PubRank

Charles D Smith

Author PubWeight™ 162.60‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 2011 10.07
2 Neuropathologic substrate of mild cognitive impairment. Arch Neurol 2006 6.26
3 Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging 2009 4.36
4 Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res 2003 3.71
5 Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death. Cancer Cell 2007 3.37
6 Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res 2005 2.98
7 TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol 2007 2.97
8 Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor. J Neurosurg 2005 2.53
9 Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons. Brain Pathol 2008 2.44
10 Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations. J Neuropathol Exp Neurol 2006 2.43
11 Hippocampal sclerosis in advanced age: clinical and pathological features. Brain 2011 2.16
12 Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther 2010 2.09
13 Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology 2012 2.08
14 PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells. Cancer Biol Ther 2009 1.97
15 Dissociation of automatic and strategic lexical-semantics: functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions. J Neurosci 2006 1.92
16 Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther 2006 1.88
17 Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol 2009 1.73
18 Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. Cancer Biol Ther 2011 1.72
19 Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase. Dig Dis Sci 2007 1.72
20 Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease. J Neuropathol Exp Neurol 2009 1.66
21 Lifelong bilingualism maintains neural efficiency for cognitive control in aging. J Neurosci 2013 1.62
22 Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathol 2011 1.62
23 Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiation. Cancer Res 2007 1.58
24 Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia. Am J Med Genet A 2008 1.57
25 Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases. Cancer Res 2006 1.56
26 Human cerebral neuropathology of Type 2 diabetes mellitus. Biochim Biophys Acta 2008 1.46
27 Age-related slowing of task switching is associated with decreased integrity of frontoparietal white matter. Neurobiol Aging 2008 1.44
28 Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease. Acta Neuropathol 2013 1.41
29 A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J Pharmacol Exp Ther 2010 1.37
30 Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase. Oncogene 2004 1.37
31 Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal. J Neurosurg 2007 1.34
32 Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640. Endocrinology 2010 1.29
33 Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. Carcinogenesis 2010 1.28
34 A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood 2009 1.28
35 Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2. Cancer Biol Ther 2011 1.24
36 Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development. Clin Cancer Res 2008 1.22
37 Alterations in multiple measures of white matter integrity in normal women at high risk for Alzheimer's disease. Neuroimage 2010 1.20
38 Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. Mol Cancer Res 2005 1.20
39 The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci U S A 2010 1.20
40 Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration. Mol Cancer Res 2011 1.18
41 Development of a syngeneic in vivo tumor model and its use in evaluating a novel P-glycoprotein modulator, PGP-4008. Oncol Res 2003 1.16
42 Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment. Neurosci Lett 2008 1.15
43 Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem 2009 1.14
44 Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing. Brain 2013 1.13
45 Discovery and characterization of inhibitors of human palmitoyl acyltransferases. Mol Cancer Ther 2006 1.13
46 Neuronal fiber pathway abnormalities in autism: an initial MRI diffusion tensor tracking study of hippocampo-fusiform and amygdalo-fusiform pathways. J Int Neuropsychol Soc 2008 1.12
47 ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol 2014 1.07
48 Cellular palmitoylation and trafficking of lipidated peptides. J Lipid Res 2007 1.07
49 White matter integrity and vulnerability to Alzheimer's disease: preliminary findings and future directions. Biochim Biophys Acta 2011 1.07
50 Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells. Neuropharmacology 2005 1.07
51 Association between male gender and cortical Lewy body pathology in large autopsy series. J Neurol 2010 1.06
52 Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. Mol Cancer Ther 2013 1.05
53 Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment. Neurobiol Aging 2008 1.05
54 Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation. J Cereb Blood Flow Metab 2013 1.04
55 Prediction of preclinical Alzheimer's disease: longitudinal rates of change in cognition. J Alzheimers Dis 2011 1.03
56 Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest New Drugs 2010 1.01
57 Mild cognitive impairment: statistical models of transition using longitudinal clinical data. Int J Alzheimers Dis 2012 1.01
58 Palmitoyl acyltransferase assays and inhibitors (Review). Mol Membr Biol 2009 1.01
59 Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells. Mol Cancer Ther 2009 1.00
60 Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunction. Biochem J 2012 1.00
61 Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. Invest Ophthalmol Vis Sci 2006 0.99
62 Characterization of human palmitoyl-acyl transferase activity using peptides that mimic distinct palmitoylation motifs. Biochem J 2003 0.99
63 Preclinical AD Workgroup staging: pathological correlates and potential challenges. Neurobiol Aging 2011 0.99
64 APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD). Genet Med 2007 0.99
65 Characterization of isoenzyme-selective inhibitors of human sphingosine kinases. PLoS One 2012 0.98
66 Adjusting for mortality when identifying risk factors for transitions to mild cognitive impairment and dementia. J Alzheimers Dis 2013 0.97
67 Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase. Inflammopharmacology 2010 0.97
68 A fluorescence-based high performance liquid chromatographic method for the characterization of palmitoyl acyl transferase activity. Anal Biochem 2002 0.96
69 Sphingosine kinase 2 mediates cerebral preconditioning and protects the mouse brain against ischemic injury. Stroke 2011 0.96
