Published in Am J Physiol Cell Physiol on September 13, 2006
NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nat Neurosci (2009) 2.71
Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth. Free Radic Biol Med (2010) 2.32
Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction. Nat Mater (2008) 2.05
Mitochondrial hormesis and diabetic complications. Diabetes (2015) 1.61
HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements. Free Radic Biol Med (2008) 1.60
Blood meal-derived heme decreases ROS levels in the midgut of Aedes aegypti and allows proliferation of intestinal microbiota. PLoS Pathog (2011) 1.57
CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest (2010) 1.41
Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers. Free Radic Biol Med (2007) 1.34
Methods for detection of mitochondrial and cellular reactive oxygen species. Antioxid Redox Signal (2012) 1.20
Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase. J Biol Chem (2009) 1.15
EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines. Free Radic Res (2010) 1.15
Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II: role of mitochondrial reactive oxygen species. J Biol Chem (2013) 1.15
20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol (2008) 1.15
Blockade of NADPH oxidase restores vasoreparative function in diabetic CD34+ cells. Invest Ophthalmol Vis Sci (2011) 1.06
Dynamic optical imaging of metabolic and NADPH oxidase-derived superoxide in live mouse brain using fluorescence lifetime unmixing. J Cereb Blood Flow Metab (2011) 1.03
Redox regulation of the AMP-activated protein kinase. PLoS One (2010) 1.03
Sestrin 2 and AMPK connect hyperglycemia to Nox4-dependent endothelial nitric oxide synthase uncoupling and matrix protein expression. Mol Cell Biol (2013) 1.03
Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency. Free Radic Biol Med (2011) 1.03
Delayed inflammatory mRNA and protein expression after spinal cord injury. J Neuroinflammation (2011) 1.01
Activation of the ACE2/angiotensin-(1-7)/Mas receptor axis enhances the reparative function of dysfunctional diabetic endothelial progenitors. Diabetes (2012) 0.98
Rapid and specific measurements of superoxide using fluorescence spectroscopy. J Biomol Screen (2012) 0.97
Severe life stress and oxidative stress in the brain: from animal models to human pathology. Antioxid Redox Signal (2012) 0.94
Activation of AMP-activated protein kinase alleviates high-glucose-induced dysfunction of brain microvascular endothelial cell tight-junction dynamics. Free Radic Biol Med (2012) 0.91
Imaging ROS signaling in cells and animals. J Mol Med (Berl) (2013) 0.90
Time-dependent effects of training on cardiovascular control in spontaneously hypertensive rats: role for brain oxidative stress and inflammation and baroreflex sensitivity. PLoS One (2014) 0.90
Protein disulfide isomerase is required for platelet-derived growth factor-induced vascular smooth muscle cell migration, Nox1 NADPH oxidase expression, and RhoGTPase activation. J Biol Chem (2012) 0.89
Proteasome inhibition represses unfolded protein response and Nox4, sensitizing vascular cells to endoplasmic reticulum stress-induced death. PLoS One (2011) 0.88
In vivo imaging of reactive oxygen species in mouse brain by using [3H]hydromethidine as a potential radical trapping radiotracer. J Cereb Blood Flow Metab (2014) 0.88
Analysis of kinetics of dihydroethidium fluorescence with superoxide using xanthine oxidase and hypoxanthine assay. Ann Biomed Eng (2012) 0.87
Delivery of Nox2-NADPH oxidase siRNA with polyketal nanoparticles for improving cardiac function following myocardial infarction. Biomaterials (2013) 0.84
Berberine improves kidney function in diabetic mice via AMPK activation. PLoS One (2014) 0.82
Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis. Cell Res (2015) 0.82
Biphasic regulation of the NADPH oxidase by HGF/c-Met signaling pathway in primary mouse hepatocytes. Biochimie (2013) 0.82
An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies. PLoS One (2014) 0.80
The effect of inorganic arsenic on endothelium-dependent relaxation: role of NADPH oxidase and hydrogen peroxide. Toxicology (2013) 0.80
