxic stress induces a cell-cycle arrest by stimulating Lon to degrade the replication initiator DnaA. Cell (2013) 1.86

Convergence of molecular, modeling, and systems approaches for an understanding of the Escherichia coli heat shock response. Microbiol Mol Biol Rev (2008) 1.79

The Rcs phosphorelay is a cell envelope stress response activated by peptidoglycan stress and contributes to intrinsic antibiotic resistance. J Bacteriol (2008) 1.67

Heat shock transcription factor σ32 co-opts the signal recognition particle to regulate protein homeostasis in E. coli. PLoS Biol (2013) 1.51

Molecular mechanisms of ethanol-induced pathogenesis revealed by RNA-sequencing. PLoS Pathog (2010) 1.47

The extracytoplasmic stress factor, sigmaE, is required to maintain cell envelope integrity in Escherichia coli. PLoS One (2008) 1.44

Sigma E controls biogenesis of the antisense RNA MicA. Nucleic Acids Res (2007) 1.38

Dissection of recognition determinants of Escherichia coli sigma32 suggests a composite -10 region with an 'extended -10' motif and a core -10 element. Mol Microbiol (2009) 1.27

ChIP on Chip: surprising results are often artifacts. BMC Genomics (2010) 1.24

Heterologous expression of plasmodial proteins for structural studies and functional annotation. Malar J (2008) 1.22

Global mapping of transcription start sites and promoter motifs in the symbiotic α-proteobacterium Sinorhizobium meliloti 1021. BMC Genomics (2013) 1.21

Regulated proteolysis in Gram-negative bacteria--how and when? Nat Rev Microbiol (2011) 1.18

Production of recombinant proteins in E. coli by the heat inducible expression system based on the phage lambda pL and/or pR promoters. Microb Cell Fact (2010) 1.18

Regulation by transcription factors in bacteria: beyond description. FEMS Microbiol Rev (2009) 1.12

Analysis of sigma32 mutants defective in chaperone-mediated feedback control reveals unexpected complexity of the heat shock response. Proc Natl Acad Sci U S A (2007) 1.04

The evolution of the phage shock protein response system: interplay between protein function, genomic organization, and system function. Mol Biol Evol (2010) 1.00

YbeY, a heat shock protein involved in translation in Escherichia coli. J Bacteriol (2009) 0.99

Stress-induced remodeling of the bacterial proteome. Curr Biol (2014) 0.98

Convergence of the transcriptional responses to heat shock and singlet oxygen stresses. PLoS Genet (2012) 0.98

Reduced capacity of alternative sigmas to melt promoters ensures stringent promoter recognition. Genes Dev (2009) 0.98

Pivotal role of the Francisella tularensis heat-shock sigma factor RpoH. Microbiology (2009) 0.97

In vitro genetic reconstruction of bacterial transcription initiation by coupled synthesis and detection of RNA polymerase holoenzyme. Nucleic Acids Res (2010) 0.97

Dual RpoH sigma factors and transcriptional plasticity in a symbiotic bacterium. J Bacteriol (2012) 0.95

The origin of a novel gene through overprinting in Escherichia coli. BMC Evol Biol (2008) 0.94

Transcriptomic analysis of Escherichia coli O157:H7 and K-12 cultures exposed to inorganic and organic acids in stationary phase reveals acidulant- and strain-specific acid tolerance responses. Appl Environ Microbiol (2010) 0.92

The heat shock protein YbeY is required for optimal activity of the 30S ribosomal subunit. J Bacteriol (2010) 0.91

Stress responses of shewanella. Int J Microbiol (2011) 0.89

Comparison of strand-specific transcriptomes of enterohemorrhagic Escherichia coli O157:H7 EDL933 (EHEC) under eleven different environmental conditions including radish sprouts and cattle feces. BMC Genomics (2014) 0.89

Global gene expression and phenotypic analysis of a Vibrio cholerae rpoH deletion mutant. J Bacteriol (2006) 0.89

