Published in Oncogene on October 30, 2006
CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization. J Biol Chem (2009) 2.81
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J Cell Biol (2008) 2.04
HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins. J Biol Chem (2009) 1.39
Clinical and correlative results of SWOG S0354: a phase II trial of CNTO328 (siltuximab), a monoclonal antibody against interleukin-6, in chemotherapy-pretreated patients with castration-resistant prostate cancer. Clin Cancer Res (2010) 1.37
Trial Watch: Monoclonal antibodies in cancer therapy. Oncoimmunology (2012) 1.34
MicroRNAs and prostate cancer. J Cell Mol Med (2008) 1.33
MBP-1 upregulates miR-29b that represses Mcl-1, collagens, and matrix-metalloproteinase-2 in prostate cancer cells. Genes Cancer (2010) 1.28
Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells. J Biol Chem (2010) 1.28
Mechanistic insights into the events that lead to synergistic induction of interleukin 6 transcription upon activation of the aryl hydrocarbon receptor and inflammatory signaling. J Biol Chem (2010) 1.27
Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. Carcinogenesis (2011) 1.20
Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells. Cancer Res (2008) 1.19
Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells. Endocr Relat Cancer (2010) 1.18
Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression. Mol Cancer (2011) 1.16
Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways. Endocr Relat Cancer (2012) 1.06
Apoptotic regulation by MCL-1 through heterodimerization. J Biol Chem (2010) 1.02
Interleukin-6: a multifunctional targetable cytokine in human prostate cancer. Mol Cell Endocrinol (2011) 1.00
Ah receptor antagonism inhibits constitutive and cytokine inducible IL6 production in head and neck tumor cell lines. Mol Carcinog (2010) 0.97
3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. J Med Chem (2014) 0.96
Loss of let-7 microRNA upregulates IL-6 in bone marrow-derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer. PLoS One (2013) 0.95
Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer. Prostate Cancer (2013) 0.94
PDGF upregulates Mcl-1 through activation of β-catenin and HIF-1α-dependent signaling in human prostate cancer cells. PLoS One (2012) 0.89
Consistent interactions between tumor cell IL-6 and macrophage TNF-α enhance the growth of human prostate cancer cells in the bone of nude mouse. Int Immunopharmacol (2011) 0.89
The multikinase inhibitor sorafenib induces caspase-dependent apoptosis in PC-3 prostate cancer cells. Asian J Androl (2010) 0.89
Proinflammatory cytokine interleukin-6 in prostate carcinogenesis. Am J Clin Exp Urol (2014) 0.87
BAD dephosphorylation and decreased expression of MCL-1 induce rapid apoptosis in prostate cancer cells. PLoS One (2013) 0.86
Zoledronic acid increases docetaxel cytotoxicity through pMEK and Mcl-1 inhibition in a hormone-sensitive prostate carcinoma cell line. J Transl Med (2008) 0.84
Heterodimerization of BAK and MCL-1 activated by detergent micelles. J Biol Chem (2010) 0.83
PIAS1 is a crucial factor for prostate cancer cell survival and a valid target in docetaxel resistant cells. Oncotarget (2014) 0.82
Pseudolaric acid B inhibits inducible cyclooxygenase-2 expression via downregulation of the NF-κB pathway in HT-29 cells. J Cancer Res Clin Oncol (2012) 0.81
miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer. Mol Endocrinol (2015) 0.81
LAP2 is widely overexpressed in diverse digestive tract cancers and regulates motility of cancer cells. PLoS One (2012) 0.80
IL6 secreted by Ewing sarcoma tumor microenvironment confers anti-apoptotic and cell-disseminating paracrine responses in Ewing sarcoma cells. BMC Cancer (2015) 0.79
Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy. Oncotarget (2015) 0.79
IL6 sensitizes prostate cancer to the antiproliferative effect of IFNα2 through IRF9. Endocr Relat Cancer (2013) 0.79
Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences. J Proteome Res (2016) 0.77
TNF-blockade in patients with advanced hormone refractory prostate cancer. Invest New Drugs (2009) 0.76
IκB-Kinase-epsilon (IKKε) over-expression promotes the growth of prostate cancer through the C/EBP-β dependent activation of IL-6 gene expression. Oncotarget (2017) 0.76
A novel tumor-promoting mechanism of IL6 and the therapeutic efficacy of tocilizumab: Hypoxia-induced IL6 is a potent autophagy initiator in glioblastoma via the p-STAT3-MIR155-3p-CREBRF pathway. Autophagy (2016) 0.76
Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer. Oncogene (2015) 0.76
Significance of Interleukin-6 in Papillary Thyroid Carcinoma. J Thyroid Res (2016) 0.75
Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature (1981) 5.66
