Published in J Cell Biol on March 01, 1990
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Nuclear targeting by the growth factor midkine. Mol Cell Biol (2002) 1.44
Neointima formation in a restenosis model is suppressed in midkine-deficient mice. J Clin Invest (2000) 1.37
Midkine induces the transformation of NIH3T3 cells. Br J Cancer (1997) 1.33
Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases. Proc Jpn Acad Ser B Phys Biol Sci (2010) 1.16
cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis. Mol Cell Biol (2007) 1.14
Expression of midkine in the early stage of carcinogenesis in human colorectal cancer. Br J Cancer (1999) 1.09
Midkine (MK), a heparin-binding growth/differentiation factor, is regulated by retinoic acid and epithelial-mesenchymal interactions in the developing mouse tooth, and affects cell proliferation and morphogenesis. J Cell Biol (1995) 1.06
Functional divergence of two zebrafish midkine growth factors following fish-specific gene duplication. Genome Res (2003) 1.06
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Midkine: a promising molecule for drug development to treat diseases of the central nervous system. Curr Pharm Des (2011) 1.04
Cellular expression of midkine-a and midkine-b during retinal development and photoreceptor regeneration in zebrafish. J Comp Neurol (2009) 0.96
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Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster. Dev Genes Evol (2005) 0.88
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Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice. PLoS One (2014) 0.85
Midkine in repair of the injured nervous system. Br J Pharmacol (2014) 0.85
Involvement of midkine in neuroblastoma tumourigenesis. Br J Pharmacol (2014) 0.84
The role of midkine in skeletal remodelling. Br J Pharmacol (2014) 0.84
Enhanced therapeutic effects of combined chemotherapeutic drugs and midkine antisense oligonucleotides for hepatocellular carcinoma. World J Gastroenterol (2007) 0.83
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Midkine expression is regulated by the circadian clock in the retina of the zebrafish. Vis Neurosci (2009) 0.80
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The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells. Respir Res (2009) 0.78
Expression of midkine and its clinical significance in esophageal squamous cell carcinoma. World J Gastroenterol (2006) 0.78
A retinoid responsive cytokine gene, MK, is preferentially expressed in the proximal tubules of the kidney and human tumor cell lines. Am J Pathol (1993) 0.77
Identification of embryonic pancreatic genes using Xenopus DNA microarrays. Dev Dyn (2009) 0.77
Midkine and Pleiotrophin Concentrations in Amniotic Fluid in Healthy and Complicated Pregnancies. PLoS One (2016) 0.76
Novel neuronal effects of midkine on embryonic cerebellar neurons examined using a defined culture system. Cell Mol Neurobiol (1999) 0.76
Downregulation of Midkine gene expression and its response to retinoic acid treatment in the nitrofen-induced hypoplastic lung. Pediatr Surg Int (2011) 0.76
Inhibitory effect of midkine-binding peptide on tumor proliferation and migration. Int J Clin Exp Pathol (2015) 0.75
Sexually Dimorphic Gene Expression Associated with Growth and Reproduction of Tongue Sole (Cynoglossus semilaevis) Revealed by Brain Transcriptome Analysis. Int J Mol Sci (2016) 0.75
From top to bottom: midkine and pleiotrophin as emerging players in immune regulation. J Leukoc Biol (2017) 0.75
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A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature (1988) 9.07
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Identification and spatial distribution of retinoids in the developing chick limb bud. Nature (1987) 3.49
Retinoic acid and thyroid hormone induce gene expression through a common responsive element. Nature (1988) 3.42
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Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo. Cell (1987) 3.17
A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-beta family. Nature (1987) 3.07
Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line. Nature (1982) 3.05
A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta. Cell (1987) 2.64
Local application of retinoic acid to the limb bond mimics the action of the polarizing region. Nature (1982) 2.48
Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood (1988) 2.13
Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox. Mol Cell Biol (1988) 2.10
Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse. EMBO J (1988) 2.08
cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Biochem Biophys Res Commun (1988) 1.95
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Retinoic acid-induced differentiation of the human promyelocytic leukemia cell line, HL-60, and fresh human leukemia cells in primary culture: a model for differentiation inducing therapy of leukemia. Eur J Haematol (1987) 0.86