Sxy induces a CRP-S regulon in Escherichia coli. J Bacteriol (2009) 0.89

The role of sigma factor RpoH1 in the pH stress response of Sinorhizobium meliloti. BMC Microbiol (2010) 0.88

Identification and quantitation of newly synthesized proteins in Escherichia coli by enrichment of azidohomoalanine-labeled peptides with diagonal chromatography. Mol Cell Proteomics (2009) 0.88

YhiQ is RsmJ, the methyltransferase responsible for methylation of G1516 in 16S rRNA of E. coli. J Mol Biol (2011) 0.88

Non-canonical protein-DNA interactions identified by ChIP are not artifacts. BMC Genomics (2013) 0.87

Technical considerations in using DNA microarrays to define regulons. Methods (2008) 0.87

Growth phase- and cell division-dependent activation and inactivation of the {sigma}32 regulon in Escherichia coli. J Bacteriol (2008) 0.86

Gene expression induced in Escherichia coli O157:H7 upon exposure to model apple juice. Appl Environ Microbiol (2009) 0.86

RNA-Seq analysis of the multipartite genome of Rhizobium etli CE3 shows different replicon contributions under heat and saline shock. BMC Genomics (2014) 0.85

Physiological response to membrane protein overexpression in E. coli. Mol Cell Proteomics (2011) 0.85

Assembly of lipopolysaccharide in Escherichia coli requires the essential LapB heat shock protein. J Biol Chem (2014) 0.85

Translation quality control is critical for bacterial responses to amino acid stress. Proc Natl Acad Sci U S A (2016) 0.85

DsrR, a novel IscA-like protein lacking iron- and Fe-S-binding functions, involved in the regulation of sulfur oxidation in Allochromatium vinosum. J Bacteriol (2010) 0.84

Integrated transcriptomic and proteomic analysis of the physiological response of Escherichia coli O157:H7 Sakai to steady-state conditions of cold and water activity stress. Mol Cell Proteomics (2011) 0.83

Proteolysis in the Escherichia coli heat shock response: a player at many levels. Curr Opin Microbiol (2011) 0.83

Integrating protein homeostasis strategies in prokaryotes. Cold Spring Harb Perspect Biol (2011) 0.83

IscR regulates RNase LS activity by repressing rnlA transcription. Genetics (2010) 0.83

Cas3 is a limiting factor for CRISPR-Cas immunity in Escherichia coli cells lacking H-NS. BMC Microbiol (2016) 0.82

Transcription analysis of central metabolism genes in Escherichia coli. Possible roles of sigma38 in their expression, as a response to carbon limitation. PLoS One (2009) 0.82

Promoters of Escherichia coli versus promoter islands: function and structure comparison. PLoS One (2013) 0.81

Promoter recognition by bacterial alternative sigma factors: the price of high selectivity? Genes Dev (2009) 0.81

Insights into the function of YciM, a heat shock membrane protein required to maintain envelope integrity in Escherichia coli. J Bacteriol (2013) 0.81

Insights into the extracytoplasmic stress response of Xanthomonas campestris pv. campestris: role and regulation of {sigma}E-dependent activity. J Bacteriol (2010) 0.81

Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in σ(E)-regulated SPI-2 gene expression. Front Microbiol (2015) 0.80

New insights on the reorganization of gene transcription in Pseudomonas putida KT2440 at elevated pressure. Microb Cell Fact (2013) 0.80

The two-component system CpxR/A represses the expression of Salmonella virulence genes by affecting the stability of the transcriptional regulator HilD. Front Microbiol (2015) 0.80

First-Step Mutations during Adaptation Restore the Expression of Hundreds of Genes. Mol Biol Evol (2015) 0.80

Global genome response of Escherichia coli O157∶H7 Sakai during dynamic changes in growth kinetics induced by an abrupt downshift in water activity. PLoS One (2014) 0.80

