Published in Biotechnol Lett on August 11, 2006
Chemosensitivity of conjunctival melanoma cell lines to target-specific chemotherapeutic agents. Graefes Arch Clin Exp Ophthalmol (2012) 1.42
Ribonucleases as novel chemotherapeutics : the ranpirnase example. BioDrugs (2008) 1.31
Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity. Curr Pharm Biotechnol (2008) 1.23
Ribonucleases as potential modalities in anticancer therapy. Eur J Pharmacol (2009) 1.16
Cytotoxic ribonucleases: the dichotomy of Coulombic forces. Biochemistry (2007) 1.09
Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes. Curr Pharm Biotechnol (2008) 1.07
The cytotoxic ribonuclease onconase targets RNA interference (siRNA). Cell Cycle (2008) 1.03
Onconase cytotoxicity relies on the distribution of its positive charge. FEBS J (2009) 0.99
Cellular uptake of ribonuclease A relies on anionic glycans. Biochemistry (2010) 0.98
Ribonuclease binase inhibits primary tumor growth and metastases via apoptosis induction in tumor cells. Cell Cycle (2013) 0.91
A hinge region cis-proline in ribonuclease A acts as a conformational gatekeeper for C-terminal domain swapping. J Mol Biol (2010) 0.89
Zebrafish RNase T2 genes and the evolution of secretory ribonucleases in animals. BMC Evol Biol (2009) 0.89
Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines. Cancer Biol Ther (2008) 0.87
Antitumor activity of ribonuclease multimers created by site-specific covalent tethering. Bioconjug Chem (2010) 0.87
Design and characterization of an HIV-specific ribonuclease zymogen. AIDS Res Hum Retroviruses (2008) 0.85
Cytostatic and cytotoxic properties of Amphinase: a novel cytotoxic ribonuclease from Rana pipiens oocytes. Cell Cycle (2007) 0.85
Arginine residues are more effective than lysine residues in eliciting the cellular uptake of onconase. Biochemistry (2011) 0.84
Contribution of electrostatics to the binding of pancreatic-type ribonucleases to membranes. Biochemistry (2013) 0.82
Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma. J Cell Physiol (2009) 0.81
Site-specific PEGylation endows a mammalian ribonuclease with antitumor activity. Cancer Biol Ther (2011) 0.81
Oxidative folding pathway of onconase, a ribonuclease homologue: insight into oxidative folding mechanisms from a study of two homologues. Biochemistry (2009) 0.81
Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer. Bioorg Med Chem Lett (2010) 0.79
Fluorogenic label to quantify the cytosolic delivery of macromolecules. Mol Biosyst (2013) 0.79
Ranpirnase and its potential for the treatment of unresectable malignant mesothelioma. Biologics (2008) 0.79
Sulforaphane potentiates RNA damage induced by different xenobiotics. PLoS One (2012) 0.77
Site-specific folate conjugation to a cytotoxic protein. Bioorg Med Chem Lett (2011) 0.77
Adsorption-induced changes in ribonuclease A structure and enzymatic activity on solid surfaces. Langmuir (2014) 0.76
A hybrid chimeric system for versatile and ultra-sensitive RNase detection. Sci Rep (2015) 0.75
Towards tricking a pathogen's protease into fighting infection: the 3D structure of a stable circularly permuted onconase variant cleavedby HIV-1 protease. PLoS One (2013) 0.75
Secretory phospholipase A2 from Arabidopsis thaliana: insights into the three-dimensional structure and the amino acids involved in catalysis. Biochemistry (2006) 1.33
Protein prosthesis: a nonnatural residue accelerates folding and increases stability. J Am Chem Soc (2003) 0.94
Endocytotic internalization as a crucial factor for the cytotoxicity of ribonucleases. J Biol Chem (2007) 0.94
Coulomb forces control the density of the collapsed unfolded state of barstar. J Mol Biol (2007) 0.90
Contribution of structural peculiarities of onconase to its high stability and folding kinetics. Biochemistry (2006) 0.87
Peptic digestion of beta-casein. Time course and fate of possible bioactive peptides. J Chromatogr A (2007) 0.85
Proline versus charge concept for protein stabilization against proteolytic attack. Protein Eng (2003) 0.84
An engineered disulfide bridge mimics the effect of calcium to protect neutral protease against local unfolding. FEBS J (2005) 0.84
Crystal structure of RNase A tandem enzymes and their interaction with the cytosolic ribonuclease inhibitor. FEBS J (2010) 0.83
Secretory phospholipase A2-alpha from Arabidopsis thaliana: functional parameters and substrate preference. Chem Phys Lipids (2007) 0.82
The propeptide is not required to produce catalytically active neutral protease from Bacillus stearothermophilus. Protein Expr Purif (2005) 0.82
Conformational stability and integrity of alpha-amylase from mung beans: evidence of kinetic intermediate in GdmCl-induced unfolding. Biophys Chem (2008) 0.82
