Published in Immunol Rev on June 01, 2006
Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies. J Virol (2008) 3.83
Phenotypic and functional heterogeneity of human memory B cells. Semin Immunol (2008) 2.85
Pathogenic mechanisms of B-lymphocyte dysfunction in HIV disease. J Allergy Clin Immunol (2008) 2.01
BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proc Natl Acad Sci U S A (2008) 1.88
Trial watch: Prognostic and predictive value of the immune infiltrate in cancer. Oncoimmunology (2012) 1.78
Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities. J Immunol (2008) 1.37
New insights into the regulation of human B-cell differentiation. Trends Immunol (2009) 1.26
Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets. Immunol Res (2009) 1.24
CpG oligonucleotides enhance proliferative and effector responses of B Cells in HIV-infected individuals. J Immunol (2008) 1.21
Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia. Proc Natl Acad Sci U S A (2008) 1.10
The agonists of TLR4 and 9 are sufficient to activate memory B cells to differentiate into plasma cells in vitro but not in vivo. J Immunol (2008) 1.06
Rheumatoid factor B cell memory leads to rapid, switched antibody-forming cell responses. J Immunol (2013) 1.03
CD73 expression is dynamically regulated in the germinal center and bone marrow plasma cells are diminished in its absence. PLoS One (2014) 0.82
Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice. PLoS One (2014) 0.81
Manipulating B cell homeostasis: a key component in the advancement of targeted strategies. Arch Immunol Ther Exp (Warsz) (2008) 0.80
Multiparameter flow cytometry and bioanalytics for B cell profiling in systemic lupus erythematosus. Methods Mol Biol (2012) 0.78
Kinetics of humoral and memory B cell response induced by the Plasmodium falciparum 19-kilodalton merozoite surface protein 1 in mice. Infect Immun (2011) 0.78
Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus. Proc Natl Acad Sci U S A (2016) 0.76
Interferon-β therapy specifically reduces pathogenic memory B cells in multiple sclerosis patients by inducing a FAS-mediated apoptosis. Immunol Cell Biol (2016) 0.76
Beyond pan-B-cell-directed therapy - new avenues and insights into the pathogenesis of SLE. Nat Rev Rheumatol (2016) 0.75
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature (2002) 11.05
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity (2006) 6.00
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med (2005) 4.85
Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science (2002) 4.21
Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity (2005) 4.06
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol (2010) 3.51
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med (2005) 3.43
Activation of autoreactive B cells by CpG dsDNA. Immunity (2003) 3.40
Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity (2007) 3.07
B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science (2012) 3.03
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest (2007) 2.81
New markers for murine memory B cells that define mutated and unmutated subsets. J Exp Med (2007) 2.65
Memory CD4+ T cells do not induce graft-versus-host disease. J Clin Invest (2003) 2.54
Langerhans cells are not required for efficient skin graft rejection. J Invest Dermatol (2008) 2.41
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood (2011) 2.33
Depletion of B cells in murine lupus: efficacy and resistance. J Immunol (2007) 2.25
Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. Blood (2008) 2.22
TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. J Immunol (2010) 2.09
Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced. J Exp Med (2002) 2.07
T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. Immunity (2008) 2.03
Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites. Eur J Immunol (2007) 2.00
Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med (2007) 2.00
NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus. Sci Transl Med (2012) 1.99
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med (2013) 1.88
BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proc Natl Acad Sci U S A (2008) 1.88
Attenuated liver fibrosis in the absence of B cells. J Clin Invest (2005) 1.82
Cutting edge: Hierarchy of maturity of murine memory B cell subsets. J Immunol (2010) 1.82
Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease. Blood (2004) 1.82
Investigation of the role of B-cells in type 1 diabetes in the NOD mouse. Diabetes (2004) 1.76
Maintenance of the plasma cell pool is independent of memory B cells. Proc Natl Acad Sci U S A (2008) 1.75
Antigen-specific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis. J Immunol (2005) 1.74
Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage. Immunity (2010) 1.70
Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors. Semin Immunol (2007) 1.69
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. J Clin Invest (2016) 1.62
Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge. Proc Natl Acad Sci U S A (2009) 1.61
Requirement of B cells for generating CD4+ T cell memory. J Immunol (2009) 1.60
A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells. Blood (2011) 1.60
Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. J Immunol (2009) 1.60
Target antigens determine graft-versus-host disease phenotype. J Immunol (2004) 1.57
Plasticity and heterogeneity in the generation of memory B cells and long-lived plasma cells: the influence of germinal center interactions and dynamics. J Immunol (2010) 1.51
Improved methods for detecting selection by mutation analysis of Ig V region sequences. Int Immunol (2008) 1.50
Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4⁺ effector memory T cells. Eur J Immunol (2011) 1.49
Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells. J Immunol (2009) 1.49
Mechanisms of central nervous system viral persistence: the critical role of antibody and B cells. J Immunol (2002) 1.48
B cells drive early T cell autoimmunity in vivo prior to dendritic cell-mediated autoantigen presentation. J Immunol (2006) 1.44
Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol (2009) 1.42
Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity (2013) 1.40
Autoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha. J Immunol (2008) 1.39
Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities. J Immunol (2008) 1.37
Detecting selection in immunoglobulin sequences. Nucleic Acids Res (2011) 1.35
Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal center. J Immunol (2005) 1.35
Estimating hypermutation rates from clonal tree data. J Immunol (2003) 1.34
In vivo imaging studies shed light on germinal-centre development. Nat Rev Immunol (2007) 1.32
Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood (2008) 1.27
Reassessing the function of immune-complex retention by follicular dendritic cells. Nat Rev Immunol (2003) 1.27
B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice. J Immunol (2011) 1.12
Histone modifications associated with somatic hypermutation. Immunity (2005) 1.10
Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells. J Immunol (2006) 1.10
Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice. J Immunol (2009) 1.10
TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation. J Immunol (2013) 1.07
Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion. J Immunol (2012) 1.05
Rheumatoid factor B cell memory leads to rapid, switched antibody-forming cell responses. J Immunol (2013) 1.03
CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation. J Immunol (2012) 1.02
Langerhans cells are not required for graft-versus-host disease. Blood (2010) 1.01
A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation. Autoimmunity (2010) 1.01
Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1. J Immunol (2013) 0.99
Context-specific BAFF-R signaling by the NF-κB and PI3K pathways. Cell Rep (2013) 0.99
Visualizing the onset and evolution of an autoantibody response in systemic autoimmunity. J Immunol (2005) 0.98
Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides. J Immunol (2009) 0.98
Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variation. Proc Natl Acad Sci U S A (2006) 0.97
Single round of antigen receptor signaling programs naive B cells to receive T cell help. Immunity (2010) 0.97
B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation. J Immunol (2006) 0.97
Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo. Proc Natl Acad Sci U S A (2011) 0.96
Langerhans cell deficiency impairs Ixodes scapularis suppression of Th1 responses in mice. Infect Immun (2009) 0.95
IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity. J Exp Med (2013) 0.95
Integrating B cell lineage information into statistical tests for detecting selection in Ig sequences. J Immunol (2013) 0.93
Antigen presentation and transfer between B cells and macrophages. Eur J Immunol (2007) 0.93
The role of innate immunity in autoimmunity. J Exp Med (2004) 0.89
Recipient B cells are not required for graft-versus-host disease induction. Biol Blood Marrow Transplant (2010) 0.88
An acquired defect in IgG-dependent phagocytosis explains the impairment in antibody-mediated cellular depletion in Lupus. J Immunol (2011) 0.88
The B cell receptor itself can activate complement to provide the complement receptor 1/2 ligand required to enhance B cell immune responses in vivo. J Exp Med (2003) 0.88
Antibody-independent B cell-intrinsic and -extrinsic roles for CD21/35. Eur J Immunol (2006) 0.86
Multiple transcription factor binding sites predict AID targeting in non-Ig genes. J Immunol (2013) 0.86
Spontaneous loss of tolerance of autoreactive B cells in Act1-deficient rheumatoid factor transgenic mice. J Immunol (2013) 0.84
Memory T cells in GVHD and GVL. Biol Blood Marrow Transplant (2008) 0.82
Rheumatoid factors in health and disease: structure, function, induction and regulation. Curr Dir Autoimmun (2003) 0.76
B cells and dendritic cells from V kappa 8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells. J Immunol (2006) 0.76
Recipient gammadelta T cells in graft-versus-host disease. Blood (2006) 0.75
Lupus and proliferative nephritis are PAD4 independent in murine models. JCI Insight (2017) 0.75
Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development. DNA Cell Biol (2002) 0.75
Autoimmunity: The genes and phenotypes of autoimmunity. Curr Opin Immunol (2004) 0.75