Published in Nat Struct Mol Biol on November 19, 2006
Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc Natl Acad Sci U S A (2010) 2.15
Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. Proc Natl Acad Sci U S A (2008) 1.95
Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties. J Gen Physiol (2007) 1.68
CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry. J Virol (2008) 1.62
ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity. EMBO J (2011) 1.43
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Independent activation of distinct pores in dimeric TMEM16A channels. J Gen Physiol (2016) 0.94
Regulatory activation is accompanied by movement in the C terminus of the Na-K-Cl cotransporter (NKCC1). J Biol Chem (2011) 0.91
Discovery of CLC transport proteins: cloning, structure, function and pathophysiology. J Physiol (2015) 0.91
Structure and gating of CLC channels and exchangers. J Physiol (2015) 0.90
Low resolution structure of a bacterial SLC26 transporter reveals dimeric stoichiometry and mobile intracellular domains. J Biol Chem (2011) 0.90
Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. J Biomed Biotechnol (2011) 0.89
Conformational changes required for H(+)/Cl(-) exchange mediated by a CLC transporter. Nat Struct Mol Biol (2014) 0.88
Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits. J Biol Chem (2011) 0.87
The coupled proton transport in the ClC-ec1 Cl(-)/H(+) antiporter. Biophys J (2011) 0.87
Divalent cations activate TRPV1 through promoting conformational change of the extracellular region. J Gen Physiol (2013) 0.86
Antiport mechanism for Cl(-)/H(+) in ClC-ec1 from normal-mode analysis. Biophys J (2010) 0.86
To ATP or not to ATP: this is the question. J Gen Physiol (2008) 0.86
Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J Biol Chem (2009) 0.86
High temperature sensitivity is intrinsic to voltage-gated potassium channels. Elife (2014) 0.85
Common gating of both CLC transporter subunits underlies voltage-dependent activation of the 2Cl-/1H+ exchanger ClC-7/Ostm1. J Biol Chem (2013) 0.84
Intracellular β-nicotinamide adenine dinucleotide inhibits the skeletal muscle ClC-1 chloride channel. J Biol Chem (2012) 0.84
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Human ClC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains. PLoS One (2007) 0.83
Regulatory phosphorylation induces extracellular conformational changes in a CLC anion channel. Biophys J (2013) 0.81
The C-terminal domain of the neutral amino acid transporter SNAT2 regulates transport activity through voltage-dependent processes. Biochem J (2011) 0.80
Patch-clamp fluorometry: electrophysiology meets fluorescence. Biophys J (2014) 0.80
GlialCAM, a CLC-2 Cl(-) channel subunit, activates the slow gate of CLC chloride channels. Biophys J (2014) 0.80
Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B. J Physiol (2015) 0.80
Regulation of ClC-2 gating by intracellular ATP. Pflugers Arch (2013) 0.79
Accessibility of the CLC-0 pore to charged methanethiosulfonate reagents. Biophys J (2010) 0.78
Modulation of the slow/common gating of CLC channels by intracellular cadmium. J Gen Physiol (2015) 0.77
Application of fluorescence resonance energy transfer in protein studies. J Mol Struct (2014) 0.76
Protein kinase C-dependent regulation of ClC-1 channels in active human muscle and its effect on fast and slow gating. J Physiol (2016) 0.76
Putting the pieces together: a crystal clear window into CLC anion channel regulation. Channels (Austin) (2011) 0.75
ClC Channels and Transporters: Structure, Physiological Functions, and Implications in Human Chloride Channelopathies. Front Pharmacol (2017) 0.75
Shape-Dependent Global Deformation Modes of Large Protein Structures. J Mol Struct (2010) 0.75
Gating and trafficking of ClC-2 chloride channel without cystathionine beta-synthase domains. J Physiol (2008) 0.75
Large-scale sequence analysis of avian influenza isolates. Science (2006) 9.87
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci U S A (2004) 7.24
Modeling sample variables with an Experimental Factor Ontology. Bioinformatics (2010) 6.27
Patients' perception of hospital care in the United States. N Engl J Med (2008) 6.10
Modeling biomedical experimental processes with OBI. J Biomed Semantics (2010) 5.36
Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation. Immunity (2011) 3.75
The structural biology of type II fatty acid biosynthesis. Annu Rev Biochem (2005) 3.69
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet (2009) 3.59
Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell (2003) 3.06
Identification of a salmonellosis outbreak by means of molecular sequencing. N Engl J Med (2011) 2.81
Determinants of asthma after severe respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol (2012) 2.27
Use of UpToDate and outcomes in US hospitals. J Hosp Med (2011) 2.19
3D MRI-based multicomponent FSI models for atherosclerotic plaques. Ann Biomed Eng (2004) 2.17