Assessment at the single-cell level identifies neuronal glutathione depletion as both a cause and effect of ischemia-reperfusion oxidative stress. J Neurosci (2015) 0.80
Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis. J Cereb Blood Flow Metab (2016) 0.79
Beneficial Effects of Physical Exercise on Functional Capacity and Skeletal Muscle Oxidative Stress in Rats with Aortic Stenosis-Induced Heart Failure. Oxid Med Cell Longev (2016) 0.79
Redox modulation of FAK controls melanoma survival--role of NOX4. PLoS One (2014) 0.78
Chemiluminescence Imaging of Superoxide Anion Detects Beta-Cell Function and Mass. PLoS One (2016) 0.77
Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase. Antioxid Redox Signal (2015) 0.76
High-Dose Polymerized Hemoglobin Fails to Alleviate Cardiac Ischemia/Reperfusion Injury due to Induction of Oxidative Damage in Coronary Artery. Oxid Med Cell Longev (2015) 0.76
Amino acids trigger down-regulation of superoxide via TORC pathway in the midgut of Rhodnius prolixus. Biosci Rep (2016) 0.75
Commentary: Superoxide Generation and Its Involvement in the Growth of Mycobacterium smegmatis. Front Microbiol (2017) 0.75
Long-Term Alteration of Reactive Oxygen Species Led to Multidrug Resistance in MCF-7 Cells. Oxid Med Cell Longev (2016) 0.75
Control of Insulin Secretion by Production of Reactive Oxygen Species: Study Performed in Pancreatic Islets from Fed and 48-Hour Fasted Wistar Rats. PLoS One (2016) 0.75
Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus. Cardiovasc Diabetol (2016) 0.75
Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. Antioxid Redox Signal (2009) 2.31
Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: A novel vascular redox pathway. Crit Care Med (2004) 2.04
Renal effects of N-acetylcysteine in patients at risk for contrast nephropathy: decrease in oxidant stress-mediated renal tubular injury. Nephrol Dial Transplant (2004) 1.89
Blood meal-derived heme decreases ROS levels in the midgut of Aedes aegypti and allows proliferation of intestinal microbiota. PLoS Pathog (2011) 1.57
Sustained decrease in superoxide dismutase activity underlies constrictive remodeling after balloon injury in rabbits. Arterioscler Thromb Vasc Biol (2003) 1.50
Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells. J Biol Chem (2005) 1.40
Cross-talk between mitochondria and NADPH oxidase: effects of mild mitochondrial dysfunction on angiotensin II-mediated increase in Nox isoform expression and activity in vascular smooth muscle cells. Antioxid Redox Signal (2009) 1.37
Oxidant generation predominates around calcifying foci and enhances progression of aortic valve calcification. Arterioscler Thromb Vasc Biol (2007) 1.33
Protein disulfide isomerase in redox cell signaling and homeostasis. Free Radic Biol Med (2012) 1.32
Assessment of superoxide production and NADPH oxidase activity by HPLC analysis of dihydroethidium oxidation products. Methods Enzymol (2008) 1.23
Functional role of NADPH oxidase in activation of platelets. Antioxid Redox Signal (2004) 1.08
Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation. Proc Natl Acad Sci U S A (2008) 1.04
Protein disulfide isomerase redox-dependent association with p47(phox): evidence for an organizer role in leukocyte NADPH oxidase activation. J Leukoc Biol (2011) 1.03
Novel role of protein disulfide isomerase in the regulation of NADPH oxidase activity: pathophysiological implications in vascular diseases. Antioxid Redox Signal (2008) 0.99
Overestimation of NADH-driven vascular oxidase activity due to lucigenin artifacts. Free Radic Biol Med (2002) 0.98
Vitamin C and vitamin E in prevention of Nonalcoholic Fatty Liver Disease (NAFLD) in choline deficient diet fed rats. Nutr J (2003) 0.98
Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages. J Leukoc Biol (2009) 0.97
Ischemic preconditioning requires increases in reactive oxygen release independent of mitochondrial K+ channel activity. Free Radic Biol Med (2005) 0.96
Alpha1D-adrenoceptor-induced relaxation on rat carotid artery is impaired during the endothelial dysfunction evoked in the early stages of hyperhomocysteinemia. Eur J Pharmacol (2006) 0.91
