P D van Helden

Author PubWeight™ 130.70‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment. N Engl J Med 1999 8.80
2 Oligonucleotide (GTG)5 as a marker for Mycobacterium tuberculosis strain identification. J Clin Microbiol 1994 3.41
3 Microevolution of the direct repeat region of Mycobacterium tuberculosis: implications for interpretation of spoligotyping data. J Clin Microbiol 2002 3.12
4 A recently evolved sublineage of the Mycobacterium tuberculosis Beijing strain family is associated with an increased ability to spread and cause disease. J Clin Microbiol 2007 2.83
5 Bacille Calmette-Guérin vaccine-induced disease in HIV-infected and HIV-uninfected children. Clin Infect Dis 2006 2.78
6 Differentiation of Mycobacterium tuberculosis complex by PCR amplification of genomic regions of difference. Int J Tuberc Lung Dis 2006 2.78
7 Purification of sputum samples through sucrose improves detection of Mycobacterium tuberculosis by polymerase chain reaction. J Clin Microbiol 1992 2.53
8 Isoniazid pharmacokinetics in children treated for respiratory tuberculosis. Arch Dis Child 2005 2.39
9 Transmission of a multidrug-resistant Mycobacterium tuberculosis strain resembling "strain W" among noninstitutionalized, human immunodeficiency virus-seronegative patients. J Infect Dis 1999 2.31
10 Baseline sputum time to detection predicts month two culture conversion and relapse in non-HIV-infected patients. Int J Tuberc Lung Dis 2010 2.00
11 Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears. Antimicrob Agents Chemother 2007 1.93
12 Mapping of IS6110 flanking regions in clinical isolates of Mycobacterium tuberculosis demonstrates genome plasticity. Mol Microbiol 2000 1.92
13 The influence of human N-acetyltransferase genotype on the early bactericidal activity of isoniazid. Clin Infect Dis 2004 1.87
14 Changing Mycobacterium tuberculosis population highlights clade-specific pathogenic characteristics. Tuberculosis (Edinb) 2008 1.81
15 Detection of mutations in drug resistance genes of Mycobacterium tuberculosis by a dot-blot hybridization strategy. Tuber Lung Dis 1999 1.77
16 Trimodality of isoniazid elimination: phenotype and genotype in patients with tuberculosis. Am J Respir Crit Care Med 1997 1.74
17 Clonal expansion of a globally disseminated lineage of Mycobacterium tuberculosis with low IS6110 copy numbers. J Clin Microbiol 2004 1.73
18 Spoligotype signatures in the Mycobacterium tuberculosis complex. J Clin Microbiol 2006 1.71
19 The diagnostic performance of the GenoType MTBDRplus version 2 line probe assay is equivalent to that of the Xpert MTB/RIF assay. J Clin Microbiol 2012 1.70
20 Disruption of coding regions by IS6110 insertion in Mycobacterium tuberculosis. Tuber Lung Dis 1999 1.67
21 Time to detection of the growth of Mycobacterium tuberculosis in MGIT 960 for determining the early bactericidal activity of antituberculosis agents. Eur J Clin Microbiol Infect Dis 2010 1.67
22 Calculation of the stability of the IS6110 banding pattern in patients with persistent Mycobacterium tuberculosis disease. J Clin Microbiol 2002 1.62
23 Discordance between mycobacterial interspersed repetitive-unit-variable-number tandem-repeat typing and IS6110 restriction fragment length polymorphism genotyping for analysis of Mycobacterium tuberculosis Beijing strains in a setting of high incidence of tuberculosis. J Clin Microbiol 2008 1.58
24 Evolution of the IS6110-based restriction fragment length polymorphism pattern during the transmission of Mycobacterium tuberculosis. J Clin Microbiol 2002 1.55
25 Genotyping of Mycobacterium tuberculosis with additional markers enhances accuracy in epidemiological studies. J Clin Microbiol 1996 1.51
26 Impact of social interactions in the community on the transmission of tuberculosis in a high incidence area. Thorax 1999 1.50
27 Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence. J Clin Microbiol 2008 1.46
28 Ethambutol resistance testing by mutation detection. Int J Tuberc Lung Dis 2006 1.46
29 Expression, characterization and subcellular localization of the Mycobacterium tuberculosis PPE gene Rv1917c. Tuberculosis (Edinb) 2001 1.44
30 Evidence that the spread of Mycobacterium tuberculosis strains with the Beijing genotype is human population dependent. J Clin Microbiol 2007 1.42
31 Demonstration of reinfection and reactivation in HIV-negative autopsied cases of secondary tuberculosis: multilesional genotyping of Mycobacterium tuberculosis utilizing IS 6110 and other repetitive element-based DNA fingerprinting. Tuberculosis (Edinb) 2001 1.42
32 Genotypic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from rural districts of the Western Cape Province of South Africa. J Clin Microbiol 2004 1.36
