| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Inflammation and cancer: how hot is the link?
|
Biochem Pharmacol
|
2006
|
5.17
|
|
2
|
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
|
Ann N Y Acad Sci
|
2006
|
2.44
|
|
3
|
Curcumin: getting back to the roots.
|
Ann N Y Acad Sci
|
2005
|
2.42
|
|
4
|
Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy.
|
Biochim Biophys Acta
|
2010
|
2.08
|
|
5
|
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.
|
Blood
|
2006
|
2.00
|
|
6
|
A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
|
Clin Cancer Res
|
2006
|
1.92
|
|
7
|
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
|
J Biol Chem
|
2006
|
1.90
|
|
8
|
Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway.
|
Cancer Res
|
2006
|
1.82
|
|
9
|
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
|
Carcinogenesis
|
2007
|
1.78
|
|
10
|
Thymoquinone: potential cure for inflammatory disorders and cancer.
|
Biochem Pharmacol
|
2011
|
1.76
|
|
11
|
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
|
Mol Cancer Res
|
2007
|
1.61
|
|
12
|
Natural products as a gold mine for arthritis treatment.
|
Curr Opin Pharmacol
|
2007
|
1.59
|
|
13
|
Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways.
|
Mol Cancer Ther
|
2008
|
1.55
|
|
14
|
Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).
|
Free Radic Biol Med
|
2007
|
1.51
|
|
15
|
The vascular endothelium and human diseases.
|
Int J Biol Sci
|
2013
|
1.49
|
|
16
|
From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer.
|
J Soc Integr Oncol
|
2007
|
1.47
|
|
17
|
Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
|
J Biol Chem
|
2006
|
1.45
|
|
18
|
Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.
|
Cancer Lett
|
2010
|
1.44
|
|
19
|
Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.
|
Int J Cancer
|
2010
|
1.42
|
|
20
|
Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products.
|
Mol Pharmacol
|
2006
|
1.41
|
|
21
|
Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.
|
Mol Cancer Ther
|
2007
|
1.36
|
|
22
|
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.
|
J Biol Chem
|
2007
|
1.34
|
|
23
|
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway.
|
Mol Cancer Res
|
2006
|
1.32
|
|
24
|
Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling.
|
Cell Microbiol
|
2008
|
1.30
|
|
25
|
Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway.
|
J Biol Chem
|
2006
|
1.29
|
|
26
|
Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma.
|
Biochim Biophys Acta
|
2012
|
1.27
|
|
27
|
From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer.
|
Expert Opin Ther Targets
|
2006
|
1.23
|
|
28
|
Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.
|
Clin Cancer Res
|
2007
|
1.22
|
|
29
|
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
|
Cancer Res
|
2008
|
1.22
|
|
30
|
Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.
|
J Immunol
|
2006
|
1.20
|
|
31
|
β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation.
|
Cancer Lett
|
2011
|
1.18
|
|
32
|
Retracted
Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.
|
Biochem Pharmacol
|
2006
|
1.16
|
|
33
|
Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo.
|
Cancer Prev Res (Phila)
|
2012
|
1.16
|
|
34
|
Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies.
|
Biochem Pharmacol
|
2013
|
1.15
|
|
35
|
Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.
|
J Biol Chem
|
2006
|
1.15
|
|
36
|
Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways.
|
Apoptosis
|
2011
|
1.14
|
|
37
|
Targeting cell signaling pathways for drug discovery: an old lock needs a new key.
|
J Cell Biochem
|
2007
|
1.14
|
|
38
|
Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells.
|
Cancer Lett
|
2010
|
1.14
|
|
39
|
Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.
|
Cancer Res
|
2008
|
1.14
|
|
40
|
Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.
|
Cancer Lett
|
2013
|
1.13
|
|
41
|
Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.
|
Biochem Pharmacol
|
2007
|
1.13
|
|
42
|
Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway.
