| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
EXPERIMENTAL PNEUMONIA BY INTRABRONCHIAL INSUFFLATION.
|
J Exp Med
|
1912
|
31.80
|
|
2
|
A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.
|
Cancer Res
|
1998
|
20.08
|
|
3
|
EXPERIMENTAL BRONCHOPNEUMONIA BY INTRABRONCHIAL INSUFFLATION.
|
J Exp Med
|
1912
|
8.95
|
|
4
|
PNEUMONIC LESIONS MADE BY INTRABRONCHIAL INSUFFLATION OF NON-VIRULENT PNEUMOCOCCI.
|
J Exp Med
|
1913
|
5.14
|
|
5
|
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.
|
Cancer Res
|
2000
|
2.99
|
|
6
|
EXPERIMENTAL CONTRIBUTION TO THE STUDY OF THE PATH BY WHICH FLUIDS ARE CARRIED FROM THE PERITONEAL CAVITY INTO THE CIRULATION.
|
J Exp Med
|
1896
|
2.94
|
|
7
|
Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagus.
|
Am J Pathol
|
1999
|
2.88
|
|
8
|
6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity.
|
Ann Intern Med
|
1989
|
2.70
|
|
9
|
THE REACTION OF THE LUNGS TO THE INTRABRONCHIAL INSUFFLATION OF KILLED VIRULENT PNEUMOCOCCI AND OF PLAIN STERILE BOUILLON.
|
J Exp Med
|
1913
|
2.53
|
|
10
|
PTEN1 is frequently mutated in primary endometrial carcinomas.
|
Nat Genet
|
1997
|
2.44
|
|
11
|
Human papillomavirus DNA sequences in esophagus squamous cell carcinoma.
|
Gastroenterology
|
1994
|
2.20
|
|
12
|
Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours.
|
Nat Genet
|
1996
|
2.19
|
|
13
|
PNEUMONIC LESIONS CAUSED BY BACILLUS MEGATHERIUM.
|
J Exp Med
|
1913
|
2.10
|
|
14
|
Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability.
|
Cancer Res
|
1999
|
2.09
|
|
15
|
E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas.
|
J Natl Cancer Inst
|
2000
|
2.05
|
|
16
|
Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis.
|
Gastroenterology
|
1999
|
2.04
|
|
17
|
Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways.
|
J Clin Pathol
|
1999
|
1.98
|
|
18
|
Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas.
|
Cancer Res
|
1998
|
1.94
|
|
19
|
On the Respiratory Changes of the Intrathoracic Pressure, measured in the Mediastinum Posterior.
|
J Physiol
|
1892
|
1.89
|
|
20
|
Loss of heterozygosity involves multiple tumor suppressor genes in human esophageal cancers.
|
Cancer Res
|
1992
|
1.65
|
|
21
|
Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia.
|
Oncogene
|
2000
|
1.63
|
|
22
|
Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.
|
Proc Natl Acad Sci U S A
|
1992
|
1.56
|
|
23
|
Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis.
|
Oncogene
|
2006
|
1.55
|
|
24
|
Global gene expression profiling in Barrett's esophagus and esophageal cancer: a comparative analysis using cDNA microarrays.
|
Oncogene
|
2002
|
1.54
|
|
25
|
17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy.
|
Cancer Res
|
1994
|
1.52
|
|
26
|
Instabilotyping: comprehensive identification of frameshift mutations caused by coding region microsatellite instability.
|
Cancer Res
|
2001
|
1.52
|
|
27
|
Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma.
|
J Natl Cancer Inst
|
2000
|
1.45
|
|
28
|
Retention in the Circulation of Dextrose in Normal and Depancreatized Animals, and the Effect of an Intravenous Injection of an Emulsion of Pancreas Upon This Retention.
|
Proc Natl Acad Sci U S A
|
1915
|
1.45
|
|
29
|
A transforming growth factor beta 1 receptor type II mutation in ulcerative colitis-associated neoplasms.
|
Gastroenterology
|
1997
|
1.42
|
|
30
|
Clonal ordering of 17p and 5q allelic losses in Barrett dysplasia and adenocarcinoma.
|
Proc Natl Acad Sci U S A
|
1993
|
1.40
|
|
31
|
THE RELATION OF THE RATE OF ABSORPTION OF ADRENALIN TO ITS GLYCOSURIC AND DIURETIC EFFECTS.
