Published in CMAJ on August 29, 2006
Stem cell delivery of therapies for brain disorders. Clin Transl Med (2014) 0.84
Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med (2003) 6.79
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA (2004) 6.74
Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat Rev Drug Discov (2006) 3.58
Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine). Int J Geriatr Psychiatry (1999) 1.74
Effects of memantine on behavioural symptoms in Alzheimer's disease patients: an analysis of the Neuropsychiatric Inventory (NPI) data of two randomised, controlled studies. Int J Geriatr Psychiatry (2005) 1.35
Rivastigmine monotherapy and combination therapy with memantine in patients with moderately severe Alzheimer's disease who failed to benefit from previous cholinesterase inhibitor treatment. Int J Clin Pract (2006) 1.07
Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy. Int Clin Psychopharmacol (2003) 0.93
Managing discontinuation syndrome in patients with dementia. J Psychiatry Neurosci (2006) 0.88
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol (2007) 18.62
A roadmap for the prevention of dementia II: Leon Thal Symposium 2008. Alzheimers Dement (2009) 10.21
Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurol (2010) 8.74
A meta-analysis of cytokines in major depression. Biol Psychiatry (2009) 7.16
Clinical diagnostic criteria for dementia associated with Parkinson's disease. Mov Disord (2007) 6.92
Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits. BMJ (2005) 6.57
A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimers Dement (2008) 6.39
Alzheimer's disease. Lancet (2011) 5.35
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol (2007) 5.09
Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. Lancet (2002) 5.05
Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol (2004) 4.66
Vascular cognitive impairment. Lancet Neurol (2003) 3.73
Antipsychotic drug use and mortality in older adults with dementia. Ann Intern Med (2007) 3.71
Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force. Mov Disord (2007) 3.48
Antipsychotic drugs and hyperglycemia in older patients with diabetes. Arch Intern Med (2009) 3.43
Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurol (2007) 3.22
Medical illness and the risk of suicide in the elderly. Arch Intern Med (2004) 3.09
Dementia with Lewy bodies. Lancet Neurol (2004) 2.66
Zinc in depression: a meta-analysis. Biol Psychiatry (2013) 2.26
Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis. CMAJ (2003) 2.18
A meta-analysis of cytokines in Alzheimer's disease. Biol Psychiatry (2010) 2.06
Contribution of informant and patient ratings to the accuracy of the mini-mental state examination in predicting probable Alzheimer's disease. J Am Geriatr Soc (2003) 1.93
Management of agitation and aggression associated with Alzheimer disease. Nat Rev Neurol (2009) 1.86
Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe. Arch Gen Psychiatry (2005) 1.85
Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study. BMJ (2005) 1.84
Efficacy of donepezil on maintenance of activities of daily living in patients with moderate to severe Alzheimer's disease and the effect on caregiver burden. J Am Geriatr Soc (2003) 1.83
Benzodiazepine use and driving: a meta-analysis. J Clin Psychiatry (2009) 1.81
Safety and efficacy of methylphenidate for apathy in Alzheimer's disease: a randomized, placebo-controlled trial. J Clin Psychiatry (2013) 1.73
Efficacy and safety of antidepressants for treatment of depression in Alzheimer's disease: a metaanalysis. Can J Psychiatry (2007) 1.72
Improvement of episodic memory in persons with mild cognitive impairment and healthy older adults: evidence from a cognitive intervention program. Dement Geriatr Cogn Disord (2006) 1.57
Training-related brain plasticity in subjects at risk of developing Alzheimer's disease. Brain (2011) 1.56
Neuropsychiatric symptoms in Alzheimer's disease: past progress and anticipation of the future. Alzheimers Dement (2013) 1.51
