1
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Discovery of anticancer agents of diverse natural origin.
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Pure Appl Chem
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2009
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2.00
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2
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Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships.
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J Nat Prod
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2011
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1.81
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3
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Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention.
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Planta Med
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2007
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1.61
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4
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Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.
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Cancer Res
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2005
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1.61
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5
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New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid.
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J Nat Prod
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2005
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1.59
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6
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Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).
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Org Biomol Chem
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2003
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1.58
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7
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Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro.
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Cancer Res
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2006
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1.27
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8
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Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae.
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J Antibiot (Tokyo)
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2012
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1.24
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9
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Bioactive constituents of the stem bark of Mitrephora glabra.
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J Nat Prod
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2009
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1.23
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10
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Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320).
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J Nat Prod
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2011
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1.16
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11
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Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).
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J Nat Prod
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2013
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1.15
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12
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Synergistic antimicrobial activity of metabolites produced by a nonobligate bacterial predator.
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Antimicrob Agents Chemother
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2003
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1.12
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13
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Use of the in vivo hollow fiber assay in natural products anticancer drug discovery.
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J Nat Prod
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2009
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1.09
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14
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Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities.
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J Pept Sci
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2012
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1.06
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15
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Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
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J Nat Prod
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2004
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1.06
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16
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Peptaibols, tetramic acid derivatives, isocoumarins, and sesquiterpenes from a Bionectria sp. (MSX 47401).
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J Nat Prod
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2013
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0.99
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17
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Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.
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Planta Med
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2009
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0.98
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18
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Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales.
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Tetrahedron Lett
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2011
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0.97
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19
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Waol A, trans-dihydrowaol A, and cis-dihydrowaol A: polyketide-derived γ-lactones from a Volutella species.
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Tetrahedron Lett
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2013
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0.96
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20
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Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022).
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J Antibiot (Tokyo)
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2011
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0.95
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21
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A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra.
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Org Lett
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2005
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0.92
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22
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Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris.
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J Nat Prod
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2002
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0.91
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23
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Apoptotic anticancer effect of alvaradoin E isolated from Alvaradoa haitiensis.
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Anticancer Res
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2005
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0.90
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24
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Enhanced bioactivity of silybin B methylation products.
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Bioorg Med Chem
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2012
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0.87
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25
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Dereplication of macrocyclic trichothecenes from extracts of filamentous fungi through UV and NMR profiles.
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J Antibiot (Tokyo)
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2010
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0.87
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26
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Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales.
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Tetrahedron Lett
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2011
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0.87
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27
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Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient.
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Cancer Chemother Pharmacol
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2005
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0.86
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28
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Design, synthesis, and biological evaluation of antibody-drug conjugates comprised of potent camptothecin analogues.
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Bioconjug Chem
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2009
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0.85
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29
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Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex.
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Cancer Chemother Pharmacol
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2005
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0.84
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30
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Phytochemical studies and cytotoxicity evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum Feinbr (Colchicaceae): two native Jordanian meadow saffrons.
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Nat Prod Res
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2006
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0.83
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31
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Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis.
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J Nat Prod
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2007
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0.83
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32
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Camptothecin analogs in malignant gliomas: comparative analysis and characterization.
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J Neurosurg
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2003
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0.81
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33
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Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).
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J Agric Food Chem
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2007
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0.81
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34
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Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando.
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Arch Pharm Res
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2003
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0.80
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35
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Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi.
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Methods Mol Biol
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2012
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0.79
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36
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Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum.
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J Nat Prod
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2002
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0.79
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37
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The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH.
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Cancer Chemother Pharmacol
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2003
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0.79
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38
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BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors.
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Cancer Chemother Pharmacol
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2010
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0.77
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39
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Novel fluoro-substituted camptothecins: in vivo antitumor activity, reduced gastrointestinal toxicity and pharmacokinetic characterization.
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Cancer Chemother Pharmacol
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2005
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0.77
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40
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Diterpene glycosides from Egletes viscosa.
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Planta Med
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2005
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0.75
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41
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Analysis of herbal teas made from the leaves of comfrey (Symphytum officinale): reduction of N-oxides results in order of magnitude increases in the measurable concentration of pyrrolizidine alkaloids.
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Public Health Nutr
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2004
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0.75
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