Actin limits enhancement of nanoparticle diffusion through cystic fibrosis sputum by mucolytics.

PubWeight™: 1.04‹?› | Rank: Top 15%

🔗 View Article (PMID 17055310)

Published in Pulm Pharmacol Ther on September 09, 2006

Authors

Victoria J Broughton-Head1, James R Smith, Jagdeep Shur, Janis K Shute

Author Affiliations

1: School of Pharmacy and Biomedical Sciences, Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, PO1 2DT, UK.

Articles citing this

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev (2008) 3.41

The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles. Biomaterials (2009) 1.54

Control of electrostatic interactions between F-actin and genetically modified lysozyme in aqueous media. Proc Natl Acad Sci U S A (2007) 1.07

Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine. Nanomedicine (Lond) (2011) 1.01

Mathematical modeling of molecular diffusion through mucus. Adv Drug Deliv Rev (2008) 0.89

Macrorheology of cystic fibrosis, chronic obstructive pulmonary disease & normal sputum. Respir Res (2009) 0.84

Immobilization of pseudorabies virus in porcine tracheal respiratory mucus revealed by single particle tracking. PLoS One (2012) 0.80

Fate of paclitaxel lipid nanocapsules in intestinal mucus in view of their oral delivery. Int J Nanomedicine (2013) 0.79

An adsorption chromatography assay to probe bulk particle transport through hydrogels. J Pharm Sci (2011) 0.79

Activity and interactions of liposomal antibiotics in presence of polyanions and sputum of patients with cystic fibrosis. PLoS One (2009) 0.79

The Mucus Barrier to Inhaled Gene Therapy. Mol Ther (2016) 0.79

Pharmaceutical nanoparticles and the mucin biopolymer barrier. Bioimpacts (2012) 0.78

Polymeric nanoparticles in development for treatment of pulmonary infectious diseases. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2016) 0.78

Dendrimer nanocarriers for transport modulation across models of the pulmonary epithelium. Mol Pharm (2015) 0.76

Advanced Therapeutic Strategies for Chronic Lung Disease Using Nanoparticle-Based Drug Delivery. J Clin Med (2016) 0.76

Magnetofection Enhances Lentiviral-Mediated Transduction of Airway Epithelial Cells through Extracellular and Cellular Barriers. Genes (Basel) (2016) 0.75

Articles by these authors

Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J (2004) 1.54

Airway remodelling in children with cystic fibrosis. Thorax (2007) 1.38

MRG15 regulates embryonic development and cell proliferation. Mol Cell Biol (2005) 1.35

A randomized, crossover study to evaluate the pharmacokinetics of amantadine and oseltamivir administered alone and in combination. PLoS One (2007) 1.12

Alveolar inflammation in cystic fibrosis. J Cyst Fibros (2010) 1.11

Plasminogen activator inhibitor-1 supports IL-8-mediated neutrophil transendothelial migration by inhibition of the constitutive shedding of endothelial IL-8/heparan sulfate/syndecan-1 complexes. J Immunol (2003) 1.10

Genetics of cellular senescence. Mech Ageing Dev (2002) 1.07

Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I. J Biol Chem (2003) 1.06

Effects of recombinant human DNase and hypertonic saline on airway inflammation in children with cystic fibrosis. Am J Respir Crit Care Med (2002) 0.95

Genome-wide association study (GWAS) of carbon isotope ratio (δ13C) in diverse soybean [Glycine max (L.) Merr.] genotypes. Theor Appl Genet (2014) 0.94

An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive-adhesive force balances. Eur J Pharm Biopharm (2007) 0.92

Endothelial activation and increased heparan sulfate expression in cystic fibrosis. Am J Respir Crit Care Med (2005) 0.91

MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. J Biol Chem (2003) 0.90

Identification of a new soybean rust resistance gene in PI 567102B. Theor Appl Genet (2012) 0.89

Safety and use of sputum induction in children with cystic fibrosis. Pediatr Pulmonol (2003) 0.88

Unfractionated heparin reduces the elasticity of sputum from patients with cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2007) 0.87

Influence of primary crystallisation conditions on the mechanical and interfacial properties of micronised budesonide for dry powder inhalation. Int J Pharm (2012) 0.86

Thermo and pH responsive polymers as gene delivery vectors: effect of polymer architecture on DNA complexation in vitro. J Control Release (2004) 0.85

Investigation into the influence of primary crystallization conditions on the mechanical properties and secondary processing behaviour of fluticasone propionate for carrier based dry powder inhaler formulations. Pharm Res (2011) 0.85

Macrorheology of cystic fibrosis, chronic obstructive pulmonary disease & normal sputum. Respir Res (2009) 0.84

Cospray-dried unfractionated heparin with L-leucine as a dry powder inhaler mucolytic for cystic fibrosis therapy. J Pharm Sci (2008) 0.83

Altered colonic mucosal Polyunsaturated Fatty Acid (PUFA) derived lipid mediators in ulcerative colitis: new insight into relationship with disease activity and pathophysiology. PLoS One (2013) 0.83

Up-regulation of the extrinsic coagulation pathway in acute asthma--a case study. J Asthma (2010) 0.83

