Published in Exp Neurol on December 08, 2006
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Mol Neurodegener (2011) 1.48
The vitamin nicotinamide: translating nutrition into clinical care. Molecules (2009) 1.36
The receptor that tames the innate immune response. Mol Med (2012) 1.19
Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies. Prog Neurobiol (2008) 1.13
Erythropoietin and oxidative stress. Curr Neurovasc Res (2008) 1.07
Oxidative stress: Biomarkers and novel therapeutic pathways. Exp Gerontol (2010) 1.04
Triple play: promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus. Biomed Pharmacother (2008) 1.02
Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia. Exp Neurol (2011) 1.00
Erythropoietin accelerates functional recovery after peripheral nerve injury. J Bone Joint Surg Am (2008) 0.99
The effect of erythropoietin on normal and neoplastic cells. Biologics (2012) 0.98
New strategies for Alzheimer's disease and cognitive impairment. Oxid Med Cell Longev (2010) 0.98
Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke. Neurobiol Dis (2010) 0.97
Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice. Exp Neurol (2007) 0.95
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX (2014) 0.94
Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor. J Neuroinflammation (2013) 0.92
Enhancement of ventricular-subventricular zone-derived neurogenesis and oligodendrogenesis by erythropoietin and its derivatives. Front Cell Neurosci (2013) 0.91
Prodeath or prosurvival: two facets of hypoxia inducible factor-1 in perinatal brain injury. Exp Neurol (2008) 0.91
Erythropoietin, forkhead proteins, and oxidative injury: biomarkers and biology. ScientificWorldJournal (2009) 0.90
Erythropoietin attenuates loss of potassium chloride co-transporters following prenatal brain injury. Mol Cell Neurosci (2014) 0.83
Comparison of Neurite Outgrowth Induced by Erythropoietin (EPO) and Carbamylated Erythropoietin (CEPO) in Hippocampal Neural Progenitor Cells. Korean J Physiol Pharmacol (2012) 0.79
Erythropoietin Modulates Cerebral and Serum Degradation Products from Excess Calpain Activation following Prenatal Hypoxia-Ischemia. Dev Neurosci (2015) 0.78
Excitotoxic insult results in a long-lasting activation of CaMKIIα and mitochondrial damage in living hippocampal neurons. PLoS One (2015) 0.78
Investigation of the protective effect of erythropoietin on spinal cord injury in rats. Exp Ther Med (2011) 0.77
Mapacalcine protects mouse neurons against hypoxia by blocking cell calcium overload. PLoS One (2013) 0.75
Neuroprotection and CD131/GDNF/AKT Pathway of Carbamylated Erythropoietin in Hypoxic Neurons. Mol Neurobiol (2016) 0.75
Direct conversion of human fibroblasts to dopaminergic neurons. Proc Natl Acad Sci U S A (2011) 4.81
Lysosomes in cell death. Oncogene (2004) 3.00
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol (2012) 2.17
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dis (2008) 2.13
The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation. ALTEX (2009) 1.97
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proc Natl Acad Sci U S A (2003) 1.88
Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells. Environ Health Perspect (2012) 1.70
Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair. Curr Drug Targets CNS Neurol Disord (2005) 1.64
The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions. J Neuroimmunol (2006) 1.57
Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents. Exp Neurol (2003) 1.54
Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbens. Neuropsychopharmacology (2004) 1.45
Toxicogenomics directory of chemically exposed human hepatocytes. Arch Toxicol (2014) 1.43
Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion. Cancer Res (2002) 1.40
Pathological apoptosis in the developing brain. Apoptosis (2007) 1.38
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. J Neurosci (2005) 1.31
Targeting chelatable iron as a therapeutic modality in Parkinson's disease. Antioxid Redox Signal (2014) 1.29
Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line. J Neurochem (2011) 1.27
Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia. Eur J Neurosci (2006) 1.25
Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity. Eur J Neurosci (2006) 1.22
Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo. Mol Med (2006) 1.21
Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives. J Cereb Blood Flow Metab (2006) 1.21
The Sonic hedgehog pathway mediates carbamylated erythropoietin-enhanced proliferation and differentiation of adult neural progenitor cells. J Biol Chem (2007) 1.20
Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection. J Immunol (2002) 1.19
Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures. J Neurosci (2005) 1.19
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*. ALTEX (2012) 1.15
Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice. Arch Toxicol (2013) 1.14
Neural transdifferentiation of mesenchymal stem cells--a critical review. APMIS (2006) 1.14
Food for thought ... on the evolution of toxicology and the phasing out of animal testing. ALTEX (2008) 1.13
Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice. Development (2007) 1.11
Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression. Brain Res (2003) 1.10
Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells. Toxicol Appl Pharmacol (2009) 1.09
Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. Hum Mol Genet (2012) 1.07
Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. ALTEX (2010) 1.06
Vesicular monoamine transporter 2 regulates the sensitivity of rat dopaminergic neurons to disturbed cytosolic dopamine levels. Brain Res (2007) 1.05
