Published in PLoS Comput Biol on August 21, 2006
Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat Prod Rep (2009) 3.74
The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A (2008) 2.71
Metamorphic enzyme assembly in polyketide diversification. Nature (2009) 2.64
ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures. Nucleic Acids Res (2008) 2.34
Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms. Nat Rev Microbiol (2010) 1.86
A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis. PLoS Comput Biol (2014) 1.54
An enzymatic atavist revealed in dual pathways for water activation. PLoS Biol (2008) 1.52
A computational screen for type I polyketide synthases in metagenomics shotgun data. PLoS One (2008) 1.44
Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteria. Appl Environ Microbiol (2010) 1.27
The origins of specificity in polyketide synthase protein interactions. PLoS Comput Biol (2007) 1.18
DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters. Nucleic Acids Res (2012) 1.09
Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones. BMC Genomics (2008) 1.04
Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria. BMC Genomics (2014) 1.02
Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthase. J Mol Biol (2014) 0.98
Emergent gene order in a model of modular polyketide synthases. Proc Natl Acad Sci U S A (2009) 0.98
Computational identification and analysis of orphan assembly-line polyketide synthases. J Antibiot (Tokyo) (2013) 0.97
Insights into the evolution of macrolactam biosynthesis through cloning and comparative analysis of the biosynthetic gene cluster for a novel macrocyclic lactam, ML-449. Appl Environ Microbiol (2009) 0.90
Horizontal gene transfer and gene conversion drive evolution of modular polyketide synthases. J Ind Microbiol Biotechnol (2012) 0.88
Polyketide synthase gene diversity within the microbiome of the sponge Arenosclera brasiliensis, endemic to the Southern Atlantic Ocean. Appl Environ Microbiol (2012) 0.86
Cryptic polyketide synthase genes in non-pathogenic Clostridium SPP. PLoS One (2012) 0.86
Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. Biochemistry (2012) 0.85
Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters. Proc Natl Acad Sci U S A (2015) 0.84
Evolutionary concepts in natural products discovery: what actinomycetes have taught us. J Ind Microbiol Biotechnol (2013) 0.83
Phylogenetic approaches to natural product structure prediction. Methods Enzymol (2012) 0.82
Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification. Appl Environ Microbiol (2010) 0.81
Annotation of the modular polyketide synthase and nonribosomal peptide synthetase gene clusters in the genome of Streptomyces tsukubaensis NRRL18488. Appl Environ Microbiol (2012) 0.76
An Integrated Metabolomic and Genomic Mining Workflow To Uncover the Biosynthetic Potential of Bacteria. mSystems (2016) 0.76
Significance of Heavy-Ion Beam Irradiation-Induced Avermectin B1a Production by Engineered Streptomyces avermitilis. Biomed Res Int (2017) 0.75
Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations. Mar Drugs (2017) 0.75
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res (1997) 175.36
MrBayes 3: Bayesian phylogenetic inference under mixed models. Bioinformatics (2003) 130.85
The rapid generation of mutation data matrices from protein sequences. Comput Appl Biosci (1992) 44.38
TREE-PUZZLE: maximum likelihood phylogenetic analysis using quartets and parallel computing. Bioinformatics (2002) 19.27
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
Enzyme recruitment in evolution of new function. Annu Rev Microbiol (1976) 6.95
Polyketide biosynthesis: a millennium review. Nat Prod Rep (2001) 6.62
Concerted and birth-and-death evolution of multigene families. Annu Rev Genet (2005) 6.37
Molecular genetics of polyketides and its comparison to fatty acid biosynthesis. Annu Rev Genet (1990) 5.22
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc Natl Acad Sci U S A (2001) 4.56
Comparison of models for nucleotide substitution used in maximum-likelihood phylogenetic estimation. Mol Biol Evol (1994) 3.64
Genetic Contributions to Understanding Polyketide Synthases. Chem Rev (1997) 3.51
Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes. Nat Biotechnol (2005) 3.49
Discovery of a new peptide natural product by Streptomyces coelicolor genome mining. Nat Chem Biol (2005) 3.17
Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species. Proc Natl Acad Sci U S A (2003) 3.15
Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases. Chembiochem (2003) 2.55
Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. Proc Natl Acad Sci U S A (1999) 2.49
The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases. Chem Biol (1999) 2.25
Evolutionary implications of bacterial polyketide synthases. Mol Biol Evol (2005) 2.06
Gene conversion and concerted evolution in bacterial genomes. FEMS Microbiol Rev (2005) 1.57
The evolution of secondary metabolism - a unifying model. Mol Microbiol (2000) 1.54
Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering. Proc Natl Acad Sci U S A (1998) 1.50
Natural products--a simple model to explain chemical diversity. Nat Prod Rep (2003) 1.47
Evolution of the chalcone synthase gene family in the genus Ipomoea. Proc Natl Acad Sci U S A (1995) 1.43
A hybrid modular polyketide synthase obtained by domain swapping. Chem Biol (1996) 1.42
Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives. J Bacteriol (1997) 1.42
Synergy and duality in peptide antibiotic mechanisms. Curr Opin Chem Biol (1999) 1.32
Evidence for recombination in the microcystin synthetase (mcy) genes of toxic cyanobacteria Microcystis spp. J Mol Evol (2004) 1.32
Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. Biochemistry (1999) 1.20
Type I polyketide synthases may have evolved through horizontal gene transfer. J Mol Evol (2005) 1.19
Theoretical considerations and computational analysis of the complexity in polyketide synthesis pathways. J Am Chem Soc (2005) 1.07
Avermectin: biochemical and molecular basis of its biosynthesis and regulation. Appl Microbiol Biotechnol (2003) 0.98
Plasticity of the streptomyces genome-evolution and engineering of new antibiotics. Curr Med Chem (2005) 0.90
Homologous recombination and RecA protein: towards a new generation of tools for genome manipulations. Trends Biotechnol (2005) 0.87
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Phylogenetic evidence for the early evolution of microcystin synthesis. Proc Natl Acad Sci U S A (2003) 2.46
Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat Biotechnol (2008) 2.35
Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria. Angew Chem Int Ed Engl (2008) 2.10
Microcystin biosynthesis in planktothrix: genes, evolution, and manipulation. J Bacteriol (2003) 2.09
Evolutionary implications of bacterial polyketide synthases. Mol Biol Evol (2005) 2.06
Abundance of active and inactive microcystin genotypes in populations of the toxic cyanobacterium Planktothrix spp. Environ Microbiol (2004) 1.85
Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa. Appl Environ Microbiol (2008) 1.79
Highly plastic genome of Microcystis aeruginosa PCC 7806, a ubiquitous toxic freshwater cyanobacterium. BMC Genomics (2008) 1.66
The cyanobacterial hepatotoxin microcystin binds to proteins and increases the fitness of microcystis under oxidative stress conditions. PLoS One (2011) 1.65
PCR-based identification of microcystin-producing genotypes of different cyanobacterial genera. Arch Microbiol (2003) 1.62
Towards clarification of the biological role of microcystins, a family of cyanobacterial toxins. Environ Microbiol (2007) 1.57
From seedling to mature plant: arabidopsis plastidial genome copy number, RNA accumulation and transcription are differentially regulated during leaf development. Plant J (2007) 1.54
Protein-mediated protection as the predominant mechanism for defining processed mRNA termini in land plant chloroplasts. Nucleic Acids Res (2011) 1.47
The primary transcriptome of barley chloroplasts: numerous noncoding RNAs and the dominating role of the plastid-encoded RNA polymerase. Plant Cell (2012) 1.47
Distribution of microcystin-producing and non-microcystin-producing Microcystis sp. in European freshwater bodies: detection of microcystins and microcystin genes in individual colonies. Syst Appl Microbiol (2004) 1.38
The cyanobacterial phytochrome Cph2 inhibits phototaxis towards blue light. Mol Microbiol (2002) 1.37
Multiple promoters are a common feature of mitochondrial genes in Arabidopsis. Nucleic Acids Res (2005) 1.36
The transcription machineries of plant mitochondria and chloroplasts: Composition, function, and regulation. J Plant Physiol (2011) 1.35
Lariat formation and a hydrolytic pathway in plant chloroplast group II intron splicing. EMBO J (2002) 1.27
Transposons inactivate biosynthesis of the nonribosomal peptide microcystin in naturally occurring Planktothrix spp. Appl Environ Microbiol (2006) 1.24
The microcystin composition of the cyanobacterium Planktothrix agardhii changes toward a more toxic variant with increasing light intensity. Appl Environ Microbiol (2005) 1.24