|
J Exp Med
|
1913
|
1.40
|
|
32
|
Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells.
|
Cancer Res
|
2001
|
1.39
|
|
33
|
Growth suppression of esophageal cancer cells by p16INK4 and p15INK4B in vitro.
|
Cancer J Sci Am
|
2006
|
1.39
|
|
34
|
AN EXPERIMENTAL STUDY OF THE ADDITIVE AND ANTAGONISTIC ACTIONS OF SODIUM OXALATE, AND SALTS OF MAGNESIUM AND CALCIUM IN THE RABBIT.
|
J Exp Med
|
1916
|
1.38
|
|
35
|
The Dynamics of Living Matter.
|
Science
|
1906
|
1.37
|
|
36
|
p53 point mutations in dysplastic and cancerous ulcerative colitis lesions.
|
Gastroenterology
|
1993
|
1.36
|
|
37
|
Appendiceal obstruction by a toothpick removed at colonoscopy.
|
Am J Gastroenterol
|
1986
|
1.33
|
|
38
|
Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line.
|
Gastroenterology
|
1996
|
1.33
|
|
39
|
Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms.
|
Cancer Res
|
1995
|
1.31
|
|
40
|
Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma.
|
Oncogene
|
2007
|
1.31
|
|
41
|
EXPERIMENTAL CHEMICAL PNEUMONIA.
|
J Exp Med
|
1918
|
1.31
|
|
42
|
Glypican-3 expression in Wilms tumor and hepatoblastoma.
|
J Pediatr Hematol Oncol
|
2001
|
1.30
|
|
43
|
ABC of colorectal cancer. Molecular basis for risk factors.
|
BMJ
|
2000
|
1.30
|
|
44
|
MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro.
|
Oncogene
|
2010
|
1.25
|
|
45
|
Microsatellite instability occurs frequently in human gastric carcinoma.
|
Oncogene
|
1994
|
1.21
|
|
46
|
Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancers.
|
Cancer Res
|
1994
|
1.20
|
|
47
|
Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer.
|
Cancer Res
|
1992
|
1.18
|
|
48
|
Allelotype analysis of oesophageal adenocarcinoma: loss of heterozygosity occurs at multiple sites.
|
Br J Cancer
|
1998
|
1.18
|
|
49
|
Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia.
|
Oncogene
|
2001
|
1.17
|
|
50
|
Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival.
|
Oncogene
|
2001
|
1.17
|
|
51
|
APC gene mutations in the mutation cluster region are rare in esophageal cancers.
|
Gastroenterology
|
1994
|
1.14
|
|
52
|
p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2.
|
Cancer Res
|
2001
|
1.11
|
|
53
|
Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1.
|
Cancer Res
|
2000
|
1.10
|
|
54
|
Frequent mutation of the E2F-4 cell cycle gene in primary human gastrointestinal tumors.
|
Cancer Res
|
1997
|
1.09
|
|
55
|
The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum.
|
Cancer Res
|
1997
|
1.09
|
|
56
|
Expression of Bcl-2 protein is decreased in colorectal adenocarcinomas with microsatellite instability.
|
Oncogene
|
1999
|
1.08
|
|
57
|
Protooncogene abnormalities in colon cancers and adenomatous polyps.
|
Gastroenterology
|
1987
|
1.07
|
|
58
|
Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis.
|
Cancer Res
|
1992
|
1.07
|
|
59
|
Following in mother's footsteps? Mother-daughter risks for insulin resistance and cardiovascular disease 15 years after gestational diabetes.
|
Diabet Med
|
2010
|
1.05
|
|
60
|
Altered messenger RNA and unique mutational profiles of p53 and Rb in human esophageal carcinomas.
|
Cancer Res
|
1993
|
1.05
|
|
61
|
Human cyclin D1 oncogene and esophageal squamous cell carcinoma.
|
Cancer
|
1995
|
1.04
|
|
62
|
Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.
|
Oncogene
|
1996
|
1.03
|
|
63
|
Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers.
|
Cancer Res
|
1991
|
0.99
|
|
64
|
p53 protein expression in ulcerative colitis-associated colorectal dysplasia and carcinoma.
|
Hum Pathol
|
1994
|
0.99
|
|
65
|
Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers.
|
Oncogene
|
1998
|
0.97
|
|
66
|
Loss of transforming growth factor-beta type II receptor gene expression in primary human esophageal cancer.
