Published in J Mol Endocrinol on December 01, 2006
Genes associated with membrane-initiated signaling of estrogen and energy homeostasis. Endocrinology (2008) 1.13
Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4. FEBS Lett (2011) 1.04
Protein kinase Cα (PKCα) regulates bone architecture and osteoblast activity. J Biol Chem (2014) 0.82
Cellular targets of estrogen signaling in regeneration of inner ear sensory epithelia. Hear Res (2009) 0.81
Evidence for gating roles of protein kinase A and protein kinase C in estradiol-induced luteinizing hormone receptor (lhcgr) expression in zebrafish ovarian follicle cells. PLoS One (2013) 0.76
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell (2010) 5.08
Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling. Mol Cell (2003) 4.67
Genetics, pathogenesis and complications of osteopetrosis. Bone (2007) 2.25
A six-gene signature predicting breast cancer lung metastasis. Cancer Res (2008) 2.09
Suppression of EGF-R signaling reduces the incidence of prostate cancer metastasis in nude mice. Endocr Relat Cancer (2006) 2.04
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL. Nat Genet (2007) 2.04
Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis. J Bone Miner Res (2003) 1.55
Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nat Med (2009) 1.52
Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis. Am J Pathol (2009) 1.46
Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes. EMBO J (2004) 1.42
A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains. Mol Cell (2002) 1.40
Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. Oncogene (2005) 1.36
Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism. Mol Cell Endocrinol (2006) 1.32
Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system. Arthritis Rheum (2006) 1.31
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans. J Clin Invest (2007) 1.29
Inhibition of protein kinase c-Src reduces the incidence of breast cancer metastases and increases survival in mice: implications for therapy. J Pharmacol Exp Ther (2006) 1.26
Bone metastasis: pathogenesis and therapeutic implications. Clin Exp Metastasis (2007) 1.23
Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice. J Cell Sci (2007) 1.20
Genotype-phenotype relationship in human ATP6i-dependent autosomal recessive osteopetrosis. Am J Pathol (2003) 1.09
Inhibition of protein kinase c-Src as a therapeutic approach for cancer and bone metastases. Anticancer Agents Med Chem (2008) 1.08
Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain. J Pain Res (2011) 1.08
A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells. J Cell Sci (2005) 1.06
IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease. Proc Natl Acad Sci U S A (2003) 1.06
Bone cells and the mechanisms of bone remodelling. Front Biosci (Elite Ed) (2012) 1.06
Osteoclast receptors and signaling. Arch Biochem Biophys (2008) 1.05
Osteomimicry: how tumor cells try to deceive the bone. Front Biosci (Schol Ed) (2010) 1.04
Imbalance of osteoclastogenesis-regulating factors in patients with celiac disease. J Bone Miner Res (2004) 1.04
Upstream open reading frames regulate the translation of the multiple mRNA variants of the estrogen receptor alpha. J Biol Chem (2002) 1.03
Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANKL/OPG ratio. J Cell Biochem (2007) 1.01
CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats. J Pain Res (2012) 1.00
The glycosaminoglycan-binding domain of PRELP acts as a cell type-specific NF-kappaB inhibitor that impairs osteoclastogenesis. J Cell Biol (2009) 0.99
Induction of autophagic cell death by a novel molecule is increased by hypoxia. Autophagy (2008) 0.99
Negative association between trunk fat, insulin resistance and skeleton in obese women. World J Diabetes (2013) 0.98
Mechanisms inducing low bone density in Duchenne muscular dystrophy in mice and humans. J Bone Miner Res (2011) 0.97
Effects of long-acting testosterone undecanoate on bone mineral density in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 36 months controlled study. Aging Male (2012) 0.96
Novel C16orf57 mutations in patients with Poikiloderma with Neutropenia: bioinformatic analysis of the protein and predicted effects of all reported mutations. Orphanet J Rare Dis (2012) 0.94
c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling. Nat Commun (2012) 0.94
Raloxifene modulates interleukin-6 and tumor necrosis factor-alpha synthesis in vivo: results from a pilot clinical study. J Clin Endocrinol Metab (2004) 0.93
Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats. Br J Pharmacol (2014) 0.93
Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice. J Bone Miner Res (2009) 0.92
E2-mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements. Mol Oncol (2008) 0.92
Receptor activator of NF-kappaB ligand enhances breast cancer-induced osteolytic lesions through upregulation of extracellular matrix metalloproteinase inducer/CD147. Cancer Res (2010) 0.92
Identification and subcellular localization of a new cystinosin isoform. Am J Physiol Renal Physiol (2008) 0.92
Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved Rotating Wall Vessel bioreactor (RWV). J Cell Biochem (2002) 0.91