Cytokinin stimulates chloroplast transcription in detached barley leaves. Plant Physiol (2008) 1.23
Inactivation of an ABC transporter gene, mcyH, results in loss of microcystin production in the cyanobacterium Microcystis aeruginosa PCC 7806. Appl Environ Microbiol (2004) 1.22
Complex chloroplast RNA metabolism: just debugging the genetic programme? BMC Biol (2008) 1.21
Environmental conditions that influence toxin biosynthesis in cyanobacteria. Environ Microbiol (2012) 1.21
High diversity of plastidial promoters in Arabidopsis thaliana. Mol Genet Genomics (2007) 1.20
An organellar maturase associates with multiple group II introns. Proc Natl Acad Sci U S A (2010) 1.18
Relaxed transcription in Arabidopsis mitochondria is counterbalanced by RNA stability control mediated by polyadenylation and polynucleotide phosphorylase. Mol Cell Biol (2006) 1.18
A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa. Mol Microbiol (2006) 1.16
Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes. Beilstein J Org Chem (2011) 1.14
Multiple alternate transcripts direct the biosynthesis of microcystin, a cyanobacterial nonribosomal peptide. Appl Environ Microbiol (2002) 1.14
Mitochondrial effects on flower and pollen development. Mitochondrion (2005) 1.11
Fewer genes than organelles: extremely low and variable gene copy numbers in mitochondria of somatic plant cells. Plant J (2010) 1.11
Phage-type RNA polymerase RPOTmp performs gene-specific transcription in mitochondria of Arabidopsis thaliana. Plant Cell (2009) 1.10
Two RpoT genes of Physcomitrella patens encode phage-type RNA polymerases with dual targeting to mitochondria and plastids. Gene (2002) 1.08
Mutation of the pentatricopeptide repeat-SMR protein SVR7 impairs accumulation and translation of chloroplast ATP synthase subunits in Arabidopsis thaliana. J Plant Res (2012) 1.08
Six active phage-type RNA polymerase genes in Nicotiana tabacum. Plant J (2002) 1.06
Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria. Appl Environ Microbiol (2009) 1.06
Chloroplast development affects expression of phage-type RNA polymerases in barley leaves. Plant J (2004) 1.06
Microvirin, a novel alpha(1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile. J Biol Chem (2010) 1.04
Evolution of metabolic diversity: insights from microbial polyketide synthases. Phytochemistry (2009) 1.04
Flower development in carrot CMS plants: mitochondria affect the expression of MADS box genes homologous to GLOBOSA and DEFICIENS. Plant J (2003) 1.04
Bioinformatic perspectives on NRPS/PKS megasynthases: advances and challenges. Nat Prod Rep (2009) 1.04
Horizontal gene transfer of two cytoskeletal elements from a eukaryote to a cyanobacterium. Curr Biol (2007) 1.04
Impaired function of the phage-type RNA polymerase RpoTp in transcription of chloroplast genes is compensated by a second phage-type RNA polymerase. Nucleic Acids Res (2007) 1.01
Arabidopsis phage-type RNA polymerases: accurate in vitro transcription of organellar genes. Plant Cell (2007) 1.01
Genetic contributions to the risk assessment of microcystin in the environment. Toxicol Appl Pharmacol (2005) 1.00
Phototaxis in the cyanobacterium Synechocystis sp. PCC 6803: role of different photoreceptors. Photochem Photobiol (2005) 0.99
Exploiting the natural diversity of microviridin gene clusters for discovery of novel tricyclic depsipeptides. Appl Environ Microbiol (2010) 0.98
A new rubisco-like protein coexists with a photosynthetic rubisco in the planktonic cyanobacteria Microcystis. J Biol Chem (2006) 0.98
Overexpression of phage-type RNA polymerase RpoTp in tobacco demonstrates its role in chloroplast transcription by recognizing a distinct promoter type. Nucleic Acids Res (2004) 0.97
Metabolic control of the tetrapyrrole biosynthetic pathway for porphyrin distribution in the barley mutant albostrians. Plant J (2003) 0.96
The languages spoken in the water body (or the biological role of cyanobacterial toxins). Front Microbiol (2012) 0.96
Bacterial type III polyketide synthases: phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads. Arch Microbiol (2006) 0.95
Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective. Chembiochem (2007) 0.95
Evolutionary mechanisms underlying secondary metabolite diversity. Prog Drug Res (2008) 0.94
Transcriptomic response to prolonged ethanol production in the cyanobacterium Synechocystis sp. PCC6803. Biotechnol Biofuels (2014) 0.94
An extracellular glycoprotein is implicated in cell-cell contacts in the toxic cyanobacterium Microcystis aeruginosa PCC 7806. J Bacteriol (2008) 0.92
