Published in Blood on September 26, 2006
The role of interleukin-2 during homeostasis and activation of the immune system. Nat Rev Immunol (2012) 3.97
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med (2009) 3.78
Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes. Nat Med (2007) 3.22
Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice. J Clin Invest (2008) 1.68
Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells. Blood (2008) 1.64
Attenuation of donor-reactive T cells allows effective control of allograft rejection using regulatory T cell therapy. Am J Transplant (2013) 1.60
Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells. Sci Transl Med (2011) 1.56
CD4(+)Foxp3(+) regulatory T cell therapy in transplantation. J Mol Cell Biol (2011) 1.45
Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning. Am J Transplant (2010) 1.36
Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol (2009) 1.35
Adoptive regulatory T-cell therapy protects against cerebral ischemia. Ann Neurol (2013) 1.30
Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harb Perspect Med (2013) 1.29
Clinical grade Treg: GMP isolation, improvement of purity by CD127 Depletion, Treg expansion, and Treg cryopreservation. PLoS One (2008) 1.26
Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy. PLoS One (2008) 1.16
CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity. J Immunol (2012) 1.12
The changed balance of regulatory and naive T cells promotes tolerance after TLI and anti-T-cell antibody conditioning. Am J Transplant (2009) 1.11
CD8α+ plasmacytoid precursor DCs induce antigen-specific regulatory T cells that enhance HSC engraftment in vivo. Blood (2010) 1.07
Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells. Diabetes (2011) 1.05
Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. J Clin Invest (2016) 0.99
Allogeneic T regulatory cell-mediated transplantation tolerance in adoptive therapy depends on dominant peripheral suppression and central tolerance. Blood (2009) 0.99
Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation. PLoS One (2010) 0.97
Induced regulatory T cells: mechanisms of conversion and suppressive potential. Hum Immunol (2012) 0.95
Anti-CD4-mediated selection of Treg in vitro - in vitro suppression does not predict in vivo capacity to prevent graft rejection. Eur J Immunol (2008) 0.95
Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun (2014) 0.95
Transplantation tolerance: lessons from experimental rodent models. Transpl Int (2007) 0.94
Rapamycin promotes the enrichment of CD4(+)CD25(hi)FoxP3(+) T regulatory cells from naïve CD4(+) T cells of baboon that suppress antiporcine xenogenic response in vitro. Transplant Proc (2009) 0.93
Ex vivo expanded human regulatory T cells can prolong survival of a human islet allograft in a humanized mouse model. Transplantation (2013) 0.92
Tolerogenic dendritic cell-regulatory T-cell interaction and the promotion of transplant tolerance. Transplantation (2009) 0.92
Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation. Front Immunol (2012) 0.91
Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells. Transl Res (2008) 0.91
Human regulatory T cells against minor histocompatibility antigens: ex vivo expansion for prevention of graft-versus-host disease. Blood (2013) 0.91
Translating tolerogenic therapies to the clinic - where do we stand? Front Immunol (2012) 0.91
Relative resistance of human CD4(+) memory T cells to suppression by CD4(+) CD25(+) regulatory T cells. Am J Transplant (2011) 0.90
Tolerogenic therapies in transplantation. Front Immunol (2012) 0.88
Promoting transplantation tolerance; adoptive regulatory T cell therapy. Clin Exp Immunol (2013) 0.88
Laminins affect T cell trafficking and allograft fate. J Clin Invest (2014) 0.88
Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation. Front Immunol (2015) 0.87
Comparative study of regulatory T cells expanded ex vivo from cord blood and adult peripheral blood. Immunology (2012) 0.86
Host-based Th2 cell therapy for prolongation of cardiac allograft viability. PLoS One (2011) 0.85
Rhesus monkey immature monocyte-derived dendritic cells generate alloantigen-specific regulatory T cells from circulating CD4+CD127-/lo T cells. Transplantation (2009) 0.85
CD45 ligation expands Tregs by promoting interactions with DCs. J Clin Invest (2014) 0.84
Outgrowth of CD4low/negCD25+ T cells with suppressor function in CD4+CD25+ T cell cultures upon polyclonal stimulation ex vivo. J Immunol (2008) 0.84
Immune tolerance induction by integrating innate and adaptive immune regulators. Cell Transplant (2009) 0.84
Rapamycin-conditioned donor dendritic cells differentiate CD4CD25Foxp3 T cells in vitro with TGF-beta1 for islet transplantation. Am J Transplant (2010) 0.84
Hematopoietic chimerism and transplantation tolerance: a role for regulatory T cells. Front Immunol (2011) 0.83
Natural and expanded CD4(+)CD25(+) regulatory T cells in bone marrow transplantation. Biol Blood Marrow Transplant (2011) 0.82
Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity. Sci Rep (2016) 0.81
Adoptive immunotherapy with the use of regulatory T cells and virus-specific T cells derived from cord blood. Cytotherapy (2015) 0.81
Obtaining regulatory T cells from uraemic patients awaiting kidney transplantation for use in clinical trials. Clin Exp Immunol (2013) 0.81
Transplant tolerance: new insights and strategies for long-term allograft acceptance. Clin Dev Immunol (2013) 0.80
New insights into the mechanisms of Treg function. Curr Opin Organ Transplant (2015) 0.80
Tolerance-inducing strategies in islet transplantation. Int J Endocrinol (2012) 0.80
High frequencies of CD62L⁺ naive regulatory T cells in allografts are associated with a low risk of acute graft-versus-host disease following unmanipulated allogeneic haematopoietic stem cell transplantation. Clin Exp Immunol (2011) 0.80
Inhibition of Pim2-prolonged skin allograft survival through the apoptosis regulation pathway. Cell Mol Immunol (2012) 0.80
Transplantation tolerance: Clinical potential of regulatory T cells. Self Nonself (2011) 0.79
Analysis of the transcriptional program of developing induced regulatory T cells. PLoS One (2011) 0.79
Lung transplantation: chronic allograft dysfunction and establishing immune tolerance. Hum Immunol (2014) 0.79
Expression of 3G11 epitope defines subpopulations of regulatory T cells with different suppressive potency. J Neurol Sci (2010) 0.79
IL-17 gene ablation does not impact Treg-mediated suppression of graft-versus-host disease after bone marrow transplantation. Biol Blood Marrow Transplant (2013) 0.78
Magnetic cell sorting and flow cytometry sorting methods for the isolation and function analysis of mouse CD4+ CD25+ Treg cells. J Zhejiang Univ Sci B (2009) 0.78
Transplantation tolerance. Pediatr Nephrol (2013) 0.78
Regulatory T Cell Therapy for Ischemic Stroke: how far from Clinical Translation? Transl Stroke Res (2016) 0.78
Can antigen-specific regulatory T cells protect against graft versus host disease and spare anti-malignancy alloresponse? Haematologica (2009) 0.77
Islet cell transplant and the incorporation of Tregs. Curr Opin Organ Transplant (2014) 0.77
Alloreactive Regulatory T Cells Allow the Generation of Mixed Chimerism and Transplant Tolerance. Front Immunol (2015) 0.76
MicroRNA-26a Promotes Regulatory T cells and Suppresses Autoimmune Diabetes in Mice. Inflammation (2016) 0.76
Generation, cryopreservation, function and in vivo persistence of ex vivo expanded cynomolgus monkey regulatory T cells. Cell Immunol (2015) 0.76
Large-scale in vitro expansion of human regulatory T cells with potent xenoantigen-specific suppression. Cytotechnology (2015) 0.76
Transplantation Tolerance Induction: Cell Therapies and Their Mechanisms. Front Immunol (2016) 0.76
Engineering an "infectious" T(reg) biomimetic through chemoselective tethering of TGF-β1 to PEG brush surfaces. Biomaterials (2015) 0.76
Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients. Am J Transplant (2016) 0.76
Lymph Node Stromal Fiber ER-TR7 Modulates CD4+ T Cell Lymph Node Trafficking and Transplant Tolerance. Transplantation (2015) 0.76
Improving the safety of tolerance induction: chimerism and cellular co-treatment strategies applied to vascularized composite allografts. Clin Dev Immunol (2012) 0.75
T regulatory cell mediated immunotherapy for solid organ transplantation: A clinical perspective. Mol Med (2016) 0.75
Hematopoietic stem cells and solid organ transplantation. Transplant Rev (Orlando) (2016) 0.75
Are we ready for the use of foxp3(+) regulatory T cells for immunodiagnosis and immunotherapy in kidney transplantation? J Transplant (2012) 0.75
Inhibition of histone methyltransferase EZH2 ameliorates early acute renal allograft rejection in rats. BMC Immunol (2016) 0.75
Upregulation of PIM2 by Underexpression of MicroRNA-135-5p Improves Survival Rates of Skin Allografts by Suppressing Apoptosis of Fibroblast Cells. Med Sci Monit (2017) 0.75
Clinical grade isolation of regulatory T cells from G-CSF mobilized peripheral blood improves with initial depletion of monocytes. Am J Blood Res (2015) 0.75
Adoptive Cell Therapy with Tregs to Improve Transplant Outcomes: The Promise and the Stumbling Blocks. Curr Transplant Rep (2016) 0.75
Regulatory T cells: Tolerance Induction in Solid Organ Transplantation. Clin Exp Immunol (2017) 0.75
IL-2-Mediated In Vivo Expansion of Regulatory T Cells Combined with CD154-CD40 Co-Stimulation Blockade but Not CTLA-4 Ig Prolongs Allograft Survival in Naive and Sensitized Mice. Front Immunol (2017) 0.75
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest (2002) 5.83
Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Gastroenterology (2005) 4.10
Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol (2006) 4.04
The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations. J Crohns Colitis (2009) 3.66
Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest (2010) 3.59
Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest (2010) 3.41
Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood (2006) 2.42
Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol (2013) 2.13
A novel pathway of alloantigen presentation by dendritic cells. J Immunol (2004) 1.94
Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest (2003) 1.87
Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol (2002) 1.84
Control of immune pathology by regulatory T cells. Novartis Found Symp (2003) 1.79
Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice. J Clin Invest (2008) 1.68
Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo. Blood (2003) 1.63
Organ transplantation: halfway through the first century. J Am Soc Nephrol (2004) 1.59
Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells. Sci Transl Med (2011) 1.56
Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes (2002) 1.43
Pathways of allorecognition: implications for transplantation tolerance. Transpl Immunol (2002) 1.41
Systematic evaluation of risk factors for diagnostic delay in inflammatory bowel disease. Inflamm Bowel Dis (2011) 1.41
Inhibition of thrombin receptor signaling on α-smooth muscle actin(+) CD34(+) progenitors leads to repair after murine immune vascular injury. Arterioscler Thromb Vasc Biol (2011) 1.39
Human CD4+CD25+ regulatory cells have marked and sustained effects on CD8+ T cell activation. Eur J Immunol (2003) 1.35
Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines. J Leukoc Biol (2002) 1.33
New spectrum of allorecognition pathways: implications for graft rejection and transplantation tolerance. Curr Opin Immunol (2004) 1.30
Cutting Edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients. J Immunol (2011) 1.25
Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression. Eur J Immunol (2006) 1.24
CD4+CD25+ regulatory T cells do not significantly contribute to direct pathway hyporesponsiveness in stable renal transplant patients. J Am Soc Nephrol (2003) 1.23
Chronic exposure to Helicobacter pylori impairs dendritic cell function and inhibits Th1 development. Infect Immun (2006) 1.21
Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28. Blood (2007) 1.20
Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease. Kidney Int (2003) 1.15
Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes. Infect Immun (2009) 1.15
Regulatory T cells as therapeutic cells. Curr Opin Organ Transplant (2008) 1.14
Immunologic monitoring. Immunol Rev (2003) 1.13
Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo. Blood (2003) 1.12
Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations. Haematologica (2012) 1.12
Regulatory T cells: customizing for the clinic. Sci Transl Med (2011) 1.10
Regulatory T cells and transplantation tolerance. Hum Immunol (2006) 1.09
Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium. Am J Transplant (2004) 1.08
CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner. Eur J Immunol (2013) 1.07
Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo. J Exp Med (2008) 1.07
Qualitatively distinct patterns of cytokines are released by human dendritic cells in response to different pathogens. Immunology (2005) 1.04
The T helper 17-regulatory T cell axis in transplant rejection and tolerance. Curr Opin Organ Transplant (2009) 1.04
The importance of the indirect pathway of allorecognition in clinical transplantation. Curr Opin Immunol (2008) 1.03
Pathways of major histocompatibility complex allorecognition. Curr Opin Organ Transplant (2008) 1.02
Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation. Clin J Am Soc Nephrol (2013) 1.01
Activated CD1d-restricted natural killer T cells secrete IL-2: innate help for CD4+CD25+ regulatory T cells? Eur J Immunol (2005) 1.01
Cohort profile: the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). Int J Epidemiol (2008) 1.01
Achieving permanent survival of islet xenografts by independent manipulation of direct and indirect T-cell responses. Diabetes (2005) 1.00
T-cell alloimmunity and chronic allograft dysfunction. Kidney Int Suppl (2010) 0.99
CD4(+) T-cell subsets in transplantation. Immunol Rev (2013) 0.98
Transplantation tolerance induced by regulatory T cells: in vivo mechanisms and sites of action. Int Immunopharmacol (2009) 0.98
Screening for tuberculosis infection before the initiation of an anti-TNF-alpha therapy. Swiss Med Wkly (2007) 0.97
When do we dare to stop biological or immunomodulatory therapy for Crohn's disease? Results of a multidisciplinary European expert panel. J Crohns Colitis (2013) 0.96
Cell therapy to promote transplantation tolerance: a winning strategy? Immunotherapy (2011) 0.96
A novel pathway of antigen presentation by dendritic and endothelial cells: Implications for allorecognition and infectious diseases. Transplantation (2006) 0.96
