Published in ACS Chem Biol on August 22, 2006
Protein arginine methylation in mammals: who, what, and why. Mol Cell (2009) 7.44
Histone arginine methylation. FEBS Lett (2010) 1.95
Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation. Mol Endocrinol (2009) 1.95
Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential. Curr Opin Drug Discov Devel (2009) 1.83
Chemical mechanisms of histone lysine and arginine modifications. Biochim Biophys Acta (2008) 1.69
Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3. Biochemistry (2010) 1.66
Protein arginine deiminase 4: evidence for a reverse protonation mechanism. Biochemistry (2007) 1.45
Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation. Arthritis Rheum (2010) 1.39
Activation of PAD4 in NET formation. Front Immunol (2012) 1.30
Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe. J Am Chem Soc (2006) 1.24
The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid Redox Signal (2011) 1.24
From arginine methylation to ADMA: a novel mechanism with therapeutic potential in chronic lung diseases. BMC Pulm Med (2009) 1.24
The protein arginine deiminases: Structure, function, inhibition, and disease. Biopolymers (2013) 1.18
Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation. Chembiochem (2010) 1.13
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors. Bioorg Med Chem (2007) 1.11
Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production. Pharmacol Res (2009) 1.11
Kinase consensus sequences: a breeding ground for crosstalk. ACS Chem Biol (2011) 1.04
Accurate localization and relative quantification of arginine methylation using nanoflow liquid chromatography coupled to electron transfer dissociation and orbitrap mass spectrometry. J Am Soc Mass Spectrom (2008) 1.03
Reactivation of L1 retrotransposon by benzo(a)pyrene involves complex genetic and epigenetic regulation. Epigenetics (2011) 1.03
A combinatorial H4 tail library for exploring the histone code. Biochemistry (2008) 0.99
Chemical biology of protein arginine modifications in epigenetic regulation. Chem Rev (2015) 0.99
Post-translational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease. J Mol Neurosci (2008) 0.96
Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment. Lancet Neurol (2013) 0.96
Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11. Br J Pharmacol (2014) 0.94
Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis. Prog Neurobiol (2008) 0.91
Chemical and biological methods to detect post-translational modifications of arginine. Biopolymers (2014) 0.88
Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. Mol Biosyst (2011) 0.88
PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression. Nat Commun (2013) 0.87
D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS Med Chem Lett (2012) 0.86
Alterations of histone modifications by cobalt compounds. Carcinogenesis (2009) 0.86
Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4. ACS Chem Biol (2011) 0.86
Extensive and varied modifications in histone H2B of wild-type and histone deacetylase 1 mutant Neurospora crassa. Biochemistry (2010) 0.85
Promiscuous partitioning of a covalent intermediate common in the pentein superfamily. Chem Biol (2008) 0.85
Azalysine analogues as probes for protein lysine deacetylation and demethylation. J Am Chem Soc (2012) 0.84
Monitoring of protein arginine deiminase activity by using fluorescence quenching: multicolor visualization of citrullination. Angew Chem Int Ed Engl (2013) 0.83
Proteomic analysis of arginine methylation sites in human cells reveals dynamic regulation during transcriptional arrest. Mol Cell Proteomics (2014) 0.83
Phosphorylation-dependent interaction of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein (YWHA) with PADI6 following oocyte maturation in mice. Biol Reprod (2008) 0.83
Protein Arginine Methylation and Citrullination in Epigenetic Regulation. ACS Chem Biol (2015) 0.81
c-Myc mediates a hypoxia-induced decrease in acetylated histone H4. Biochimie (2009) 0.81
Ab initio QM/MM free-energy studies of arginine deiminase catalysis: the protonation state of the Cys nucleophile. J Phys Chem B (2011) 0.81
Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases. Nat Commun (2016) 0.80
Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation. Curr Drug Targets (2015) 0.79
Chemical Proteomic Platform To Identify Citrullinated Proteins. ACS Chem Biol (2015) 0.79
DNA Methylation: a New Player in Multiple Sclerosis. Mol Neurobiol (2016) 0.76
Comparative Monomethylarginine Proteomics Suggests that Protein Arginine Methyltransferase 1 (PRMT1) is a Significant Contributor to Arginine Monomethylation in Toxoplasma gondii. Mol Cell Proteomics (2017) 0.75
Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation. Cell Chem Biol (2016) 0.75
Development of substrate-selective probes for affinity pulldown of histone demethylases. ACS Chem Biol (2014) 0.75
Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase. Biochemistry (2005) 1.65
The quorum-quenching lactonase from Bacillus thuringiensis is a metalloprotein. Biochemistry (2005) 1.50
Substrate-assisted cysteine deprotonation in the mechanism of dimethylargininase (DDAH) from Pseudomonas aeruginosa. Biochemistry (2006) 1.34
Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis. Proc Natl Acad Sci U S A (2005) 1.34
Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 1. Product-bound structures. Biochemistry (2008) 1.22
Structure and specificity of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciens. Biochemistry (2007) 1.13
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide. Biochemistry (2009) 1.07
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia. J Biol Chem (2007) 1.06
Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis. Biochemistry (2005) 1.06
Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 2. Substrate modeling and active site mutations. Biochemistry (2008) 1.01
Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase. Protein Sci (2003) 1.01
Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53. J Biol Chem (2011) 1.01
Characterization of purified New Delhi metallo-β-lactamase-1. Biochemistry (2011) 1.01
Discovery of halopyridines as quiescent affinity labels: inactivation of dimethylarginine dimethylaminohydrolase. J Am Chem Soc (2011) 0.97
A universal, vector-based system for nucleic acid reading-frame selection. Protein Eng (2002) 0.96
Mechanistic similarity and diversity among the guanidine-modifying members of the pentein superfamily. Biochim Biophys Acta (2010) 0.95
On the mechanism of dimethylarginine dimethylaminohydrolase inactivation by 4-halopyridines. J Am Chem Soc (2011) 0.90
The quorum-quenching metallo-gamma-lactonase from Bacillus thuringiensis exhibits a leaving group thio effect. Biochemistry (2006) 0.90
Structural and functional modularity of proteins in the de novo purine biosynthetic pathway. Protein Sci (2009) 0.90
Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. Mol Biosyst (2011) 0.88
A click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase. J Am Chem Soc (2009) 0.88
Enzymic disruption of N-aroyl-L-homoserine lactone-based quorum sensing. Chembiochem (2010) 0.86
Rational design of a transition state analogue with picomolar affinity for Pseudomonas aeruginosa PvdQ, a siderophore biosynthetic enzyme. ACS Chem Biol (2013) 0.85
Promiscuous partitioning of a covalent intermediate common in the pentein superfamily. Chem Biol (2008) 0.85
A continuous spectrophotometric assay for dimethylarginine dimethylaminohydrolase. Anal Biochem (2005) 0.84
Screening for dimethylarginine dimethylaminohydrolase inhibitors reveals ebselen as a bioavailable inactivator. ACS Med Chem Lett (2011) 0.84
Arabidopsis thaliana mitochondrial glyoxalase 2-1 exhibits beta-lactamase activity. Biochemistry (2009) 0.84
Characterization of C-alkyl amidines as bioavailable covalent reversible inhibitors of human DDAH-1. ChemMedChem (2011) 0.83
A continuous, fluorescent, high-throughput assay for human dimethylarginine dimethylaminohydrolase-1. J Biomol Screen (2011) 0.83
n-Alkylboronic acid inhibitors reveal determinants of ligand specificity in the quorum-quenching and siderophore biosynthetic enzyme PvdQ. Biochemistry (2014) 0.81
Heterologous overexpression, purification, and in vitro characterization of AHL lactonases. Methods Mol Biol (2011) 0.79
Metal displacement and stoichiometry of protein-metal complexes under native conditions using capillary electrophoresis/mass spectrometry. Rapid Commun Mass Spectrom (2010) 0.79
Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase. Bioorg Med Chem (2012) 0.78
Structural and Biochemical Characterization of AidC, a Quorum-Quenching Lactonase with Atypical Selectivity. Biochemistry (2015) 0.78
An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening. Bioorg Med Chem (2013) 0.78
A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis. Biochemistry (2013) 0.78
Developing an irreversible inhibitor of human DDAH-1, an enzyme upregulated in melanoma. ChemMedChem (2014) 0.77
"Clicking" on the lights to reveal bacterial social networking. Chembiochem (2012) 0.77
Covalent inhibition of New Delhi metallo-β-lactamase-1 (NDM-1) by cefaclor. Chembiochem (2014) 0.76
Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ. ACS Chem Biol (2017) 0.75
Probing the interaction of Aspergillomarasmine A (AMA) with metallo-β-lactamases NDM-1, VIM-2, and IMP-7. ACS Infect Dis (2017) 0.75