Development- and tissue-specific expression of the RpoT gene family of Arabidopsis encoding mitochondrial and plastid RNA polymerases. Planta (2005) 0.90
Insights into the physiology and ecology of the brackish-water-adapted Cyanobacterium Nodularia spumigena CCY9414 based on a genome-transcriptome analysis. PLoS One (2013) 0.89
Metabolomic analysis indicates a pivotal role of the hepatotoxin microcystin in high light adaptation of Microcystis. Environ Microbiol (2014) 0.88
Microcystin production revisited: conjugate formation makes a major contribution. Environ Microbiol (2013) 0.86
Abscisic acid represses the transcription of chloroplast genes. J Exp Bot (2013) 0.85
A mitochondrial rRNA dimethyladenosine methyltransferase in Arabidopsis. Plant J (2009) 0.85
Detection of hepatotoxic Microcystis strains by PCR with intact cells from both culture and environmental samples. Arch Microbiol (2002) 0.85
A Type II polyketide synthase from the gram-negative Bacterium Stigmatella aurantiaca is involved in Aurachin alkaloid biosynthesis. Angew Chem Int Ed Engl (2007) 0.85
Mitochondrial atp9 genes from petaloid male-sterile and male-fertile carrots differ in their status of heteroplasmy, recombination involvement, post-transcriptional processing as well as accumulation of RNA and protein product. Theor Appl Genet (2014) 0.84
Chloroplast DNA in mature and senescing leaves: a reappraisal. Plant Cell (2014) 0.83
Biparental inheritance of plastidial and mitochondrial DNA and hybrid variegation in Pelargonium. Mol Genet Genomics (2009) 0.83
Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs). Antiviral Res (2011) 0.83
The mcyF gene of the microcystin biosynthetic gene cluster from Microcystis aeruginosa encodes an aspartate racemase. Biochem J (2003) 0.83
Leader peptide and a membrane protein scaffold guide the biosynthesis of the tricyclic peptide microviridin. Chem Biol (2011) 0.82
Evolution of plant phage-type RNA polymerases: the genome of the basal angiosperm Nuphar advena encodes two mitochondrial and one plastid phage-type RNA polymerases. BMC Evol Biol (2010) 0.82
Red and far-red light alter the transcript profile in the cyanobacterium Synechocystis sp. PCC 6803: impact of cyanobacterial phytochromes. FEBS Lett (2005) 0.82
Evolution of phage-type RNA polymerases in higher plants: characterization of the single phage-type RNA polymerase gene from Selaginella moellendorffii. J Mol Evol (2009) 0.81
A polyketide interferes with cellular differentiation in the symbiotic cyanobacterium Nostoc punctiforme. Environ Microbiol Rep (2011) 0.81
The white barley mutant albostrians shows enhanced resistance to the biotroph Blumeria graminis f. sp. hordei. Mol Plant Microbe Interact (2004) 0.78
Combinatorial polyketide biosynthesis at higher stage. Mol Syst Biol (2005) 0.78
Casting a net: fibres produced by Microcystis sp. in field and laboratory populations. Environ Microbiol Rep (2012) 0.78
Functional assessment of mycosporine-like amino acids in Microcystis aeruginosa strain PCC 7806. Environ Microbiol (2014) 0.78
Characterization of two Myb-like transcription factors binding to CAB promoters in wheat and barley. Plant Mol Biol (2003) 0.78
Faithful transcription initiation from a mitochondrial promoter in transgenic plastids. Nucleic Acids Res (2007) 0.78
Involvement of cyanobacterial phytochromes in growth under different light qualities and quantities. Photochem Photobiol (2004) 0.78
Reverse protection assay: a tool to analyze transcriptional rates from individual promoters. Plant Methods (2011) 0.78
Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions. Angew Chem Int Ed Engl (2014) 0.77
Cyanobacteria as a source of natural products. Methods Enzymol (2012) 0.77
Functional analysis of environmental DNA-derived microviridins provides new insights into the diversity of the tricyclic peptide family. Appl Environ Microbiol (2013) 0.77
Unique properties of eukaryote-type actin and profilin horizontally transferred to cyanobacteria. PLoS One (2012) 0.77
Biparental inheritance of organelles in Pelargonium: evidence for intergenomic recombination of mitochondrial DNA. Planta (2012) 0.77
Methyl jasmonate, gibberellic acid, and auxin affect transcription and transcript accumulation of chloroplast genes in barley. J Plant Physiol (2011) 0.77
Measurement of transcription rates in Arabidopsis chloroplasts. Methods Mol Biol (2011) 0.76
The barley plastome mutant CL2 affects expression of nuclear and chloroplast housekeeping genes in a cell-age dependent manner. Mol Genet Genomics (2008) 0.76