A comparative kinetic and thermodynamic perspective of the σ-competition model in Escherichia coli. Biophys J (2012) 0.80

The MiaA tRNA modification enzyme is necessary for robust RpoS expression in Escherichia coli. J Bacteriol (2013) 0.80

Nonnative disulfide bond formation activates the σ32-dependent heat shock response in Escherichia coli. J Bacteriol (2013) 0.80

Proteome analysis of the UVB-resistant marine bacterium Photobacterium angustum S14. PLoS One (2012) 0.80

Identification of commensal Escherichia coli genes involved in biofilm resistance to pathogen colonization. PLoS One (2013) 0.79

Using DNA microarrays to assay part function. Methods Enzymol (2011) 0.79

Transcriptional analysis of the hsp70 gene in a haloarchaeon Natrinema sp. J7 under heat and cold stress. Extremophiles (2009) 0.79

Mapping the Regulatory Network for Salmonella enterica Serovar Typhimurium Invasion. MBio (2016) 0.78

A bacteriophage-encoded J-domain protein interacts with the DnaK/Hsp70 chaperone and stabilizes the heat-shock factor σ32 of Escherichia coli. PLoS Genet (2012) 0.78

Signal correlations in ecological niches can shape the organization and evolution of bacterial gene regulatory networks. Adv Microb Physiol (2012) 0.78

YoeB toxin is activated during thermal stress. Microbiologyopen (2015) 0.78

Anti-Sigma Factors in E. coli: Common Regulatory Mechanisms Controlling Sigma Factors Availability. Curr Genomics (2013) 0.78

Genetic and phenotypic characterization of the heat shock response in Pseudomonas putida. Microbiologyopen (2014) 0.78

Expanding the regulatory network governed by the extracytoplasmic function sigma factor σH in Corynebacterium glutamicum. J Bacteriol (2014) 0.78

Substitution of a highly conserved histidine in the Escherichia coli heat shock transcription factor, sigma32, affects promoter utilization in vitro and leads to overexpression of the biofilm-associated flu protein in vivo. J Bacteriol (2007) 0.78

"Non-canonical protein-DNA interactions identified by ChIP are not artifacts": response. BMC Genomics (2013) 0.77

Global genome response of Escherichia coli O157∶H7 Sakai during dynamic changes in growth kinetics induced by an abrupt temperature downshift. PLoS One (2014) 0.77

Transcription of Ehrlichia chaffeensis genes is accomplished by RNA polymerase holoenzyme containing either sigma 32 or sigma 70. PLoS One (2013) 0.77

Escherichia coli thioredoxin-like protein YbbN contains an atypical tetratricopeptide repeat motif and is a negative regulator of GroEL. J Biol Chem (2011) 0.77

Predicting statistical properties of open reading frames in bacterial genomes. PLoS One (2012) 0.76

Strong spurious transcription likely contributes to DNA insert bias in typical metagenomic clone libraries. Microbiome (2015) 0.76

Transient growth arrest in Escherichia coli induced by chromosome condensation. PLoS One (2013) 0.76

Expression of the translocator protein (TSPO) from Pseudomonas fluorescens Pf0-1 requires the stress regulatory sigma factors AlgU and RpoH. Front Microbiol (2015) 0.76

SigmoID: a user-friendly tool for improving bacterial genome annotation through analysis of transcription control signals. PeerJ (2016) 0.75

The Two-Component System CpxRA Negatively Regulates the Locus of Enterocyte Effacement of Enterohemorrhagic Escherichia coli Involving σ(32) and Lon protease. Front Cell Infect Microbiol (2016) 0.75

A Sinorhizobium meliloti RpoH-Regulated Gene Is Involved in Iron-Sulfur Protein Metabolism and Effective Plant Symbiosis under Intrinsic Iron Limitation. J Bacteriol (2016) 0.75

The Escherichia coli rpoS-dependent htrC gene is not involved in the heat shock response. J Bacteriol (2006) 0.75