Characterisation and functionality of inhalation anhydrous lactose. Int J Pharm (2010) 0.82

Factors affecting defining the quality and functionality of excipients used in the manufacture of dry powder inhaler products. Drug Dev Ind Pharm (2008) 0.82

Identification of a single gene for seed coat impermeability in soybean PI 594619. Theor Appl Genet (2014) 0.82

Genetics and mapping of adult plant rust resistance in soybean PI 587886 and PI 587880A. Theor Appl Genet (2009) 0.81

Cytokine mucosal expression in ulcerative colitis, the relationship between cytokine release and disease activity. J Crohns Colitis (2012) 0.81

The aging factor in health and disease: the promise of basic research on aging. Aging Clin Exp Res (2004) 0.81

Stockpiling oseltamivir: Roche clarifies data for improved mortality with oseltamivir. BMJ (2005) 0.81

Adsorbed poly(ethyleneoxide)-poly(propyleneoxide) copolymers on synthetic surfaces: spectroscopy and microscopy of polymer structures and effects on adhesion of skin-borne bacteria. J Biomed Mater Res (2002) 0.81

An investigation into the effect of fine lactose particles on the fluidization behaviour and aerosolization performance of carrier-based dry powder inhaler formulations. AAPS PharmSciTech (2014) 0.80

Novel biocompatible chitosan decorated single-walled carbon nanotubes (SWNTs) for biomedical applications: theoretical and experimental investigations. Phys Chem Chem Phys (2010) 0.80

Grafted thermo- and pH responsive co-polymers: surface-properties and bacterial adsorption. Int J Pharm (2005) 0.80

Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo. Mol Pharm (2011) 0.79

Engineering of crystalline combination inhalation particles of a long-acting beta2-agonist and a corticosteroid. Pharm Res (2009) 0.79

N-Octyl-O-sulfate chitosan stabilises single wall carbon nanotubes in aqueous media and bestows biocompatibility. Nanoscale (2009) 0.78

The role of force control agents in high-dose dry powder inhaler formulations. J Pharm Sci (2009) 0.78

A copper-hydrogen peroxide redox system induces dityrosine cross-links and chemokine oligomerisation. Cytokine (2011) 0.78

Abrupt telomere shortening in normal human fibroblasts. Exp Gerontol (2010) 0.78

The influence of crystal habit on the prediction of dry powder inhalation formulation performance using the cohesive-adhesive force balance approach. Drug Dev Ind Pharm (2008) 0.77

The spray drying of unfractionated heparin: optimization of the operating parameters. Drug Dev Ind Pharm (2008) 0.77

Receptors for hyaluronic acid and poliovirus: a combinatorial role in glioma invasion? PLoS One (2012) 0.77

Defining the critical material attributes of lactose monohydrate in carrier based dry powder inhaler formulations using artificial neural networks. AAPS PharmSciTech (2014) 0.76

Host Suitability of Diverse Lines of Phaseolus vulgaris to Multiple Populations of Heterodera glycines. J Nematol (2003) 0.76

Free secretory component from cystic fibrosis sputa displays the cystic fibrosis glycosylation phenotype. Am J Respir Crit Care Med (2003) 0.76

Responses of nitrogen metabolism and seed nutrition to drought stress in soybean genotypes differing in slow-wilting phenotype. Front Plant Sci (2013) 0.76

Human mid-gestation amniotic fluid contains interleukin-16 bioactivity. Immunology (2009) 0.76

A soybean mapping population specific to the early soybean production system. DNA Seq (2007) 0.75

The influence of secondary processing on the structural relaxation dynamics of fluticasone propionate. AAPS PharmSciTech (2014) 0.75

Effect of the covalently linked fatty acid 18-MEA on the nanotribology of hair's outermost surface. J Struct Biol (2005) 0.75

Functional characterisation of human cells harbouring a novel t(2p;7p) translocation involving TNS3 and EXOC6B genes. BMC Med Genet (2013) 0.75

Oseltamivir effectiveness in seasonal influenza patients taking symptomatic therapy: retrospective analysis of RCT data. Int J Clin Pharmacol Ther (2013) 0.75

Analysis of 2-oxothiazolidine-4-carboxylic acid by hydrophilic interaction liquid chromatography: application for ocular delivery using chitosan nanoparticles. Anal Bioanal Chem (2015) 0.75

Towards boron neutron capture therapy: the formulation and preliminary in vitro evaluation of liposomal vehicles for the therapeutic delivery of the dequalinium salt of bis-nido-carborane. Bioorg Med Chem Lett (2013) 0.75

Erratum to: Genome-wide association study (GWAS) of carbon isotope ratio (δ(13)C) in diverse soybean [Glycine max (L.) Merr.] genotypes. Theor Appl Genet (2015) 0.75

Heparin molecularly imprinted surfaces for the attenuation of complement activation in blood. Biomater Sci (2015) 0.75

Diameter-selective solubilization of carbon nanotubes by lipid micelles. J Nanosci Nanotechnol (2008) 0.75

Multifunctional poly(alkyl methacrylate) films for dental care. Biomed Mater (2011) 0.75

The use of atomic force microscopy to study the conditioning of micronised budesonide. Int J Pharm (2008) 0.75