Published in Chembiochem on December 01, 2006
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A soluble, magnesium-independent prenyltransferase catalyzes reverse and regular C-prenylations and O-prenylations of aromatic substrates. FEBS Lett (2007) 1.23
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Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. J Bacteriol (2007) 0.99
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Genome sequence of Sphingomonas wittichii DP58, the first reported phenazine-1-carboxylic acid-degrading strain. J Bacteriol (2012) 0.84
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Genomic insights into the evolution of hybrid isoprenoid biosynthetic gene clusters in the MAR4 marine streptomycete clade. BMC Genomics (2015) 0.79
Functional characterization of the promiscuous prenyltransferase responsible for furaquinocin biosynthesis: identification of a physiological polyketide substrate and its prenylated reaction products. J Biol Chem (2010) 0.79
Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis. Appl Environ Microbiol (2010) 0.77
Identification of the Lomofungin Biosynthesis Gene Cluster and Associated Flavin-Dependent Monooxygenase Gene in Streptomyces lomondensis S015. PLoS One (2015) 0.75
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Randomized controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria. Trans R Soc Trop Med Hyg (2004) 3.52
Influence of willow bark extract on cyclooxygenase activity and on tumor necrosis factor alpha or interleukin 1 beta release in vitro and ex vivo. Clin Pharmacol Ther (2003) 2.08
Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell (2012) 1.65
Dexamethasone concentration gradients along scala tympani after application to the round window membrane. Otol Neurotol (2008) 1.57
Diversity and evolution of the phenazine biosynthesis pathway. Appl Environ Microbiol (2009) 1.51
CloQ, a prenyltransferase involved in clorobiocin biosynthesis. Proc Natl Acad Sci U S A (2003) 1.50
Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics. Microbiology (2002) 1.49
The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria. Proc Natl Acad Sci U S A (2009) 1.48
Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg (2004) 1.43
Cochlear microdialysis for quantification of dexamethasone and fluorescein entry into scala tympani during round window administration. Hear Res (2006) 1.43
Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3. Cancer Res (2009) 1.34
Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway. J Biol Chem (2009) 1.26
A soluble, magnesium-independent prenyltransferase catalyzes reverse and regular C-prenylations and O-prenylations of aromatic substrates. FEBS Lett (2007) 1.23
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040. Arch Microbiol (2002) 1.19
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action. Antimicrob Agents Chemother (2005) 1.16
Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis. Antimicrob Agents Chemother (2004) 1.13
Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus. J Biol Chem (2009) 1.10
Identification of a napsamycin biosynthesis gene cluster by genome mining. Chembiochem (2010) 1.09
Analysis of the liposidomycin gene cluster leads to the identification of new caprazamycin derivatives. Chembiochem (2010) 1.09
Effects of deletions of mbtH-like genes on clorobiocin biosynthesis in Streptomyces coelicolor. Microbiology (2007) 1.09
Evolutionary relationships of microbial aromatic prenyltransferases. PLoS One (2011) 1.09
Prenyl transfer to aromatic substrates in the biosynthesis of aminocoumarins, meroterpenoids and phenazines: the ABBA prenyltransferase family. Phytochemistry (2009) 1.08
Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs. Chem Biol (2003) 1.08
Developmental-stage-specific assembly of ParB complexes in Streptomyces coelicolor hyphae. J Bacteriol (2005) 1.05
Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters. Appl Environ Microbiol (2005) 1.04
The actinobacteria-specific gene wblA controls major developmental transitions in Streptomyces coelicolor A3(2). Microbiology (2011) 1.03
In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach. Chem Biol (2004) 1.00
Coiled-coil protein Scy is a key component of a multiprotein assembly controlling polarized growth in Streptomyces. Proc Natl Acad Sci U S A (2013) 1.00
Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring. Angew Chem Int Ed Engl (2004) 1.00
Structural basis of the interaction of MbtH-like proteins, putative regulators of nonribosomal peptide biosynthesis, with adenylating enzymes. J Biol Chem (2012) 0.97
Biosynthesis of the isoprenoid moieties of furanonaphthoquinone I and endophenazine A in Streptomyces cinnamonensis DSM 1042. J Org Chem (2007) 0.96
Structure and mechanism of the magnesium-independent aromatic prenyltransferase CloQ from the clorobiocin biosynthetic pathway. J Mol Biol (2010) 0.96
Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics. J Antimicrob Chemother (2011) 0.96
Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection. BMC Cancer (2009) 0.96
CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis. J Biol Chem (2003) 0.95
CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin. Chembiochem (2003) 0.93
Metabonomics in cancer diagnosis: mass spectrometry-based profiling of urinary nucleosides from breast cancer patients. Biomarkers (2008) 0.93