33 Spread of an emerging Mycobacterium tuberculosis drug-resistant strain in the western Cape of South Africa. Int J Tuberc Lung Dis 2007 1.33
34 Drug-resistant tuberculosis epidemic in the Western Cape driven by a virulent Beijing genotype strain. Int J Tuberc Lung Dis 2010 1.32
35 Putative compensatory mutations in the rpoC gene of rifampin-resistant Mycobacterium tuberculosis are associated with ongoing transmission. Antimicrob Agents Chemother 2012 1.31
36 Adult-to-child transmission of tuberculosis: household or community contact? Int J Tuberc Lung Dis 2003 1.31
37 Hypomethylation of DNA in pathological conditions of the human prostate. Cancer Res 1987 1.30
38 Molecular evolution of Mycobacterium tuberculosis: phylogenetic reconstruction of clonal expansion. Tuberculosis (Edinb) 2001 1.24
39 Novel method for rapid measurement of growth of mycobacteria in detergent-free media. J Clin Microbiol 1998 1.20
40 Mycobacterium tuberculosis strains with the Beijing genotype demonstrate variability in virulence associated with transmission. Tuberculosis (Edinb) 2010 1.20
41 The influence of dose and N-acetyltransferase-2 (NAT2) genotype and phenotype on the pharmacokinetics and pharmacodynamics of isoniazid. Eur J Clin Pharmacol 2007 1.20
42 Sequence polymorphism in the rrs gene of Mycobacterium tuberculosis is deeply rooted within an evolutionary clade and is not associated with streptomycin resistance. J Clin Microbiol 2001 1.17
43 inhA promoter mutations: a gateway to extensively drug-resistant tuberculosis in South Africa? Int J Tuberc Lung Dis 2011 1.17
44 Identification of MDR-TB Beijing/W and other Mycobacterium tuberculosis genotypes in Nairobi, Kenya. Int J Tuberc Lung Dis 2004 1.14
45 An outbreak of drug-resistant tuberculosis caused by a Beijing strain in the western Cape, South Africa. Int J Tuberc Lung Dis 2006 1.14
46 Improved method for the routine identification of toxigenic Escherichia coli by DNA amplification of a conserved region of the heat-labile toxin A subunit. J Clin Microbiol 1991 1.14
47 Fluorometric assay for testing rifampin susceptibility of Mycobacterium tuberculosis complex. J Clin Microbiol 2008 1.13
48 Mycobacterium tuberculosis population structure determines the outcome of genetics-based second-line drug resistance testing. Antimicrob Agents Chemother 2012 1.12
49 The clinical relevance of Mycobacterial pharmacogenetics. Tuberculosis (Edinb) 2009 1.11
50 Time to liquid culture positivity can substitute for colony counting on agar plates in early bactericidal activity studies of antituberculosis agents. Clin Microbiol Infect 2011 1.11
51 Historic and recent events contribute to the disease dynamics of Beijing-like Mycobacterium tuberculosis isolates in a high incidence region. Int J Tuberc Lung Dis 2002 1.10
52 Changes in leucocyte and lymphocyte subsets during tuberculosis treatment; prominence of CD3dimCD56+ natural killer T cells in fast treatment responders. Clin Exp Immunol 2006 1.09
53 Polymerase chain reaction in the diagnosis of tuberculous meningitis. Scand J Infect Dis 1993 1.06
54 Mutations in katG gene sequences in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis are rare. Antimicrob Agents Chemother 1995 1.05
55 No evidence for point mutations in codons 12, 13, and 61 of the ras gene in a high-incidence area for esophageal and gastric cancers. Cancer Res 1990 1.03
56 katG mutations in isoniazid-resistant strains of Mycobacterium tuberculosis are not infrequent. Antimicrob Agents Chemother 1996 1.02
57 Polymerase chain reaction in the diagnosis of urinary tract tuberculosis. Urol Res 1996 1.01
58 Resistance to pyrazinamide and ethambutol compromises MDR/XDR-TB treatment. S Afr Med J 2009 1.01
59 IS6110-mediated deletion polymorphism in the direct repeat region of clinical isolates of Mycobacterium tuberculosis. J Bacteriol 2003 0.99
60 Mycobacterium tuberculosis transmission is not related to household genotype in a setting of high endemicity. J Clin Microbiol 2009 0.98
61 Use of spoligotyping for accurate classification of recurrent tuberculosis. J Clin Microbiol 2002 0.97
62 Use of genetic distance as a measure of ongoing transmission of Mycobacterium tuberculosis. J Clin Microbiol 2003 0.96
63 Diversity of in vitro cytokine responses by human macrophages to infection by mycobacterium tuberculosis strains. Cell Biol Int 2001 0.96
64 The role of molecular epidemiology in low-income, high-burden countries. Int J Tuberc Lung Dis 2009 0.96
65 Age-related methylation changes in DNA may reflect the proliferative potential of organs. Mutat Res 1990 0.95
66 Ethionamide cross- and co-resistance in children with isoniazid-resistant tuberculosis. Int J Tuberc Lung Dis 2009 0.94
67 Mutation rate and the emergence of drug resistance in Mycobacterium tuberculosis. J Antimicrob Chemother 2013 0.94
68 SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population. Hum Genet 2007 0.93
