PubRank

B Tümmler

Author PubWeight™ 144.47‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440. Environ Microbiol 2002 8.11
2 Genome fingerprinting of Pseudomonas aeruginosa indicates colonization of cystic fibrosis siblings with closely related strains. J Clin Microbiol 1988 4.27
3 A major Pseudomonas aeruginosa clone common to patients and aquatic habitats. Appl Environ Microbiol 1994 3.02
4 Epidemiology of chronic Pseudomonas aeruginosa infections in cystic fibrosis. J Infect Dis 1994 2.64
5 A physical genome map of Pseudomonas aeruginosa PAO. EMBO J 1989 2.60
6 Achieving 100% typeability of Pseudomonas aeruginosa by pulsed-field gel electrophoresis. J Clin Microbiol 2000 2.41
7 Identification of Burkholderia spp. in the clinical microbiology laboratory: comparison of conventional and molecular methods. J Clin Microbiol 1999 2.36
8 Small-colony variants of Pseudomonas aeruginosa in cystic fibrosis. Clin Infect Dis 1999 2.18
9 Sequence diversity of Pseudomonas aeruginosa: impact on population structure and genome evolution. J Bacteriol 2000 1.98
10 New approaches in genome analysis by pulsed-field gel electrophoresis: application to the analysis of Pseudomonas species. Mol Microbiol 1991 1.98
11 DeltaF508 CFTR protein expression in tissues from patients with cystic fibrosis. J Clin Invest 1999 1.97
12 Comparative genome mapping of Pseudomonas aeruginosa PAO with P. aeruginosa C, which belongs to a major clone in cystic fibrosis patients and aquatic habitats. J Bacteriol 1996 1.93
13 Large genome rearrangements discovered by the detailed analysis of 21 Pseudomonas aeruginosa clone C isolates found in environment and disease habitats. J Mol Biol 1997 1.93
14 Concordant genotype of upper and lower airways P aeruginosa and S aureus isolates in cystic fibrosis. Thorax 2009 1.90
15 Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother 1986 1.83
16 Study of pyoverdine type and production by Pseudomonas aeruginosa isolated from cystic fibrosis patients: prevalence of type II pyoverdine isolates and accumulation of pyoverdine-negative mutations. Arch Microbiol 2001 1.73
17 A physical genome map of the Burkholderia cepacia type strain. Mol Microbiol 1995 1.73
18 Genomic mapping of Pseudomonas aeruginosa PAO. Microbiology 1994 1.69
19 Physical and genetic map of the Neisseria gonorrhoeae strain MS11-N198 chromosome. Mol Microbiol 1991 1.67
20 DNA concentration and length in sputum of patients with cystic fibrosis during inhalation with recombinant human DNase. Thorax 1995 1.67
21 Chloride conductance and genetic background modulate the cystic fibrosis phenotype of Delta F508 homozygous twins and siblings. J Clin Invest 2001 1.63
22 Genetic diversity of flagellins of Pseudomonas aeruginosa. FEBS Lett 1996 1.57
23 Physical genome analysis of bacteria. Electrophoresis 1993 1.56
24 Synthesis of multiple N-acylhomoserine lactones is wide-spread among the members of the Burkholderia cepacia complex. Syst Appl Microbiol 2001 1.54
25 Genetic determinants of airways' colonisation with Pseudomonas aeruginosa in cystic fibrosis. Lancet 1993 1.42
26 The impact of two-dimensional pulsed-field gel electrophoresis techniques for the consistent and complete mapping of bacterial genomes: refined physical map of Pseudomonas aeruginosa PAO. Nucleic Acids Res 1991 1.42
27 Clinical presentation of exclusive cystic fibrosis lung disease. Thorax 1999 1.39
28 Characterization of a novel 21-kb deletion, CFTRdele2,3(21 kb), in the CFTR gene: a cystic fibrosis mutation of Slavic origin common in Central and East Europe. Hum Genet 2000 1.37