Physiological Response of Escherichia coli O157:H7 Sakai to Dynamic Changes in Temperature and Water Activity as Experienced during Carcass Chilling. Mol Cell Proteomics (2016) 0.75

DegP Chaperone Suppresses Toxic Inner Membrane Translocation Intermediates. PLoS One (2016) 0.75

Silencing of Essential Genes within a Highly Coordinated Operon in Escherichia coli. Appl Environ Microbiol (2015) 0.75

Modulation of the E. coli rpoH Temperature Sensor with Triptycene-Based Small Molecules. Angew Chem Int Ed Engl (2016) 0.75

Sequence determinants spanning -35 motif and AT-rich spacer region impacting Ehrlichia chaffeensis Sigma 70-dependent promoter activity of two differentially expressed p28 outer membrane protein genes. DNA Res (2016) 0.75

The whole set of the constitutive promoters recognized by four minor sigma subunits of Escherichia coli RNA polymerase. PLoS One (2017) 0.75

Global Gene-expression Analysis of the Response of Salmonella Enteritidis to Egg White Exposure Reveals Multiple Egg White-imposed Stress Responses. Front Microbiol (2017) 0.75

The Potential Link between Thermal Resistance and Virulence in Salmonella: A Review. Front Vet Sci (2017) 0.75

Articles cited by this

Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88

WebLogo: a sequence logo generator. Genome Res (2004) 59.58

Speculations on the functions of the major heat shock and glucose-regulated proteins. Cell (1986) 10.35

Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research. DNA Res (2006) 9.85

The htpR gene product of E. coli is a sigma factor for heat-shock promoters. Cell (1984) 9.51

Identification of a sex-factor-affinity site in E. coli as gamma delta. Cold Spring Harb Symp Quant Biol (1981) 8.26

A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase. Science (1993) 7.42

Genome-wide expression profiling in Escherichia coli K-12. Nucleic Acids Res (1999) 7.20

Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous. Proc Natl Acad Sci U S A (1984) 7.20

Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs. J Mol Biol (1974) 6.60

Consensus sequence for Escherichia coli heat shock gene promoters. Proc Natl Acad Sci U S A (1985) 6.04

The heat shock response of E. coli is regulated by changes in the concentration of sigma 32. Nature (1987) 5.95

Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly. Science (1990) 5.88

The activity of sigma E, an Escherichia coli heat-inducible sigma-factor, is modulated by expression of outer membrane proteins. Genes Dev (1993) 5.00

Ribosomes as sensors of heat and cold shock in Escherichia coli. Proc Natl Acad Sci U S A (1990) 4.92

Genome-wide analysis of the general stress response network in Escherichia coli: sigmaS-dependent genes, promoters, and sigma factor selectivity. J Bacteriol (2005) 4.86

Transient rates of synthesis of individual polypeptides in E. coli following temperature shifts. Cell (1978) 4.66

Conserved and variable functions of the sigmaE stress response in related genomes. PLoS Biol (2006) 4.46

Transient regulation of protein synthesis in Escherichia coli upon shift-up of growth temperature. J Bacteriol (1978) 4.38

OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain. Cell (2003) 4.21

The Escherichia coli K-12 "wild types" W3110 and MG1655 have an rph frameshift mutation that leads to pyrimidine starvation due to low pyrE expression levels. J Bacteriol (1993) 4.10

Genome-wide analysis of the biology of stress responses through heat shock transcription factor. Mol Cell Biol (2004) 3.61

The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner. Cell (1990) 3.51

Sequence of the lon gene in Escherichia coli. A heat-shock gene which encodes the ATP-dependent protease La. J Biol Chem (1988) 3.21

Degradation of sigma 32, the heat shock regulator in Escherichia coli, is governed by HflB. Proc Natl Acad Sci U S A (1995) 3.20