|
Biochem Pharmacol
|
2011
|
1.12
|
|
43
|
Nuclear factor-kappa B: from clone to clinic.
|
Curr Mol Med
|
2007
|
1.11
|
|
44
|
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.
|
Mol Cancer Ther
|
2009
|
1.09
|
|
45
|
Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.
|
Clin Cancer Res
|
2010
|
1.09
|
|
46
|
Back to basics: how natural products can provide the basis for new therapeutics.
|
Expert Opin Investig Drugs
|
2007
|
1.08
|
|
47
|
Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4.
|
Mol Cancer
|
2011
|
1.08
|
|
48
|
Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT.
|
PLoS One
|
2012
|
1.07
|
|
49
|
Targeting cell signaling and apoptotic pathways by dietary agents: role in the prevention and treatment of cancer.
|
Nutr Cancer
|
2011
|
1.06
|
|
50
|
Polo-like kinase inhibitors: an emerging opportunity for cancer therapeutics.
|
Expert Opin Investig Drugs
|
2010
|
1.06
|
|
51
|
Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice.
|
J Mol Med (Berl)
|
2011
|
1.05
|
|
52
|
Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1.
|
J Immunol
|
2007
|
1.05
|
|
53
|
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
|
Blood
|
2007
|
1.03
|
|
54
|
Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: potential role in prevention and therapy of cancer.
|
Cancer Lett
|
2012
|
1.02
|
|
55
|
Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells.
|
Biochem Pharmacol
|
2010
|
1.00
|
|
56
|
Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway.
|
Biochem Pharmacol
|
2007
|
1.00
|
|
57
|
Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway.
|
Br J Pharmacol
|
2010
|
1.00
|
|
58
|
Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.
|
J Cell Physiol
|
2012
|
0.99
|
|
59
|
Role of epigenetics in inflammation-associated diseases.
|
Subcell Biochem
|
2013
|
0.98
|
|
60
|
DEAD-box helicase DP103 defines metastatic potential of human breast cancers.
|
J Clin Invest
|
2014
|
0.97
|
|
61
|
Targeting PPARγ Signaling Cascade for the Prevention and Treatment of Prostate Cancer.
|
PPAR Res
|
2012
|
0.97
|
|
62
|
Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model.
|
Int J Cancer
|
2011
|
0.97
|
|
63
|
γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.
|
Br J Pharmacol
|
2011
|
0.97
|
|
64
|
First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.
|
Clin Cancer Res
|
2012
|
0.97
|
|
65
|
Key cell signaling pathways modulated by zerumbone: role in the prevention and treatment of cancer.
|
Biochem Pharmacol
|
2012
|
0.96
|
|
66
|
Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.
|
Br J Pharmacol
|
2013
|
0.95
|
|
67
|
Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.
|
Eur J Pharmacol
|
2012
|
0.95
|
|
68
|
Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.
|
Br J Pharmacol
|
2011
|
0.95
|
|
69
|
Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco.
|
Int J Cancer
|
2007
|
0.93
|
|
70
|
Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.
|
J Biol Chem
|
2012
|
0.92
|
|
71
|
Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells.
|
J Pharmacol Exp Ther
|
2010
|
0.91
|
|
72
|
Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis.
|
Clin Cancer Res
|
2007
|
0.91
|
|
73
|
Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways.
|
PLoS One
|
2012
|
0.90
|
|
74
|
Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma.
|
PLoS One
|
2013
|
0.90
|
|
75
|
Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells.
|
Mol Pharmacol
|
2008
|
0.90
|
|
76
|
Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS.
|
PLoS One
|
2013
|
0.90
|
|
77
|
Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model.
|
Oncotarget
|
2014
|
0.89
|
|
78
|
Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades.
|
Prostate
|
2012
|
0.89
|
|
79
|
Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo.
|
Mol Cancer
|
2014
|
0.89
|
|
80
|
Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand through modulation of NF-kappaB pathway.
