Published in Toxicol Sci on December 05, 2006
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A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. Free Radic Biol Med (2006) 1.04
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Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes. Toxicol Appl Pharmacol (2006) 0.92
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Mitochondrial permeability transition as a source of superoxide anion induced by the nitroaromatic drug nimesulide in vitro. Free Radic Biol Med (2005) 0.88
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Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction. Chem Biol Interact (2010) 0.85
Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity. Toxicol Appl Pharmacol (2009) 0.85
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Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury. Hepatology (2014) 0.82
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Integrative toxicoproteomics implicates impaired mitochondrial glutathione import as an off-target effect of troglitazone. J Proteome Res (2013) 0.77
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Nimesulide-induced electrophile stress activates Nrf2 in human hepatocytes and mice but is not sufficient to induce hepatotoxicity in Nrf2-deficient mice. Chem Res Toxicol (2010) 0.76
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Lipid peroxidation-independent mechanisms of vitamin e-mediated protection against cyclosporine a-induced hepatocellular toxicity and apoptosis. Toxicol Mech Methods (2003) 0.75