Published in Metab Eng on June 30, 2006
Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev (2008) 7.87
Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci (2010) 6.30
Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer (2009) 3.05
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab (2012) 2.86
Is cancer a disease of abnormal cellular metabolism? New angles on an old idea. Genet Med (2008) 1.50
Central carbon metabolism in the progression of mammary carcinoma. Breast Cancer Res Treat (2007) 1.16
Isotopically nonstationary 13C flux analysis of Myc-induced metabolic reprogramming in B-cells. Metab Eng (2012) 1.08
Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from Rhizobium etli. Biochemistry (2011) 1.05
How does cancer cell metabolism affect tumor migration and invasion? Cell Adh Migr (2013) 1.04
A genome-wide association scan on estrogen receptor-negative breast cancer. Breast Cancer Res (2010) 1.02
Single-cell analysis demonstrates how nutrient deprivation creates apoptotic and quiescent cell populations in tumor cylindroids. Biotechnol Bioeng (2008) 0.94
Inhibitors of Pyruvate Carboxylase. Open Enzym Inhib J (2010) 0.93
Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells. PLoS One (2009) 0.92
Mapping cancer cell metabolism with(13)C flux analysis: Recent progress and future challenges. J Carcinog (2013) 0.88
A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect. Biophys J (2016) 0.86
Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture. Integr Biol (Camb) (2014) 0.84
Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells. J Steroid Biochem Mol Biol (2015) 0.82
Active and inactive metabolic pathways in tumor spheroids: determination by GC-MS. Biotechnol Prog (2010) 0.82
The Impact of Soy Isoflavones on MCF-7 and MDA-MB-231 Breast Cancer Cells Using a Global Metabolomic Approach. Int J Mol Sci (2016) 0.75
Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress. Oncotarget (2016) 0.75
Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. Sci Rep (2017) 0.75
Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science (2011) 6.93
The challenge of enzyme cost in the production of lignocellulosic biofuels. Biotechnol Bioeng (2011) 2.47
Three-dimensional cellular microarray for high-throughput toxicology assays. Proc Natl Acad Sci U S A (2007) 2.09
Identification and characterization of a multidomain hyperthermophilic cellulase from an archaeal enrichment. Nat Commun (2011) 1.64
High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research. Trends Biotechnol (2009) 1.56
Next-generation biomass feedstocks for biofuel production. Genome Biol (2008) 1.47
Engineering protein filaments with enhanced thermostability for nanomaterials. Biotechnol J (2012) 1.43
An evaluation of cellulose saccharification and fermentation with an engineered Saccharomyces cerevisiae capable of cellobiose and xylose utilization. Biotechnol J (2012) 1.40
Three-dimensional cell culture microarray for high-throughput studies of stem cell fate. Biotechnol Bioeng (2010) 1.22
Initial- and processive-cut products reveal cellobiohydrolase rate limitations and the role of companion enzymes. Biochemistry (2011) 1.21
Role of alcohols in growth, lipid composition, and membrane fluidity of yeasts, bacteria, and archaea. Appl Environ Microbiol (2011) 1.19
Anaerobic central metabolic pathways in Shewanella oneidensis MR-1 reinterpreted in the light of isotopic metabolite labeling. J Bacteriol (2006) 1.17
Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses. Proc Natl Acad Sci U S A (2005) 1.13
Pressure effects on intra- and intermolecular interactions within proteins. Biochim Biophys Acta (2002) 1.09
Ionic liquid pretreatment of cellulosic biomass: enzymatic hydrolysis and ionic liquid recycle. Biotechnol Bioeng (2010) 1.07
Nature versus nurture: developing enzymes that function under extreme conditions. Annu Rev Chem Biomol Eng (2012) 1.07
On-chip, cell-based microarray immunofluorescence assay for high-throughput analysis of target proteins. Anal Chem (2008) 1.06