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Complete nucleotide sequences of all three poliovirus serotype genomes. Implication for genetic relationship, gene function and antigenic determinants. J Mol Biol (1984) 8.06
Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology (2000) 4.27
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Endo-beta-N-acetylglucosaminidase acting on carbohydrate moieties of glycoproteins. Purification and properties of the enzyme from Diplococcus pneumoniae. J Biol Chem (1974) 1.99
cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Biochem Biophys Res Commun (1988) 1.95
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A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis. Dev Biol (1998) 1.94
Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J Natl Cancer Inst (1996) 1.93
Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. J Biol Chem (1999) 1.83
Fractionation of glycopeptides by affinity column chromatography on concanavalin A-sepharose. J Biochem (1975) 1.72
Differential expression of pleiotrophin and midkine in advanced neuroblastomas. Cancer Res (1995) 1.72
Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis (1998) 1.70
Molecular recognition of the identity-determinant set of isoleucine transfer RNA from Escherichia coli. J Mol Biol (1994) 1.68
Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons. J Neurochem (1999) 1.63
Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. Mol Biol Cell (1999) 1.60
Vascular endothelial growth factor expression in primary esophageal squamous cell carcinoma. Association with angiogenesis and tumor progression. Cancer (1997) 1.60
Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions. J Biol Chem (2000) 1.55
A new family of heparin-binding growth/differentiation factors: increased midkine expression in Wilms' tumor and other human carcinomas. Cancer Res (1993) 1.55
Expression of desmoglein I and plakoglobin in skin carcinomas. J Cutan Pathol (2000) 1.53
A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates. Gastroenterology (2001) 1.53
In situ visualization of ultraviolet-light-induced DNA damage repair in locally irradiated human fibroblasts. J Invest Dermatol (2001) 1.52
Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. Carcinogenesis (2001) 1.49
A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta. J Biol Chem (1999) 1.46
Tau in cerebrospinal fluid: a potential diagnostic marker in Alzheimer's disease. Ann Neurol (1995) 1.46
Complete antithrombin deficiency in mice results in embryonic lethality. J Clin Invest (2000) 1.44
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Long-term outcomes of endoscopic submucosal dissection for undifferentiated-type early gastric cancer. Endoscopy (2012) 1.41
Impact of final coronary flow velocity reserve on late outcome following stent implantation. Eur Heart J (2002) 1.41
Midkine is involved in neutrophil infiltration into the tubulointerstitium in ischemic renal injury. J Immunol (2001) 1.40
Midkine, a retinoic acid-inducible growth/differentiation factor: immunochemical evidence for the function and distribution. Dev Biol (1993) 1.39
Increased midkine gene expression in human gastrointestinal cancers. Jpn J Cancer Res (1995) 1.39
Neointima formation in a restenosis model is suppressed in midkine-deficient mice. J Clin Invest (2000) 1.37
Serum midkine levels are increased in patients with various types of carcinomas. Br J Cancer (2000) 1.34
Midkine induces the transformation of NIH3T3 cells. Br J Cancer (1997) 1.33
Necrotizing lymphadenitis: a review of clinicopathological, immunohistochemical and ultrastructural studies. Hematol Oncol (1991) 1.32
Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis. Development (1995) 1.30
Cell-surface glycopeptides: growth-dependent changes in the carbohydrate-peptide linkage region. J Mol Biol (1973) 1.29
Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice. J Biol Chem (2001) 1.26
Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1. J Biol Chem (1996) 1.26
Identification by large-scale screening of phytochrome-regulated genes in etiolated seedlings of Arabidopsis using a fluorescent differential display technique. Plant Physiol (2000) 1.24
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An evaluation of a new antiviral agent "virazole" against influenza virus infections. Tohoku J Exp Med (1973) 1.23
Reticulocalbin, a novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs and a carboxyl-terminal HDEL sequence. J Biol Chem (1993) 1.22
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Abnormalities of sensory and memory functions in mice lacking Bsg gene. Biochem Biophys Res Commun (1997) 1.22
Antisense oligodeoxynucleotide targeted to Midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells. Cancer Res (2001) 1.22
Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese. Alcohol Clin Exp Res (1996) 1.21
