| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Cancer is a preventable disease that requires major lifestyle changes.
|
Pharm Res
|
2008
|
3.28
|
|
2
|
Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.
|
Ann N Y Acad Sci
|
2009
|
3.27
|
|
3
|
Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
|
Trends Pharmacol Sci
|
2008
|
3.16
|
|
4
|
Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe.
|
Clin Cancer Res
|
2009
|
2.98
|
|
5
|
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
|
Biochem Pharmacol
|
2008
|
2.95
|
|
6
|
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
|
Ann N Y Acad Sci
|
2006
|
2.44
|
|
7
|
Nuclear factor-kappaB activation: from bench to bedside.
|
Exp Biol Med (Maywood)
|
2008
|
2.19
|
|
8
|
Retracted
Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo.
|
Biochem Pharmacol
|
2009
|
2.12
|
|
9
|
TNF: a master switch for inflammation to cancer.
|
Front Biosci
|
2008
|
1.91
|
|
10
|
The molecular inflammatory process in aging.
|
Antioxid Redox Signal
|
2006
|
1.86
|
|
11
|
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
|
Carcinogenesis
|
2007
|
1.78
|
|
12
|
Cancer drug discovery by repurposing: teaching new tricks to old dogs.
|
Trends Pharmacol Sci
|
2013
|
1.72
|
|
13
|
Natural products as a gold mine for arthritis treatment.
|
Curr Opin Pharmacol
|
2007
|
1.59
|
|
14
|
A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.
|
Mol Cancer Ther
|
2010
|
1.58
|
|
15
|
Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.
|
Curr Drug Targets
|
2011
|
1.53
|
|
16
|
Concern
Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.
|
Blood
|
2007
|
1.52
|
|
17
|
Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).
|
Free Radic Biol Med
|
2007
|
1.51
|
|
18
|
The role of chalcones in suppression of NF-κB-mediated inflammation and cancer.
|
Int Immunopharmacol
|
2010
|
1.50
|
|
19
|
Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer.
|
Cancer Res
|
2008
|
1.45
|
|
20
|
Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species.
|
Cancer Res
|
2009
|
1.43
|
|
21
|
Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway.
|
Cancer Res
|
2010
|
1.37
|
|
22
|
Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis.
|
Cancer Res
|
2009
|
1.36
|
|
23
|
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.
|
J Biol Chem
|
2007
|
1.34
|
|
24
|
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway.
|
Mol Cancer Res
|
2006
|
1.32
|
|
25
|
Potential of spice-derived phytochemicals for cancer prevention.
|
Planta Med
|
2008
|
1.28
|
|
26
|
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
|
Cancer Res
|
2008
|
1.22
|
|
27
|
Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers.
|
Br J Pharmacol
|
2013
|
1.21
|
|
28
|
Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors.
|
Cancer Res
|
2009
|
1.20
|
|
29
|
Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.
|
Toxins (Basel)
|
2010
|
1.19
|
|
30
|
{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.
|
Cancer Res
|
2010
|
1.17
|
|
31
|
Protein kinase D1 promotes anchorage-independent growth, invasion, and angiogenesis by human pancreatic cancer cells.
|
J Cell Physiol
|
2011
|
1.16
|
|
32
|
Retracted
Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.
|
Biochem Pharmacol
|
2006
|
1.16
|
|
33
|
Retracted
Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.
|
Biochem Pharmacol
|
2010
|
1.16
|
|
34
|
Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise.
|
Antioxid Redox Signal
|
2006
|
1.15
|
|
35
|
Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.
|
Cancer Res
|
2008
|
1.14
|
|
36
|
Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways.
|
Carcinogenesis
|
2011
|
1.13
|
|
37
|
Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.
|
Mol Cancer Res
|
2009
|
1.11
|
|
38
|
Targeting TNF for Treatment of Cancer and Autoimmunity.
|
Adv Exp Med Biol
|
2009
|
1.11
|
|
39
|
Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins.
|
Mol Cancer Ther
|
2010
|
1.10
|
|
40
|
Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis.
|
Exp Biol Med (Maywood)
|
2009
|
1.10
|
|
41
|
Age-associated chronic diseases require age-old medicine: role of chronic inflammation.
|
Prev Med
|
2011
|
1.09
|
|
42
|
NF-κB in cancer: a matter of life and death.
|
Cancer Discov
|
2011
|
1.09
|
|
43
|
K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.
|
Mol Cancer Res
|
2009
|
1.06
|
|
44
|
Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.
|
Clin Cancer Res
|
2012
|
1.05
|
|
45
|
Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer.
|
Biochem Pharmacol
|
2010
|
1.05
|
|
46
|
Retracted
Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers.
|
Biochem Pharmacol
|
2009
|
1.04
|
|
47
|
Multitargeting by turmeric, the golden spice: From kitchen to clinic.
|
Mol Nutr Food Res
|
2012
|
1.02
|
|
48
|
Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1.