Transcription from a heat-inducible promoter causes heat shock regulation of the sigma subunit of E. coli RNA polymerase. Cell (1984) 3.10

Oxidative protein folding is driven by the electron transport system. Cell (1999) 3.09

Chaperone activity with a redox switch. Cell (1999) 3.00

Identification of an UP element consensus sequence for bacterial promoters. Proc Natl Acad Sci U S A (1998) 2.80

Global regulation of gene expression in Escherichia coli. J Bacteriol (1993) 2.65

The DnaK chaperone modulates the heat shock response of Escherichia coli by binding to the sigma 32 transcription factor. Proc Natl Acad Sci U S A (1992) 2.63

Temperature-induced synthesis of specific proteins in Escherichia coli: evidence for transcriptional control. J Bacteriol (1980) 2.59

RNA methylation under heat shock control. Mol Cell (2000) 2.58

A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32. EMBO J (1996) 2.55

Translational induction of heat shock transcription factor sigma32: evidence for a built-in RNA thermosensor. Genes Dev (1999) 2.30

GenProtEC: an updated and improved analysis of functions of Escherichia coli K-12 proteins. Nucleic Acids Res (2004) 2.27

IscR-dependent gene expression links iron-sulphur cluster assembly to the control of O2-regulated genes in Escherichia coli. Mol Microbiol (2006) 2.26

Eukaryotic Mr 83,000 heat shock protein has a homologue in Escherichia coli. Proc Natl Acad Sci U S A (1987) 2.25

A new heat-shock gene, ppiD, encodes a peptidyl-prolyl isomerase required for folding of outer membrane proteins in Escherichia coli. EMBO J (1998) 2.18

Surviving heat shock: control strategies for robustness and performance. Proc Natl Acad Sci U S A (2005) 2.12

Retracted Renaturation of denatured lambda repressor requires heat shock proteins. Cell (1990) 2.05

The Escherichia coli heat shock gene htpY: mutational analysis, cloning, sequencing, and transcriptional regulation. J Bacteriol (1993) 2.03

The activity of sigma 32 is reduced under conditions of excess heat shock protein production in Escherichia coli. Genes Dev (1989) 1.90

Sequence analysis and transcriptional regulation of the Escherichia coli grpE gene, encoding a heat shock protein. Nucleic Acids Res (1988) 1.87

Sequence analysis of four new heat-shock genes constituting the hslTS/ibpAB and hslVU operons in Escherichia coli. Gene (1993) 1.82

Growth inhibition mediated by excess negative supercoiling: the interplay between transcription elongation, R-loop formation and DNA topology. Mol Microbiol (2006) 1.76

A new Escherichia coli heat shock gene, htrC, whose product is essential for viability only at high temperatures. J Bacteriol (1990) 1.76

A chaperone network controls the heat shock response in E. coli. Genes Dev (2004) 1.63

Why is carbonic anhydrase essential to Escherichia coli? J Bacteriol (2003) 1.61

Expression of ClpB, an analog of the ATP-dependent protease regulatory subunit in Escherichia coli, is controlled by a heat shock sigma factor (sigma 32). J Bacteriol (1991) 1.61

Heat-induced synthesis of sigma32 in Escherichia coli: structural and functional dissection of rpoH mRNA secondary structure. J Bacteriol (1999) 1.57

Characterization of twenty-six new heat shock genes of Escherichia coli. J Bacteriol (1993) 1.52

The global transcriptional response of Escherichia coli to induced sigma 32 protein involves sigma 32 regulon activation followed by inactivation and degradation of sigma 32 in vivo. J Biol Chem (2005) 1.51

Heat shock regulation in the ftsH null mutant of Escherichia coli: dissection of stability and activity control mechanisms of sigma32 in vivo. Mol Microbiol (1998) 1.48

Heat induction of sigma 32 synthesis mediated by mRNA secondary structure: a primary step of the heat shock response in Escherichia coli. Nucleic Acids Res (1993) 1.46