|
Lab Invest
|
1996
|
0.97
|
|
67
|
The MTS1 gene is frequently mutated in primary human esophageal tumors.
|
Oncogene
|
1994
|
0.96
|
|
68
|
EFFECT OF INTRABRONCHIAL INSUFFLATION OF SOLUTIONS OF SOME INORGANIC SALTS.
|
J Exp Med
|
1918
|
0.95
|
|
69
|
THE DEPLORABLE CONTRAST BETWEEN INTRANATIONAL AND INTERNATIONAL ETHICS AND THE MISSION OF MEDICAL SCIENCE AND MEDICAL MEN.
|
Science
|
1915
|
0.94
|
|
70
|
Recurrent pancreatitis caused by vegetable matter obstruction.
|
Am J Gastroenterol
|
1986
|
0.94
|
|
71
|
Alterations of transforming growth factor-beta 1 receptor type II occur in ulcerative colitis-associated carcinomas, sporadic colorectal neoplasms, and esophageal carcinomas, but not in gastric neoplasms.
|
Hum Cell
|
1996
|
0.94
|
|
72
|
The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract.
|
Oncogene
|
1999
|
0.94
|
|
73
|
Kaposi's sarcoma occurring in association with ulcerative colitis.
|
Am J Gastroenterol
|
1987
|
0.92
|
|
74
|
The MspI polymorphism in intron 6 of p53 (TP53) detected by digestion of PCR products.
|
Nucleic Acids Res
|
1991
|
0.92
|
|
75
|
FHIT gene alterations in esophageal cancer and ulcerative colitis (UC).
|
Oncogene
|
1997
|
0.91
|
|
76
|
Nature and course of pancreatitis caused by 6-mercaptopurine in the treatment of inflammatory bowel disease.
|
Gastroenterology
|
1986
|
0.91
|
|
77
|
Allelic deletions of MCC/APC and p53 are frequent late events in human gastric carcinogenesis.
|
Gastroenterology
|
1994
|
0.90
|
|
78
|
Frequent loss of heterozygosity on chromosome 9 in adenocarcinoma and squamous cell carcinoma of the esophagus.
|
Cancer Res
|
1994
|
0.90
|
|
79
|
Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors.
|
Cell Growth Differ
|
1996
|
0.89
|
|
80
|
THE CHARACTER OF THE PNEUMONIC LESIONS PRODUCED BY INTRABRONCHIAL INSUFFLATION OF VIRULENT STREPTOCOCCI.
|
J Exp Med
|
1913
|
0.89
|
|
81
|
The molecular basis for carcinogenesis in metaplastic columnar-lined esophagus.
|
Gastroenterol Clin North Am
|
1997
|
0.89
|
|
82
|
Deficient transforming growth factor-beta1 activation and excessive insulin-like growth factor II (IGFII) expression in IGFII receptor-mutant tumors.
|
Cancer Res
|
1997
|
0.89
|
|
83
|
Explant organ culture: a review.
|
Cytotechnology
|
1991
|
0.88
|
|
84
|
Sequence alterations of insulin-like growth factor binding protein 3 in neoplastic and normal gastrointestinal tissues.
|
Cancer Res
|
1998
|
0.88
|
|
85
|
Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas.
|
Hum Mutat
|
1997
|
0.87
|
|
86
|
Loss of heterozygosity of p53 in oral cancers demonstrated by the polymerase chain reaction.
|
Cancer
|
1993
|
0.87
|
|
87
|
Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells.
|
Oncogene
|
1999
|
0.87
|
|
88
|
Anti-p53 antibodies in patients with Barrett's esophagus or esophageal carcinoma can predate cancer diagnosis.
|
Gastroenterology
|
1998
|
0.86
|
|
89
|
Genomic DNA and messenger RNA expression alterations of the CDKN2B and CDKN2 genes in esophageal squamous carcinoma cell lines.
|
Genes Chromosomes Cancer
|
1995
|
0.85
|
|
90
|
On the Paths of Absorption from the Peritoneal Cavity.
|
J Physiol
|
1897
|
0.84
|
|
91
|
P53 gene protein overexpression predicts results of trimodality therapy in esophageal cancer patients.
|
Ann Thorac Surg
|
1999
|
0.83
|
|
92
|
Loss of heterozygosity involving the APC gene in oral squamous cell carcinomas.