In vivo bone metastases, osteoclastogenic ability, and phenotypic characterization of human breast cancer cells. Bone (2004) 0.91
Genetic risk factors in typical haemolytic uraemic syndrome. Nephrol Dial Transplant (2008) 0.90
Effect of titanium carbide coating on the osseointegration response in vitro and in vivo. Biomaterials (2007) 0.89
Recent advances in mesenchymal stem cell immunomodulation: the role of microvesicles. Cell Transplant (2013) 0.89
A new heterozygous mutation (R714C) of the osteopetrosis gene, pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts. J Bone Miner Res (2008) 0.89
Multivalent supramolecular dendrimer-based drugs. Biomacromolecules (2010) 0.88
An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity. Nat Biotechnol (2002) 0.88
Global transcriptome analysis in mouse calvarial osteoblasts highlights sets of genes regulated by modeled microgravity and identifies a "mechanoresponsive osteoblast gene signature". J Cell Biochem (2009) 0.88
Arterial aneurysms: autosomal dominant polycystic kidney disease, Marfan syndrome or both? Clin Exp Nephrol (2013) 0.87
Increase in cytosolic Ca2+ induced by elevation of extracellular Ca2+ in skeletal myogenic cells. Am J Physiol Cell Physiol (2002) 0.87
POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage and outcome in ovarian carcinomas. PLoS One (2010) 0.86
Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems. J Med Chem (2008) 0.85
Evaluation of metastatic potential in prostate carcinoma: an in vivo model. Int J Oncol (2004) 0.85
Polymorphisms of the CLCN7 gene are associated with BMD in women. J Bone Miner Res (2005) 0.85
Treatment of body composition changes in obese and overweight older adults: insight into the phenotype of sarcopenic obesity. Endocrine (2014) 0.84
Effectiveness of teriparatide treatment on back pain-related functional limitations in individuals affected by severe osteoporosis: a prospective pilot study. Clin Cases Miner Bone Metab (2012) 0.84
Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation. Bone (2004) 0.84
NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains. Mol Biol Cell (2012) 0.84
Estrogen induces repression of the breast cancer and salivary gland expression gene in an estrogen receptor alpha-dependent manner. Cancer Res (2008) 0.84
CLCN7 and TCIRG1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals. J Bone Miner Res (2014) 0.83
Evidence for the host contribution in the definition of preferential insertion sites of the elements of Bari 1 transposon family in Drosophila melanogaster. J Mol Evol (2002) 0.83
Increased expression of a set of genes enriched in oxygen binding function discloses a predisposition of breast cancer bone metastases to generate metastasis spread in multiple organs. J Bone Miner Res (2012) 0.83
Age-associated (cardio)metabolic diseases and cross-talk between adipose tissue and skeleton: endocrine aspects. Horm Mol Biol Clin Investig (2014) 0.82
Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression. BMC Cancer (2014) 0.82
Analysis of human alveolar osteoblast behavior on a nano-hydroxyapatite substrate: an in vitro study. BMC Oral Health (2014) 0.82
Expanding the role of Src and protein-tyrosine phosphatases balance in modulating osteoblast metabolism: lessons from mice. Biochimie (2010) 0.82
Design of novel three-phase PCL/TZ-HA biomaterials for use in bone regeneration applications. J Mater Sci Mater Med (2010) 0.81
Efficacy of CR3294, a new benzamidine derivative, in the prevention of 5-fluorouracil-induced gastrointestinal mucositis and diarrhea in mice. Cancer Chemother Pharmacol (2009) 0.81
Characterization and expression of different pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide receptors in rat ovarian follicles. J Endocrinol (2006) 0.81
Progress towards the identification of new aggrecanase inhibitors. Curr Med Chem (2009) 0.81
A novel promoter is involved in the expression of estrogen receptor alpha in human testis and epididymis. Endocrinology (2002) 0.81
Osteoblast-conditioned media stimulate membrane vesicle shedding in prostate cancer cells. Int J Oncol (2006) 0.81
Adipose, bone and muscle tissues as new endocrine organs: role of reciprocal regulation for osteoporosis and obesity development. Horm Mol Biol Clin Investig (2014) 0.81
Lipocalin 2: a new mechanoresponding gene regulating bone homeostasis. J Bone Miner Res (2015) 0.80
Habitual fish intake and clinically silent carotid atherosclerosis. Nutr J (2014) 0.80
Experimental pharmacology of glucosamine sulfate. Int J Rheumatol (2011) 0.80
The tight relationship between osteoclasts and the immune system. Inflamm Allergy Drug Targets (2012) 0.80
Exposure to phosphodiesterase type 5 inhibitors stimulates aromatase expression in human adipocytes in vitro. J Sex Med (2010) 0.80
Proline/arginine-rich end leucine-rich repeat protein N-terminus is a novel osteoclast antagonist that counteracts bone loss. J Bone Miner Res (2013) 0.80
Differential characteristics of bone quality and bone turnover biochemical markers in patients with hip fragility fractures and hip osteoarthritis: results of a clinical pilot study. Aging Clin Exp Res (2011) 0.79
Committed osteoclast precursors colonize the bone and improve the phenotype of a mouse model of autosomal recessive osteopetrosis. J Bone Miner Res (2010) 0.79