Indefinite mouse heart allograft survival in recipient treated with CD4(+)CD25(+) regulatory T cells with indirect allospecificity and short term immunosuppression. Transpl Immunol (2009) 0.94
Monitoring of in vivo function of superparamagnetic iron oxide labelled murine dendritic cells during anti-tumour vaccination. PLoS One (2011) 0.94
Generation and expansion of human CD4+ CD25+ regulatory T cells with indirect allospecificity: Potential reagents to promote donor-specific transplantation tolerance. Transplantation (2006) 0.93
A 'biomarker signature' for tolerance in transplantation. Nat Rev Nephrol (2010) 0.93
Dendritic cells from CML patients have altered actin organization, reduced antigen processing, and impaired migration. Blood (2002) 0.93
Extraintestinal manifestations of Crohn's disease. Digestion (2008) 0.93
Comparison of fecal biota from specific pathogen free and feral mice. Anaerobe (2006) 0.92
Acquisition of HLA-DR and costimulatory molecules by T cells from allogeneic antigen presenting cells. Am J Transplant (2005) 0.91
Cross-species costimulation: relative contributions of CD80, CD86, and CD40. Transplantation (2003) 0.91
First-line therapies in inflammatory bowel disease. Digestion (2012) 0.91
Towards the identification of biomarkers of transplantation tolerance. Nat Rev Immunol (2009) 0.91
Acquisition of MHC:peptide complexes by dendritic cells contributes to the generation of antiviral CD8+ T cell immunity in vivo. J Immunol (2012) 0.91
Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation. Front Immunol (2012) 0.91
Regulatory T cells in the control of transplantation tolerance and autoimmunity. Am J Transplant (2003) 0.91
Analysis of the peripheral T-cell repertoire in kidney transplant patients. Eur J Immunol (2010) 0.89
Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. Blood (2005) 0.89
In vivo SPECT reporter gene imaging of regulatory T cells. PLoS One (2011) 0.89
Fibrostenotic Crohn's disease. Digestion (2008) 0.88
Induction of tumor-specific T-cell responses by vaccination with tumor lysate-loaded dendritic cells in colorectal cancer patients with carcinoembryonic-antigen positive tumors. Cancer Immunol Immunother (2007) 0.88
IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation. Blood (2003) 0.87
Origin and biology of the allogeneic response. Cold Spring Harb Perspect Med (2013) 0.87
Regulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role? Transplant Rev (Orlando) (2010) 0.87
Expansion of hepatitis C-specific CD4+CD25+ regulatory T cells after viral clearance: a mechanism to limit collateral damage? J Allergy Clin Immunol (2008) 0.86
Regulatory T cell therapy for the induction of clinical organ transplantation tolerance. Semin Immunol (2011) 0.86
Regulation of rat and human T-cell immune response by pharmacologically modified dendritic cells. Transplantation (2009) 0.86
From current immunosuppressive strategies to clinical tolerance of allografts. Transpl Int (2007) 0.85
Obstructive fibrostenotic Crohn's disease. Digestion (2005) 0.85
Extraintestinal manifestations of Crohn's disease. Digestion (2005) 0.85
In-vitro generation and characterisation of murine CD4+CD25+ regulatory T cells with indirect allospecificity. Int Immunopharmacol (2006) 0.85
Report of the ECCO workshop on anti-TNF therapy failures in inflammatory bowel diseases: biological roles and effects of TNF and TNF antagonists. J Crohns Colitis (2010) 0.85
Everolimus and basiliximab permit suppression by human CD4+CD25+ cells in vitro. Am J Transplant (2005) 0.85
Patients' information-seeking activity is associated with treatment compliance in inflammatory bowel disease patients. Scand J Gastroenterol (2014) 0.84
Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis. J Neuroimmunol (2005) 0.83
Endothelial cell cytoprotection induced in vitro by allo- or xenoreactive antibodies is mediated by signaling through adenosine A2 receptors. Eur J Immunol (2003) 0.83
In vivo delivery of antigens by adenovirus dodecahedron induces cellular and humoral immune responses to elicit antitumor immunity. Mol Ther (2010) 0.83
Transitional-2 B cells acquire regulatory function during tolerance induction and contribute to allograft survival. Eur J Immunol (2014) 0.83
Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism. Blood (2003) 0.83
Chronic graft loss. Immunological and non-immunological factors. Contrib Nephrol (2005) 0.82
Evaluating appropriateness of treatment for Crohn's disease: feasibility of an explicit approach. Digestion (2007) 0.82
T cell signaling targets for enhancing regulatory or effector function. Sci Signal (2012) 0.82
Characteristics of non-responders to self-reported questionnaires in a large inflammatory bowel disease cohort study. Scand J Gastroenterol (2015) 0.81
Tolerant T cells display impaired trafficking ability. Eur J Immunol (2005) 0.81
Appropriate therapy for fistulizing and fibrostenotic Crohn's disease: Results of a multidisciplinary expert panel - EPACT II. J Crohns Colitis (2009) 0.81