Signal transduction pathways in response to protein misfolding in the extracytoplasmic compartments of E. coli: role of two new phosphoprotein phosphatases PrpA and PrpB. EMBO J (1997) 1.45

Identification of a novel class of target genes and a novel type of binding sequence of heat shock transcription factor in Saccharomyces cerevisiae. J Biol Chem (2005) 1.44

The htrM gene, whose product is essential for Escherichia coli viability only at elevated temperatures, is identical to the rfaD gene. Nucleic Acids Res (1991) 1.43

On the mechanism of FtsH-dependent degradation of the sigma 32 transcriptional regulator of Escherichia coli and the role of the Dnak chaperone machine. Mol Microbiol (1999) 1.42

Antiterminator-dependent modulation of transcription elongation rates by NusB and NusG. Mol Microbiol (1999) 1.41

Transcription of the mutL repair, miaA tRNA modification, hfq pleiotropic regulator, and hflA region protease genes of Escherichia coli K-12 from clustered Esigma32-specific promoters during heat shock. J Bacteriol (1996) 1.39

Transcription of the Escherichia coli rrnB P1 promoter by the heat shock RNA polymerase (E sigma 32) in vitro. J Bacteriol (1993) 1.38

The Cpx stress response system of Escherichia coli senses plasma membrane proteins and controls HtpX, a membrane protease with a cytosolic active site. Genes Cells (2002) 1.34

RapA, a bacterial homolog of SWI2/SNF2, stimulates RNA polymerase recycling in transcription. Genes Dev (2001) 1.32

Host control of plasmid replication: requirement for the sigma factor sigma 32 in transcription of mini-F replication initiator gene. Proc Natl Acad Sci U S A (1987) 1.28

In vivo effect of NusB and NusG on rRNA transcription antitermination. J Bacteriol (2004) 1.26

Active increase in cardiolipin synthesis in the stationary growth phase and its physiological significance in Escherichia coli. FEBS Lett (1993) 1.26

Direct interaction between Escherichia coli RNA polymerase and the zinc ribbon domains of DNA topoisomerase I. J Biol Chem (2003) 1.24

Hsp15: a ribosome-associated heat shock protein. EMBO J (2000) 1.22

Improving promoter prediction for the NNPP2.2 algorithm: a case study using Escherichia coli DNA sequences. Bioinformatics (2004) 1.19

The Escherichia coli gapA gene is transcribed by the vegetative RNA polymerase holoenzyme E sigma 70 and by the heat shock RNA polymerase E sigma 32. J Bacteriol (1994) 1.14

Isolation, characterization, and sequence of an Escherichia coli heat shock gene, htpX. J Bacteriol (1991) 1.13

Transient shut off of Escherichia coli heat shock protein synthesis upon temperature shift down. Biochem Biophys Res Commun (1989) 1.09

Sigma 32-dependent promoter activity in vivo: sequence determinants of the groE promoter. J Bacteriol (2003) 1.06

Differential ability of sigma(s) and sigma70 of Escherichia coli to utilize promoters containing half or full UP-element sites. Mol Microbiol (2005) 1.05

Heat shock-dependent transcriptional activation of the metA gene of Escherichia coli. J Bacteriol (1995) 0.99

Identification of a heat shock promoter in the topA gene of Escherichia coli. J Bacteriol (1990) 0.98

Effect of the deletion of the sigma 32-dependent promoter (P1) of the Escherichia coli topoisomerase I gene on thermotolerance. Mol Microbiol (1996) 0.97

Effects of reduced levels of GroE chaperones on protein metabolism: enhanced synthesis of heat shock proteins during steady-state growth of Escherichia coli. J Bacteriol (1994) 0.97

Heat shock RNA polymerase (E sigma(32)) is involved in the transcription of mlc and crucial for induction of the Mlc regulon by glucose in Escherichia coli. J Biol Chem (2001) 0.94