|
Mol Pharmacol
|
2008
|
1.02
|
|
49
|
Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.
|
Int J Cancer
|
2010
|
1.01
|
|
50
|
Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line.
|
Eur J Pharmacol
|
2009
|
0.97
|
|
51
|
Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors.
|
Mol Cancer Ther
|
2010
|
0.96
|
|
52
|
Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
|
J Mol Med (Berl)
|
2010
|
0.96
|
|
53
|
Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers.
|
Int J Cancer
|
2011
|
0.95
|
|
54
|
Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer.
|
Cancer Prev Res (Phila)
|
2010
|
0.93
|
|
55
|
5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
|
Mol Cancer Res
|
2010
|
0.93
|
|
56
|
Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.
|
Mol Pharmacol
|
2010
|
0.91
|
|
57
|
Chemopreventive and chemotherapeutic potential of curcumin in breast cancer.
|
Curr Drug Targets
|
2012
|
0.91
|
|
58
|
Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation.
|
Phytother Res
|
2009
|
0.90
|
|
59
|
Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells.
|
Breast Cancer Res
|
2012
|
0.90
|
|
60
|
Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells.
|
Mol Pharmacol
|
2008
|
0.90
|
|
61
|
The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo.
|
Neoplasia
|
2010
|
0.90
|
|
62
|
Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products.
|
Mol Cancer Res
|
2010
|
0.90
|
|
63
|
Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression.
|
Int J Cancer
|
2011
|
0.89
|
|
64
|
Retracted
3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.
|
J Biol Chem
|
2011
|
0.89
|
|
65
|
Retracted
Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.
|
Biochem Pharmacol
|
2011
|
0.88
|
|
66
|
Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family.
|
Carcinogenesis
|
2012
|
0.88
|
|
67
|
NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway.
|
FEBS Lett
|
2004
|
0.87
|
|
68
|
Epidermal growth factor down-regulates the expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells.
|
Cancer
|
2010
|
0.87
|
|
69
|
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.
|
Biochem Pharmacol
|
2008
|
0.86
|
|
70
|
Retracted
Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors.
|
Biochem Pharmacol
|
2011
|
0.85
|
|
71
|
Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets.
|
Int J Cancer
|
2011
|
0.85
|
|
72
|
Evidence that genetic deletion of the TNF receptor p60 or p80 inhibits Fas mediated apoptosis in macrophages.
|
Biochem Pharmacol
|
2007
|
0.85
|
|
73
|
Therapeutic Potential of VEGI/TL1A in Autoimmunity and Cancer.
|
Adv Exp Med Biol
|
2009
|
0.84
|
|
74
|
Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer.
|
Oncol Rep
|
2013
|
0.83
|
|
75
|
TNF-alpha-induced mitochondrial alterations in human T cells requires FADD and caspase-8 activation but not RIP and caspase-3 activation.
|
Antioxid Redox Signal
|
2010
|
0.82
|
|
76
|
Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro.
|
Biochem Pharmacol
|
2010
|
0.81
|
|
77
|
Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.
|
PLoS One
|
2011
|
0.81
|
|
78
|
A Dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways.
|
Anticancer Res
|
2010
|
0.81
|
|
79
|
The relationship between inflammation and cancer is analogous to that between fuel and fire.
|
Oncology (Williston Park)
|
2011
|
0.81
|
|
80
|
Prevention and Treatment of Colorectal Cancer by Natural Agents From Mother Nature.
|
Curr Colorectal Cancer Rep
|
2013
|
0.80
|
|
81
|
Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis.
|
Mol Cancer Ther
|
2008
|
0.79
|
|
82
|
Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway.
|
Antioxid Redox Signal
|
2011
|
0.79
|
|
83
|
The therapeutic effects of rGel/BLyS fusion toxin in in vitro and in vivo models of mantle cell lymphoma.
|
Biochem Pharmacol
|
2012
|
0.78
|
|
84
|
Inhibitory action of salicylideneamino-2-thiophenol on NF-κB signaling cascade and cyclooxygenase-2 in HNE-treated endothelial cells.
|
Arch Pharm Res
|
2013
|
0.78
|
|
85
|
The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma.
|
Biochem Pharmacol
|
2010
|
0.77
|
|
86
|
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
|
Mol Pharmacol
|
2010
|
0.77
|
|
87
|
Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.
|
J Biol Chem
|
2016
|
0.76
|
|
88
|
WITHDRAWN: Cardamonin Inhibits Osteoclastogenesis Induced by Tumor Cells Through Interruption of the Signaling Pathway Activated by Receptor Activator of NF-κB Ligand.
|
Cancer Lett
|
2011
|
0.75
|
|
89
|
Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
|
J Biol Chem
|
2016
|
0.75
|
|
90
|
3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.
|
J Biol Chem
|
2016
|
0.75
|