Pharmacotherapy of Alzheimer disease. Can J Psychiatry (2007) 1.43
Should physicians prescribe cognitive enhancers to healthy individuals? CMAJ (2012) 1.41
Recommendations of the 4th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD4). Can Geriatr J (2012) 1.39
Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer's disease. Int Psychogeriatr (2008) 1.39
Effect of regulatory warnings on antipsychotic prescription rates among elderly patients with dementia: a population-based time-series analysis. CMAJ (2008) 1.34
Review of Alzheimer's disease scales: is there a need for a new multi-domain scale for therapy evaluation in medical practice? Alzheimers Res Ther (2010) 1.30
Old and homeless: a review and survey of older adults who use shelters in an urban setting. Can J Psychiatry (2003) 1.30
Probing brain reward system function in major depressive disorder: altered response to dextroamphetamine. Arch Gen Psychiatry (2002) 1.26
IPA survey of brief cognitive screening instruments. Int Psychogeriatr (2006) 1.26
Diagnosis and treatment of dementia: 6. Management of severe Alzheimer disease. CMAJ (2008) 1.21
Antidepressants for agitation and psychosis in dementia. Cochrane Database Syst Rev (2011) 1.18
Emerging therapies for vascular dementia and vascular cognitive impairment. Stroke (2004) 1.17
Seropositivity to herpes simplex virus antibodies and risk of Alzheimer's disease: a population-based cohort study. PLoS One (2008) 1.17
Exposure to general anesthesia and risk of Alzheimer's disease: a systematic review and meta-analysis. BMC Geriatr (2011) 1.16
Cognitive complaint in mild cognitive impairment and Alzheimer's disease. J Int Neuropsychol Soc (2008) 1.16
Early-onset familial Alzheimer's disease (EOFAD). Can J Neurol Sci (2012) 1.12
Sharing the responsibility for assessing the risk of the driver with dementia. CMAJ (2007) 1.12
Working memory and control of attention in persons with Alzheimer's disease and mild cognitive impairment. Neuropsychology (2007) 1.11
Predicting cognitive decline in Alzheimer's disease: an integrated analysis. Alzheimers Dement (2010) 1.11
Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: a randomized, double-blind, placebo-controlled trial. Stroke (2005) 1.08
Update on the pharmacological treatment of Alzheimer's disease. Curr Neuropharmacol (2010) 1.07
Antidepressants, warfarin, and the risk of hemorrhage. J Clin Psychopharmacol (2005) 1.07
Antipsychotic use in the elderly: shifting trends and increasing costs. Int J Geriatr Psychiatry (2005) 1.06
Mild cognitive impairment: an operational definition and its conversion rate to Alzheimer's disease. Dement Geriatr Cogn Disord (2005) 1.06
Initiation of benzodiazepines in the elderly after hospitalization. J Gen Intern Med (2007) 1.05
Alzhemed: a potential treatment for Alzheimer's disease. Curr Alzheimer Res (2007) 1.05
Methodological issues in primary prevention trials for neurodegenerative dementia. J Alzheimers Dis (2009) 1.04
The concept of vascular cognitive impairment. Front Neurol Neurosci (2009) 1.03
Creating a transatlantic research enterprise for preventing Alzheimer's disease. Alzheimers Dement (2009) 1.02
Prevention trials in Alzheimer's disease: an EU-US task force report. Prog Neurobiol (2011) 1.02
Efficacy and safety of donepezil in patients with more severe Alzheimer's disease: a subgroup analysis from a randomized, placebo-controlled trial. Int J Geriatr Psychiatry (2005) 1.01
Pharmacological treatments for neuropsychiatric symptoms of dementia in long-term care: a systematic review. Int Psychogeriatr (2012) 1.01
Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). Arch Med Sci (2011) 1.01
The role of dopamine in symptoms and treatment of apathy in Alzheimer's disease. CNS Neurosci Ther (2010) 1.00
Effects of ω-3 fatty acids on cognitive performance: a meta-analysis. Neurobiol Aging (2012) 1.00
REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease. Sleep (2006) 1.00
