Reactive oxygen species-induced activation of the MAP kinase signaling pathways.

Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91

Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med (2010) 7.31

Redox regulation of cell survival. Antioxid Redox Signal (2008) 4.33

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY) (2011) 2.72

Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways? J Signal Transduct (2011) 2.11

The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol (2012) 2.09

Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome. Proc Natl Acad Sci U S A (2011) 1.80

The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Cancer Res (2008) 1.75

Oxidative stress in diabetic nephropathy. Curr Med Chem (2010) 1.70

Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells. Br J Cancer (2012) 1.53

Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties. Br J Cancer (2011) 1.53

Managing the challenge of chemically reactive metabolites in drug development. Nat Rev Drug Discov (2011) 1.45

Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One (2009) 1.42

The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway. Mol Pharmacol (2008) 1.37

Redox regulation of epidermal growth factor receptor signaling through cysteine oxidation. Biochemistry (2012) 1.35

Leydig cells: From stem cells to aging. Mol Cell Endocrinol (2009) 1.32

Potentiation of epithelial innate host responses by intercellular communication. PLoS Pathog (2010) 1.31

Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS Pathog (2011) 1.27

Retracted TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways. Am J Physiol Lung Cell Mol Physiol (2007) 1.26

Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle. Circulation (2008) 1.24

Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem (2011) 1.23

Reactive oxygen species controls endometriosis progression. Am J Pathol (2009) 1.18

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease. Hum Mol Genet (2009) 1.14

Glial influence on the blood brain barrier. Glia (2013) 1.12

Hydrogen peroxide priming modulates abiotic oxidative stress tolerance: insights from ROS detoxification and scavenging. Front Plant Sci (2015) 1.11

The ubiquitin ligase RPM-1 and the p38 MAPK PMK-3 regulate AMPA receptor trafficking. PLoS One (2009) 1.09

MAP Kinases and Prostate Cancer. J Signal Transduct (2011) 1.06

Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide. Toxicol Appl Pharmacol (2010) 1.06

Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression. PLoS One (2011) 1.06

Oxidative stress and neurodegenerative disorders. Int J Mol Sci (2013) 1.04

Immune mechanisms linked to depression via oxidative stress and neuroprogression. Immunology (2015) 1.04

Redox regulation of protein kinases. Crit Rev Biochem Mol Biol (2013) 1.03

Oxidative-dependent integration of signal transduction with intercellular gap junctional communication in the control of gene expression. Antioxid Redox Signal (2009) 1.03

Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent. Toxicol Appl Pharmacol (2009) 1.02

Quercetin potentiates insulin secretion and protects INS-1 pancreatic β-cells against oxidative damage via the ERK1/2 pathway. Br J Pharmacol (2010) 1.02

Subtoxic levels hydrogen peroxide-induced production of interleukin-6 by retinal pigment epithelial cells. Mol Vis (2010) 1.02

Protease-activated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol (2010) 1.00

Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells. Cancer Prev Res (Phila) (2012) 0.99

Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries. Autophagy (2013) 0.97

Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells. J Biol Chem (2012) 0.96

MKP-1 negatively regulates LPS-mediated IL-1β production through p38 activation and HIF-1α expression. Cell Signal (2017) 0.96

Manganese chloride stimulates rat microglia to release hydrogen peroxide. Toxicol Lett (2007) 0.95

Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals. FASEB J (2009) 0.94

Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma. Free Radic Biol Med (2014) 0.94

ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia. Oncogene (2010) 0.94

Docosahexaenoic acid-induced apoptosis is mediated by activation of mitogen-activated protein kinases in human cancer cells. BMC Cancer (2014) 0.93

Single-cell redox imaging demonstrates a distinctive response of dopaminergic neurons to oxidative insults. Antioxid Redox Signal (2011) 0.92

ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration. PLoS Genet (2015) 0.92

Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding. Proc Natl Acad Sci U S A (2010) 0.92

The mTOR/AKT inhibitor temsirolimus prevents deep infiltrating endometriosis in mice. Am J Pathol (2011) 0.91

Interactions between calcium and reactive oxygen species in pulmonary arterial smooth muscle responses to hypoxia. Respir Physiol Neurobiol (2010) 0.91

HO-1 induction by CO-RM2 attenuates TNF-α-induced cytosolic phospholipase A2 expression via inhibition of PKCα-dependent NADPH oxidase/ROS and NF-κB. Mediators Inflamm (2014) 0.90

Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury. PLoS One (2011) 0.90

Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases. Neurochem Int (2007) 0.89

Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection. J Virol (2012) 0.89

Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. Sci Rep (2015) 0.89

NADPH oxidase 4 regulates cardiomyocyte differentiation via redox activation of c-Jun protein and the cis-regulation of GATA-4 gene transcription. J Biol Chem (2013) 0.89

Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem (2009) 0.88

Regulation of breast tumorigenesis through acid sensors. Oncogene (2015) 0.87

Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to fas ligand. Cell Transplant (2012) 0.87

Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. J Immunol (2009) 0.86

Effect of glutathione redox state on Leydig cell susceptibility to acute oxidative stress. Mol Cell Endocrinol (2010) 0.86

A candidate anti-HIV reservoir compound, auranofin, exerts a selective 'anti-memory' effect by exploiting the baseline oxidative status of lymphocytes. Cell Death Dis (2013) 0.86

Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality control in male mice. PLoS One (2012) 0.86

JNK and NADPH oxidase involved in fluoride-induced oxidative stress in BV-2 microglia cells. Mediators Inflamm (2013) 0.86

Evodiamine synergizes with doxorubicin in the treatment of chemoresistant human breast cancer without inhibiting P-glycoprotein. PLoS One (2014) 0.84

Heme-induced ROS in Trypanosoma cruzi activates CaMKII-like that triggers epimastigote proliferation. One helpful effect of ROS. PLoS One (2011) 0.84

Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis. PLoS One (2014) 0.84

Polyhydroxylated fullerene attenuates oxidative stress-induced apoptosis via a fortifying Nrf2-regulated cellular antioxidant defence system. Int J Nanomedicine (2014) 0.84

Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras. J Pineal Res (2008) 0.83

B7-H4 downregulation induces mitochondrial dysfunction and enhances doxorubicin sensitivity via the cAMP/CREB/PGC1-α signaling pathway in HeLa cells. Pflugers Arch (2014) 0.83

T33, a novel peroxisome proliferator-activated receptor γ/α agonist, exerts neuroprotective action via its anti-inflammatory activities. Acta Pharmacol Sin (2011) 0.82

Mitochondria in the center of human eosinophil apoptosis and survival. Int J Mol Sci (2014) 0.82

Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis. Cell Res (2015) 0.82

Reactive oxygen species from human astrocytes induced functional impairment and oxidative damage. Neurochem Res (2013) 0.82

Retinoic acid stimulation of VEGF secretion from human endometrial stromal cells is mediated by production of reactive oxygen species. J Physiol (2010) 0.81

Gene Transcriptional and Metabolic Profile Changes in Mimetic Aging Mice Induced by D-Galactose. PLoS One (2015) 0.81

Heteronemin, a Spongean Sesterterpene, Induces Cell Apoptosis and Autophagy in Human Renal Carcinoma Cells. Biomed Res Int (2015) 0.81

Mitochondrial genome variations in advanced stage endometriosis: a study in South Indian population. PLoS One (2012) 0.81

Mechanotransduction in the endothelium: role of membrane proteins and reactive oxygen species in sensing, transduction, and transmission of the signal with altered blood flow. Antioxid Redox Signal (2014) 0.81

Synergistic signaling of tumor cell invasiveness by hepatocyte growth factor and hypoxia. J Biol Chem (2014) 0.80

A redox signalling globin is essential for reproduction in Caenorhabditis elegans. Nat Commun (2015) 0.80

Role of the ERK pathway for oxidant-induced parthanatos in human lymphocytes. PLoS One (2014) 0.80

A mathematical model of intercellular signaling during epithelial wound healing. J Theor Biol (2010) 0.79

Antioxidant treatment regulates the humoral immune response during acute viral infection. J Virol (2012) 0.79

Aging modifies brain region-specific vulnerability to experimental oxidative stress induced by low dose hydrogen peroxide. Age (Dordr) (2007) 0.79

Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea. Virol J (2012) 0.79

FOXO responses to Porphyromonas gingivalis in epithelial cells. Cell Microbiol (2015) 0.79

Cerium oxide nanoparticles attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension. Biomaterials (2014) 0.78

Measuring the constitutive activation of c-Jun N-terminal kinase isoforms. Methods Enzymol (2010) 0.78

A novel blood-brain barrier co-culture system for drug targeting of Alzheimer's disease: establishment by using acitretin as a model drug. PLoS One (2014) 0.78

The beneficial effect of melatonin in brain endothelial cells against oxygen-glucose deprivation followed by reperfusion-induced injury. Oxid Med Cell Longev (2014) 0.78

Interplay between Hepatitis C Virus and Redox Cell Signaling. Int J Mol Sci (2013) 0.78

The identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations. PLoS One (2013) 0.78

Antioxidants in Cardiovascular Therapy: Panacea or False Hope? Front Cardiovasc Med (2015) 0.78

Neuroprotective effects of Liriope platyphylla extract against hydrogen peroxide-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. BMC Complement Altern Med (2015) 0.78

Targeting MAPK Signaling in Age-Related Macular Degeneration. Ophthalmol Eye Dis (2016) 0.77

The decay of Redox-stress Response Capacity is a substantive characteristic of aging: Revising the redox theory of aging. Redox Biol (2016) 0.77

Role of N-acetylcysteine and GSH redox system on total and active MMP-2 in intestinal myofibroblasts of Crohn's disease patients. Int J Colorectal Dis (2012) 0.77

A mutation in the NADH-dehydrogenase subunit 2 suppresses fibroblast aging. Oncotarget (2015) 0.77

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta (2006) 7.33

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget (2011) 3.43

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Adv Enzyme Regul (2006) 3.32

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget (2012) 1.96

Inhibition of the CaM-kinases augments cell death in response to oxygen radicals and oxygen radical inducing cancer therapies in MCF-7 human breast cancer cells. Cancer Biol Ther (2006) 1.48

B-raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells. Cell Cycle (2004) 1.43

Redox regulation of the calcium/calmodulin-dependent protein kinases. J Biol Chem (2004) 1.39

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells. Oncogene (2003) 1.21

Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells. Cell Cycle (2011) 1.17

Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy. Oncotarget (2011) 1.16

Advances in targeting signal transduction pathways. Oncotarget (2012) 1.06

Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells. Cancer Res (2005) 1.04

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines. Mol Cancer Ther (2007) 1.03

The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it? Expert Opin Ther Targets (2005) 1.02

Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance. Adv Enzyme Regul (2007) 1.01

EGF induces cell motility and multi-drug resistance gene expression in breast cancer cells. Cell Cycle (2006) 0.97

Participation of the calcium/calmodulin-dependent kinases in hydrogen peroxide-induced Ikappa B phosphorylation in human T lymphocytes. J Biol Chem (2002) 0.96

Activation of the calcium/calmodulin-dependent protein kinases as a consequence of oxidative stress. Antioxid Redox Signal (2006) 0.94

Molecular pathways leading to oxidative stress-induced phosphorylation of Akt. Antioxid Redox Signal (2006) 0.93

Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy. Adv Enzyme Regul (2008) 0.89

Signaling intermediates (MAPK and PI3K) as therapeutic targets in NSCLC. Curr Pharm Des (2014) 0.86

Cell death of MCF-7 human breast cancer cells induced by EGFR activation in the absence of other growth factors. Cell Cycle (2006) 0.83

Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy. Expert Opin Ther Targets (2005) 0.83

Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine. Cell Cycle (2012) 0.83

Targeting the cancer initiating cell: the Achilles' heel of cancer. Adv Enzyme Regul (2010) 0.82

Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines. Cell Cycle (2005) 0.80

GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity. Cancer Biol Ther (2008) 0.80

Inhibition of CREB transcriptional activity in human T lymphocytes by oxidative stress. Free Radic Biol Med (2005) 0.80

Models of anergy in the human Jurkat T cell line. Assay Drug Dev Technol (2003) 0.80

Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment. Adv Biol Regul (2012) 0.79

Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells. Oncogene (2004) 0.78

Combining chemo-, hormonal and targeted therapies to treat breast cancer (Review). Mol Med Rep (2011) 0.77

Reactive oxygen intermediates and signaling through kinase pathways. Antioxid Redox Signal (2006) 0.77

OSU-03012 in the treatment of glioblastoma. Mol Pharmacol (2006) 0.77

Novel approaches to target cancer initiating cells-eliminating the root of the cancer. Adv Biol Regul (2012) 0.76

Effects of endogenous epidermal growth factor receptor signaling on DNA synthesis and ERK activation in a cytokine-dependent hematopoietic cell line. Cell Cycle (2005) 0.75

A new hope for treatment of glioblastomas. Cancer Biol Ther (2003) 0.75

Fibroblastic, hematopoietic, and hormone responsive epithelial cell lines and culture conditions for elucidation of signal transduction and drug resistance pathways by gene transfer. Methods Mol Biol (2003) 0.75

Elucidation of signal transduction pathways by retroviral infection of cells with modified oncogenes. Methods Mol Biol (2003) 0.75

Elucidation of signal transduction pathways by transfection of cells with modified oncogenes. Methods Mol Biol (2003) 0.75