Biocatalysis in semi-aqueous and nearly anhydrous conditions. Curr Opin Biotechnol (2005) 1.04
Photopatterning enzymes on polymer monoliths in microfluidic devices for steady-state kinetic analysis and spatially separated multi-enzyme reactions. Anal Chem (2007) 1.01
Integration of chemical catalysis with extractive fermentation to produce fuels. Nature (2012) 1.00
A mechanistic model of the enzymatic hydrolysis of cellulose. Biotechnol Bioeng (2010) 0.99
A single-molecule analysis reveals morphological targets for cellulase synergy. Nat Chem Biol (2013) 0.99
Redesigning Escherichia coli metabolism for anaerobic production of isobutanol. Appl Environ Microbiol (2011) 0.98
Electrokinetic stretching of tethered DNA. Biophys J (2003) 0.97
Escherichia coli for biofuel production: bridging the gap from promise to practice. Trends Biotechnol (2012) 0.97
Metabolic and morphological differences between rapidly proliferating cancerous and normal breast epithelial cells. Biotechnol Prog (2008) 0.96
Influence of a three-dimensional, microarray environment on human cell culture in drug screening systems. Biomaterials (2012) 0.95
Biological characterisation of Haliclona (?gellius) sp.: sponge and associated microorganisms. Microb Ecol (2009) 0.94
Effect of alcohols on aqueous lysozyme-lysozyme interactions from static light-scattering measurements. Biophys Chem (2004) 0.94
Engineering cytochrome P450 enzymes for improved activity towards biomimetic 1,4-NADH cofactors. Chembiochem (2008) 0.94
Multiple approaches to enhance the cultivability of bacteria associated with the marine sponge Haliclona (gellius) sp. Appl Environ Microbiol (2011) 0.94
Tying up the loose ends: circular permutation decreases the proteolytic susceptibility of recombinant proteins. Protein Eng Des Sel (2009) 0.93
Uranyl precipitation by Pseudomonas aeruginosa via controlled polyphosphate metabolism. Appl Environ Microbiol (2004) 0.92
Active-site motions and polarity enhance catalytic turnover of hydrated subtilisin dissolved in organic solvents. J Am Chem Soc (2009) 0.90
Transcriptional profiling of the hyperthermophilic methanarchaeon Methanococcus jannaschii in response to lethal heat and non-lethal cold shock. Environ Microbiol (2005) 0.90
Tracing determinants of dual substrate specificity in glycoside hydrolase family 5. J Biol Chem (2012) 0.89
A kinetic model describing Shewanella oneidensis MR-1 growth, substrate consumption, and product secretion. Biotechnol Bioeng (2007) 0.89
Identification of novel biomass-degrading enzymes from genomic dark matter: Populating genomic sequence space with functional annotation. Biotechnol Bioeng (2014) 0.88
Combinatorial formulation of biocatalyst preparations for increased activity in organic solvents: salt activation of penicillin amidase. Biotechnol Bioeng (2004) 0.88
Binding modules alter the activity of chimeric cellulases: Effects of biomass pretreatment and enzyme source. Biotechnol Bioeng (2010) 0.88
N-Terminal labeling of filamentous phage to create cancer marker imaging agents. ACS Nano (2012) 0.88
The importance of pyroglutamate in cellulase Cel7A. Biotechnol Bioeng (2014) 0.87
A mechanistic model for rational design of optimal cellulase mixtures. Biotechnol Bioeng (2011) 0.87
Amyloid fibril formation by peptide LYS (11-36) in aqueous trifluoroethanol. Biomacromolecules (2004) 0.86
Water dynamics and salt-activation of enzymes in organic media: mechanistic implications revealed by NMR spectroscopy. Proc Natl Acad Sci U S A (2006) 0.86
Transcriptional responses of the deep-sea hyperthermophile Methanocaldococcus jannaschii under shifting extremes of temperature and pressure. Extremophiles (2007) 0.85
Biocatalyst activity in nonaqueous environments correlates with centisecond-range protein motions. Proc Natl Acad Sci U S A (2008) 0.85
Rupture of the cell envelope by decompression of the deep-sea methanogen Methanococcus jannaschii. Appl Environ Microbiol (2002) 0.85
