Published in Am J Med Genet C Semin Med Genet on August 15, 2006
Retracted Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem Biophys Res Commun (2008) 1.91
Down syndrome--recent progress and future prospects. Hum Mol Genet (2009) 1.85
Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proc Natl Acad Sci U S A (2008) 1.54
Retracted Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. J Biol Chem (2009) 1.53
Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis (2010) 1.19
Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions. Mamm Genome (2011) 1.08
Molecular basis of pharmacotherapies for cognition in Down syndrome. Trends Pharmacol Sci (2009) 1.04
On the promise of pharmacotherapies targeted at cognitive and neurodegenerative components of Down syndrome. Dev Neurosci (2011) 0.99
Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins. RNA Biol (2010) 0.98
Small regulatory RNAs in neurodevelopmental disorders. Hum Mol Genet (2009) 0.96
Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801. Genes Brain Behav (2008) 0.92
Gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for Down Syndrome screening. PLoS One (2011) 0.91
Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimers Dement (2014) 0.90
Noncoding RNAs in mental retardation. Clin Genet (2009) 0.86
Extracellular chromosome 21-derived microRNAs in euploid & aneuploid pregnancies. Indian J Med Res (2013) 0.83
From abnormal hippocampal synaptic plasticity in down syndrome mouse models to cognitive disability in down syndrome. Neural Plast (2012) 0.82
β-Secretases, Alzheimer's Disease, and Down Syndrome. Curr Gerontol Geriatr Res (2012) 0.81
The mouse model of Down syndrome Ts65Dn presents visual deficits as assessed by pattern visual evoked potentials. Invest Ophthalmol Vis Sci (2010) 0.81
The cognitive phenotype of Down syndrome: insights from intracellular network analysis. NeuroRx (2006) 0.80
Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS). BMC Med Genomics (2014) 0.79
Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media. Mamm Genome (2013) 0.76
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 26.58
Towards a proteome-scale map of the human protein-protein interaction network. Nature (2005) 24.76
Global mapping of the yeast genetic interaction network. Science (2004) 21.34
A protein interaction map of Drosophila melanogaster. Science (2003) 20.06
A map of the interactome network of the metazoan C. elegans. Science (2004) 15.60
Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci (2005) 8.96
Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol (2004) 7.17
Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature (2000) 6.67
Identification of 315 genes essential for early zebrafish development. Proc Natl Acad Sci U S A (2004) 5.54
The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell (2002) 5.35
Accessory factors in clathrin-dependent synaptic vesicle endocytosis. Nat Rev Neurosci (2000) 4.72
Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell (1999) 4.70
Elevated gene expression levels distinguish human from non-human primate brains. Proc Natl Acad Sci U S A (2003) 4.69
Mitogen-activated protein kinases in synaptic plasticity and memory. Curr Opin Neurobiol (2004) 4.59
Human chromosome 21 gene expression atlas in the mouse. Nature (2002) 4.36
Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J (1995) 4.23
A chromosome 21 critical region does not cause specific Down syndrome phenotypes. Science (2004) 4.16
DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature (2004) 4.12
A role for adult neurogenesis in spatial long-term memory. Neuroscience (2005) 4.06
Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat Neurosci (2005) 3.67
A first-draft human protein-interaction map. Genome Biol (2004) 3.64
Chromosome 21 and down syndrome: from genomics to pathophysiology. Nat Rev Genet (2004) 3.58
Genomic analysis of essentiality within protein networks. Trends Genet (2004) 3.52
A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem (2000) 3.26
Basic helix-loop-helix factors in cortical development. Neuron (2003) 3.21
Analyzing protein function on a genomic scale: the importance of gold-standard positives and negatives for network prediction. Curr Opin Microbiol (2004) 2.92
Pain expression and stimulus localisation in individuals with Down's syndrome. Lancet (2000) 2.90
Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome. Nat Genet (1997) 2.81
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature (2002) 2.79
The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Curr Biol (2002) 2.74
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci (2000) 2.54
Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice. Mol Cell Biol (2002) 2.51
FlyRNAi: the Drosophila RNAi screening center database. Nucleic Acids Res (2006) 2.43
Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A (1998) 2.32
Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice. J Neurosci (2005) 2.27
Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. Hum Mol Genet (2001) 2.24
Glutamate receptors in the mammalian central nervous system. Prog Neurobiol (1998) 2.16
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem (2005) 2.03
Evolutionarily conserved human targets of adenosine to inosine RNA editing. Nucleic Acids Res (2005) 1.96
Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions. Gene (2003) 1.93
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein. Neuroscience (1999) 1.88
Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. Proc Natl Acad Sci U S A (1997) 1.88
S100B in brain damage and neurodegeneration. Microsc Res Tech (2003) 1.85
Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. Proc Natl Acad Sci U S A (2003) 1.84