Protein disulfide isomerase and host-pathogen interaction. ScientificWorldJournal (2011) 0.91
Tobacco smoke induces ventricular remodeling associated with an increase in NADPH oxidase activity. Cell Physiol Biochem (2011) 0.90
Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress. World J Gastroenterol (2003) 0.90
Protein disulfide isomerase is required for platelet-derived growth factor-induced vascular smooth muscle cell migration, Nox1 NADPH oxidase expression, and RhoGTPase activation. J Biol Chem (2012) 0.89
Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis. PLoS One (2011) 0.89
Prevention and reversion of nonalcoholic steatohepatitis in OB/OB mice by S-nitroso-N-acetylcysteine treatment. J Am Coll Nutr (2008) 0.89
Protein disulfide isomerase overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression: effects of nitrosothiol exposure. Arch Biochem Biophys (2009) 0.88
Proteasome inhibition represses unfolded protein response and Nox4, sensitizing vascular cells to endoplasmic reticulum stress-induced death. PLoS One (2011) 0.88
Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway. Free Radic Biol Med (2011) 0.88
Identification of novel interaction between ADAM17 (a disintegrin and metalloprotease 17) and thioredoxin-1. J Biol Chem (2012) 0.88
Effects of high adherence to mediterranean or low-fat diets in medicated secondary prevention patients. Am J Cardiol (2011) 0.87
Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats. World J Gastroenterol (2006) 0.87
Circulating microparticles as therapeutic targets in cardiovascular diseases. Recent Pat Cardiovasc Drug Discov (2007) 0.85
A histopathological comparison of different definitions for quantifying in-stent neointimal tissue: implications for the validity of intracoronary ultrasound and optical coherence tomography measurements. Cardiovasc Diagn Ther (2011) 0.85
Calorie restriction increases cerebral mitochondrial respiratory capacity in a NO•-mediated mechanism: impact on neuronal survival. Free Radic Biol Med (2012) 0.84
Quantitation of superoxide generation and substrate utilization by vascular NAD(P)H oxidase. Am J Physiol Heart Circ Physiol (2002) 0.84
Influence of N- acetylcysteine on oxidative stress in slow-twitch soleus muscle of heart failure rats. Cell Physiol Biochem (2015) 0.84
Angiotensin II chronic infusion induces B1 receptor expression in aorta of rats. Hypertension (2007) 0.83
Physiological and pathological role of the ubiquitin-proteasome system in the vascular smooth muscle cell. Cardiovasc Res (2012) 0.83
Antioxidant activity of uruguayan propolis. In vitro and cellular assays. J Agric Food Chem (2011) 0.82
Serum from calorie-restricted rats activates vascular cell eNOS through enhanced insulin signaling mediated by adiponectin. PLoS One (2012) 0.80
Chronic hyperhomocysteinemia impairs vascular function in ovariectomized rat carotid arteries. Amino Acids (2009) 0.80
Redox processes underlying the vascular repair reaction. World J Surg (2004) 0.79
Loss of CD40 endogenous S-nitrosylation during inflammatory response in endotoxemic mice and patients with sepsis. Shock (2010) 0.78
Quiescin sulfhydryl oxidase (QSOX) is expressed in the human atheroma core: possible role in apoptosis. In Vitro Cell Dev Biol Anim (2011) 0.78
Ursodeoxycholic acid ameliorates experimental ileitis counteracting intestinal barrier dysfunction and oxidative stress. Dig Dis Sci (2004) 0.78
Evaluation of mild hyperhomocysteinemia during the development of atherosclerosis in apolipoprotein E-deficient and normal mice. Exp Mol Pathol (2010) 0.76
Reciprocal regulation of 11β-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor expression by dexamethasone inhibits human coronary artery smooth muscle cell proliferation in vitro. Mol Cell Biochem (2010) 0.75
Obesity and insulin resistance: "window" to myocardial dysfunction. Arq Bras Cardiol (2011) 0.75
Vascular calcification: pathophysiology and clinical implications. Einstein (Sao Paulo) (2013) 0.75
Adult rats are more sensitive to the vascular effects induced by hyperhomocysteinemia than young rats. Vascul Pharmacol (2010) 0.75