Identification and functional analysis of a delta-6 desaturase from the marine microalga Glossomastix chrysoplasta. Mar Biotechnol (NY) (2007) 0.85
Protein aggregation in silico. Trends Biotechnol (2007) 0.85
In vitro cytotoxicities of ionic liquids: effect of cation rings, functional groups, and anions. Environ Toxicol (2009) 0.84
Biased clique shuffling reveals stabilizing mutations in cellulase Cel7A. Biotechnol Bioeng (2012) 0.84
Cytochrome P450 (CYP) enzymes and the development of CYP biosensors. Biosens Bioelectron (2012) 0.84
Mechanical nanosensor based on FRET within a thermosome: damage-reporting polymeric materials. Angew Chem Int Ed Engl (2009) 0.84
The hydrodynamics of DNA electrophoretic stretch and relaxation in a polymer solution. Biophys J (2004) 0.84
Nonaqueous biocatalytic synthesis of new cytotoxic doxorubicin derivatives: exploiting unexpected differences in the regioselectivity of salt-activated and solubilized subtilisin. J Am Chem Soc (2002) 0.83
Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS. Anal Biochem (2004) 0.83
Dramatic thermal stability of virus-polymer conjugates in hydrophobic solvents. Langmuir (2010) 0.83
Dibenzothiophene biodesulfurization pathway improvement using diagnostic GFP fusions. Biotechnol Bioeng (2004) 0.83
Self-renaturing enzymes: design of an enzyme-chaperone chimera as a new approach to enzyme stabilization. Biotechnol Bioeng (2009) 0.82
Interactions of lysozyme in guanidinium chloride solutions from static and dynamic light-scattering measurements. Biotechnol Bioeng (2005) 0.82
Solid-phase peptide synthesis by ion-paired alpha-chymotrypsin in nonaqueous media. Biotechnol Bioeng (2003) 0.82
Elucidating mechanisms of solvent toxicity in ethanologenic Escherichia coli. Biotechnol Bioeng (2010) 0.82
Solubilization and stabilization of bacteriophage MS2 in organic solvents. Biotechnol Bioeng (2007) 0.81
Reduced protein adsorption at solid interfaces by sugar excipients. Biotechnol Bioeng (2004) 0.81
Biotemplated metal nanowires using hyperthermophilic protein filaments. Small (2009) 0.81
High-throughput screening of biocatalytic activity: applications in drug discovery. Curr Opin Chem Biol (2006) 0.81
A model for optimizing the enzymatic hydrolysis of ionic liquid-pretreated lignocellulose. Bioresour Technol (2012) 0.81
Sol-gel encapsulated enzyme arrays for high-throughput screening of biocatalytic activity. Biotechnol Bioeng (2002) 0.80
The role of electrolytes on protein adsorption at a hydrophilic solid-water interface. Colloids Surf B Biointerfaces (2009) 0.80
Molecular imprinting of enzymes with water-insoluble ligands for nonaqueous biocatalysis. J Am Chem Soc (2002) 0.80
High-throughput in vitro glycoside hydrolase (HIGH) screening for enzyme discovery. Angew Chem Int Ed Engl (2011) 0.79
Rational shape engineering of the filamentous protein gamma prefoldin through incremental gene truncation. Biopolymers (2009) 0.79
Rapid and quantitative measurement of metabolic stability without chromatography or mass spectrometry. J Am Chem Soc (2011) 0.79
Direct solubilization of enzyme aggregates with enhanced activity in nonaqueous media. Biotechnol Bioeng (2007) 0.79
Pressure affects transcription profiles of Methanocaldococcus jannaschii despite the absence of barophilic growth under gas-transfer limitation. Environ Microbiol (2006) 0.78
Effect of single-point sequence alterations on the aggregation propensity of a model protein. J Am Chem Soc (2006) 0.78
Extraction of lignins from aqueous-ionic liquid mixtures by organic solvents. Biotechnol Bioeng (2011) 0.78
Physiological role of Acyl coenzyme A synthetase homologs in lipid metabolism in Neurospora crassa. Eukaryot Cell (2013) 0.78
Redirecting the inactivation pathway of penicillin amidase and increasing amoxicillin production via a thermophilic molecular chaperone. Biotechnol Bioeng (2009) 0.78
Metabolic enzyme microarray coupled with miniaturized cell-culture array technology for high-throughput toxicity screening. Methods Mol Biol (2010) 0.78