Published in BMC Neurosci on December 01, 2006
Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats. PLoS One (2010) 1.70
Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells. PLoS One (2014) 1.40
Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats. Chin Med (2010) 0.98
PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. Cell Logist (2012) 0.97
Tissue distribution of berberine and its metabolites after oral administration in rats. PLoS One (2013) 0.90
Decrease in the production of β-amyloid by berberine inhibition of the expression of β-secretase in HEK293 cells. BMC Neurosci (2011) 0.89
Molecular basis of inhibitory activities of berberine against pathogenic enzymes in Alzheimer's disease. ScientificWorldJournal (2012) 0.88
Low energy laser light (632.8 nm) suppresses amyloid-β peptide-induced oxidative and inflammatory responses in astrocytes. Neuroscience (2010) 0.84
Effect of berberine on depression- and anxiety-like behaviors and activation of the noradrenergic system induced by development of morphine dependence in rats. Korean J Physiol Pharmacol (2012) 0.84
Effects of berberine on β-secretase activity in a rabbit model of Alzheimer's disease. Arch Med Sci (2013) 0.83
Antinociceptive effect of berberine on visceral hypersensitivity in rats. World J Gastroenterol (2013) 0.82
Berberine promotes axonal regeneration in injured nerves of the peripheral nervous system. J Med Food (2012) 0.82
Phellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats. Korean J Physiol Pharmacol (2012) 0.81
Mitochondria and NMDA receptor-dependent toxicity of berberine sensitizes neurons to glutamate and rotenone injury. PLoS One (2014) 0.81
Therapeutic Effect of Berberine on Huntington's Disease Transgenic Mouse Model. PLoS One (2015) 0.79
Natural products as promising drug candidates for the treatment of Alzheimer's disease: molecular mechanism aspect. Curr Neuropharmacol (2013) 0.78
Berberine protects against light-induced photoreceptor degeneration in the mouse retina. Exp Eye Res (2015) 0.78
Neuroinflammation in overnutrition-induced diseases. Vitam Horm (2013) 0.78
Berberine Inhibits the Release of Glutamate in Nerve Terminals from Rat Cerebral Cortex. PLoS One (2013) 0.76
Disruption of neurogenesis by hypothalamic inflammation in obesity or aging. Rev Endocr Metab Disord (2013) 0.75
Comparison of Two Old Phytochemicals versus Two Newly Researched Plant-Derived Compounds: Potential for Brain and Other Relevant Ailments. Evid Based Complement Alternat Med (2014) 0.75
Protective Effects of Otophylloside N on Pentylenetetrazol-Induced Neuronal Injury In vitro and In vivo. Front Pharmacol (2016) 0.75
Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer's Disease Model Rats Induced by Aβ1-42. Evid Based Complement Alternat Med (2016) 0.75
Possible role of P-glycoprotein in the neuroprotective mechanism of berberine in intracerebroventricular streptozotocin-induced cognitive dysfunction. Psychopharmacology (Berl) (2015) 0.75
Role of berberine in Alzheimer's disease. Neuropsychiatr Dis Treat (2016) 0.75
Berberis vulgaris and its constituent berberine as antidotes and protective agents against natural or chemical toxicities. Iran J Basic Med Sci (2017) 0.75
Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats. Iran J Basic Med Sci (2017) 0.75
The Effects of Chunghyul-Dan, an Agent of Korean Medicine, on a Mouse Model of Traumatic Brain Injury. Evid Based Complement Alternat Med (2017) 0.75
Risk of cardiovascular events associated with selective COX-2 inhibitors. JAMA (2001) 13.93
Inflammation and Alzheimer's disease. Neurobiol Aging (2000) 12.56
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron (2006) 6.38
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA (2003) 6.34
Risk of Alzheimer's disease and duration of NSAID use. Neurology (1997) 4.06
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med (2004) 3.92
Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ (2003) 2.74
The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Lett (2004) 2.15
Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes. Nat Genet (2006) 2.09
Interleukin-1beta promotes repair of the CNS. J Neurosci (2001) 1.92
Effects of berberine on glucose metabolism in vitro. Metabolism (2002) 1.74
Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine. J Lipid Res (2006) 1.65
Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma. Biol Pharm Bull (2005) 1.64
Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway. Biochem Biophys Res Commun (2006) 1.63
Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacol Sin (2004) 1.45
Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice. Glia (2006) 1.41
Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids. Int J Immunopharmacol (1996) 1.34
Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study. Neurology (2000) 1.33
NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 1.27
Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner. J Neurosci (2006) 1.24
Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol (2003) 1.20
Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol (1999) 1.16
Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study. BMC Geriatr (2005) 1.03
Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. J Biomed Sci (2005) 1.02
Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury. Biochem Pharmacol (2006) 0.96
Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. Brain Res (2004) 0.96
Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice. Acta Pharmacol Sin (2005) 0.94
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids. Biosci Biotechnol Biochem (2002) 0.93
[Effect of berberine on the differentiation of adipocyte]. Zhonghua Yi Xue Za Zhi (2003) 0.92
Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model. Atherosclerosis (2005) 0.90
Anticachectic effects of Coptidis rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce interleukin 6. Cancer Lett (2000) 0.88
Effects of neutral sulfate berberine on LPS-induced cardiomyocyte TNF-alpha secretion, abnormal calcium cycling, and cardiac dysfunction in rats. Acta Pharmacol Sin (2006) 0.88
Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. Thromb Res (2002) 0.84
Activation of peritoneal macrophages by berberine-type alkaloids in terms of induction of cytostatic activity. Int J Immunopharmacol (1984) 0.83
Acetylcholinesterase inhibitors from Stephania venosa tuber. J Pharm Pharmacol (2006) 0.82
Potassium channels have a key role in neurodegeneration. Lancet Neurol (2006) 0.79
Cardiovascular risk and COX-2 inhibition in rheumatological practice. J Hum Hypertens (2005) 0.78