69 Mycobacterial growth in human macrophages: variation according to donor, inoculum and bacterial strain. Cell Biol Int 2001 0.92
70 Detection of Mycobacterium tuberculosis infection in dogs in a high-risk setting. Res Vet Sci 2011 0.89
71 Effect of study duration on the interpretation of tuberculosis molecular epidemiology investigations. Tuberculosis (Edinb) 2009 0.89
72 The complete amino-acid sequence of histone H2B from the mollusc Patella granatina. Eur J Biochem 1979 0.87
73 p53 and p16/CDKN2 gene mutations in esophageal tumors from a high-incidence area in South Africa. Int J Cancer 1998 0.87
74 Pulmonary Mycobacterium tuberculosis (Beijing strain) infection in a stray dog. J S Afr Vet Assoc 2008 0.87
75 The complete amino-acid sequence of histone H2B from erythrocytes of the adult domestic fowl Gallus domesticus. Biochim Biophys Acta 1982 0.86
76 Minimal inhibitory concentration of isoniazid in isoniazid-resistant Mycobacterium tuberculosis isolates from children. Eur J Clin Microbiol Infect Dis 2007 0.86
77 Acute helminth infection enhances early macrophage mediated control of mycobacterial infection. Mucosal Immunol 2012 0.86
78 Prediction of delayed treatment response in pulmonary tuberculosis: use of time to positivity values of Bactec cultures. Tuberculosis (Edinb) 2008 0.84
79 Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains. J Clin Microbiol 2014 0.83
80 A theoretical consideration of the lysine-rich histones: H1 from a mammal and an echinoderm, H5 from erythrocytes. J Theor Biol 1982 0.82
81 Empirical evaluation of conditions influencing the polymerase chain reaction: enterotoxigenic Escherichia coli as a test case. Eur J Clin Chem Clin Biochem 1993 0.82
82 Phage-based detection of bacterial pathogens. Analyst 2014 0.81
83 Functional effects of CRP binding to nuclei. Immunology 1986 0.81
84 Rifampicin resistance in Mycobacterium tuberculosis--rapid detection and implications in chemotherapy. S Afr Med J 1996 0.80
85 Spectrum of non-tuberculous mycobacteria identified using standard biochemical testing vs. 16S sequencing. Int J Tuberc Lung Dis 2012 0.80
86 Mycobacteria and disease in southern Africa. Transbound Emerg Dis 2013 0.79
87 Identification of C to T mutation at position -236 bp in the human NRAMP1 gene promoter. Immunogenetics 1996 0.79
88 Oligonucleotide (GTG)5 as an epidemiological tool in the study of nontuberculous mycobacteria. J Clin Microbiol 1997 0.79
89 Transmission of multidrug-resistant strains of Mycobacterium tuberculosis in a high incidence community. Eur J Clin Microbiol Infect Dis 1997 0.79
90 Allografted keratinocytes used to accelerate the treatment of burn wounds are replaced by recipient cells. Burns 1990 0.78
91 The detection of Mycobacterium tuberculosis in bone marrow aspirate using the polymerase chain reaction. Tuber Lung Dis 1994 0.78
92 Factors influencing peak expiratory flow in teenage boys. S Afr Med J 2001 0.78
93 Comparative analysis of a putative tuberculosis-susceptibility gene, MC3R, and pseudogene sequences in cattle, African buffalo, hyena, rhinoceros and other African bovids and ruminants. Cytogenet Genome Res 2012 0.77
94 Inhibition of transcription by adriamycin is a consequence of the loss of negative superhelicity in DNA mediated by topoisomerase II. Mol Cell Biochem 1990 0.76
95 Tuberculosis research--the way forward. S Afr Med J 1996 0.75
96 Adequacy of 6-month follow-up in chemotherapy trials. Int J Tuberc Lung Dis 2010 0.75
97 Reconsidering global targets for tuberculosis control. Bull World Health Organ 2009 0.75
98 Mycobacterial interspersed repetitive-unit-variable-number tandem-repeat analysis and Beijing/W family of Mycobacterium tuberculosis. J Clin Microbiol 2011 0.75
99 Analysis of allele-specific methylation. Trends Genet 1990 0.75
100 Wildlife tuberculosis. Preface. Transbound Emerg Dis 2013 0.75
101 Second episode of tuberculosis in an HIV-infected child: relapse or reinfection? J Infect 2000 0.75
102 Tuberculosis: the struggle continues. Clin Chem Lab Med 2002 0.75
103 The subunit structure of heart muscle chalones. Biochem Biophys Res Commun 1982 0.75
104 Mycobacterium tuberculosis DNA in erythema induratum of Bazin. Lancet 1993 0.75
105 Evacuated tubes and possible false-positive PCR results with blood samples. S Afr Med J 1995 0.75
106 A method to analyze allele-specific methylation. Biotechniques 1990 0.75
107 Interferon--the clinical experience. S Afr Med J 1983 0.75
108 Detection of Mutations in Mycobacterium tuberculosis by a Dot Blot Hybridization Strategy. Methods Mol Med 2001 0.75
109 Rapid genomic diversification of Helicobacter pylori. Electrophoresis 1999 0.75
110 Structural alterations in chromatin during myogenesis in the chicken. Mol Cell Biochem 1988 0.75