Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.

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Published in Oncogene on August 14, 2006

Authors

F L Delarue1, J Adnane, B Joshi, M A Blaskovich, D-A Wang, J Hawker, F Bizouarn, J Ohkanda, K Zhu, A D Hamilton, S Chellappan, S M Sebti

Author Affiliations

1: Drug Discovery Program at H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

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