Insect immunity. Purification and properties of three inducible bactericidal proteins from hemolymph of immunized pupae of Hyalophora cecropia. Eur J Biochem (1980) 4.35
A progressive approach to the problem of foodborne infections. Am J Public Health (1977) 4.11
Health surveillance of preschool children. Br Med J (Clin Res Ed) (1986) 3.98
Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res (1994) 3.43
Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus. J Virol (1993) 3.37
Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma. J Exp Med (1984) 3.31
Insect immunity. Attacins, a family of antibacterial proteins from Hyalophora cecropia. EMBO J (1983) 3.27
Neopterin as a marker for activated cell-mediated immunity: application in HIV infection. Immunol Today (1988) 3.13
A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 3.08
A peptidoglycan recognition protein in innate immunity conserved from insects to humans. Proc Natl Acad Sci U S A (1998) 2.81
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep (2001) 2.70
The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies. J Immunol (1984) 2.70
Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin Chem (1997) 2.39
Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system. Br J Cancer (1999) 2.34
Neopterin as a marker for immune system activation. Curr Drug Metab (2002) 2.25
A shared antigenic determinant between natural killer cells and nervous tissue. Nature (1984) 2.24
Sertraline in children and adolescents with obsessive-compulsive disorder: a multicenter randomized controlled trial. JAMA (1998) 2.20
Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin. Nature (1996) 2.17
Immunohistochemical localization of interleukin-6 and its receptor in benign, premalignant and malignant prostate tissue. J Pathol (2000) 2.11
Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor. Cancer Res (1998) 2.07
Interleukin-6 and prostate cancer progression. Cytokine Growth Factor Rev (2001) 2.03
Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42. J Biol Chem (1997) 2.02
Gay, lesbian, and bisexual youth risks for emotional, physical, and social problems: results from a community-based survey. J Am Acad Child Adolesc Psychiatry (1999) 2.02
Altered striatal function in a mutant mouse lacking D1A dopamine receptors. Proc Natl Acad Sci U S A (1994) 2.01
Mammalian peptidoglycan recognition protein binds peptidoglycan with high affinity, is expressed in neutrophils, and inhibits bacterial growth. J Biol Chem (2000) 1.99
The bowel habit of young children. Arch Dis Child (1984) 1.95
Immune activation and psoriasis. Lancet (1991) 1.93
The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene. EMBO J (1989) 1.93
Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels. Leukemia (2007) 1.89
A humoral stress response in Drosophila. Curr Biol (2001) 1.82
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts. J Exp Med (1990) 1.81
The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane. EMBO J (1995) 1.79
Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis. Eur J Haematol (1995) 1.74
Humoral immunity in Cecropia pupae. Curr Top Microbiol Immunol (1981) 1.74
Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone. Mol Endocrinol (1993) 1.73
Androgen receptors in prostate cancer. Endocr Relat Cancer (2002) 1.71
Long-term effect of preventive therapy for tuberculosis in a cohort of HIV-infected Zambian adults. AIDS (2001) 1.63
Distant metastases from prostatic carcinoma express androgen receptor protein. Cancer Res (1995) 1.63
Perinatal cardiac arrest. Quality of the survivors. Arch Dis Child (1975) 1.63
Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science (1991) 1.62
Vascular complications in lumbar disk surgery: report of four cases. Neuroradiology (1996) 1.62
Respiratory syncytial virus infection of the newborn. Br Med J (1970) 1.62
Pesticides in groundwater: the aldicarb story in Suffolk County, NY. Am J Public Health (1982) 1.61
Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway. EMBO J (1993) 1.61
Ascitic interleukin-12 is an independent prognostic factor in ovarian cancer. J Clin Oncol (1998) 1.61
Posttraumatic stress disorder among female juvenile offenders. J Am Acad Child Adolesc Psychiatry (1998) 1.60
Neopterin as marker for activation of cellular immunity: immunologic basis and clinical application. Adv Clin Chem (1989) 1.59
Characterization of inhibitor A, a protease from Bacillus thuringiensis which degrades attacins and cecropins, two classes of antibacterial proteins in insects. Eur J Biochem (1984) 1.59
N-terminal analogues of cecropin A: synthesis, antibacterial activity, and conformational properties. Biochemistry (1985) 1.53
Mitochondrial and cytosolic branched-chain amino acid transaminases from yeast, homologs of the myc oncogene-regulated Eca39 protein. J Biol Chem (1996) 1.53