|
Oral Surg Oral Med Oral Pathol
|
1994
|
0.83
|
|
93
|
Activation of a cryptic splice site of PTEN and loss of heterozygosity in benign skin lesions in Cowden disease.
|
J Invest Dermatol
|
2001
|
0.82
|
|
94
|
Colon carcinogenesis in inflammatory bowel disease.
|
Inflamm Bowel Dis
|
1995
|
0.82
|
|
95
|
The Behaviour of the Red Blood-corpuscles when shaken with Indifferent Substances.
|
J Physiol
|
1885
|
0.81
|
|
96
|
Thyroid disease with monoclonal (immunoglobulin G lambda) antibody to triiodothyronine and thyroxine.
|
J Clin Endocrinol Metab
|
1983
|
0.80
|
|
97
|
Rodent cell transformation and immediate early gene expression following 60-Hz magnetic field exposure.
|
Environ Health Perspect
|
1996
|
0.79
|
|
98
|
p53 mutational status and survival of human breast cancer MCF-7 cell variants after exposure to X rays or fission neutrons.
|
Radiat Res
|
1995
|
0.79
|
|
99
|
Multiple target sites of allelic imbalance on chromosome 17 in Barrett's oesophageal cancer.
|
Oncogene
|
1999
|
0.79
|
|
100
|
A unique p53 intragenic deletion flanked by short direct repeats results in loss of mRNA expression in a human esophageal carcinoma.
|
Carcinogenesis
|
1994
|
0.79
|
|
101
|
Tumor genomics vs. tumor genetics: a paradigm shift?
|
Gastroenterology
|
2001
|
0.79
|
|
102
|
Dr. Strange DNA, or how I learned to stop cloning and love the computer.
|
Gastroenterology
|
1995
|
0.78
|
|
103
|
THE POSTMORTEM RIGOR OF THE MAMMALIAN HEART AND THE INFLUENCE OF AN ANTEMORTEM STIMULATION OF THE PNEUMOGASTRIC NERVES UPON ITS DEVELOPMENT.
|
J Exp Med
|
1909
|
0.78
|
|
104
|
RAS gene activation in acute myelogenous leukemia: analysis by in vitro amplification and DNA base sequence determination.
|
Genes Chromosomes Cancer
|
1990
|
0.78
|
|
105
|
HEADSHIP AND ORGANIZATION OF CLINICAL DEPARTMENTS OF FIRST-CLASS MEDICAL SCHOOLS.
|
Science
|
1914
|
0.77
|
|
106
|
THE FACTORS OF SAFETY IN ANIMAL STRUCTURE AND ANIMAL ECONOMY.
|
Science
|
1907
|
0.77
|
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107
|
New guidelines for the management of diabetes: a physician's guide. Steering Committee for the Revision of the Clinical Practice Guidelines for the Management of Diabetes in Canada.
|
CMAJ
|
1998
|
0.77
|
|
108
|
Csa-19, a radiation-responsive human gene, identified by an unbiased two-gel cDNA library screening method in human cancer cells.
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Oncogene
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1997
|
0.77
|
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109
|
On a Difference in the Influence upon Inflammation between the Section of the Sympathetic Nerve and the Removal of the sympathetic Ganglion.
|
J Med Res
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1903
|
0.76
|
|
110
|
The apoptotic regulatory gene, BCL10, is mutated in sporadic mismatch repair deficient colorectal cancers.
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Cell Death Differ
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2000
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0.76
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111
|
Low prevalence of the APC I1307K sequence in Jewish and non-Jewish patients with inflammatory bowel disease.
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Oncogene
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1999
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0.76
|
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112
|
E2F-4 mutation in hereditary non-polyposis colorectal cancer.
|
J Exp Clin Cancer Res
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2002
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0.76
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113
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Apparent protection from instability of repeat sequences in cancer-related genes in replication error positive gastrointestinal cancers.
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Oncogene
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1997
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0.75
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114
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THE EFFECT OF PAINTING THE PANCREAS WITH ADRENALIN UPON HYPERGLYCEMIA AND GLYCOSURIA.
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J Exp Med
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1918
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0.75
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115
|
EMIL DU BOIS-REYMOND.
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Science
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1897
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0.75
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116
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THE INTRAVENOUS INJECTION OF MAGNESIUM SULPHATE FOR ANESTHESIA IN ANIMALS.
