PubRank

Hamsa Puthalakath

Author PubWeight™ 38.10‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 2002 5.98
2 Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med 2007 3.09
3 Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci U S A 2006 3.06
4 To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions. Mol Cell 2008 2.97
5 Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J Exp Med 2003 2.77
6 Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate. Nat Cell Biol 2004 2.42
7 A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J Cell Biol 2008 2.04
8 Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol 2007 1.97
9 Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim. Immunity 2009 1.73
10 CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers. Nat Immunol 2005 1.43
11 Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma. Blood 2007 1.22
12 Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway. IUBMB Life 2008 1.18
13 MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation. J Immunol 2009 1.17
14 What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain. Immunol Cell Biol 2007 1.10
15 Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochem J 2004 1.07
16 Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim. EMBO Rep 2010 1.02
17 BH3-only proteins: a 20-year stock-take. FEBS J 2015 0.89
18 Endoplasmic reticulum stress and BCL-2 family members. Adv Exp Med Biol 2010 0.87
19 Role of p53 in cAMP/PKA pathway mediated apoptosis. Apoptosis 2013 0.83
20 The PKA paradox: is Bim the answer? Cell Cycle 2011 0.81
21 Ubiquitylation and cancer development. Curr Cancer Drug Targets 2008 0.79