Published in IUBMB Life on September 01, 2006
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
CA-074Me protection against anthrax lethal toxin. Infect Immun (2009) 1.55
Killing a cancer: what are the alternatives? Nat Rev Cancer (2012) 1.30
Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells. Part Fibre Toxicol (2010) 1.22
Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence. Am J Pathol (2012) 1.16
The position of lysosomes within the cell determines their luminal pH. J Cell Biol (2016) 1.13
Endolysosomal proteases and their inhibitors in immunity. Nat Rev Immunol (2009) 1.10
(-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilization. PLoS One (2012) 0.99
Aberrant Ca2+ handling in lysosomal storage disorders. Cell Calcium (2010) 0.91
Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis. J Biol Chem (2012) 0.88
The involvement of lysosomes in myocardial aging and disease. Curr Cardiol Rev (2008) 0.88
TRPML: transporters of metals in lysosomes essential for cell survival? Cell Calcium (2011) 0.88
Alterations in oxidative markers in the cerebellum and peripheral organs in MPS I mice. Cell Mol Neurobiol (2008) 0.88
Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells. J Proteomics (2009) 0.86
Lipid peroxidation causes endosomal antigen release for cross-presentation. Sci Rep (2016) 0.86
Protein Oxidation in Aging: Does It Play a Role in Aging Progression? Antioxid Redox Signal (2014) 0.85
The endolysosomal system in cell death and survival. Cold Spring Harb Perspect Biol (2013) 0.85
Synergistic induction of apoptosis by salinomycin and gefitinib through lysosomal and mitochondrial dependent pathway overcomes gefitinib resistance in colorectal cancer. Oncotarget (2017) 0.84
Autophagy of metallothioneins prevents TNF-induced oxidative stress and toxicity in hepatoma cells. Autophagy (2015) 0.80
Oxidative stress and the homeodynamics of iron metabolism. Biomolecules (2015) 0.79
Biphasic activity of chloroquine in human colorectal cancer cells. Balsaenggwa Saengsig (2014) 0.78
Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D. Molecules (2014) 0.78
Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes. Cell Death Discov (2016) 0.77
DNA degradation and its defects. Cold Spring Harb Perspect Biol (2014) 0.77
Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma. Oncotarget (2016) 0.76
Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes. Sci Rep (2016) 0.75
Targeted iron oxide nanoparticles for the enhancement of radiation therapy. Biomaterials (2016) 0.75
Protein kinase C-δ isoform mediates lysosome labilization in DNA damage-induced apoptosis. Int J Oncol (2010) 0.75
Synergistic Anticancer Action of Lysosomal Membrane Permeabilization and Glycolysis Inhibition. J Biol Chem (2016) 0.75
Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration. Hum Mol Genet (2016) 0.75
Oxidative profile exhibited by Mucopolysaccharidosis type IVA patients at diagnosis: Increased keratan urinary levels. Mol Genet Metab Rep (2017) 0.75
Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway. Sci Rep (2016) 0.75
Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosis. Biochem Biophys Rep (2017) 0.75
The acidic transformed nano-VO2 causes macrophage cell death by the induction of lysosomal membrane permeabilization and Ca(2+) efflux. Toxicol Rep (2015) 0.75
A transient outward current in a mammalian central neurone blocked by 4-aminopyridine. Nature (1982) 2.94
Relation between shapes of post-synaptic potentials and changes in firing probability of cat motoneurones. J Physiol (1983) 2.92
Parametric and nonparametric multipoint linkage analysis with imprinting and two-locus-trait models: application to mite sensitization. Am J Hum Genet (2000) 2.70
A stellar relic from the early Milky Way. Nature (2002) 2.56
Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells. Leukemia (2007) 2.35
Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. Cell Death Differ (2009) 2.33
Long-term potentiation in the hippocampus using depolarizing current pulses as the conditioning stimulus to single volley synaptic potentials. J Neurosci (1987) 2.30
A probable stellar solution to the cosmological lithium discrepancy. Nature (2006) 2.28
Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radic Biol Med (1993) 2.22
Direct and indirect activation of nerve cells by electrical pulses applied extracellularly. J Physiol (1976) 2.03
Facilitated induction of hippocampal long-lasting potentiation during blockade of inhibition. Nature (1983) 1.99
Mutations in the BRAF and N-ras genes in childhood acute lymphoblastic leukaemia. Leukemia (2005) 1.95
Influence of stretch-evoked synaptic potentials on firing probability of cat spinal motoneurones. J Physiol (1984) 1.89
Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem J (2001) 1.80