RNA polymerase holoenzymes can share a single transcription start site for the Pm promoter. Critical nucleotides in the -7 to -18 region are needed to select between RNA polymerase with sigma38 or sigma32. J Biol Chem (2005) 0.88

Expression of different-size transcripts from the clpP-clpX operon of Escherichia coli during carbon deprivation. J Bacteriol (2000) 0.86

CRP.cAMP-dependent transcription activation of the Escherichia coli pts Po promoter by the heat shock RNA polymerase (Esigma32) in vitro. Mol Cells (1998) 0.79

Articles by these authors

Multiple sigma subunits and the partitioning of bacterial transcription space. Annu Rev Microbiol (2003) 5.36

From the regulation of peptidoglycan synthesis to bacterial growth and morphology. Nat Rev Microbiol (2011) 4.98

Conserved and variable functions of the sigmaE stress response in related genomes. PLoS Biol (2006) 4.46

OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain. Cell (2003) 4.21

Phenotypic landscape of a bacterial cell. Cell (2010) 3.50

Regulation of the Escherichia coli sigma-dependent envelope stress response. Mol Microbiol (2004) 3.35

High-throughput, quantitative analyses of genetic interactions in E. coli. Nat Methods (2008) 3.17

DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response. Genes Dev (2002) 3.13

Regulation of peptidoglycan synthesis by outer-membrane proteins. Cell (2010) 2.86

Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo. Cell (2011) 2.55

Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA. Mol Cell (2003) 2.50

Minimal machinery of RNA polymerase holoenzyme sufficient for promoter melting. Science (2004) 2.28

An open letter to Elias Zerhouni. Science (2005) 2.19

Design principles of the proteolytic cascade governing the sigmaE-mediated envelope stress response in Escherichia coli: keys to graded, buffered, and rapid signal transduction. Genes Dev (2007) 1.99

Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH. Mol Cell (2003) 1.94

Characterization of six lipoproteins in the sigmaE regulon. J Bacteriol (2005) 1.91

Insights into transcriptional regulation and sigma competition from an equilibrium model of RNA polymerase binding to DNA. Proc Natl Acad Sci U S A (2006) 1.91

Hfq modulates the sigmaE-mediated envelope stress response and the sigma32-mediated cytoplasmic stress response in Escherichia coli. J Bacteriol (2006) 1.86

Convergence of molecular, modeling, and systems approaches for an understanding of the Escherichia coli heat shock response. Microbiol Mol Biol Rev (2008) 1.79

Views of transcription initiation. Cell (2002) 1.78

Directed evolution of substrate-optimized GroEL/S chaperonins. Cell (2002) 1.71

SigmaE regulates and is regulated by a small RNA in Escherichia coli. J Bacteriol (2007) 1.68

Fine-tuning of the Escherichia coli sigmaE envelope stress response relies on multiple mechanisms to inhibit signal-independent proteolysis of the transmembrane anti-sigma factor, RseA. Genes Dev (2004) 1.66

A chaperone network controls the heat shock response in E. coli. Genes Dev (2004) 1.63

The transcription factor DksA prevents conflicts between DNA replication and transcription machinery. Cell (2010) 1.60

Bacterial sigma factors: a historical, structural, and genomic perspective. Annu Rev Microbiol (2014) 1.49

Transcriptional infidelity promotes heritable phenotypic change in a bistable gene network. PLoS Biol (2009) 1.48

Small RNAs endow a transcriptional activator with essential repressor functions for single-tier control of a global stress regulon. Proc Natl Acad Sci U S A (2011) 1.46

Regulation of the alternative sigma factor sigma(E) during initiation, adaptation, and shutoff of the extracytoplasmic heat shock response in Escherichia coli. J Bacteriol (2003) 1.44

ATP-dependent proteases differ substantially in their ability to unfold globular proteins. J Biol Chem (2009) 1.32

Engineered proteins detect spontaneous DNA breakage in human and bacterial cells. Elife (2013) 1.28