29 Genome organization of Pseudomonas stutzeri and resulting taxonomic and evolutionary considerations. Int J Syst Bacteriol 1997 1.37
30 Rhamnolipid of Pseudomonas aeruginosa in sputum of cystic fibrosis patients. Lancet 1987 1.29
31 Categories of deltaF508 homozygous cystic fibrosis twin and sibling pairs with distinct phenotypic characteristics. Twin Res 2000 1.29
32 Monitoring genome evolution ex vivo: reversible chromosomal integration of a 106 kb plasmid at two tRNA(Lys) gene loci in sequential Pseudomonas aeruginosa airway isolates. Microbiology 2000 1.29
33 Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis. FEMS Microbiol Lett 2000 1.28
34 Chronic Pseudomonas aeruginosa infection definition: EuroCareCF Working Group report. J Cyst Fibros 2011 1.28
35 Gradient of genomic diversity in the Pseudomonas aeruginosa chromosome. Mol Microbiol 1995 1.24
36 Pulmonary exacerbation: towards a definition for use in clinical trials. Report from the EuroCareCF Working Group on outcome parameters in clinical trials. J Cyst Fibros 2011 1.23
37 Structural and functional implications of sequence diversity of Pseudomonas aeruginosa genes oriC, ampC and fliC. Electrophoresis 1998 1.21
38 Virulence factors of Pseudomonas aeruginosa. Antibiot Chemother (1971) 1987 1.21
39 Long-term tobramycin aerosol therapy in cystic fibrosis. Pediatr Pulmonol 1989 1.20
40 Quantitation of mRNA by the kinetic polymerase chain reaction assay: a tool for monitoring P-glycoprotein gene expression. Anal Biochem 1991 1.14
41 Safety and immunogenicity of an intranasal Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers. Vaccine 2001 1.12
42 Residual chloride secretion in intestinal tissue of deltaF508 homozygous twins and siblings with cystic fibrosis. The European CF Twin and Sibling Study Consortium. Gastroenterology 2000 1.10
43 CFTR and differentiation markers expression in non-CF and delta F 508 homozygous CF nasal epithelium. J Clin Invest 1995 1.10
44 Complex pattern of the myelo-monocytic differentiation antigens MRP8 and MRP14 during chronic airway inflammation. Immunobiology 1992 1.08
45 Pulsed-field gel electrophoresis analysis of a Pseudomonas aeruginosa pathovar. Electrophoresis 1993 1.08
46 Distinguishing species of the Burkholderia cepacia complex and Burkholderia gladioli by automated ribotyping. J Clin Microbiol 2000 1.07
47 Large chromosomal inversions occur in Pseudomonas aeruginosa clone C strains isolated from cystic fibrosis patients. FEMS Microbiol Lett 1997 1.06
48 Recommendations for quality improvement in genetic testing for cystic fibrosis. European Concerted Action on Cystic Fibrosis. Eur J Hum Genet 2000 1.06
49 Noncyclic crown-type polyethers, pyridinophane cryptands, and their alkali metal ion complexes: synthesis, complex stability, and kinetics. J Am Chem Soc 1977 1.04
50 Cystic fibrosis with three mutations in the cystic fibrosis transmembrane conductance regulator gene. Hum Genet 1991 1.03
51 Fatal outcome of lung transplantation in cystic fibrosis patients due to small-colony variants of the Burkholderia cepacia complex. Eur J Clin Microbiol Infect Dis 2003 1.01
52 Decreased expression of the CFTR protein in remodeled human nasal epithelium from non-cystic fibrosis patients. Lab Invest 1995 0.99
53 Comparison of type IV-pilin genes of Pseudomonas aeruginosa of various habitats has uncovered a novel unusual sequence. FEMS Microbiol Lett 1995 0.99
54 Treatment of pseudomonas aeruginosa colonisation in cystic fibrosis. Arch Dis Child 1989 0.99
55 Quantitative expression patterns of multidrug-resistance P-glycoprotein (MDR1) and differentially spliced cystic-fibrosis transmembrane-conductance regulator mRNA transcripts in human epithelia. Eur J Biochem 1992 0.98