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J Exp Med
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1916
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0.75
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117
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Cytogenetic studies of primary cultures of esophageal squamous cell carcinoma.
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Cancer Genet Cytogenet
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1993
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0.75
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118
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THE DOMAIN OF PHYSIOLOGY AND ITS RELATIONS TO MEDICINE.
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Science
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1904
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0.75
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119
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BIGEL analysis of gene expression in HL60 cells exposed to X rays or 60 Hz magnetic fields.
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Radiat Res
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1998
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0.75
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120
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c-myc amplification coexistent with activating N-ras point mutation in the biphenotypic leukemic cell line RED-3.
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Leukemia
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1989
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0.75
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121
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Direct radioactive labeling of unpurified PCR products using Klenow fragment.
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Biotechniques
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1991
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0.75
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122
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Direct radioactive labeling of polymerase chain reaction products.
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Methods Mol Biol
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1993
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0.75
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123
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Microsatellite instability is infrequent in neuroblastoma.
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Cancer Epidemiol Biomarkers Prev
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1995
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0.75
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124
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Microsatellite Analysis of the Insulin-Like Growth Factor II Receptor in Colorectal Carcinomas.
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Methods Mol Med
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2001
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0.75
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125
|
Historical profiles. Our aims. S. J. Meltzer. Presidential address.
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Gastroenterology
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1979
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0.75
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126
|
AN EXPERIMENTAL STUDY OF THE QUESTION OF ASPIRATION OF FOREIGN MATERIAL INTO THE AIR PASSAGES DURING INTRATRACHEAL INSUFFLATION.
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J Exp Med
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1911
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0.75
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127
|
ON ABSORPTION FROM INTRAMUSCULAR TISSUE.
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J Exp Med
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1911
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0.75
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128
|
FRATERNITAS MEDICORUM; A REPORT AND A DISCUSSION.
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Science
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1916
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0.75
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129
|
THE STATUS OF RESPIRATION IN THE METHODS OF DIFFERENTIAL PRESSURE COMPARED WITH THAT UNDER THE METHOD OF INTRATRACHEAL INSUFFLATION.
|
J Exp Med
|
1911
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0.75
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130
|
On the Clotting of Blood of nephrectomized Rabbits.
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J Med Res
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1904
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0.75
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131
|
Frontiers in gastroenterology: new clinical and research opportunities.
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Md Med J
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1991
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0.75
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132
|
A PROTEST.
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Science
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1908
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0.75
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133
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THE POSTMORTEM RIGOR OF THE MAMMALIAN HEART AND THE INFLUENCE OF AN ANTEMORTEM STIMULATION OF THE PNEUMOGASTRIC NERVES UPON ITS DEVELOPMENT.
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J Exp Med
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1909
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0.75
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134
|
Direct radioactive labeling of polymerase chain reaction products.
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Methods Mol Biol
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1996
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0.75
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135
|
PROFESSOR HUGO KRONECKER.
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Science
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1914
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0.75
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136
|
The Influence of Morphin Upon the Elimination of Intravenously Injected Dextrose in Dogs.
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Proc Natl Acad Sci U S A
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1916
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0.75
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137
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Effect of naturally occurring E2F-4 alterations on transcriptional activation and proliferation in transfected cells.
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Lab Invest
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2001
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0.75
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138
|
THE NEEDS OF MEN OF SCIENCE IN RUMANIA.
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Science
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1920
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0.75
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139
|
The Influence of Nephrectomy upon Absorption - an Experimental Study from the Rockefeller Institute for Medical Research.
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J Med Res
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1903
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0.75
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140
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AN EXPERIMENTAL STUDY OF THE DIRECT INOCULATION OF BACTERIA INTO THE SPLEEN OF LIVING ANIMALS; AND A CONTRIBUTION TO THE KNOWLEDGE OF THE IMPORTANCE OF A LESION IN ANIMAL TISSUE FOR THE LODGMENT AND MULTIPLICATION OF BACTERIA WITHIN IT.
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J Exp Med
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1898
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0.75
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141
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Colon polyps in Beckwith-Wiedmann syndrome: role of imprinted genes.
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Gastroenterology
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2000
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0.75
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142
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Experiments relating to the Question of Fixation of Strychnine in Animal Tissues.
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J Med Res
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1903
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0.75
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