Electronic health records' limited successes suggest more targeted uses. Health Aff (Millwood) (2010) 2.17
Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc Natl Acad Sci U S A (2010) 2.15
DNA-templated Ag nanocluster formation. J Am Chem Soc (2004) 2.13
Human epithelial cancers secrete immunoglobulin g with unidentified specificity to promote growth and survival of tumor cells. Cancer Res (2003) 2.00
Does affiliation of physician groups with one another produce higher quality primary care? J Gen Intern Med (2007) 1.93
Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry (2005) 1.92
Local maximal stress hypothesis and computational plaque vulnerability index for atherosclerotic plaque assessment. Ann Biomed Eng (2005) 1.89
Sites of rupture in human atherosclerotic carotid plaques are associated with high structural stresses: an in vivo MRI-based 3D fluid-structure interaction study. Stroke (2009) 1.81
Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. Chest (2008) 1.80
Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nat Cell Biol (2009) 1.80
The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol Cell Biol (2004) 1.77
An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. Cancer Res (2007) 1.73
On the evolutionary history, population genetics and diversity among isolates of Salmonella Enteritidis PFGE pattern JEGX01.0004. PLoS One (2013) 1.69
Enhanced recovery after surgery programs versus traditional care for colorectal surgery: a meta-analysis of randomized controlled trials. Dis Colon Rectum (2013) 1.69
Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties. J Gen Physiol (2007) 1.68
Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Lett (2008) 1.68
Transitional cell carcinoma in renal transplant recipients: a single center experience. Int J Urol (2008) 1.67
Assignment of orthologous genes via genome rearrangement. IEEE/ACM Trans Comput Biol Bioinform (2006) 1.66
Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channels. J Gen Physiol (2003) 1.58
Multiple organ infection and the pathogenesis of SARS. J Exp Med (2005) 1.58
Distribution of lymphoid neoplasms in China: analysis of 4,638 cases according to the World Health Organization classification. Am J Clin Pathol (2012) 1.53
In Vivo/Ex Vivo MRI-Based 3D Non-Newtonian FSI Models for Human Atherosclerotic Plaques Compared with Fluid/Wall-Only Models. Comput Model Eng Sci (2007) 1.51
Dickkopf-3 attenuates pressure overload-induced cardiac remodelling. Cardiovasc Res (2014) 1.49
Amyopathic dermatomyositis or dermatomyositis-like skin disease: retrospective review of 16 cases with amyopathic dermatomyositis. Clin Rheumatol (2009) 1.47
GFP-based FRET analysis in live cells. Brain Res (2006) 1.46
Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents. J Gen Physiol (2003) 1.46
Risk factors for late renal dysfunction after pediatric heart transplantation: a multi-institutional study. Pediatr Transplant (2011) 1.45
Models of beta-amyloid ion channels in the membrane suggest that channel formation in the bilayer is a dynamic process. Biophys J (2007) 1.44
Drug-target interaction prediction by learning from local information and neighbors. Bioinformatics (2012) 1.44
Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J Biol Chem (2003) 1.43
Passive tumor targeting of renal-clearable luminescent gold nanoparticles: long tumor retention and fast normal tissue clearance. J Am Chem Soc (2013) 1.43
New structures help the modeling of toxic amyloidbeta ion channels. Trends Biochem Sci (2008) 1.43
Luminescent gold nanoparticles with efficient renal clearance. Angew Chem Int Ed Engl (2011) 1.41
Quantifying effects of plaque structure and material properties on stress distributions in human atherosclerotic plaques using 3D FSI models. J Biomech Eng (2005) 1.38
Introduction to the CSBio2014 special issue. J Bioinform Comput Biol (2015) 1.37
Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction. J Biol Chem (2003) 1.36
The solution structure of acyl carrier protein from Mycobacterium tuberculosis. J Biol Chem (2002) 1.36
Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem (2008) 1.35
Effect of stenosis asymmetry on blood flow and artery compression: a three-dimensional fluid-structure interaction model. Ann Biomed Eng (2003) 1.34
Radiographic structural abnormalities associated with premature, natural hip-joint failure. J Bone Joint Surg Am (2011) 1.33
Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men. Cancer Sci (2011) 1.32
MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression. J Pathol (2005) 1.32
Structure-function based design of small molecule inhibitors targeting Rho family GTPases. Curr Top Med Chem (2006) 1.31
Protein adsorption on oligo(ethylene glycol)-terminated alkanethiolate self-assembled monolayers: The molecular basis for nonfouling behavior. J Phys Chem B (2005) 1.31
Electronic health records: use, barriers and satisfaction among physicians who care for black and Hispanic patients. J Eval Clin Pract (2008) 1.27
Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway. J Biol Chem (2004) 1.27
Quantification of regional myocardial oxygenation by magnetic resonance imaging: validation with positron emission tomography. Circ Cardiovasc Imaging (2009) 1.27
Concurrent multimodality image segmentation by active contours for radiotherapy treatment planning. Med Phys (2007) 1.26
Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: insights into nonfouling properties of zwitterionic materials. J Am Chem Soc (2005) 1.26
Graphene oxide stabilized polyethylene glycol for heat storage. Phys Chem Chem Phys (2012) 1.24
The crosstalk between EGF, IGF, and Insulin cell signaling pathways--computational and experimental analysis. BMC Syst Biol (2009) 1.24
Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2. Blood (2005) 1.23
Characterization of the Drosophila gene-switch system in aging studies: a cautionary tale. Aging Cell (2008) 1.23
MicroRNA-19 (miR-19) regulates tissue factor expression in breast cancer cells. J Biol Chem (2010) 1.23
In vivo IVUS-based 3-D fluid-structure interaction models with cyclic bending and anisotropic vessel properties for human atherosclerotic coronary plaque mechanical analysis. IEEE Trans Biomed Eng (2009) 1.23
PEGylation and zwitterionization: pros and cons in the renal clearance and tumor targeting of near-IR-emitting gold nanoparticles. Angew Chem Int Ed Engl (2013) 1.23
Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targets. Nucleic Acids Res (2007) 1.22
Fast mapping of myocardial blood flow with MR first-pass perfusion imaging. Magn Reson Med (2008) 1.22
Rational design and applications of a Rac GTPase-specific small molecule inhibitor. Methods Enzymol (2006) 1.22
Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. J Gen Physiol (2012) 1.21
Does the Leapfrog program help identify high-quality hospitals? Jt Comm J Qual Patient Saf (2008) 1.21
Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH. J Gen Physiol (2007) 1.21
Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase. Mol Cell Biol (2002) 1.21
Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res (2010) 1.19
Altered left ventricular geometry changes the border zone temporal distribution of stress in an experimental model of left ventricular aneurysm: a finite element model study. Circulation (2002) 1.18
3D MRI-based anisotropic FSI models with cyclic bending for human coronary atherosclerotic plaque mechanical analysis. J Biomech Eng (2009) 1.17
3D critical plaque wall stress is a better predictor of carotid plaque rupture sites than flow shear stress: An in vivo MRI-based 3D FSI study. J Biomech Eng (2010) 1.16
Intramyocardial injection of allogenic bone marrow-derived mesenchymal stem cells without immunosuppression preserves cardiac function in a porcine model of myocardial infarction. J Cardiovasc Pharmacol Ther (2005) 1.15
An experimental study on the ultimate strength of the adventitia and media of human atherosclerotic carotid arteries in circumferential and axial directions. J Biomech (2009) 1.15
Replication and cumulative effects of GWAS-identified genetic variations for prostate cancer in Asians: a case-control study in the ChinaPCa consortium. Carcinogenesis (2011) 1.15
Draft genome sequences of 21 Salmonella enterica serovar enteritidis strains. J Bacteriol (2012) 1.15
Improvement of quantification of myocardial first-pass perfusion mapping: a temporal and spatial wavelet denoising method. Magn Reson Med (2006) 1.15
Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy. Hypertension (2013) 1.15
Evidence of an emerging digital divide among hospitals that care for the poor. Health Aff (Millwood) (2009) 1.15
Interaction between the internal motif KTXXXI of Idax and mDvl PDZ domain. Biochem Biophys Res Commun (2004) 1.14
Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics. Angew Chem Int Ed Engl (2012) 1.14
The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin. J Mol Biol (2006) 1.13
Single-molecule optoelectronics. Acc Chem Res (2005) 1.13
The characteristics and performance of hospitals that care for elderly Hispanic Americans. Health Aff (Millwood) (2008) 1.13
Nanoparticle-free single molecule anti-stokes Raman spectroscopy. Phys Rev Lett (2005) 1.13
Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat. Eur J Pharmacol (2008) 1.12
ATP inhibition of CLC-1 is controlled by oxidation and reduction. J Gen Physiol (2008) 1.12
Tongxinluo (Tong xin luo or Tong-xin-luo) capsule for unstable angina pectoris. Cochrane Database Syst Rev (2006) 1.11
Patient-specific artery shrinkage and 3D zero-stress state in multi-component 3D FSI models for carotid atherosclerotic plaques based on in vivo MRI data. Mol Cell Biomech (2009) 1.11
Molecular imaging of atherosclerotic plaque with (64)Cu-labeled natriuretic peptide and PET. J Nucl Med (2009) 1.09
Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance. Hepatology (2014) 1.09
Basal cell carcinoma does metastasize. Dermatol Online J (2008) 1.08