56 Interdigitated gel phase bilayers formed by unsaturated synthetic and bacterial glycerolipids in the presence of polymyxin B and glycerol. Biochim Biophys Acta 1993 0.97
57 Cystic fibrosis-type mutational analysis in the ATP-binding cassette transporter signature of human P-glycoprotein MDR1. J Biol Chem 1994 0.97
58 Cystic-fibrosis-like disease unrelated to the cystic fibrosis transmembrane conductance regulator. Hum Genet 1998 0.96
59 A novel exon in the cystic fibrosis transmembrane conductance regulator gene activated by the nonsense mutation E92X in airway epithelial cells of patients with cystic fibrosis. J Clin Invest 1994 0.96
60 Genotype analysis of cystic fibrosis patients in relation to pancreatic sufficiency. Lancet 1990 0.96
61 A new missense mutation (E92K) in the first transmembrane domain of the CFTR gene causes a benign cystic fibrosis phenotype. Hum Mol Genet 1993 0.94
62 Disrespectful type IV pilins. Mol Microbiol 1997 0.94
63 Strategies of Pseudomonas aeruginosa to colonize and to persist in the cystic fibrosis lung. Scand J Gastroenterol Suppl 1988 0.93
64 Exon 9 of the CFTR gene: splice site haplotypes and cystic fibrosis mutations. Hum Genet 1994 0.93
65 Differential genome analysis of bacteria by genomic subtractive hybridization and pulsed field gel electrophoresis. Electrophoresis 1998 0.93
66 Four novel cystic fibrosis mutations in splice junction sequences affecting the CFTR nucleotide binding folds. Genomics 1993 0.93
67 A novel model for the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator. FEBS Lett 1997 0.93
68 Cloning of prokaryotic genomes in yeast artificial chromosomes: application to the population genetics of Pseudomonas aeruginosa. Electrophoresis 1998 0.93
69 Haplotype analysis of 94 cystic fibrosis mutations with seven polymorphic CFTR DNA markers. Hum Mutat 1996 0.92
70 Lung surfactant in a cystic fibrosis animal model: increased alveolar phospholipid pool size without altered composition and surface tension function in cftrm1HGU/m1HGU mice. Thorax 1997 0.90
71 Comparative hygienic surveillance of contamination with pseudomonads in a cystic fibrosis ward over a 4-year period. J Hosp Infect 1995 0.90
72 Diversity of the basic defect of homozygous CFTR mutation genotypes in humans. J Med Genet 2008 0.90
73 Whole DNA genome typing. Antibiot Chemother (1971) 1991 0.89
74 Transcript analysis of CFTR nonsense mutations in lymphocytes and nasal epithelial cells from cystic fibrosis patients. Hum Mutat 1995 0.89
75 Applicability of different antibodies for immunohistochemical localization of CFTR in sweat glands from healthy controls and from patients with cystic fibrosis. J Histochem Cytochem 2000 0.87
76 ATP depletion induces a loss of respiratory epithelium functional integrity and down-regulates CFTR (cystic fibrosis transmembrane conductance regulator) expression. J Biol Chem 1997 0.87
77 Interaction of polymyxin B nonapeptide with anionic phospholipids. Biochemistry 1987 0.87
78 Sinonasal persistence of Pseudomonas aeruginosa after lung transplantation. J Cyst Fibros 2011 0.87
79 Epidemiology of chronic Pseudomonas aeruginosa infections in the airways of lung transplant recipients with cystic fibrosis. Thorax 1997 0.86
80 Pulmonary microbial infection in mice: comparison of different application methods and correlation of bacterial numbers and histopathology. Exp Toxicol Pathol 2002 0.86
81 Direct sputum analysis of Pseudomonas aeruginosa macrorestriction fragment genotypes in patients with cystic fibrosis. Med Microbiol Immunol 1997 0.86