Pharmacokinetics of ketoprofen following single oral, intramuscular and rectal doses and after repeated oral administration. Eur J Clin Pharmacol (1980) 1.21
Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: chemotactic activity to neutrophils and association with inflammatory synovitis. J Biochem (1997) 1.21
New structural characteristic of the large glycopeptides from transformed cells. Nature (1976) 1.21
Expression of basigin, a member of the immunoglobulin superfamily, in the mouse central nervous system. Neurosci Res (1998) 1.20
Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour. Genes Cells (1998) 1.20
Cell surface carbohydrates of embryonal carcinoma cells: polysaccharidic side chains of F9 antigens and of receptors to two lectins, FBP and PNA. Cell (1979) 1.19
The transcription factor EGR-1 suppresses transformation of human fibrosarcoma HT1080 cells by coordinated induction of transforming growth factor-beta1, fibronectin, and plasminogen activator inhibitor-1. J Biol Chem (1999) 1.18
Increased expression of midkine during the progression of human astrocytomas. Neurosci Lett (1997) 1.18
The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. J Biochem (1991) 1.18
Presenilin-1 polymorphism and Alzheimer's disease. Lancet (1996) 1.18
A retinoic acid-responsive gene, MK, found in the teratocarcinoma system. Heterogeneity of the transcript and the nature of the translation product. J Biol Chem (1990) 1.18
Haptotactic migration induced by midkine. Involvement of protein-tyrosine phosphatase zeta. Mitogen-activated protein kinase, and phosphatidylinositol 3-kinase. J Biol Chem (2001) 1.17
Midkine rescues Wilms' tumor cells from cisplatin-induced apoptosis: regulation of Bcl-2 expression by Midkine. J Biochem (2000) 1.17
Characterization of mannose-labeled glycopeptides from human diploid cells and their growth-dependent alterations. J Biol Chem (1976) 1.16
Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-->3 fucosyltransferase VII and newly cloned GlcNAcbeta:6-sulfotransferase cDNA. Proc Natl Acad Sci U S A (1999) 1.15
Purification of recombinant midkine and examination of its biological activities: functional comparison of new heparin binding factors. Biochem Biophys Res Commun (1991) 1.15
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p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis. Oncogene (1999) 1.14
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Retinal dysfunction in basigin deficiency. Invest Ophthalmol Vis Sci (2000) 1.13
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Immunohistochemical analysis of midkine expression in human prostate carcinoma. Oncology (1999) 1.10
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Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain. Eur J Biochem (2000) 1.09
Expression of midkine in the early stage of carcinogenesis in human colorectal cancer. Br J Cancer (1999) 1.09
Identification of nucleolin as a binding protein for midkine (MK) and heparin-binding growth associated molecule (HB-GAM). J Biochem (1994) 1.09
Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics. Alcohol Clin Exp Res (1999) 1.09
Retinoic acid responsive gene product, midkine, has neurotrophic functions for mouse spinal cord and dorsal root ganglion neurons in culture. J Neurosci Res (1993) 1.08
Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase. J Biol Chem (1998) 1.08
Rescue of photoreceptors from the damaging effects of constant light by midkine, a retinoic acid-responsive gene product. Invest Ophthalmol Vis Sci (1994) 1.08
Randomized comparison of primary stenting and provisional balloon angioplasty guided by flow velocity measurement. Doppler Endpoints Balloon Angioplasty Trial Europe (DEBATE) II Study Group. Circulation (2000) 1.08
Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation. J Bone Miner Res (1995) 1.08
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Methionyl-tRNA synthetase gene from an extreme thermophile, Thermus thermophilus HB8. Molecular cloning, primary-structure analysis, expression in Escherichia coli, and site-directed mutagenesis. J Biol Chem (1991) 1.07
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LDL receptor-related protein as a component of the midkine receptor. Biochem Biophys Res Commun (2000) 1.06
Midkine enhances fibrinolytic activity of bovine endothelial cells. J Biol Chem (1995) 1.06
Midkine (MK), a heparin-binding growth/differentiation factor, is regulated by retinoic acid and epithelial-mesenchymal interactions in the developing mouse tooth, and affects cell proliferation and morphogenesis. J Cell Biol (1995) 1.06
Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells. J Biol Chem (1994) 1.05
Solution structure of midkine, a new heparin-binding growth factor. EMBO J (1997) 1.05
Midkine is present in the early stage of cerebral infarct. Brain Res Dev Brain Res (1995) 1.04