Dissection of recognition determinants of Escherichia coli sigma32 suggests a composite -10 region with an 'extended -10' motif and a core -10 element. Mol Microbiol (2009) 1.27

Module-based analysis of robustness tradeoffs in the heat shock response system. PLoS Comput Biol (2006) 1.23

Architectural requirements for optimal activation by tandem CRP molecules at a class I CRP-dependent promoter. FEMS Microbiol Lett (2002) 1.22

A hydrophobic patch on the flap-tip helix of E.coli RNA polymerase mediates sigma(70) region 4 function. J Mol Biol (2004) 1.21

Promoter strength properties of the complete sigma E regulon of Escherichia coli and Salmonella enterica. J Bacteriol (2009) 1.19

Mutational analysis of Escherichia coli sigma28 and its target promoters reveals recognition of a composite -10 region, comprised of an 'extended -10' motif and a core -10 element. Mol Microbiol (2009) 1.19

Dual molecular signals mediate the bacterial response to outer-membrane stress. Science (2013) 1.13

TraR, a homolog of a RNAP secondary channel interactor, modulates transcription. PLoS Genet (2009) 1.07

Super DksAs: substitutions in DksA enhancing its effects on transcription initiation. EMBO J (2009) 1.07

Separation of recombination and SOS response in Escherichia coli RecA suggests LexA interaction sites. PLoS Genet (2011) 1.07

The sigma(E) stress response is required for stress-induced mutation and amplification in Escherichia coli. Mol Microbiol (2010) 1.04

Analysis of sigma32 mutants defective in chaperone-mediated feedback control reveals unexpected complexity of the heat shock response. Proc Natl Acad Sci U S A (2007) 1.04

Signal integration by DegS and RseB governs the σ E-mediated envelope stress response in Escherichia coli. Proc Natl Acad Sci U S A (2011) 1.02

Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters. Mol Syst Biol (2013) 1.02

Recruitment of host ATP-dependent proteases by bacteriophage lambda. J Struct Biol (2004) 0.98

Reduced capacity of alternative sigmas to melt promoters ensures stringent promoter recognition. Genes Dev (2009) 0.98

Heritable change caused by transient transcription errors. PLoS Genet (2013) 0.97

Predicting the strength of UP-elements and full-length E. coli σE promoters. Nucleic Acids Res (2011) 0.95

Epigenetic switches: can infidelity govern fate in microbes? Curr Opin Microbiol (2011) 0.94

The crystal structure Escherichia coli Spy. Protein Sci (2010) 0.92

Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis. J Am Chem Soc (2012) 0.87

Unexpected stress-reducing effect of PhaP, a poly(3-hydroxybutyrate) granule-associated protein, in Escherichia coli. Appl Environ Microbiol (2011) 0.86

Characterization of a novel RNA polymerase mutant that alters DksA activity. J Bacteriol (2013) 0.84

Altering the interaction between sigma70 and RNA polymerase generates complexes with distinct transcription-elongation properties. Proc Natl Acad Sci U S A (2005) 0.84

Assay of Escherichia coli RNA polymerase: sigma-core interactions. Methods Enzymol (2003) 0.83

Analyzing the interaction of RseA and RseB, the two negative regulators of the sigmaE envelope stress response, using a combined bioinformatic and experimental strategy. J Biol Chem (2008) 0.82

An extra-cytoplasmic function sigma factor and anti-sigma factor control carotenoid biosynthesis in Azospirillum brasilense. Microbiology (2008) 0.79

Using DNA microarrays to assay part function. Methods Enzymol (2011) 0.79

The crystal structure of the periplasmic domain of Vibrio parahaemolyticus CpxA. Protein Sci (2012) 0.78

Correction: A Chemical-Genomic Screen of Neglected Antibiotics Reveals Illicit Transport of Kasugamycin and Blasticidin S. PLoS Genet (2017) 0.75