Genetics of diabetic retinopathy.

Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy. Diabetes (2008) 1.36

The role of genetics in susceptibility to diabetic retinopathy. Int Ophthalmol Clin (2009) 1.30

Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci (2008) 1.29

Heritability of proliferative diabetic retinopathy. Diabetes (2008) 1.25

Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe). Invest Ophthalmol Vis Sci (2011) 1.22

Candidate genes for proliferative diabetic retinopathy. Biomed Res Int (2013) 1.19

Identification of Diabetic Retinopathy Genes through a Genome-Wide Association Study among Mexican-Americans from Starr County, Texas. J Ophthalmol (2010) 1.14

Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes. Mol Vis (2011) 1.01

Challenges in elucidating the genetics of diabetic retinopathy. JAMA Ophthalmol (2014) 0.93

Plasminogen activator inhibitor-1 4G/5G polymorphism and retinopathy risk in type 2 diabetes: a meta-analysis. BMC Med (2013) 0.86

Association of CFH and CFB gene polymorphisms with retinopathy in type 2 diabetic patients. Mediators Inflamm (2013) 0.85

EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes. Mol Vis (2008) 0.85

Diabetic retinopathy is associated with oxidative stress and mitigation of gene expression of antioxidant enzymes. Int J Gen Med (2013) 0.82

Update on genetics and diabetic retinopathy. Clin Ophthalmol (2015) 0.81

Current and future approaches in the prevention and treatment of diabetic retinopathy. Clin Ophthalmol (2008) 0.81

High prevalence of diabetic retinopathy and lack of association with integrin α2 gene polymorphisms in patients with type 2 diabetes from Northeastern Mexico. Exp Ther Med (2015) 0.80

Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population. J Transl Med (2015) 0.76

Cannabidiol As a Putative Novel Therapy for Diabetic Retinopathy: A Postulated Mechanism of Action as an Entry Point for Biomarker-Guided Clinical Development. Curr Pharmacogenomics Person Med (2009) 0.76

MnSOD Val16Ala polymorphism associated with retinopathy risk in diabetes: a PRISMA-compliant Meta-analysis of case-control studies. Int J Ophthalmol (2017) 0.75

Genetic and epigenetic modifications in the pathogenesis of diabetic retinopathy: a molecular link to regulate gene expression. New Front Ophthalmol (2016) 0.75

Altered sex ratio in offspring of mothers with insulin-dependent diabetes mellitus. Lancet (1998) 3.45

Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes. Proc Natl Acad Sci U S A (1997) 3.15

Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate. Proc Natl Acad Sci U S A (1993) 2.29

American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations. J Endocrinol Invest (2010) 2.20

Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans. Diabetologia (2008) 1.94

Regulation of adipocytokines and insulin resistance. Diabetologia (2003) 1.90

Association of interleukin-6, C-reactive protein, interleukin-10 and adiponectin plasma concentrations with measures of obesity, insulin sensitivity and glucose metabolism. Exp Clin Endocrinol Diabetes (2005) 1.76

New surface-hardened, low-modulus, corrosion-resistant Ti-13Nb-13Zr alloy for total hip arthroplasty. Biomed Mater Eng (1994) 1.67

Reduction of thyroid nodule volume by levothyroxine and iodine alone and in combination: a randomized, placebo-controlled trial. J Clin Endocrinol Metab (2011) 1.52

Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes. Diabetologia (2002) 1.52

Detection of thyroid-stimulating hormone receptor and Gsalpha mutations: in 75 toxic thyroid nodules by denaturing gradient gel electrophoresis. J Mol Med (Berl) (2001) 1.45

Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes. FEBS Lett (2001) 1.42

American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: Executive Summary of recommendations. J Endocrinol Invest (2010) 1.40

Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase. J Biol Chem (2001) 1.39

American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. J Endocrinol Invest (2010) 1.39

Thyroid nodules: a review of current guidelines, practices, and prospects. Eur J Endocrinol (2008) 1.39

Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes. Diabetologia (2007) 1.36

Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,. Biochemistry (1997) 1.32

NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer. J Biol Chem (2001) 1.31

Interobserver variation for ultrasound determination of thyroid nodule volumes. Thyroid (2005) 1.28

Reduced expression of Th1-associated chemokine receptors on peripheral blood lymphocytes at diagnosis of type 1 diabetes. Diabetes (2002) 1.22

Thyroid cancer in patients with hyperthyroidism. Horm Metab Res (2012) 1.08

Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity. Biochemistry (1996) 1.07

Insulin resistance-inducing cytokines differentially regulate SOCS mRNA expression via growth factor- and Jak/Stat-signaling pathways in 3T3-L1 adipocytes. J Endocrinol (2004) 1.05

Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes. Biochem Biophys Res Commun (2001) 1.03

Role of the third intracellular loop for the activation of gonadotropin receptors. Mol Endocrinol (1999) 1.02

Central vaspin administration acutely reduces food intake and has sustained blood glucose-lowering effects. Diabetologia (2011) 1.02

Retinol binding protein 4 (RBP4) is primarily associated with adipose tissue mass in children. Int J Pediatr Obes (2010) 1.01

Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism. J Clin Endocrinol Metab (1997) 1.01

Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy. Diabetologia (2006) 0.99

Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes. Horm Metab Res (2003) 0.99

Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology. Diabetologia (2012) 0.98

Vaspin is related to gender, puberty and deteriorating insulin sensitivity in children. Int J Obes (Lond) (2010) 0.95

A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation. Mol Endocrinol (2001) 0.94

Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits. Horm Metab Res (2009) 0.94

Novel TSHR germline mutation (Met463Val) masquerading as Graves' disease in a large Welsh kindred with hyperthyroidism. Thyroid (2000) 0.93

Adipokines and adipocyte targets in the future management of obesity and the metabolic syndrome. Mini Rev Med Chem (2007) 0.93

The E23K variant of KCNJ11 and the risk for severe sulfonylurea-induced hypoglycemia in patients with type 2 diabetes. Horm Metab Res (2009) 0.93

Neurohumoral stimulation in type-2-diabetes as an emerging disease concept. Cardiovasc Diabetol (2004) 0.92

Identification of the catalytic base in long chain acyl-CoA dehydrogenase. Biochemistry (1994) 0.92

The role of thiocyanate in the etiology of goiter in an industrial metropolitan area. Eur J Endocrinol (2006) 0.92

Effect of triamcinolone acetonide on proliferation of retinal endothelial cells in vitro and in vivo. Br J Ophthalmol (2005) 0.92

Sex-specific effect of the Val1483Ile polymorphism in the fatty acid synthase gene (FAS) on body mass index and lipid profile in Caucasian children. Int J Obes (Lond) (2006) 0.90

Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum. Exp Clin Endocrinol Diabetes (2010) 0.90

Biological activity of activating thyroid-stimulating hormone receptor mutants depends on the cellular context. Endocrinology (2003) 0.89

An aromatic environment in the vicinity of serine 281 is a structural requirement for thyrotropin receptor function. Endocrinology (2006) 0.89

Impact of the Thr789Ala variant of the von Willebrand factor levels, on ristocetin co-factor and collagen binding capacity and its association with coronary heart disease in patients with diabetes mellitus type 2. Exp Clin Endocrinol Diabetes (2005) 0.88

Linkage of familial euthyroid goiter to the multinodular goiter-1 locus and exclusion of the candidate genes thyroglobulin, thyroperoxidase, and Na+/I- symporter. J Clin Endocrinol Metab (1999) 0.88

Improvement of insulin sensitivity after adrenalectomy in patients with pheochromocytoma. J Clin Endocrinol Metab (2003) 0.88

Genetic variation in the vaspin gene affects circulating serum vaspin concentrations. Int J Obes (Lond) (2012) 0.88

Does tumor heterogeneity limit the use of the Weiss criteria in the evaluation of adrenocortical tumors? J Endocrinol Invest (2004) 0.87

Lack of association between peroxisome proliferator-activated receptor-gamma-2 gene variants and the occurrence of coronary heart disease in patients with diabetes mellitus. Eur J Endocrinol (2002) 0.87

Heme oxygenase and cardiac function in ischemic/reperfused rat hearts. Free Radic Biol Med (1999) 0.87

Questionnaire on management of nodular thyroid disease (Annual Meeting of the Thyroid Section of the German Society of Endocrinology 2003). Exp Clin Endocrinol Diabetes (2005) 0.86

Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound. Eur J Clin Invest (2009) 0.86

Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor--a basally active GPCR. Cell Mol Life Sci (2008) 0.86

Search for mitochondrial DNA mutation at position 3243 in German patients with a positive family history of maternal diabetes mellitus. Exp Clin Endocrinol Diabetes (2001) 0.86

Plasma levels of tumor necrosis factor-alpha, angiotensin II, growth hormone, and IGF-I are not elevated in insulin-resistant obese individuals with impaired glucose tolerance. Diabetes Care (2001) 0.86

Kinetics of integrin expression in the mouse model of proliferative retinopathy and success of secondary intervention with cyclic RGD peptides. Diabetologia (2002) 0.85

Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. Biochem Biophys Res Commun (1998) 0.85

DGGE is more sensitive for the detection of somatic point mutations than direct sequencing. Biotechniques (1999) 0.85

Evaluation of insulin-like growth factor II, cyclooxygenase-2, ets-1 and thyroid-specific thyroglobulin mRNA expression in benign and malignant thyroid tumours. Eur J Endocrinol (2005) 0.85

Effects of oxidative stress on the expression of antioxidative defense enzymes in spontaneously hypertensive rat hearts. Free Radic Biol Med (2000) 0.85

Endothelial survival factors and spatial completion, but not pericyte coverage of retinal capillaries determine vessel plasticity. FASEB J (2005) 0.85

Analysis of the relationship between PPAR-gamma 2 gene variants and severe insulin resistance in obese patients with impaired glucose tolerance. Exp Clin Endocrinol Diabetes (2003) 0.85

Acromegaly in a family without a mutation in the menin gene. Exp Clin Endocrinol Diabetes (1999) 0.85

Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient. Exp Clin Endocrinol Diabetes (2005) 0.85

Isoproterenol is a positive regulator of the suppressor of cytokine signaling-3 gene expression in 3T3-L1 adipocytes. J Endocrinol (2002) 0.84

Accuracy and clinical use of a novel aiming device for frameless stereotactic brain biopsy. Minim Invasive Neurosurg (2008) 0.84

Type 2 diabetes mellitus in children and adolescents: a review from a European perspective. Horm Res (2003) 0.84

Cytokine gene expression in autoimmune thyroiditis in BioBreeding/Worcester rats. Thyroid (1999) 0.84

SOM230 (pasireotide) and temozolomide achieve sustained control of tumour progression and ACTH secretion in pituitary carcinoma with widespread metastases. Exp Clin Endocrinol Diabetes (2010) 0.84

A SNP haplotype of the forkhead transcription factor FOXO1A gene may have a protective effect against type 2 diabetes in German Caucasians. Diabetes Metab (2007) 0.84

Iodine deficiency activates antioxidant genes and causes DNA damage in the thyroid gland of rats and mice. Biochim Biophys Acta (2007) 0.84

Frequency of somatic MEN1 gene mutations in monoclonal parathyroid tumours of patients with primary hyperparathyroidism. Eur J Endocrinol (2000) 0.83

Somatic mutations in the thyrotropin receptor gene and not in the Gs alpha protein gene in 31 toxic thyroid nodules. J Clin Endocrinol Metab (1997) 0.83

Isoproterenol inhibits resistin gene expression through a G(S)-protein-coupled pathway in 3T3-L1 adipocytes. FEBS Lett (2001) 0.83

Variable phenotype associated with Ser505Asn-activating thyrotropin-receptor germline mutation. Thyroid (1999) 0.83

Sporadic congenital hyperthyroidism due to a spontaneous germline mutation in the thyrotropin receptor gene. J Clin Endocrinol Metab (1997) 0.83

Evaluation of peroxisome proliferator-activated receptor-gamma expression in benign and malignant thyroid pathologies. Thyroid (2005) 0.83

Suppression of aquaporin adipose gene expression by isoproterenol, TNFalpha, and dexamethasone. Horm Metab Res (2003) 0.83

Frequency of the calcium-sensing receptor variant A986S in patients with primary hyperparathyroidism. Eur J Endocrinol (2001) 0.83

Lack of consistent association of thyrotropin receptor mutations in vitro activity with the clinical course of patients with sporadic non-autoimmune hyperthyroidism. J Endocrinol Invest (2009) 0.82

Functional characterization of five constitutively activating thyrotrophin receptor mutations. Clin Endocrinol (Oxf) (2000) 0.82

Transcription of thyroid autoantigens in non-expressing tissues. Exp Clin Endocrinol Diabetes (1998) 0.82

Late manifestation of subclinical hyperthyroidism after goitrogenesis in an index patient with a N670S TSH receptor germline mutation masquerading as TSH receptor antibody negative Graves' disease. Horm Metab Res (2012) 0.82

Thyrotoxic crisis in Graves' disease: indication for immediate surgery. Klin Wochenschr (1990) 0.82

Initial hemocompatibility studies of titanium and zirconium alloys: prekallikrein activation, fibrinogen adsorption, and their correlation with surface electrochemical properties. J Biomed Mater Res (1996) 0.81

Subclinical hyperthyroidism: physical and mental state of patients. Eur Arch Psychiatry Clin Neurosci (1992) 0.81

Zebrafish: a model for understanding diabetic complications. Exp Clin Endocrinol Diabetes (2012) 0.81

Thyrotropin receptor mutations as a tool to understand thyrotropin receptor action. J Mol Med (Berl) (2001) 0.81

Suppression of melanoma cell proliferation by histidine decarboxylase specific antisense oligonucleotides. J Invest Dermatol (2001) 0.81

Neuro-endocrine and neuropsychological outcome after aneurysmal subarachnoid hemorrhage (aSAH): a prospective cohort study. Exp Clin Endocrinol Diabetes (2010) 0.81

Evidence for a more pronounced effect of genetic predisposition than environmental factors on goitrogenesis by a case control study in an area with low normal iodine supply. Horm Metab Res (2011) 0.81

Iodine nutrition, nodular thyroid disease, and urinary iodine excretion in a German university study population. Thyroid (2005) 0.81

Metabolic syndrome and aging in Wistar Ottawa Karlsburg W rats. Int J Obes Relat Metab Disord (2002) 0.81

Deletions in the third intracellular loop of the thyrotropin receptor. A new mechanism for constitutive activation. J Biol Chem (1998) 0.81

Constitutively active receptors as a disease-causing mechanism. Mol Cell Endocrinol (1994) 0.81

Mutations of the TSH receptor as cause of congenital hyperthyroidism. Exp Clin Endocrinol Diabetes (1996) 0.81

Multiple relapses of hyperthyroidism after thyroid surgeries in a patient with long term follow-up of sporadic non-autoimmune hyperthyroidism. Exp Clin Endocrinol Diabetes (2008) 0.80