|
Int J Cancer
|
2008
|
0.88
|
|
81
|
Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products.
|
Nutr Cancer
|
2007
|
0.87
|
|
82
|
Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases.
|
Cancer Res
|
2007
|
0.86
|
|
83
|
Evidence that genetic deletion of the TNF receptor p60 or p80 inhibits Fas mediated apoptosis in macrophages.
|
Biochem Pharmacol
|
2007
|
0.85
|
|
84
|
Y-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model.
|
Oncotarget
|
2014
|
0.83
|
|
85
|
NF-κB in cancer therapy.
|
Arch Toxicol
|
2015
|
0.83
|
|
86
|
TNF-alpha-induced mitochondrial alterations in human T cells requires FADD and caspase-8 activation but not RIP and caspase-3 activation.
|
Antioxid Redox Signal
|
2010
|
0.82
|
|
87
|
Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signaling cascades leading to the suppression of growth and survival of head and neck carcinoma.
|
Cancer Prev Res (Phila)
|
2013
|
0.82
|
|
88
|
β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products.
|
Apoptosis
|
2014
|
0.81
|
|
89
|
Identification of a novel Calotropis procera protein that can suppress tumor growth in breast cancer through the suppression of NF-κB pathway.
|
PLoS One
|
2012
|
0.81
|
|
90
|
β-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase.
|
Mol Carcinog
|
2013
|
0.81
|
|
91
|
Cellular uptake of ginsenosides in Korean white ginseng and red ginseng and their apoptotic activities in human breast cancer cells.
|
Planta Med
|
2010
|
0.80
|
|
92
|
Plant-based hydrocarbon esters from Tragia involucrata possess antimicrobial and anti-inflammatory activities.
|
Infect Disord Drug Targets
|
2013
|
0.80
|
|
93
|
An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins.
|
Apoptosis
|
2013
|
0.79
|
|
94
|
Involvement of MAP kinase signal transduction pathway in UVB-induced activation of macrophages in vitro.
|
Immunol Lett
|
2003
|
0.78
|
|
95
|
The butanol fraction of guava (Psidium cattleianum Sabine) leaf extract suppresses MMP-2 and MMP-9 expression and activity through the suppression of the ERK1/2 MAPK signaling pathway.
|
Nutr Cancer
|
2012
|
0.77
|
|
96
|
Role of protein kinase Cdelta in UV-B-induced apoptosis of macrophages in vitro.
|
Cell Signal
|
2005
|
0.77
|
|
97
|
Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products.
|
J Mol Med (Berl)
|
2014
|
0.77
|
|
98
|
NMR structure of Carcinoscorpius rotundicauda thioredoxin-related protein 16 and its role in regulating transcription factor NF-κB activity.
|
J Biol Chem
|
2012
|
0.77
|
|
99
|
Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review.
|
Anticancer Drugs
|
2015
|
0.77
|
|
100
|
Potential role of targeted therapies in the treatment of triple-negative breast cancer.
|
Anticancer Drugs
|
2016
|
0.77
|
|
101
|
Involvement of fas/fas ligand in ultraviolet B-induced apoptosis of murine peritoneal macrophages.
|
Toxicol Mech Methods
|
2004
|
0.76
|
|
102
|
Correction: Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo.
|
PLoS One
|
2017
|
0.75
|
|
103
|
Identification of novel peroxisome proliferator-activated receptor-gamma (PPARγ) agonists using molecular modeling method.
|
J Comput Aided Mol Des
|
2014
|
0.75
|
|
104
|
Caspase-9 and Bax/Bcl-2 regulation in ultraviolet B-induced apoptosis of murine peritoneal macrophages.
|
Toxicol Mech Methods
|
2004
|
0.75
|
|
105
|
Anti-Inflammatory activity of Angelica keiskei through suppression of mitogen-activated protein kinases and nuclear factor-kappaB activation pathways.
|
J Med Food
|
2010
|
0.75
|