Cerebrospinal fluid viral load, intrathecal immunoactivation, and cerebrospinal fluid monocytic cell count in HIV-1 infection. J Acquir Immune Defic Syndr (1999) 1.53
Psychiatric phenomenology of child and adolescent bipolar offspring. J Am Acad Child Adolesc Psychiatry (2000) 1.53
Metastatic lesions from prostate cancer do not express oestrogen and progesterone receptors. J Pathol (1997) 1.52
Verocay body--prominent cutaneous schwannoma. Am J Dermatopathol (1997) 1.52
Early maturation as a risk factor for aggression and delinquency in adolescent girls: A review. Int J Clin Pract (2006) 1.51
vpr deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeys. J Virol (1995) 1.51
An evaluation of low-cost progression markers in HIV-1 seropositive Zambians. HIV Med (2000) 1.51
Clear cell dermatofibroma. Case report of an unusual fibrohistiocytic lesion. Am J Surg Pathol (1996) 1.50
Autoantibodies in infectious mononucleosis have specificity for the glycine-alanine repeating region of the Epstein-Barr virus nuclear antigen. J Exp Med (1987) 1.50
A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice. Proc Natl Acad Sci U S A (1996) 1.48
Poor adolescent expectant mothers: can we assess their potential for child abuse? J Adolesc Health (2001) 1.48
Neopterin as a new biochemical marker for diagnosis of allograft rejection. Experience based upon evaluation of 100 consecutive cases. Transplantation (1983) 1.47
The catalytic mechanism of carbonic anhydrase. Hydrogen-isotope effects on the kinetic parameters of the human C isoenzyme. Eur J Biochem (1975) 1.46
Sclerotic lipoma: lipomas simulating sclerotic fibroma. Histopathology (1997) 1.45
Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer. Br J Cancer (2002) 1.44
Mortality experiences among talc workers: a follow-up study. J Occup Med (1974) 1.43
The presence of IgG antibodies against beta2-glycoprotein I predicts the risk of thrombosis in patients with the lupus anticoagulant. J Thromb Haemost (2005) 1.43
Human macrophages degrade tryptophan upon induction by interferon-gamma. Life Sci (1987) 1.42
Antifungal properties of selective serotonin reuptake inhibitors against Aspergillus species in vitro. J Antimicrob Chemother (2001) 1.42
Regulation of prostatic growth and function by peptide growth factors. Prostate (1996) 1.42
Complex alternative splicing of the GH-V gene in the human testis. Eur J Endocrinol (1998) 1.41
Marker of peripheral blood granulocytes and monocytes of man recognized by two monoclonal antibodies VEP8 and VEP9 involves the trisaccharide 3-fucosyl-N-acetyllactosamine. Eur J Immunol (1983) 1.41
Reducing HIV transmission by seronegative blood. Lancet (1992) 1.41
Mortality among talc miners and millers in New York State. Arch Environ Health (1967) 1.40
Cardiovascular effects of desipramine in children. J Am Acad Child Adolesc Psychiatry (1989) 1.40
Evaluation of the adaptive learning environments model. Except Child (1988) 1.40
Altered iron metabolism and the anemia of chronic disease: a role of immune activation. Blood (1992) 1.39
Selected tickborne infections. A review of Lyme disease, Rocky Mountain spotted fever, and babesiosis. N Y State J Med (1989) 1.38
Maturation and pro-peptide cleavage of beta-secretase. J Biol Chem (2000) 1.38
Liberty. J Med Ethics (1976) 1.37
Ectopic growth-hormone production and osteoarthropathy in carcinoma of the bronchus. Lancet (1968) 1.35
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP. J Biol Chem (1993) 1.35
Insect immunity: isolation and structure of cecropins B and D from pupae of the Chinese oak silk moth, Antheraea pernyi. Eur J Biochem (1982) 1.35
Pteridines as a new marker to detect human T cells activated by allogeneic or modified self major histocompatibility complex (MHC) determinants. J Immunol (1983) 1.34
Survey of gastroenteritis in children admitted to hospital in Newcastle upon Tyne in 1971-5. Br Med J (1977) 1.33
Efficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques. J Virol (2001) 1.33
Potential role of immune system activation-associated production of neopterin derivatives in humans. Inflamm Res (2003) 1.32
Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma. Biochem J (1989) 1.31
Interferon-gamma-induced conversion of tryptophan: immunologic and neuropsychiatric aspects. Curr Med Chem (2003) 1.31
Effects of systematic formative evaluation: a meta-analysis. Except Child (1986) 1.29
Antifungal activity against Candida species of the selective serotonin-reuptake inhibitor, sertraline. Clin Infect Dis (2001) 1.29
Rapid development of vaccine protection in macaques by live-attenuated simian immunodeficiency virus. J Gen Virol (1996) 1.27
The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo. J Virol (1999) 1.26
Body dissatisfaction and dieting in young children. Int J Eat Disord (2000) 1.26
Androgen receptor--an update of mechanisms of action in prostate cancer. Urol Res (2000) 1.25