Structural studies of the Vibrio cholerae O-antigen. Carbohydr Res (1982) 1.78
Firing behaviour of a neurone model based on the afterhyperpolarization conductance time course and algebraical summation. Adaptation and steady state firing. Acta Physiol Scand (1974) 1.71
Autophagy, organelles and ageing. J Pathol (2007) 1.64
Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture. Biochem J (2001) 1.56
Monoclonal antibodies against Vibrio cholerae lipopolysaccharide. Infect Immun (1982) 1.55
Plasma exudation as a first line respiratory mucosal defence. Clin Exp Allergy (1991) 1.52
Evidence for two types of afterhyperpolarization in CA1 pyramidal cells in the hippocampus. Brain Res (1981) 1.48
Induction of cell death by the lysosomotropic detergent MSDH. FEBS Lett (2000) 1.46
Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning. Cardiovasc Res (2001) 1.45
Update of the International Banff Schema for Liver Allograft Rejection: working recommendations for the histopathologic staging and reporting of chronic rejection. An International Panel. Hepatology (2000) 1.44
Quantal variability at glutamatergic synapses in area CA1 of the rat neonatal hippocampus. J Physiol (2001) 1.42
Firing behaviour of a neurone model based on the afterhyperpolarization conductance time course. First interval firing. Acta Physiol Scand (1974) 1.39
Afterhyperpolarization conductance time course in lumbar motoneurones of the cat. Acta Physiol Scand (1974) 1.37
Facilitation of hippocampal long-lasting potentiation by GABA antagonists. Acta Physiol Scand (1985) 1.36
Hydrogen peroxide production by liver mitochondria in different species. Mech Ageing Dev (1990) 1.35
Postsynaptic control of hippocampal long-term potentiation. J Physiol (Paris) (1986) 1.35
Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radic Biol Med (1995) 1.30
Lipofuscin: mechanisms of formation and increase with age. APMIS (1998) 1.29
Relations among passive electrical properties of lumbar alpha-motoneurones of the cat. J Physiol (1984) 1.28
Long-term potentiation involves enhanced synaptic excitation relative to synaptic inhibition in guinea-pig hippocampus. J Physiol (1987) 1.27
Regulation of repetitive firing in motoneurones by the afterhyperpolarization conductance. Brain Res (1971) 1.22
An investigation of threshold properties among cat spinal alpha-motoneurones. J Physiol (1984) 1.21
Hippocampal long-lasting potentiation produced by pairing single volleys and brief conditioning tetani evoked in separate afferents. J Neurosci (1986) 1.21
Hippocampal long-term potentiation is induced by pairing single afferent volleys with intracellularly injected depolarizing current pulses. Acta Physiol Scand (1986) 1.21
Mitochondrial production of pro-oxidants and cellular senescence. Mutat Res (1992) 1.21
Saturating summation of the afterhyperpolarization conductance in spinal motoneurones: a mechanism for 'secondary range' repetitive firing. Brain Res (1978) 1.19
Vesicle release probability and pre-primed pool at glutamatergic synapses in area CA1 of the rat neonatal hippocampus. J Physiol (2001) 1.18
The toxicity to macrophages of oxidized low-density lipoprotein is mediated through lysosomal damage. Atherosclerosis (1997) 1.17
Photooxidative damage to lysosomes of cultured macrophages by acridine orange. Photochem Photobiol (1990) 1.13
The comparative biology of neuromelanin and lipofuscin in the human brain. Cell Mol Life Sci (2008) 1.13
Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis. Mech Ageing Dev (1998) 1.12
Lysosomal heterogeneity between and within cells with respect to resistance against oxidative stress. Histochem J (1998) 1.10
alpha-tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation. FEBS Lett (1999) 1.09
Immunological characterization of Vibrio cholerae O:1 lipopolysaccharide, O-side chain, and core with monoclonal antibodies. Infect Immun (1985) 1.09
Respiratory distress syndrome and thrombotic, non-bacterial endocarditis after amitriptyline overdose. Acta Med Scand (1977) 1.09
Changes in field excitatory postsynaptic potential shape induced by tetanization in the CA1 region of the guinea-pig hippocampal slice. Neuroscience (1990) 1.08
Firing behaviour of dorsal spinocerebellar tract neurones. J Physiol (1978) 1.08
A possible correlate of the postsynaptic condition for long-lasting potentiation in the guinea pig hippocampus in vitro. Neurosci Lett (1984) 1.07
Lipofuscin as an indicator of oxidative stress and aging. Adv Exp Med Biol (1989) 1.06
Large long-lasting potentiation in the dentate gyrus in vitro during blockade of inhibition. Brain Res (1983) 1.05
Cytochemical evidence for the leakage of acid phosphatase through ultrastructurally intact lysosomal membranes. Histochem J (1972) 1.05