70 Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease. Inflammopharmacology 2010 0.95
71 Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A 2012 0.95
72 The emotional ramifications of unmet need in dementia caregiving. Am J Alzheimers Dis Other Demen 2005 0.94
73 Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal. Neurosurg Focus 2006 0.94
74 Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents. Cancer Biol Ther 2011 0.93
75 Experimental osteoarthritis in rats is attenuated by ABC294640, a selective inhibitor of sphingosine kinase-2. Pharmacology 2011 0.92
76 Functional response in ventral temporal cortex differentiates mild cognitive impairment from normal aging. Hum Brain Mapp 2010 0.91
77 Sorafenib sensitizes solid tumors to Apo2L/TRAIL and Apo2L/TRAIL receptor agonist antibodies by the Jak2-Stat3-Mcl1 axis. PLoS One 2013 0.91
78 Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. J Hepatol 2011 0.91
79 DHHC20: a human palmitoyl acyltransferase that causes cellular transformation. Mol Membr Biol 2010 0.91
80 Human experience seeking correlates with hippocampus volume: convergent evidence from manual tracing and voxel-based morphometry. Neuropsychologia 2007 0.90
81 "End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction? J Alzheimers Dis 2011 0.90
82 Synthetic and pharmacological studies on new simplified analogues of the potent actin-targeting Jaspamide. Bioorg Med Chem 2008 0.90
83 Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma. Cancer Biol Ther 2009 0.89
84 Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem 2004 0.88
85 Clinical practice guidelines for pediatric appendicitis evaluation can decrease computed tomography utilization while maintaining diagnostic accuracy. Pediatr Emerg Care 2013 0.88
86 Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter. Toxicol Appl Pharmacol 2013 0.88
87 Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis. Rheumatol Int 2012 0.88
88 Discovery and evaluation of inhibitors of human ceramidase. Mol Cancer Ther 2011 0.87
89 Synthesis, solution structure, and bioactivity of six new simplified analogues of the natural cyclodepsipeptide jaspamide. Bioorg Med Chem 2005 0.87
90 Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. PLoS One 2012 0.87
91 Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort. Dement Geriatr Cogn Disord 2013 0.86
92 Alzheimer's disease and head circumference. J Alzheimers Dis 2006 0.86
93 Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-based inhibitors of human N-myristoyltransferase-1. J Pharmacol Exp Ther 2004 0.86
94 N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef. J Gen Virol 2008 0.85
95 African Americans with memory loss: findings from a community clinic in Lexington, Kentucky. Nurs Clin North Am 2008 0.85
96 Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer. Cancer Biol Ther 2011 0.85
97 Discovery of novel antitumor antimitotic agents that also reverse tumor resistance. J Med Chem 2007 0.84
98 A functional magnetic resonance imaging study in patients with benign essential blepharospasm. J Neuroophthalmol 2003 0.84
99 Secondary dementia caregiving and its consequences. Am J Alzheimers Dis Other Demen 2003 0.84
100 Regional brain response to faces of humans and dogs. Brain Res Cogn Brain Res 2004 0.83
101 Characterization and partial purification of protein fatty acyltransferase activity from rat liver. Biochim Biophys Acta 2003 0.82
102 Synthesis, conformational analysis, and cytotoxicity of new analogues of the natural cyclodepsipeptide jaspamide. J Nat Prod 2004 0.82
103 Partial least squares for discrimination in fMRI data. Magn Reson Imaging 2012 0.82
104 Mid-fusiform activation during object discrimination reflects the process of differentiating structural descriptions. J Cogn Neurosci 2008 0.82
105 FLT-PET may not be a reliable indicator of therapeutic response in p53-null malignancy. Int J Oncol 2011 0.81
106 Alien hand syndrome. Neurology 2006 0.81
107 Aging influences the neural correlates of lexical decision but not automatic semantic priming. Cereb Cortex 2009 0.81
108 Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature. J Neuropathol Exp Neurol 2015 0.80
109 The characteristics of dementia caregiving onset. Am J Alzheimers Dis Other Demen 2003 0.80
110 Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. J Biol Chem 2014 0.79
111 Research on Parkinson disease. J Neurosurg 2005 0.79
112 Multimodal imaging evidence for axonal and myelin deterioration in amnestic mild cognitive impairment. J Alzheimers Dis 2012 0.79
113 Improved synthesis of a fluorogenic ceramidase substrate. Bioorg Med Chem 2010 0.79
114 Comparison of the anti-cyclic citrullinated peptide and rheumatoid factor in rheumatoid arthritis at an arthritis center. Saudi Med J 2009 0.79
115 Sydenham's chorea in the age of MRI: a case report and review. Pediatr Neurol 2002 0.78
116 Task deactivation reductions and atrophy within parietal default mode regions are overlapping but only weakly correlated in mild cognitive impairment. J Alzheimers Dis 2011 0.78
117 Reply: GDNF poses troubling questions for doctors, drug maker. Ann Neurol 2006 0.78
118 Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent. Am J Pathol 2012 0.78
119 Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment. J Clin Exp Neuropsychol 2013 0.78
120 Dopaminergic modulation of memory and affective processing in Parkinson depression. Psychiatry Res 2013 0.78
121 Megalencephalic leukoencephalopathy with subcortical cysts in two siblings owing to two novel mutations: case reports and review of the literature. J Child Neurol 2005 0.77
122 In vitro and cellular assays for palmitoyl acyltransferases using fluorescent lipidated peptides. Methods 2006 0.77
123 Assessing the discriminant ability, reliability, and comparability of multiple short forms of the Boston Naming Test in an Alzheimer's disease center cohort. Dement Geriatr Cogn Disord 2015 0.76
124 Giant fibrous hamartoma of infancy: a report of two cases and review of the literature. J Am Acad Dermatol 2010 0.75
125 Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as microtubule inhibitors. Bioorg Med Chem 2013 0.75
126 2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance. Bioorg Med Chem 2011 0.75
127 Thermal injury in children. J S C Med Assoc 2004 0.75
128 Homonymous hemianopsia complicating treatment of postoperative epistaxis. Neurology 2006 0.75
129 An unusual complication of cancer treatment for acute lymphoblastic leukemia. J Neurooncol 2005 0.75