Impact of the C-terminal disulfide bond on the folding and stability of onconase. Chembiochem (2010) 0.82
The interdependence between catalytic activity, conformational stability, and cytotoxicity of onconase. Cancer Biol Ther (2007) 0.82
The folding pathway of onconase is directed by a conserved intermediate. Biochemistry (2009) 0.80
Calcium-induced membrane microdomains trigger plant phospholipase D activity. Chembiochem (2008) 0.80
Substrate specificity in phospholipid transformations by plant phospholipase D isoenzymes. Phytochemistry (2009) 0.79
Boilysin and thermolysin in dipeptide synthesis: a comparative study. Biotechnol Appl Biochem (2002) 0.79
Modulation of phospholipase D activity in vitro. Biochim Biophys Acta (2009) 0.79
Phospholipase D-catalyzed synthesis of new phospholipids with polar head groups. Chem Phys Lipids (2008) 0.78
The stability of engineered thermostable neutral proteases from Bacillus stearothermophilus in organic solvents and detergents. Biotechnol Bioeng (2007) 0.78
Probing the unfolding region of ribonuclease A by site-directed mutagenesis. Eur J Biochem (2004) 0.78
Probing conserved amino acids in phospholipase D (Brassica oleracea var. capitata) for their importance in hydrolysis and transphosphatidylation activity. Protein Eng Des Sel (2006) 0.78
Production of synthetically created phospholipase A(2) variants with industrial impact. Biotechnol Bioeng (2007) 0.77
Fast amide proton exchange reveals close relation between native-state dynamics and unfolding kinetics. J Am Chem Soc (2009) 0.77
Phospholipid acylhydrolases trigger membrane degradation during fungal sporogenesis. Fungal Genet Biol (2011) 0.77
Two highly homologous phospholipase D isoenzymes from Papaver somniferum L. with different transphosphatidylation potential. Biochim Biophys Acta (2005) 0.77
Spectrophotometric determination of phosphatidic acid via iron(III) complexation for assaying phospholipase D activity. Anal Biochem (2009) 0.76
Disulfide bonds of phospholipase A2 from bee venom yield discrete contributions to its conformational stability. Biochimie (2010) 0.76
Identification of phospholipase D from cabbage as N-terminally acetylated PLD2. J Protein Chem (2002) 0.76
Lanthanides as substitutes for calcium ions in the activation of plant α-type phospholipase D. Biol Chem (2014) 0.75
Insights into the structure of plant alpha-type phospholipase D. FEBS J (2007) 0.75
Alpha-amylase from mung beans (Vigna radiata)--correlation of biochemical properties and tertiary structure by homology modelling. Phytochemistry (2007) 0.75
Dissecting the effect of trifluoroethanol on ribonuclease A. Subtle structural changes detected by nonspecific proteases. Eur J Biochem (2002) 0.75
Mass spectrometric characterization of peptides derived by peptic cleavage of bovine beta-casein. J Chromatogr A (2004) 0.75
Fe(III)-resorcylate as a spectrophotometric probe for phospholipid-cation interactions. Anal Biochem (2013) 0.75
Two uncommon phospholipase D isoenzymes from poppy seedlings (Papaver somniferum L.). Biochim Biophys Acta (2003) 0.75
pH-Stat titration allows the continuous determination of ribonuclease A activity toward cytidine 2',3'-cyclic monophosphate at high substrate concentrations. Anal Biochem (2002) 0.75
Activity of phospholipase C in two-phase systems. Anal Biochem (2002) 0.75
New cardiolipin analogs synthesized by phospholipase D-catalyzed transphosphatidylation. Chem Phys Lipids (2012) 0.75
Thermodynamic stability and native-state dynamics of porcine pancreatic phospholipase A2 studied by 1H NMR spectroscopic measurements. Adv Exp Med Biol (2009) 0.75
Differences in the effect of phosphatidylinositol 4,5-bisphosphate on the hydrolytic and transphosphatidylation activities of membrane-bound phospholipase D from poppy seedlings. Plant Physiol Biochem (2013) 0.75
Discrimination between the regioisomeric 1,2- and 1,3-diacylglycerophosphocholines by phospholipases. Chem Phys Lipids (2010) 0.75
Behaviour of a recombinant cabbage (Brassica oleracea) phospholipase D immobilized on CNBr-activated and antibody supports. Biotechnol Appl Biochem (2004) 0.75
The transphosphatidylation potential of a membrane-bound phospholipase D from poppy seedlings. Phytochemistry (2010) 0.75
Refolding of the non-specific neutral protease from Bacillus stearothermophilus proceeds via an autoproteolytically sensitive intermediate. Biophys Chem (2010) 0.75
Screening for nutritive peptides that modify cholesterol 7alpha-hydroxylase expression. J Agric Food Chem (2008) 0.75
Identification of three phases in Onconase refolding. FEBS J (2007) 0.75
Inhibition of pancreatic ribonuclease A aggregation by antibodies raised against the native enzyme and its N-terminal dodecapeptide. Protein Pept Lett (2006) 0.75