Monoclonal antibodies against group- and type-specific lipopolysaccharide antigens of Vibrio cholerae O:1. J Clin Microbiol (1983) 1.05
Ionotropic glutamate receptors. Their possible role in the expression of hippocampal synaptic plasticity. Mol Neurobiol (1996) 1.05
Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products. Free Radic Biol Med (2000) 1.05
Changes in motoneurone electrical properties following axotomy. J Physiol (1979) 1.05
Tumour-infiltrating lymphocytes in metastatic malignant melanoma and response to interferon alpha treatment. Br J Cancer (1996) 1.03
Regiospecific synthesis of 4-(2-oxoalkyl)pyridines. Org Lett (2001) 1.03
Physiological mechanisms underlying long-term potentiation. Trends Neurosci (1988) 1.02
The demonstration of acid phosphatase in vitro cultured tissue cells. Studies on the significance of fixation, tonicity and permeability. Histochem J (1972) 1.01
Factors explaining heterogeneity in short-term synaptic dynamics of hippocampal glutamatergic synapses in the neonatal rat. J Physiol (2001) 1.01
Paired-pulse plasticity at the single release site level: an experimental and computational study. J Neurosci (2001) 1.01
Delayed oxidant-induced cell death involves activation of phospholipase A2. FEBS Lett (2001) 1.01
Superoxide anion radical production in different animal species. Mech Ageing Dev (1989) 1.01
On long-lasting potentiation in the hippocampus: a proposed mechanism for its dependence on coincident pre- and postsynaptic activity. Acta Physiol Scand (1985) 1.00
Protection against oxidant-mediated lysosomal rupture: a new anti-apoptotic activity of Bcl-2? FEBS Lett (2000) 1.00
Improved renal function after early conversion from a calcineurin inhibitor to everolimus: a randomized trial in kidney transplantation. Am J Transplant (2012) 1.00
Relationship between antioxidant defenses and longevity in different mammalian species. Mech Ageing Dev (1990) 0.99
Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation. Arterioscler Thromb Vasc Biol (1998) 0.99
Airway permeability. Clin Exp Allergy (1995) 0.99
A synaptic potential following single volleys in the hippocampal CA1 region possibly involved in the induction of long-lasting potentiation. Acta Physiol Scand (1985) 0.99
Nonexocytotic release of endogenous noradrenaline in the ischemic and anoxic rat heart: mechanism and metabolic requirements. Circ Res (1987) 0.98
Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation. Exp Gerontol (1999) 0.97
Congenital myasthenic syndrome associated with episodic apnea and sudden infant death. Neuromuscul Disord (2002) 0.97
Electrophoretic and immunochemical studies of Micrurus snake venoms. Toxicon (1994) 0.97
Dysphagia and its consequences in the elderly. Dysphagia (1991) 0.97
Effects of axotomy on the distribution of passive electrical properties of cat motoneurones. J Physiol (1984) 0.96
Beta-carotene-loaded nanostructured lipid carriers. J Food Sci (2008) 0.96
Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosis. FEBS Lett (2001) 0.96
Detection of the response regulator AgrA in the cytosolic fraction of Staphylococcus aureus by monoclonal antibodies. FEMS Microbiol Lett (1996) 0.96
Lipofuscin accumulation in cultured retinal pigment epithelial cells reduces their phagocytic capacity. Curr Eye Res (1998) 0.95
On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes. Mech Ageing Dev (1998) 0.95
Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress. Free Radic Res (1998) 0.95
Subepithelial hydrostatic pressure may regulate plasma exudation across the mucosa. Int Arch Allergy Appl Immunol (1990) 0.95
Effect of repetitive activation on the afterhyperpolarization in dorsal spinocerebellar tract neurones. J Physiol (1978) 0.95
Rapid detection of Vibrio cholerae O:1 by motility inhibition and immunofluorescence with monoclonal antibodies. Eur J Clin Microbiol (1985) 0.94
On the direct Fourier method for computer tomography. IEEE Trans Med Imaging (2000) 0.94
On re-excitation of feline motoneurones: its mechanism and consequences. J Physiol (1984) 0.94
Effects of chronic partial deafferentiation on the electrical properties of lumbar alpha-motoneurones in the cat. Brain Res (1982) 0.93
Correlations of Ki-67 and PCNA to DNA ploidy, S-phase fraction and survival in uveal melanoma. Eur J Cancer (1996) 0.93
Iron in human atheroma and LDL oxidation by macrophages following erythrophagocytosis. Atherosclerosis (1996) 0.93
Developmental changes in release properties of the CA3-CA1 glutamate synapse in rat hippocampus. J Neurophysiol (2004) 0.93
Sympatho-adrenergic activation of the ischemic myocardium and its arrhythmogenic impact. Herz (1995) 0.92
Lipofuscin accumulation and ageing of fibroblasts. Gerontology (1995) 0.92
On the biological relevance of MHC class II and B7 expression by tumour cells in melanoma metastases. Br J Cancer (2003) 0.92