PubRank

Ted R Hupp

Author PubWeight™ 77.25‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012 20.08
2 Drug discovery and p53. Drug Discov Today 2003 2.34
3 Dual-site regulation of MDM2 E3-ubiquitin ligase activity. Mol Cell 2006 2.09
4 DNA-dependent acetylation of p53 by the transcription coactivator p300. J Biol Chem 2002 1.59
5 The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. J Biol Chem 2002 1.50
6 The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage. Mol Cell Proteomics 2004 1.42
7 The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53. Mol Cell Biol 2003 1.33
8 Hypoxia attenuates the p53 response to cellular damage. Oncogene 2003 1.31
9 Mage-A cancer/testis antigens inhibit p53 function by blocking its interaction with chromatin. Cancer Res 2010 1.27
10 CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability. J Biol Chem 2009 1.19
11 DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing. J Biol Chem 2008 1.19
12 Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53. Mol Cell Biol 2004 1.16
13 The regulation of MDM2 by multisite phosphorylation--opportunities for molecular-based intervention to target tumours? Semin Cancer Biol 2009 1.13
14 The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway. Aging (Albany NY) 2009 1.12
15 Drug discovery and mutant p53. Trends Cell Biol 2010 1.04
16 p63: the phantom of the tumor suppressor. Cell Cycle 2007 1.04
17 The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members. Mol Cell Biol 2007 1.01
18 A function for the RING finger domain in the allosteric control of MDM2 conformation and activity. J Biol Chem 2009 1.01
19 How phosphorylation controls p53. Cell Cycle 2011 0.99
20 Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death. FEBS J 2009 0.97
21 A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection. J Biol Chem 2008 0.96
22 The emergence of the conserved AAA+ ATPases Pontin and Reptin on the signaling landscape. Sci Signal 2013 0.94
23 Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2. Biochem J 2004 0.90
24 Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models. J Immunol Methods 2012 0.90
25 Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif. J Chem Biol 2009 0.90
26 On the mechanism of sequence-specific DNA-dependent acetylation of p53: the acetylation motif is exposed upon DNA binding. J Mol Biol 2005 0.89
27 A divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin. J Mol Biol 2010 0.89
28 The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury. FEBS J 2006 0.89
29 Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo. Biochem J 2006 0.89
30 p21(WAF1) is component of a positive feedback loop that maintains the p53 transcriptional program. Cell Cycle 2011 0.89
31 DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation. Mol Cancer 2010 0.88
32 Chemical states of the N-terminal "lid" of MDM2 regulate p53 binding: simulations reveal complexities of modulation. Cell Cycle 2011 0.87
33 The role of modelling in identifying drug targets for diseases of the cell cycle. J R Soc Interface 2006 0.87
34 Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2. Cancer Lett 2013 0.87
35 Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein. J Mol Biol 2004 0.86
36 Chemical genetics approach to identify peptide ligands that selectively stimulate DAPK-1 kinase activity. Biochemistry 2007 0.85
37 ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1. FEBS J 2008 0.85
38 Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry. J Am Soc Mass Spectrom 2011 0.85
39 The N-terminal interferon-binding domain (IBiD) homology domain of p300 binds to peptides with homology to the p53 transactivation domain. J Biol Chem 2004 0.84
40 The alternative splice variant of DAPK-1, s-DAPK-1, induces proteasome-independent DAPK-1 destabilization. Mol Cell Biochem 2009 0.84
41 CK2-site phosphorylation of p53 is induced in DeltaNp63 expressing basal stem cells in UVB irradiated human skin. Cell Cycle 2006 0.84
42 A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1. J Biol Chem 2011 0.84
43 The effects of phosphomimetic lid mutation on the thermostability of the N-terminal domain of MDM2. J Mol Biol 2010 0.84
44 Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2. Biochemistry 2007 0.83
45 Evaluating DAPK as a therapeutic target. Apoptosis 2014 0.83
46 Signaling to p53: the use of phospho-specific antibodies to probe for in vivo kinase activation. Methods Mol Biol 2003 0.82
47 A novel p53 phosphorylation site within the MDM2 ubiquitination signal: I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function. J Biol Chem 2010 0.81
48 Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry. Proteomics 2013 0.80
49 Nanosensing protein allostery using a bivalent mouse double minute two (MDM2) assay. Proc Natl Acad Sci U S A 2012 0.80
50 Intrasteric regulation of MDM2. Trends Biochem Sci 2003 0.80
51 Engineering a synthetic cell panel to identify signalling components reprogrammed by the cell growth regulator anterior gradient-2. Mol Biosyst 2014 0.79
52 Exploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growth. PLoS One 2012 0.79
53 A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53. J Biol Chem 2010 0.79
54 The molecular dynamics of MDM2. Cell Cycle 2010 0.79
55 Novel insights into DAPK autophagic signalling using peptide aptamer combinatorial protein-interaction screens. Autophagy 2008 0.78
56 Multienzyme assembly of a p53 transcription complex. Nat Struct Mol Biol 2007 0.78
57 Development of a fluorescent monoclonal antibody-based assay to measure the allosteric effects of synthetic peptides on self-oligomerization of AGR2 protein. Protein Sci 2013 0.77
58 Use of oesophageal stress response proteins as potential biomarkers in the screening for Barrett's oesophagus. Eur J Gastroenterol Hepatol 2008 0.77
59 The regulation of CHK2 in human cancer. Oncogene 2004 0.77
60 Quantitative proteomic profiling of pleomorphic human sarcoma identifies CLIC1 as a dominant pro-oncogenic receptor expressed in diverse sarcoma types. J Proteome Res 2014 0.77
61 A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway. Bioorg Med Chem Lett 2013 0.76
62 Protein kinases coordinately regulate the p53: Delta Np63 alpha axis after DNA damage. Cell Cycle 2008 0.75
63 Erratum: CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity. iScience 2022 0.75