Reducing the variability of antibiotic production in Streptomyces by cultivation in 24-square deepwell plates. J Biosci Bioeng (2009) 0.93
RNA 3'-tail synthesis in Streptomyces: in vitro and in vivo activities of RNase PH, the SCO3896 gene product and polynucleotide phosphorylase. Microbiology (2006) 0.93
An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. Eur J Biochem (2003) 0.93
Assembly and heterologous expression of the coumermycin A1 gene cluster and production of new derivatives by genetic engineering. Chembiochem (2008) 0.92
Resistance genes of aminocoumarin producers: two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin. Antimicrob Agents Chemother (2003) 0.92
Role of MbtH-like proteins in the adenylation of tyrosine during aminocoumarin and vancomycin biosynthesis. J Biol Chem (2011) 0.92
The biosynthetic genes for prenylated phenazines are located at two different chromosomal loci of Streptomyces cinnamonensis DSM 1042. Microb Biotechnol (2010) 0.92
Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster. PLoS One (2013) 0.91
Identification of a topoisomerase IV in actinobacteria: purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489. Microbiology (2004) 0.91
Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and heterologous production of the unique antibiotic roseoflavin. J Bacteriol (2012) 0.91
Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis: results of 2 randomized double-blind controlled trials. J Rheumatol (2004) 0.90
Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling. BMC Biochem (2007) 0.90
Expression of Cre recombinase during transient phage infection permits efficient marker removal in Streptomyces. Nucleic Acids Res (2006) 0.90
Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway. BMC Cancer (2006) 0.88
S-Adenosylmethionine (SAM) and antibiotic biosynthesis: effect of external addition of SAM and of overexpression of SAM biosynthesis genes on novobiocin production in Streptomyces. Arch Microbiol (2010) 0.88
Bioinformatical evaluation of modified nucleosides as biomedical markers in diagnosis of breast cancer. Anal Chim Acta (2008) 0.88
NovG, a DNA-binding protein acting as a positive regulator of novobiocin biosynthesis. Microbiology (2005) 0.87
New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach utilizing the carbamoyltransferase NovN. Chem Biol (2004) 0.87
Molecular replacement in the 'twilight zone': structure determination of the non-haem iron oxygenase NovR from Streptomyces spheroides through repeated density modification of a poor molecular-replacement solution. Acta Crystallogr D Biol Crystallogr (2006) 0.87
Dexamethasone levels and base-to-apex concentration gradients in the scala tympani perilymph after intracochlear delivery in the guinea pig. Otol Neurotol (2012) 0.87
Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis. Antimicrob Agents Chemother (2006) 0.87
Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase. Chem Biol (2011) 0.86
Crystallization and preliminary X-ray analysis of the aromatic prenyltransferase CloQ from the clorobiocin biosynthetic cluster of Streptomyces roseochromogenes. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.86
A new arylsulfate sulfotransferase involved in liponucleoside antibiotic biosynthesis in streptomycetes. J Biol Chem (2010) 0.86
Overexpression, purification and characterization of SimL, an amide synthetase involved in simocyclinone biosynthesis. Arch Microbiol (2005) 0.86
A new group of aromatic prenyltransferases in fungi, catalyzing a 2,7-dihydroxynaphthalene 3-dimethylallyl-transferase reaction. J Biol Chem (2010) 0.86
Determination of phenprocoumon, warfarin and their monohydroxylated metabolites in human plasma and urine by liquid chromatography-mass spectrometry after solid-phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci (2004) 0.85
Herba Artemisiae annuae tea preparation compared to sulfadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria in adults: a randomized double-blind clinical trial. Trop Doct (2008) 0.85
Improved mutasynthetic approaches for the production of modified aminocoumarin antibiotics. Chem Biol (2007) 0.85
HPLC-MS/MS analysis of willow bark extracts contained in pharmaceutical preparations. Phytochem Anal (2005) 0.85
Structure-based engineering increased the catalytic turnover rate of a novel phenazine prenyltransferase. PLoS One (2012) 0.84
A two-step sulfation in antibiotic biosynthesis requires a type III polyketide synthase. Nat Chem Biol (2013) 0.84
Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains. Chem Biol (2004) 0.84
Mutational analysis of a phenazine biosynthetic gene cluster in Streptomyces anulatus 9663. Beilstein J Org Chem (2012) 0.84
Heterologous expression of the biosynthetic gene clusters of coumermycin A(1), clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains. Biopolymers (2010) 0.84
The biosynthetic gene clusters of aminocoumarin antibiotics. Planta Med (2006) 0.83
SIRT3 deficiency impairs mitochondrial and contractile function in the heart. Basic Res Cardiol (2015) 0.83
Functional characterizations of novWUS involved in novobiocin biosynthesis from Streptomyces spheroides. Arch Biochem Biophys (2005) 0.83
Biological activities of novel gyrase inhibitors of the aminocoumarin class. Antimicrob Agents Chemother (2008) 0.82
Novobiocin biosynthesis: inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation. Arch Microbiol (2003) 0.82
Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN. Biochemistry (2004) 0.82