Published in Neurobiol Dis on November 13, 2006
Cyanobacterial Blooms and the Occurrence of the neurotoxin beta-N-methylamino-L-alanine (BMAA) in South Florida Aquatic Food Webs. Harmful Algae (2010) 1.36
The non-protein amino acid BMAA is misincorporated into human proteins in place of L-serine causing protein misfolding and aggregation. PLoS One (2013) 1.33
Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure. Proc Natl Acad Sci U S A (2010) 1.30
Production of the neurotoxin BMAA by a marine cyanobacterium. Mar Drugs (2007) 1.15
Does α-amino-β-methylaminopropionic acid (BMAA) play a role in neurodegeneration? Int J Environ Res Public Health (2011) 1.02
The cyanobacteria derived toxin Beta-N-methylamino-L-alanine and amyotrophic lateral sclerosis. Toxins (Basel) (2010) 0.98
A comparative study on three analytical methods for the determination of the neurotoxin BMAA in cyanobacteria. PLoS One (2012) 0.94
Parkinson-dementia complex and development of a new stable isotope dilution assay for BMAA detection in tissue. Toxicol Appl Pharmacol (2009) 0.93
Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam. Proc Natl Acad Sci U S A (2014) 0.92
Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence? Front Neurosci (2015) 0.92
Neonatal exposure to the cyanobacterial toxin BMAA induces changes in protein expression and neurodegeneration in adult hippocampus. Toxicol Sci (2012) 0.90
Gliotoxicity of the cyanotoxin, β-methyl-amino-L-alanine (BMAA). Sci Rep (2013) 0.83
Natural toxins implicated in the development of Parkinson's disease. Ther Adv Neurol Disord (2011) 0.83
BMAA inhibits nitrogen fixation in the cyanobacterium Nostoc sp. PCC 7120. Mar Drugs (2013) 0.79
Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme. BMJ Open (2014) 0.78
Biotransfer of β-N-methylamino-L-alanine (BMAA) in a eutrophicated freshwater lake. Mar Drugs (2015) 0.78
Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord. Exp Neurol (2014) 0.77
Bloom Dynamics of Cyanobacteria and Their Toxins: Environmental Health Impacts and Mitigation Strategies. Front Microbiol (2015) 0.77
Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects. Front Microbiol (2017) 0.77
Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Sci Rep (2016) 0.76
Regulation of System xc(-) by Pharmacological Manipulation of Cellular Thiols. Oxid Med Cell Longev (2015) 0.76
β-N-methylamino-L-alanine induces neurological deficits and shortened life span in Drosophila. Toxins (Basel) (2010) 0.76
ALS-linked SOD1 in glial cells enhances ß-N-Methylamino L-Alanine (BMAA)-induced toxicity in Drosophila. F1000Res (2012) 0.76
Prominent human health impacts from several marine microbes: history, ecology, and public health implications. Int J Microbiol (2010) 0.76
Equilibrium Dynamics of β-N-Methylamino-L-Alanine (BMAA) and Its Carbamate Adducts at Physiological Conditions. PLoS One (2016) 0.75
New Typical Vector of Neurotoxin β-N-Methylamino-l-Alanine (BMAA) in the Marine Benthic Ecosystem. Mar Drugs (2016) 0.75
Acute β-N-Methylamino-L-alanine Toxicity in a Mouse Model. J Toxicol (2015) 0.75
β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling. Amino Acids (2017) 0.75
Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med (1999) 5.08
Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J Neurosci Methods (1987) 3.47
An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid. N Engl J Med (1990) 3.17
Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam. Neurology (2002) 2.99
Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin. Science (1987) 2.48
Return of the cycad hypothesis - does the amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health? Neuropathol Appl Neurobiol (2005) 2.26
Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J Neurosci (1995) 2.20
Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam. Proc Natl Acad Sci U S A (2003) 2.20
Carboxyfullerenes as neuroprotective agents. Proc Natl Acad Sci U S A (1997) 2.05
Diverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acid. Proc Natl Acad Sci U S A (2005) 1.92
Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults. NeuroRx (2004) 1.91
Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? J Neurosci Methods (2000) 1.68
A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam. Proc Natl Acad Sci U S A (2004) 1.67
Inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release evoked by metabotropic agonists and backpropagating action potentials in hippocampal CA1 pyramidal neurons. J Neurosci (2000) 1.53
Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man. J Neural Transm (Vienna) (1996) 1.45
Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J Neurosci (1993) 1.44
Glutamate receptors and Parkinson's disease: opportunities for intervention. Drugs Aging (2003) 1.44
2-Amino-3-(methylamino)-propanoic acid (BMAA) in cycad flour: an unlikely cause of amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Neurology (1990) 1.40
Role of oxidative stress in neurodegeneration: recent developments in assay methods for oxidative stress and nutraceutical antioxidants. Prog Neuropsychopharmacol Biol Psychiatry (2004) 1.39
The biological effects and mode of action of L-canavanine, a structural analogue of L-arginine. Q Rev Biol (1977) 1.27
BMAA selectively injures motor neurons via AMPA/kainate receptor activation. Exp Neurol (2006) 1.22
A site of alcohol action in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor. J Biol Chem (2003) 1.13
Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models. Int J Dev Neurosci (2004) 1.12
Neurotoxicity of beta-N-methylamino-L-alanine (BMAA) and beta-N-oxalylamino-L-alanine (BOAA) on cultured cortical neurons. Brain Res (1989) 1.10
Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC. Neurology (2005) 1.10
Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death. J Neurosci (2006) 1.09
The activation of metabotropic glutamate receptors protects nerve cells from oxidative stress. J Neurosci (1998) 1.07
Slowly triggered excitotoxicity occurs by necrosis in cortical cultures. Neuroscience (1997) 1.02
The nonfibrillar amyloid beta-peptide induces apoptotic neuronal cell death: involvement of its C-terminal fusogenic domain. J Neurochem (1999) 1.00
Beta-N-methylamino-L-alanine neurotoxicity: requirement for bicarbonate as a cofactor. Science (1988) 0.97
Lack of behavioral and neuropathological effects of dietary beta-methylamino-L-alanine (BMAA) in mice. Pharmacol Biochem Behav (2006) 0.93
The cycad neurotoxic amino acid, beta-N-methylamino-L-alanine (BMAA), elevates intracellular calcium levels in dissociated rat brain cells. J Ethnopharmacol (2002) 0.92
Beta-N-methylamino-L-alanine. Chronic oral administration is not neurotoxic to mice. J Neurol Sci (1989) 0.91
Specific antagonism of excitotoxic action of 'uncommon' amino acids assayed in organotypic mouse cortical cultures. Brain Res (1987) 0.90
1-Methyl-4-phenylpyridine (MPP+) induces oxidative stress in the rodent. Life Sci (1986) 0.83
Danthron inhibits the neurotoxicity induced by various compounds causing oxidative damages including beta-amyloid (25-35) in primary cortical cultures. Biol Pharm Bull (2004) 0.80
A distinct death mechanism is induced by 1-methyl-4-phenylpyridinium or by 6-hydroxydopamine in cultured rat cortical neurons: degradation and dephosphorylation of tau. Neurosci Lett (2003) 0.78
Acute excitotoxicity in chick retina caused by the unusual amino acids BOAA and BMAA: effects of MK-801 and kynurenate. Neurosci Lett (1989) 0.78
Neurotrophic factor effects on oxidative stress-induced neuronal death. Neurochem Res (2003) 0.77
GABA(A) receptors as molecular sites of ethanol action. Direct or indirect actions? Curr Top Med Chem (2002) 1.27
A selective G betagamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol. Proc Natl Acad Sci U S A (2008) 1.17
Modulation of glycine-activated ion channel function by G-protein betagamma subunits. Nat Neurosci (2003) 1.16
A site of alcohol action in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor. J Biol Chem (2003) 1.13
A site in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor regulates desensitization and ion channel gating. J Biol Chem (2002) 1.11
Synaptotoxicity of Alzheimer beta amyloid can be explained by its membrane perforating property. PLoS One (2010) 1.05
Molecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation. J Biol Chem (2010) 1.03
The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor. J Biol Chem (2008) 1.03
Sites in the fourth membrane-associated domain regulate alcohol sensitivity of the NMDA receptor. Neuropharmacology (2004) 1.00
An interaction involving an arginine residue in the cytoplasmic domain of the 5-HT3A receptor contributes to receptor desensitization mechanism. J Biol Chem (2006) 0.98
Interactions among positions in the third and fourth membrane-associated domains at the intersubunit interface of the N-methyl-D-aspartate receptor forming sites of alcohol action. J Biol Chem (2012) 0.96
A Single phenylalanine residue in the main intracellular loop of α1 γ-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol. Anesthesiology (2011) 0.92
Conserved extracellular cysteines differentially regulate the inhibitory effect of ethanol in rat P2X4 receptors. Biochem Biophys Res Commun (2009) 0.92
Ethanol is a fast channel inhibitor of P2X4 receptors. J Pharmacol Exp Ther (2011) 0.90
Functional interactions of alcohol-sensitive sites in the N-methyl-D-aspartate receptor M3 and M4 domains. J Biol Chem (2008) 0.90
Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin. J Biol Chem (2010) 0.84
Modulation of 5-HT3 receptor desensitization by the light chain of microtubule-associated protein 1B expressed in HEK 293 cells. J Physiol (2007) 0.84
Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies. Neuropharmacology (2008) 0.83
Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors. Biochem Biophys Res Commun (2008) 0.83
Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer's disease. Neurobiol Aging (2013) 0.81
A novel alcohol-sensitive position in the N-methyl-D-aspartate receptor GluN2A subunit M3 domain regulates agonist affinity and ion channel gating. Mol Pharmacol (2013) 0.81
Dynorphin A inhibits NMDA receptors through a pH-dependent mechanism. Mol Cell Neurosci (2003) 0.79
Role of extracellular histidines in agonist sensitivity of the rat P2X4 receptor. Neurosci Lett (2004) 0.79
Arginine 246 of the pretransmembrane domain 1 region alters 2,2,2-trichloroethanol action in the 5-hydroxytryptamine3A receptor. J Pharmacol Exp Ther (2007) 0.79
Ethanol sensitivity of recombinant homomeric and heteromeric AMPA receptor subunits expressed in Xenopus oocytes. Alcohol Clin Exp Res (2003) 0.78
Conserved extracellular cysteines differentially regulate the potentiation produced by Zn2+ in rat P2X4 receptors. Eur J Pharmacol (2013) 0.76
Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons. Neuropharmacology (2009) 0.75