1
|
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.
|
J Biol Chem
|
2004
|
5.05
|
2
|
Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells.
|
Cell Metab
|
2012
|
2.43
|
3
|
Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.
|
Cancer Res
|
2007
|
2.31
|
4
|
Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers.
|
Cancer Res
|
2007
|
2.06
|
5
|
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.
|
Proc Natl Acad Sci U S A
|
2011
|
2.01
|
6
|
Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer.
|
J Clin Oncol
|
2003
|
1.92
|
7
|
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.
|
Cancer Res
|
2002
|
1.84
|
8
|
New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes.
|
Blood
|
2010
|
1.82
|
9
|
DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.
|
Cancer Res
|
2011
|
1.78
|
10
|
Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival.
|
Clin Cancer Res
|
2002
|
1.74
|
11
|
Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer.
|
Int J Radiat Oncol Biol Phys
|
2002
|
1.74
|
12
|
Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer.
|
Cancer Res
|
2002
|
1.68
|
13
|
Increased angiogenesis and lymphangiogenesis in inflammatory versus noninflammatory breast cancer by real-time reverse transcriptase-PCR gene expression quantification.
|
Clin Cancer Res
|
2004
|
1.59
|
14
|
Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
|
J Biol Chem
|
2004
|
1.58
|
15
|
Vascular endothelial growth factor (VEGF) is expressed by neoplastic Hodgkin-Reed-Sternberg cells in Hodgkin's disease.
|
J Pathol
|
2002
|
1.53
|
16
|
The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth.
|
Cancer Res
|
2010
|
1.40
|
17
|
The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer.
|
Clin Cancer Res
|
2005
|
1.38
|
18
|
Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.
|
Clin Cancer Res
|
2012
|
1.30
|
19
|
Expression of TRAIL and TRAIL receptors in normal and malignant tissues.
|
Cell Res
|
2005
|
1.25
|
20
|
DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.
|
J Pathol
|
2003
|
1.22
|
21
|
Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1.
|
Proc Natl Acad Sci U S A
|
2009
|
1.20
|
22
|
BNIP3 as a progression marker in primary human breast cancer; opposing functions in in situ versus invasive cancer.
|
Clin Cancer Res
|
2007
|
1.19
|
23
|
Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer.
|
Am J Pathol
|
2010
|
1.17
|
24
|
Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts.
|
J Oncol
|
2010
|
1.14
|
25
|
BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability.
|
J Neurosci
|
2008
|
1.12
|
26
|
The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer.
|
Cancer
|
2006
|
1.11
|
27
|
An investigation into the prognostic significance of necrosis and hypoxia in high grade and invasive bladder cancer.
|
J Urol
|
2007
|
1.10
|
28
|
Phosphorylated KDR is expressed in the neoplastic and stromal elements of human renal tumours and shuttles from cell membrane to nucleus.
|
J Pathol
|
2004
|
1.06
|
29
|
Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases.
|
Ann N Y Acad Sci
|
2009
|
1.06
|
30
|
Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis.
|
Gynecol Oncol
|
2006
|
1.04
|
31
|
CD31 angiogenesis and combined expression of HIF-1α and HIF-2α are prognostic in primary clear-cell renal cell carcinoma (CC-RCC), but HIFα transcriptional products are not: implications for antiangiogenic trials and HIFα biomarker studies in primary CC-RCC.
|
Carcinogenesis
|
2012
|
1.01
|
32
|
TRAP1 regulates proliferation, mitochondrial function, and has prognostic significance in NSCLC.
|
Mol Cancer Res
|
2014
|
0.99
|
33
|
Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins.
|
Leuk Lymphoma
|
2008
|
0.98
|
34
|
CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha.
|
Cancer Res
|
2004
|
0.98
|
35
|
Expression of key hypoxia sensing prolyl-hydroxylases PHD1, -2 and -3 in pancreaticobiliary cancer.
|
Histopathology
|
2010
|
0.97
|
36
|
Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts.
|
J Mol Med (Berl)
|
2013
|
0.95
|
37
|
Low-dose IFN-gamma induces tumor MHC expression in metastatic malignant melanoma.
|
Clin Cancer Res
|
2003
|
0.95
|
38
|
Angiogenin is up-regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival.
|
J Pathol
|
2005
|
0.94
|
39
|
Pharmacokinetic study of cisplatin and infusional etoposide phosphate in advanced breast cancer with correlation of response to topoisomerase IIalpha expression.
|
Clin Cancer Res
|
2003
|
0.94
|
40
|
Induction of the vascular endothelial growth factor pathway in the brain of adults with fatal falciparum malaria is a non-specific response to severe disease.
|
Histopathology
|
2010
|
0.93
|
41
|
Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer.
|
Breast Cancer Res
|
2007
|
0.93
|
42
|
Relation of erythropoietin and erythropoietin receptor expression to hypoxia and anemia in head and neck squamous cell carcinoma.
|
Clin Cancer Res
|
2005
|
0.93
|
43
|
Phosphorylated KDR expression in endometrial cancer cells relates to HIF1alpha/VEGF pathway and unfavourable prognosis.
|
Mod Pathol
|
2006
|
0.91
|
44
|
Expression of the forkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the androgen receptor in prostate cancer but is not directly regulated by androgens or hypoxia.
|
Prostate
|
2007
|
0.88
|
45
|
Retracted
Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues.
|
Histopathology
|
2009
|
0.88
|
46
|
Expression of terminally glycosylated calcitonin receptor-like receptor in uterine leiomyoma: endothelial phenotype and association with microvascular density.
|
Clin Cancer Res
|
2006
|
0.86
|
47
|
Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway.
|
Cancer Lett
|
2008
|
0.84
|
48
|
Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines.
|
Prostate
|
2008
|
0.84
|
49
|
Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation.
|
Hematol Oncol
|
2008
|
0.83
|
50
|
Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma.
|
Histopathology
|
2012
|
0.83
|
51
|
Expression and cellular localization of vascular endothelial growth factor A and its receptors in acute and chronic leukemias: an immunohistochemical study.
|
Hum Pathol
|
2005
|
0.83
|
52
|
The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis.
|
Clin Cancer Res
|
2013
|
0.82
|
53
|
Nuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis.
|
J Urol
|
2011
|
0.81
|
54
|
The role of blood glucose availability and fatigue in the development of cognitive impairment during combat training.
|
Aviat Space Environ Med
|
2004
|
0.76
|
55
|
Biological and Prognostic Significance of the Morphological Types and Vascular Patterns in Colorectal Liver Metastases (CRLM): Looking Beyond the Tumor Margin.
|
Medicine (Baltimore)
|
2016
|
0.76
|
56
|
JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues.
|
Virchows Arch
|
2014
|
0.76
|
57
|
Immunohistological recognition of cyclin D1 expression by non-lymphoid cells among lymphoid neoplastic cells.
|
APMIS
|
2013
|
0.75
|