Published in J Med Chem on November 30, 2006
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Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication. Cell Host Microbe (2011) 1.43
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Protein array identification of substrates of the Epstein-Barr virus protein kinase BGLF4. J Virol (2009) 1.21
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The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production. J Virol (2010) 1.12
Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases. PLoS Pathog (2010) 1.10
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Expression of the human cytomegalovirus UL97 gene in a chimeric guinea pig cytomegalovirus (GPCMV) results in viable virus with increased susceptibility to ganciclovir and maribavir. Antiviral Res (2008) 0.81
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Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. Am J Hum Genet (2007) 2.74
Structural analysis of the protein phosphatase 1 docking motif: molecular description of binding specificities identifies interacting proteins. Chem Biol (2006) 2.08
Proteolytic activation of the 1918 influenza virus hemagglutinin. J Virol (2009) 2.05
S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients. J Virol (2004) 1.80
Cellular p32 recruits cytomegalovirus kinase pUL97 to redistribute the nuclear lamina. J Biol Chem (2005) 1.77
Host response dynamics following lethal infection of rhesus macaques with Zaire ebolavirus. J Infect Dis (2011) 1.75
Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. Am J Hum Genet (2009) 1.71
AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine. J Mol Model (2005) 1.69
Endotheliotropic elephant herpesvirus, the first betaherpesvirus with a thymidine kinase gene. J Gen Virol (2006) 1.61
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Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression. Hum Mutat (2010) 1.59
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The interleukin-10 family of cytokines. Trends Immunol (2002) 1.54
Human TBX1 missense mutations cause gain of function resulting in the same phenotype as 22q11.2 deletions. Am J Hum Genet (2007) 1.51
Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors. J Virol (2006) 1.49
Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques. J Virol (2010) 1.47
MAP4-dependent regulation of microtubule formation affects centrosome, cilia, and Golgi architecture as a central mechanism in growth regulation. Hum Mutat (2014) 1.45
Severely incapacitating mutations in patients with extreme short stature identify RNA-processing endoribonuclease RMRP as an essential cell growth regulator. Am J Hum Genet (2005) 1.40
The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. J Biol Chem (2004) 1.38
Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron. Free Radic Biol Med (2004) 1.37
LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus. Virology (2005) 1.37
Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6). Eur Heart J (2011) 1.37
Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses. J Mol Med (Berl) (2001) 1.33
Ebola virus enters host cells by macropinocytosis and clathrin-mediated endocytosis. J Infect Dis (2011) 1.33
Replication-deficient ebolavirus as a vaccine candidate. J Virol (2009) 1.32
DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J Virol (2006) 1.31
Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain. Emerg Infect Dis (2015) 1.31
Cytomegaloviral proteins pUL50 and pUL53 are associated with the nuclear lamina and interact with cellular protein kinase C. J Gen Virol (2007) 1.30
Dual selection pressure by drugs and HLA class I-restricted immune responses on human immunodeficiency virus type 1 protease. J Virol (2007) 1.28
Focus on antivirally active sulfated polysaccharides: from structure-activity analysis to clinical evaluation. Glycobiology (2008) 1.27
Vesicular stomatitis virus-based vaccine protects hamsters against lethal challenge with Andes virus. J Virol (2011) 1.26
Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation. Clin Infect Dis (2008) 1.23
Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge. Virology (2008) 1.21
A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment. J Virol (2010) 1.21
Nanopore Sequencing as a Rapidly Deployable Ebola Outbreak Tool. Emerg Infect Dis (2016) 1.20
Mutations in IL36RN in patients with generalized pustular psoriasis. J Invest Dermatol (2013) 1.17
Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck. Biochemistry (2002) 1.17
B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies. PLoS Pathog (2011) 1.16
Cytomegaloviral proteins that associate with the nuclear lamina: components of a postulated nuclear egress complex. J Gen Virol (2009) 1.16
The Ebola virus glycoprotein contributes to but is not sufficient for virulence in vivo. PLoS Pathog (2012) 1.16
Estrogen and progesterone receptors: from molecular structures to clinical targets. Cell Mol Life Sci (2009) 1.16