82 A HinfI polymorphism in the cystic fibrosis gene CFTR. Nucleic Acids Res 1991 0.85
83 Comparative mapping of the Pseudomonas aeruginosa PAO genome with rare-cutter linking clones or two-dimensional pulsed-field gel electrophoresis protocols. Electrophoresis 1993 0.85
84 Long-term tobramycin aerosol therapy of chronic Pseudomonas aeruginosa infection in patients with cystic fibrosis. Scand J Gastroenterol Suppl 1988 0.84
85 General method of rapid Smith/Birnstiel mapping adds for gap closure in shotgun microbial genome sequencing projects: application to Pseudomonas putida KT2440. Nucleic Acids Res 2001 0.84
86 Expression levels of FAS are regulated through an evolutionary conserved element in intron 2, which modulates cystic fibrosis disease severity. Genes Immun 2008 0.84
87 Friend or foe: genetic and functional characterization of plant endophytic Pseudomonas aeruginosa. Environ Microbiol 2012 0.83
88 A cystic fibrosis allele encoding missense mutations in both nucleotide binding folds of the cystic fibrosis transmembrane conductance regulator. Hum Mutat 1992 0.83
89 Bacterial genome mapping. J Biotechnol 1994 0.82
90 Pathogenicity islands and PAI-like structures in Pseudomonas species. Curr Top Microbiol Immunol 2002 0.82
91 Frequency of the F508 deletion in the CFTR gene in Turkish cystic fibrosis patients. Hum Genet 1990 0.82
92 Smith/Birnstiel mapping of genome rearrangements in Pseudomonas aeruginosa. Electrophoresis 1998 0.81
93 Localization of the iodomycin binding site in hamster P-glycoprotein. J Biol Chem 1997 0.81
94 Analysis of microsatellites by direct blotting electrophoresis and chemiluminescence detection. Electrophoresis 1995 0.81
95 Preparation and utility of a radioiodinated analogue of daunomycin in the study of multidrug resistance. Mol Pharmacol 1989 0.81
96 Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent rapamycin. Eur J Pharmacol 1993 0.80
97 Decreased expression of the cystic fibrosis transmembrane conductance regulator protein in remodeled airway epithelium from lung transplanted patients. Hum Pathol 1997 0.80
98 Fast kinetic analysis of drug transport in multidrug resistant cells using a pulsed quench-flow apparatus. Biochem Biophys Res Commun 1990 0.80
99 Sodium dependence of the epithelial sodium conductance expressed in Xenopus laevis oocytes. Pflugers Arch 1991 0.80
100 [Turkish infant with hypoelectrolytemia and metabolic alkalosis as the sole manifestations of a mild form of cystic fibrosis (mutation D110H)]. Klin Padiatr 2000 0.79
101 Immune response in cystic fibrosis to outer membrane proteins of Pseudomonas aeruginosa. Zentralbl Bakteriol Mikrobiol Hyg A 1988 0.79
102 Interdigitation of phosphatidylcholine and phosphatidylethanolamine mixed with complexes of acidic lipids and polymyxin B or polymyxin B nonapeptide. Biochim Biophys Acta 1989 0.79
103 A donor splice mutation (405 + 1 G-->A) in cystic fibrosis associated with exon skipping in epithelial CFTR mRNA. Hum Mol Genet 1993 0.79
104 A termination mutation (2143delT) in the CFTR gene of German cystic fibrosis patients. Hum Genet 1992 0.78
105 Pulsed field gel electrophoresis of bacterial DNA isolated directly from patients' sputa. Nucleic Acids Res 1995 0.78
106 A PacI/SwaI map of the Pseudomonas aeruginosa PAO chromosome. Electrophoresis 1993 0.78
107 A novel frame-shift mutation in exon 4 of the cystic fibrosis gene (435insA) demonstrates the ambiguity of restriction analysis for mutation screening. Hum Mol Genet 1992 0.78
108 Membrane permeability of Pseudomonas aeruginosa to 4-quinolones. Zentralbl Bakteriol Mikrobiol Hyg A 1987 0.78
