Published in Drug Discov Today on September 07, 2006
Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration. Mol Neurobiol (2008) 1.93
Role of proteasomes in disease. BMC Biochem (2007) 1.65
Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature (2008) 1.55
Neurite consolidation is an active process requiring constant repression of protrusive activity. EMBO J (2008) 1.46
Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation. J Biol Chem (2010) 1.40
Mitochondrial membrane permeabilization and cell death during myocardial infarction: roles of calcium and reactive oxygen species. Future Cardiol (2012) 1.15
Tau-based treatment strategies in neurodegenerative diseases. Neurotherapeutics (2008) 1.13
Incorporation of noncanonical amino acids into Rosetta and use in computational protein-peptide interface design. PLoS One (2012) 1.02
Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna. PLoS Genet (2011) 0.93
Adaptive modifications in the calpain/calpastatin system in brain cells after persistent alteration in Ca2+ homeostasis. J Biol Chem (2009) 0.89
Inhibition of mitochondrial membrane permeability as a putative pharmacological target for cardioprotection. Curr Med Chem (2009) 0.89
Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels. BMC Med Genet (2007) 0.86
Genetic myostatin decrease in the golden retriever muscular dystrophy model does not significantly affect the ubiquitin proteasome system despite enhancing the severity of disease. Am J Transl Res (2013) 0.84
Calpain and the glutamatergic synapse. Front Biosci (Schol Ed) (2009) 0.84
Regulation of the calpain and ubiquitin-proteasome systems in a canine model of muscular dystrophy. Muscle Nerve (2011) 0.83
Calpains: potential targets for alternative chemotherapeutic intervention against human pathogenic trypanosomatids. Curr Med Chem (2013) 0.82
Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of duchenne muscular dystrophy. Front Pharmacol (2012) 0.82
Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinoma. PLoS One (2013) 0.82
Beneficial effects of antecedent exercise training on limb motor function and calpain expression in a rat model of stroke. J Phys Ther Sci (2013) 0.81
Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity. Cardiovasc Diabetol (2008) 0.81
Inhibition of calpain but not caspase activity by spectrin fragments. Cell Mol Biol Lett (2010) 0.79
Cardiac protective effects of dexrazoxane on animal cardiotoxicity model induced by anthracycline combined with trastuzumab is associated with upregulation of calpain-2. Medicine (Baltimore) (2015) 0.78
A novel strategy for therapeutic intervention for the genetic disease: preventing proteolytic cleavage using small chemical compound. Int J Biochem Cell Biol (2010) 0.77
Mechanism of action of thalassospiramides, a new class of calpain inhibitors. Sci Rep (2015) 0.77
CalpB modulates border cell migration in Drosophila egg chambers. BMC Dev Biol (2012) 0.77
Homology modeling study of bovine μ-calpain inhibitor-binding domains. Int J Mol Sci (2014) 0.76
Why calpain inhibitors are interesting leading compounds to search for new therapeutic options to treat leishmaniasis? Parasitology (2016) 0.75
Calpastatin Overexpression Preserves Cognitive Function Following Seizures, While Maintaining Post-Injury Neurogenesis. Front Mol Neurosci (2017) 0.75
Critical role of calpain in inflammation. Biomed Rep (2016) 0.75
Affinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin. PLoS One (2017) 0.75
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis. BMC Genomics (2008) 1.64
Pyrosequencing protocol using a universal biotinylated primer for mutation detection and SNP genotyping. Nat Protoc (2007) 1.61
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. J Alzheimers Dis (2010) 1.19
Violence against women in Mexico: a study of abuse before and during pregnancy. Am J Public Health (2003) 1.13
Sex and body mass index specific regulation of blood pressure by CYP19A1 gene variants. Hypertension (2007) 1.06
GOLPH2 gene markers are not associated with Alzheimer's disease in a sample of the Spanish population. J Alzheimers Dis (2009) 1.02
Association of NOS3 gene with metabolic syndrome in hypertensive patients. Thromb Haemost (2004) 0.88
Genetic analysis of CAV1 gene in hypertension and metabolic syndrome. Thromb Haemost (2006) 0.84
Genetic analysis of the GRM1 gene in human melanoma susceptibility. Eur J Hum Genet (2007) 0.84
Genetic analysis of caveolin-1 and eNOS genes in colorectal cancer. Oncol Rep (2006) 0.84
Re: Polymorphisms associated with circulating sex hormone levels in postmenopausal women. J Natl Cancer Inst (2005) 0.81
Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in male infertility and the polygenic nature of the pathology. Fertil Steril (2005) 0.80
Genetic analysis of candidate SNPs for metabolic syndrome in obstructive sleep apnea (OSA). Gene (2013) 0.79
Analysis of the ERalpha germline PvuII marker in breast cancer risk. Med Sci Monit (2008) 0.78
Lack of association between NOS3 Glu298Asp and breast cancer risk: a case-control study. Breast Cancer Res Treat (2006) 0.78
Exploring allelic imbalance within paraffin-embedded tumor biopsies using pyrosequencing technology. Clin Chem Lab Med (2006) 0.78
Identification of a protective haplogenotype within CAPN10 gene influencing colorectal cancer susceptibility. J Gastroenterol Hepatol (2007) 0.78
Detection of pvull polymorphism within intron 1 of ESR1 gene by real-time PCR. Clin Chem Lab Med (2003) 0.78
Methylation alterations are not a major cause of PTTG1 misregulation. BMC Cancer (2008) 0.77
Genetic and genomic insights into age at natural menopause. Genome Med (2009) 0.75
Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke. Thromb Haemost (2016) 0.75