Novel mode of phosphorylation-triggered reorganization of the nuclear lamina during nuclear egress of human cytomegalovirus. J Biol Chem (2010) 1.14
Protein kinase inhibitors of the quinazoline class exert anti-cytomegaloviral activity in vitro and in vivo. Antiviral Res (2008) 1.14
The anti-malaria drug artesunate inhibits replication of cytomegalovirus in vitro and in vivo. Antiviral Res (2005) 1.14
CD and NMR studies of prion protein (PrP) helix 1. Novel implications for its role in the PrPC-->PrPSc conversion process. J Biol Chem (2003) 1.13
Variants in ASB10 are associated with open-angle glaucoma. Hum Mol Genet (2011) 1.12
Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models. Neurogenetics (2009) 1.10
Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor. Biochem Biophys Res Commun (2004) 1.10
The Ebola virus glycoprotein and HIV-1 Vpu employ different strategies to counteract the antiviral factor tetherin. J Infect Dis (2011) 1.10
The Merits of Malaria Diagnostics during an Ebola Virus Disease Outbreak. Emerg Infect Dis (2016) 1.08
A computational strategy for the prediction of functional linear peptide motifs in proteins. Bioinformatics (2007) 1.07
Independent NF1 and PTPN11 mutations in a family with neurofibromatosis-Noonan syndrome. Am J Med Genet A (2009) 1.07
Antibody quality and protection from lethal Ebola virus challenge in nonhuman primates immunized with rabies virus based bivalent vaccine. PLoS Pathog (2013) 1.07
Single immunization with a monovalent vesicular stomatitis virus-based vaccine protects nonhuman primates against heterologous challenge with Bundibugyo ebolavirus. J Infect Dis (2011) 1.03
Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I. Hum Mutat (2011) 1.03
Cytomegaloviral protein kinase pUL97 interacts with the nuclear mRNA export factor pUL69 to modulate its intranuclear localization and activity. J Gen Virol (2009) 1.02
De novo mutations in the genome organizer CTCF cause intellectual disability. Am J Hum Genet (2013) 1.01
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A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition. J Physiol (2010) 1.01
Profiling of WDR36 missense variants in German patients with glaucoma. Invest Ophthalmol Vis Sci (2008) 1.00
A dual phenotype of periventricular nodular heterotopia and frontometaphyseal dysplasia in one patient caused by a single FLNA mutation leading to two functionally different aberrant transcripts. Am J Hum Genet (2004) 1.00
Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme. Hum Mutat (2008) 1.00
Inhibition of Marburg virus budding by nonneutralizing antibodies to the envelope glycoprotein. J Virol (2012) 1.00
Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome. Mol Genet Metab (2008) 0.99
Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice. ACS Chem Neurosci (2010) 0.98
Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity. Protein Sci (2005) 0.97
Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons. Hum Mol Genet (2013) 0.96
Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution. Nucleic Acids Res (2006) 0.96
Binding, domain orientation, and dynamics of the Lck SH3-SH2 domain pair and comparison with other Src-family kinases. Biochemistry (2005) 0.95
Conformational switch upon phosphorylation: human CDK inhibitor p19INK4d between the native and partially folded state. ACS Chem Biol (2009) 0.94
Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53. J Biol Chem (2012) 0.94
Antiviral activity of Arthrospira-derived spirulan-like substances. Antiviral Res (2006) 0.94
Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. Genes Dev (2006) 0.93
Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. J Biol Chem (2003) 0.93
Differential contribution of EF-hands to the Ca²⁺-dependent activation in the plant two-pore channel TPC1. Plant J (2011) 0.93
Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs. J Mol Biol (2006) 0.93
Mapping of conserved and species-specific antibody epitopes on the Ebola virus nucleoprotein. Virus Res (2013) 0.92
Human cytomegalovirus kinetics following institution of artesunate after hematopoietic stem cell transplantation. Antiviral Res (2011) 0.91
Protective efficacy of a bivalent recombinant vesicular stomatitis virus vaccine in the Syrian hamster model of lethal Ebola virus infection. J Infect Dis (2011) 0.91
The unique antiviral activity of artesunate is broadly effective against human cytomegaloviruses including therapy-resistant mutants. Antiviral Res (2011) 0.91
Structure predictions and interaction studies indicate homology of separase N-terminal regulatory domains and Drosophila THR. Cell Cycle (2004) 0.91
Characterization of Lck-binding elements in the herpesviral regulatory Tip protein. Biochemistry (2004) 0.91
Impact of polymorphisms in the DC-SIGNR neck domain on the interaction with pathogens. Virology (2006) 0.91
Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors. J Virol (2004) 0.91