The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility. Nat Med (2000) 1.79
ADAR gene family and A-to-I RNA editing: diverse roles in posttranscriptional gene regulation. Prog Nucleic Acid Res Mol Biol (2005) 1.78
Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome. Genome Res (2004) 1.75
Subunit composition of kainate receptors in hippocampal interneurons. Neuron (2000) 1.66
Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy. Proc Natl Acad Sci U S A (2003) 1.60
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci (2003) 1.59
Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome. Neurosci Lett (1998) 1.43
A new role for IQ motif proteins in regulating calmodulin function. J Biol Chem (2003) 1.43
Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice. Nat Genet (1998) 1.42
Neuroanatomy of Down's syndrome: a high-resolution MRI study. Am J Psychiatry (2001) 1.35
Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells. J Biol Chem (2001) 1.34
Calcineurin in memory and bidirectional plasticity. Biochem Biophys Res Commun (2003) 1.33
A common protein interaction domain links two recently identified epilepsy genes. Hum Mol Genet (2002) 1.29
Glial protein S100B modulates long-term neuronal synaptic plasticity. Proc Natl Acad Sci U S A (2002) 1.27
Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory. Proc Natl Acad Sci U S A (2001) 1.27
Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex. Nat Neurosci (2001) 1.26
Activation of heteromeric G protein-gated inward rectifier K+ channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons. Proc Natl Acad Sci U S A (1997) 1.24
Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome. Hum Mol Genet (2000) 1.23
Protective effects of estrogen and selective estrogen receptor modulators in the brain. Biol Reprod (2002) 1.23
Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration. J Neuropathol Exp Neurol (2004) 1.20
Enhanced calcium transients in glial cells in neonatal cerebellar cultures derived from S100B null mice. Exp Cell Res (2000) 1.15
The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation. Proc Natl Acad Sci U S A (2003) 1.14
Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice. J Neurosci (2005) 1.14
Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome. Exp Neurol (2006) 1.12
MRI volumes of the hippocampus and amygdala in adults with Down's syndrome with and without dementia. Am J Psychiatry (1999) 1.07
Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids. J Biol Chem (1999) 1.07
SUMO and transcriptional repression: dynamic interactions between the MAP kinase and SUMO pathways. Cell Cycle (2003) 1.04
Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants. Mol Cell Biol (2002) 1.03
Predicting pathway perturbations in Down syndrome. J Neural Transm Suppl (2003) 1.02
Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome. Hum Mol Genet (1999) 1.02
Neuregulin-1-stimulated phosphorylation of GABP in skeletal muscle cells. Biochemistry (2001) 1.01
Craniofacial abnormalities resulting from targeted disruption of the murine Sim2 gene. Dev Dyn (2002) 0.97
Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein. Free Radic Biol Med (2003) 0.96
Similar levels of long-term potentiation in amyloid precursor protein -null and wild-type mice in the CA1 region of picrotoxin treated slices. Neurosci Lett (2000) 0.94
Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. Mol Endocrinol (2003) 0.93
Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome. Neurosci Lett (2005) 0.93
Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3. Mol Psychiatry (2006) 0.90
A murine model for Down syndrome shows reduced responsiveness to pain. Neuroreport (1999) 0.86
Functional and morphological alterations in compound transgenic mice overexpressing Cu/Zn superoxide dismutase and amyloid precursor protein [correction]. Eur J Neurosci (2004) 0.86
Magnetic resonance imaging evaluation of delayed myelination in Down syndrome: a case report and review of the literature. J Child Neurol (1992) 0.85
Tissue-specific overexpression of the HSA21 gene GABPalpha: implications for DS. Biochim Biophys Acta (2004) 0.84
Building protein interaction maps for Down's syndrome. Brief Funct Genomic Proteomic (2004) 0.82
Enhanced epileptogenesis in S100B knockout mice. Brain Res Mol Brain Res (2002) 0.80
Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down Syndrome. Brain Res (2004) 0.77
Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav Immun (2009) 1.36
Down syndrome and genetics - a case of linked histories. Nat Rev Genet (2005) 1.31
Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome. Physiol Behav (2004) 1.24
Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome. Exp Neurol (2006) 1.12
Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome. Behav Brain Res (2004) 1.04
Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine. Learn Mem (2011) 0.98
The mouse model of Down syndrome Ts65Dn presents visual deficits as assessed by pattern visual evoked potentials. Invest Ophthalmol Vis Sci (2010) 0.81
Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development of morphine tolerance. J Pharmacol Exp Ther (2008) 0.80
Machine learning methods predict locomotor response to MK-801 in mouse models of down syndrome. J Neurogenet (2011) 0.78
Protein profiles associated with context fear conditioning and their modulation by memantine. Mol Cell Proteomics (2014) 0.78
5-HT(1A) Receptor Null Mutant Mice Responding Under a Differential-Reinforcement-of-Low-Rate 72-Second Schedule of Reinforcement. Open Neuropsychopharmacol J (2008) 0.78
Deletion of the GluR5 subunit of kainate receptors affects cocaine sensitivity and preference. Neurosci Lett (2009) 0.77
Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome. Neuroreport (2006) 0.77