Sensitization to the lysosomal cell death pathway upon immortalization and transformation. Cancer Res (2004) 1.05
Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol (2014) 1.03
The network formation assay: a spatially standardized neurite outgrowth analytical display for neurotoxicity screening. Lab Chip (2010) 1.02
A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system. Stem Cells (2009) 1.01
The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function. J Neurochem (2006) 1.00
Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants. Arch Toxicol (2013) 1.00
From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol (2014) 1.00
The Center for Alternatives to Animal Testing - Europe (CAAT-EU): a transatlantic bridge for the paradigm shift in toxicology. ALTEX (2010) 0.99
Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite. J Biol Chem (2010) 0.99
Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD95-driven apoptosis. J Neurochem (2004) 0.97
Innate immunity and brain inflammation: the key role of complement. Expert Rev Mol Med (2003) 0.97
Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors. Proc Natl Acad Sci U S A (2010) 0.96
Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice. J Immunol (2010) 0.96
Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure. Toxicol Sci (2011) 0.95
Functional and immunochemical characterisation of different antibodies against the erythropoietin receptor. J Neurosci Methods (2007) 0.95
High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO). Thromb Haemost (2008) 0.95
Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis. J Cell Biol (2005) 0.95
Assessment of chemical-induced impairment of human neurite outgrowth by multiparametric live cell imaging in high-density cultures. Toxicol Sci (2011) 0.94
Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347. J Immunol (2004) 0.94
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX (2014) 0.94
Zbtb20-induced CA1 pyramidal neuron development and area enlargement in the cerebral midline cortex of mice. Cereb Cortex (2009) 0.93
The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy. ALTEX (2008) 0.93
TLR2 hypersensitivity of astrocytes as functional consequence of previous inflammatory episodes. J Immunol (2011) 0.93
Metabolomics in toxicology and preclinical research. ALTEX (2013) 0.93
Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies. J Neurochem (2013) 0.93
The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin. J Neurochem (2004) 0.93
The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans. ALTEX (2012) 0.93
Population control of resident and immigrant microglia by mitosis and apoptosis. Am J Pathol (2007) 0.92
Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis. Neuropharmacology (2005) 0.92
Compound selection for in vitro modeling of developmental neurotoxicity. Front Biosci (Landmark Ed) (2012) 0.91
Erythropoietin: not just about erythropoiesis. Lancet (2010) 0.90
Inhibition of microglial inflammation by the MLK inhibitor CEP-1347. J Neurochem (2005) 0.90
The dentate mossy fibers: structural organization, development and plasticity. Prog Brain Res (2007) 0.90
Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts. Neurotoxicology (2011) 0.90
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol (2015) 0.90
Colchicine induces apoptosis in organotypic hippocampal slice cultures. Brain Res (2003) 0.89
Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases. ALTEX (2013) 0.89
A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles. Arch Toxicol (2012) 0.89
Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention: assessment of currently available pharmacological tools. Eur J Pharmacol (2004) 0.88
Molecular basis for detection of invading pathogens in the brain. J Neurosci Res (2008) 0.88
Therapeutic window for nonerythropoietic carbamylated-erythropoietin to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits. Brain Res (2008) 0.88
Extensive transcriptional regulation of chromatin modifiers during human neurodevelopment. PLoS One (2012) 0.87
Asialoerythropoietin is not effective in the R6/2 line of Huntington's disease mice. BMC Neurosci (2004) 0.87
Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures. FASEB J (2003) 0.87
International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. Arch Toxicol (2015) 0.87
GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells. Glia (2011) 0.86
The assessment of repeated dose toxicity in vitro: a proposed approach. The report and recommendations of ECVAM workshop 56. Altern Lab Anim (2006) 0.86
Instruments for assessing risk of bias and other methodological criteria of animal studies: omission of well-established methods. Environ Health Perspect (2014) 0.86
Pilocarpine-induced seizure-like activity with increased BNDF and neuropeptide Y expression in organotypic hippocampal slice cultures. Brain Res (2002) 0.86
CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice. Eur J Pharmacol (2005) 0.86
Highlight report: towards the replacement of in vivo repeated dose systemic toxicity testing. Arch Toxicol (2012) 0.86
Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing. Arch Toxicol (2013) 0.85
Alpha-synuclein binds to the inner membrane of mitochondria in an α-helical conformation. Chembiochem (2014) 0.85
Uncoupling of ATP-depletion and cell death in human dopaminergic neurons. Neurotoxicology (2011) 0.85
Immunotoxic depletion of microglia in mouse hippocampal slice cultures enhances ischemia-like neurodegeneration. Brain Res (2009) 0.85
Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin. Brain Res (2002) 0.84
Critical evaluation of the use of dogs in biomedical research and testing in Europe. ALTEX (2011) 0.83
Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions. ALTEX (2012) 0.83