Mental health-related drug utilization among older adults: prevalence, trends, and costs. Am J Geriatr Psychiatry (2005) 0.99
Disease progression in vascular cognitive impairment: cognitive, functional and behavioural outcomes in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) cohort study. J Neurol Sci (2006) 0.99
How much are atypical antipsychotic agents being used, and do they reach the populations who need them? A Canadian experience. Clin Ther (2002) 0.99
Persistence and adherence with dementia pharmacotherapy: relevance of patient, provider, and system factors. Can J Psychiatry (2014) 0.98
Canadian Outcomes Study in Dementia: study methods and patient characteristics. Can J Psychiatry (2004) 0.98
The effects of lithium on renal function in older adults--a systematic review. J Geriatr Psychiatry Neurol (2012) 0.98
Adverse drug events in cognitively impaired elderly patients. Dement Geriatr Cogn Disord (2007) 0.98
The relationship between variations in antipsychotic prescribing across nursing homes and short-term mortality: quality of care implications. Med Care (2009) 0.98
Management of post traumatic stress disorder after childbirth: a review. J Psychosom Obstet Gynaecol (2010) 0.96
The assessment of recognition memory using the Remember/Know procedure in amnestic mild cognitive impairment and probable Alzheimer's disease. Brain Cogn (2009) 0.96
The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease. Expert Opin Drug Saf (2004) 0.96
Effectiveness of donepezil in reducing clinical worsening in patients with mild-to-moderate alzheimer's disease. Dement Geriatr Cogn Disord (2009) 0.96
Long-term progression of Alzheimer's disease in patients under antidementia drugs. Alzheimers Dement (2011) 0.96
GABAergic function in Alzheimer's disease: evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia. Can J Psychiatry (2004) 0.96
Inhibition impairments in Alzheimer's disease, mild cognitive impairment and healthy aging: effect of congruency proportion in a Stroop task. Neuropsychologia (2009) 0.96
A SPECT study of apathy in Alzheimer's disease. Dement Geriatr Cogn Disord (2007) 0.95
Relationship between hair cortisol concentrations and depressive symptoms in patients with coronary artery disease. Neuropsychiatr Dis Treat (2010) 0.95
Efficacy and feasibility of nonpharmacological interventions for neuropsychiatric symptoms of dementia in long term care: a systematic review. J Am Med Dir Assoc (2012) 0.95
Comorbid depression and anxiety in later life: patterns of association, subjective well-being, and impairment. Am J Geriatr Psychiatry (2008) 0.93
Clinical practice guidelines for severe Alzheimer's disease. Alzheimers Dement (2007) 0.92
The relationship between inflammatory markers and post stroke cognitive impairment. J Geriatr Psychiatry Neurol (2010) 0.92
The Consortium to Investigate Vascular Impairment of Cognition: methods and first findings. Can J Neurol Sci (2003) 0.92
Recollection and familiarity in aging individuals with mild cognitive impairment and Alzheimer's disease: a literature review. Neuropsychol Rev (2014) 0.92
Brain reward system activity in major depression and comorbid nicotine dependence. J Pharmacol Exp Ther (2002) 0.91
Verbal memory performance and completion of cardiac rehabilitation in patients with coronary artery disease. Psychosom Med (2011) 0.91
Interleukin-17 in post-stroke neurodegeneration. Neurosci Biobehav Rev (2013) 0.91
Electroconvulsive therapy in older adults: 13-year trends. Can J Psychiatry (2006) 0.90
Dissociation between brain amyloid deposition and metabolism in early mild cognitive impairment. PLoS One (2012) 0.90
Effects of 2-week treatment with temazepam and diphenhydramine in elderly insomniacs: a randomized, placebo-controlled trial. J Clin Psychopharmacol (2008) 0.89
Current place of monoamine oxidase inhibitors in the treatment of depression. CNS Drugs (2013) 0.89
A randomized, placebo-controlled trial of the discontinuation of long-term antipsychotics in dementia. Int Psychogeriatr (2002) 0.89