109 Identification and localization of three photobinding sites of iodoarylazidoprazosin in hamster P-glycoprotein. Eur J Biochem 2001 0.78
110 Cystic fibrosis patients with the 3272-26A>G splicing mutation have milder disease than F508del homozygotes: a large European study. J Med Genet 2001 0.78
111 Selective expression of an amiloride-inhibitable Na+ conductance from mRNA of respiratory epithelium in Xenopus laevis oocytes. Am J Physiol 1989 0.78
112 Anthracenyl crown ethers and cryptands as fluorescent probes for solid-phase transitions of phosphatidylcholines: syntheses and phospholipid membrane studies. Biochemistry 1984 0.77
113 Buccal adherence of Pseudomonas aeruginosa in patients with cystic fibrosis under long-term therapy with azithromycin. Infection 2001 0.77
114 Characterization of the porcine transferrin gene (TF) and its association with disease severity following an experimental Actinobacillus pleuropneumoniae infection. Anim Genet 2009 0.77
115 Equilibrium, kinetic and photoaffinity labeling studies of daunomycin binding to P-glycoprotein-containing membranes of multidrug-resistant Chinese hamster ovary cells. Eur J Biochem 1989 0.77
116 Comparison of type IV-pilin genes of Pseudomonas aeruginosa of various habitats has uncovered a novel unusual sequence. FEMS Microbiol Lett 1995 0.77
117 Primary sequence of the human ribosomal protein L37a. Nucleic Acids Res 1992 0.77
118 Mild course of cystic fibrosis associated with heterozygosity for infrequent mutations in the first nucleotide-binding fold of CFTR. Acta Paediatr 1992 0.76
119 Genetic determinants in cystic fibrosis. Lancet 1991 0.75
120 Competitive inhibition of photoaffinity labelling of P-glycoprotein by anticancer drugs and modulators including S9788. Eur J Pharmacol 1996 0.75
121 [Theory and practice of macrorestriction analysis for the clonal analysis of pathogens]. Immun Infekt 1995 0.75
122 [Local immunization against P. aeruginosa with an outer-membrane-protein vaccine]. Pneumologie 1991 0.75
123 Complex mutation 4114 ATA-->TT in exon 22 of the cystic fibrosis gene CFTR. Hum Mutat 1993 0.75
124 Iodomycin and iodipine, a structural analogue of azidopine, bind to a common domain in hamster P-glycoprotein. Eur J Biochem 1999 0.75
125 Severe splice site mutation preceding exon 9 of the CFTR gene. Hum Mol Genet 1993 0.75
126 Open chain crown-type polyethers and pyridinophane cryptands act as ionophores upon frog motor nerve and isolated rat heart cells. Biochim Biophys Acta 1978 0.75
127 DNA typing of a cystic fibrosis family with borderline sweat tests. Acta Paediatr Scand 1988 0.75
128 Use of spin labels to determine the percentage of interdigitated lipid in complexes with polymyxin B and polymyxin B nonapeptide. Biochim Biophys Acta 1989 0.75
129 Segregation of cystic fibrosis allele. Nature 1988 0.75
130 [Cystic fibrosis: long-term treatment at a specialized centre, and its prognostic value (author's transl)]. Monatsschr Kinderheilkd 1982 0.75
131 A 32-bp deletion (2991del32) in the cystic fibrosis gene associated with CFTR mRNA reduction. Hum Mutat 1994 0.75
132 Kinetics of the subtransition of asymmetrically substituted phosphatidylcholines. Biochemistry 1984 0.75
133 Systematic study of the hydrolysis of 4-methylumbelliferylguanidinobenzoate in plasma from patients with cystic fibrosis and controls. Clin Chim Acta 1982 0.75
134 The golden age of bacterial genomics. Electrophoresis 1998 0.75
135 A gene regulating the time dependence of alpha-L-fucosidase concentration is closely linked with the structural gene in man. Hum Genet 1984 0.75